The role of RNA interference in heterochromatic silencing View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-09

AUTHORS

Zachary Lippman, Rob Martienssen

ABSTRACT

Soon after its discovery 75 years ago, heterochromatin, a dense chromosomal material, was found to silence genes. But its importance in regulating gene expression was controversial. Long thought to be inert, heterochromatin is now known to give rise to small RNAs, which, by means of RNA interference, direct the modification of proteins and DNA in heterochromatic repeats and transposable elements. Heterochromatin has thus emerged as a key factor in epigenetic regulation of gene expression, chromosome behaviour and evolution. More... »

PAGES

364-370

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature02875

    DOI

    http://dx.doi.org/10.1038/nature02875

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039222604

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15372044


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