Genetic analysis of genome-wide variation in human gene expression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-08

AUTHORS

Michael Morley, Cliona M. Molony, Teresa M. Weber, James L. Devlin, Kathryn G. Ewens, Richard S. Spielman, Vivian G. Cheung

ABSTRACT

Natural variation in gene expression is extensive in humans and other organisms, and variation in the baseline expression level of many genes has a heritable component. To localize the genetic determinants of these quantitative traits (expression phenotypes) in humans, we used microarrays to measure gene expression levels and performed genome-wide linkage analysis for expression levels of 3,554 genes in 14 large families. For approximately 1,000 expression phenotypes, there was significant evidence of linkage to specific chromosomal regions. Both cis- and trans-acting loci regulate variation in the expression levels of genes, although most act in trans. Many gene expression phenotypes are influenced by several genetic determinants. Furthermore, we found hotspots of transcriptional regulation where significant evidence of linkage for several expression phenotypes (up to 31) coincides, and expression levels of many genes that share the same regulatory region are significantly correlated. The combination of microarray techniques for phenotyping and linkage analysis for quantitative traits allows the genetic mapping of determinants that contribute to variation in human gene expression. More... »

PAGES

743

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature02797

DOI

http://dx.doi.org/10.1038/nature02797

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042359509

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15269782


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Linkage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Children's Hospital of Philadelphia", 
          "id": "https://www.grid.ac/institutes/grid.239552.a", 
          "name": [
            "Department of Pediatrics, University of Pennsylvania", 
            "The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morley", 
        "givenName": "Michael", 
        "id": "sg:person.0652035552.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652035552.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Genetics, University of Pennsylvania"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Molony", 
        "givenName": "Cliona M.", 
        "id": "sg:person.01270542375.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270542375.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children's Hospital of Philadelphia", 
          "id": "https://www.grid.ac/institutes/grid.239552.a", 
          "name": [
            "Department of Pediatrics, University of Pennsylvania", 
            "The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weber", 
        "givenName": "Teresa M.", 
        "id": "sg:person.0773436044.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773436044.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Genetics, University of Pennsylvania"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Devlin", 
        "givenName": "James L.", 
        "id": "sg:person.01000715304.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000715304.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Genetics, University of Pennsylvania"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ewens", 
        "givenName": "Kathryn G.", 
        "id": "sg:person.01167127165.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167127165.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Genetics, University of Pennsylvania"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spielman", 
        "givenName": "Richard S.", 
        "id": "sg:person.01267777204.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267777204.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Children's Hospital of Philadelphia", 
          "id": "https://www.grid.ac/institutes/grid.239552.a", 
          "name": [
            "Department of Pediatrics, University of Pennsylvania", 
            "Department of Genetics, University of Pennsylvania", 
            "The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheung", 
        "givenName": "Vivian G.", 
        "id": "sg:person.01247117763.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247117763.17"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/1475-4924-1-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001591994", 
          "https://doi.org/10.1186/1475-4924-1-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013710656", 
          "https://doi.org/10.1038/ng1094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1094", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013710656", 
          "https://doi.org/10.1038/ng1094"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013881040", 
          "https://doi.org/10.1038/ng1036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013881040", 
          "https://doi.org/10.1038/ng1036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.112212199", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016844565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1069516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017387178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1056794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019683539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/79896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020624693", 
          "https://doi.org/10.1038/79896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/79896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020624693", 
          "https://doi.org/10.1038/79896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01066731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023647884", 
          "https://doi.org/10.1007/bf01066731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000072312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025736360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1088328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030171389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030965756", 
          "https://doi.org/10.1038/ng1222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030965756", 
          "https://doi.org/10.1038/ng1222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035744248", 
          "https://doi.org/10.1038/nature01434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035744248", 
          "https://doi.org/10.1038/nature01434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1195-241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040726560", 
          "https://doi.org/10.1038/ng1195-241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041343500", 
          "https://doi.org/10.1038/ng786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041343500", 
          "https://doi.org/10.1038/ng786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044334187", 
          "https://doi.org/10.1038/ng983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044334187", 
          "https://doi.org/10.1038/ng983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0888-7543(90)90491-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046245784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/10.10.1077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050135506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/302698", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058610264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/377137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058670231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/377137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058670231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/sqb.2003.68.403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060415984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1072545", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062446620"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-08", 
    "datePublishedReg": "2004-08-01", 
    "description": "Natural variation in gene expression is extensive in humans and other organisms, and variation in the baseline expression level of many genes has a heritable component. To localize the genetic determinants of these quantitative traits (expression phenotypes) in humans, we used microarrays to measure gene expression levels and performed genome-wide linkage analysis for expression levels of 3,554 genes in 14 large families. For approximately 1,000 expression phenotypes, there was significant evidence of linkage to specific chromosomal regions. Both cis- and trans-acting loci regulate variation in the expression levels of genes, although most act in trans. Many gene expression phenotypes are influenced by several genetic determinants. Furthermore, we found hotspots of transcriptional regulation where significant evidence of linkage for several expression phenotypes (up to 31) coincides, and expression levels of many genes that share the same regulatory region are significantly correlated. The combination of microarray techniques for phenotyping and linkage analysis for quantitative traits allows the genetic mapping of determinants that contribute to variation in human gene expression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature02797", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2519750", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "7001", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "430"
      }
    ], 
    "name": "Genetic analysis of genome-wide variation in human gene expression", 
    "pagination": "743", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c9c6da8c608296fb98a709484102b24502c7346aeb134f322855265695a42761"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15269782"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature02797"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042359509"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature02797", 
      "https://app.dimensions.ai/details/publication/pub.1042359509"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29203_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature02797"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature02797'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature02797'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature02797'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature02797'


 

This table displays all metadata directly associated to this object as RDF triples.

256 TRIPLES      21 PREDICATES      65 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature02797 schema:about N1e1079c65e9840598d86d20b717f2c3c
2 N316b30fae3d643faa4e6503684b251f4
3 N370ed2d3ee6748919f361c7ef6376e52
4 N40527ca2d373483e825073f9cd730f52
5 N59db1f7a1a20464a9b15eda7d7d6fc0d
6 N82a5090501c04db0b28a6a26f2ace9de
7 N86f165a542f74e1f80819e50555139cb
8 N94f34650d44149e495af942b5af937a0
9 N99613d1d1ac2475faade895be30a6f29
10 Nba6cf310eb1c417a9ddfd35b1593f567
11 Nbb6498a11a02426aba83b324dacfe4b5
12 Nd1481049d8a141489b57f710d5b0c571
13 Nd3f8594d9dcb40aebceb421f65fe5370
14 Ne65b0f8bdbf040a98e84952db0225d48
15 Nef8c306b97a24dd3aec80836662c480d
16 anzsrc-for:06
17 anzsrc-for:0604
18 schema:author Nec31f3238cc54bf2a60df9e095bc2db2
19 schema:citation sg:pub.10.1007/bf01066731
20 sg:pub.10.1038/79896
21 sg:pub.10.1038/nature01434
22 sg:pub.10.1038/ng1036
23 sg:pub.10.1038/ng1094
24 sg:pub.10.1038/ng1195-241
25 sg:pub.10.1038/ng1222
26 sg:pub.10.1038/ng786
27 sg:pub.10.1038/ng983
28 sg:pub.10.1186/1475-4924-1-5
29 https://doi.org/10.1016/0888-7543(90)90491-c
30 https://doi.org/10.1073/pnas.112212199
31 https://doi.org/10.1086/302698
32 https://doi.org/10.1086/377137
33 https://doi.org/10.1093/hmg/10.10.1077
34 https://doi.org/10.1101/sqb.2003.68.403
35 https://doi.org/10.1126/science.1056794
36 https://doi.org/10.1126/science.1069516
37 https://doi.org/10.1126/science.1072545
38 https://doi.org/10.1126/science.1088328
39 https://doi.org/10.1159/000072312
40 schema:datePublished 2004-08
41 schema:datePublishedReg 2004-08-01
42 schema:description Natural variation in gene expression is extensive in humans and other organisms, and variation in the baseline expression level of many genes has a heritable component. To localize the genetic determinants of these quantitative traits (expression phenotypes) in humans, we used microarrays to measure gene expression levels and performed genome-wide linkage analysis for expression levels of 3,554 genes in 14 large families. For approximately 1,000 expression phenotypes, there was significant evidence of linkage to specific chromosomal regions. Both cis- and trans-acting loci regulate variation in the expression levels of genes, although most act in trans. Many gene expression phenotypes are influenced by several genetic determinants. Furthermore, we found hotspots of transcriptional regulation where significant evidence of linkage for several expression phenotypes (up to 31) coincides, and expression levels of many genes that share the same regulatory region are significantly correlated. The combination of microarray techniques for phenotyping and linkage analysis for quantitative traits allows the genetic mapping of determinants that contribute to variation in human gene expression.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree true
46 schema:isPartOf N93ee074951484081a77345ce1501567b
47 N9d45eeeea6e04c60ab0a6844d8928933
48 sg:journal.1018957
49 schema:name Genetic analysis of genome-wide variation in human gene expression
50 schema:pagination 743
51 schema:productId N03c26820c0a64e69b479be6ff4c80e67
52 N12a45971a70743f6b601862d29010906
53 N765a0da8f210498b99459617a9e0b3fa
54 N9d9392cfd04b426185872b9513fa9b71
55 Nf390528ccf164a10baf62e4759162b9d
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042359509
57 https://doi.org/10.1038/nature02797
58 schema:sdDatePublished 2019-04-11T11:54
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher N870230b7b42a401c96becccddf6324e6
61 schema:url https://www.nature.com/articles/nature02797
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N03c26820c0a64e69b479be6ff4c80e67 schema:name nlm_unique_id
66 schema:value 0410462
67 rdf:type schema:PropertyValue
68 N12a45971a70743f6b601862d29010906 schema:name dimensions_id
69 schema:value pub.1042359509
70 rdf:type schema:PropertyValue
71 N18f5a1114cc84710a7042e20502a18c5 rdf:first sg:person.01270542375.51
72 rdf:rest N52c66d3c605c4c4ab44f684e36ea8571
73 N1e1079c65e9840598d86d20b717f2c3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Gene Expression Regulation
75 rdf:type schema:DefinedTerm
76 N316b30fae3d643faa4e6503684b251f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name RNA, Messenger
78 rdf:type schema:DefinedTerm
79 N339bf601f2fa49028e21f82960a92618 rdf:first sg:person.01267777204.49
80 rdf:rest Nb19a278f1ff24b4fa0d0c8477b940b68
81 N34d5735da6cf49c39363b045a4b84e0b rdf:first sg:person.01000715304.29
82 rdf:rest Na669a58e614d4ca2910b715f313d57ee
83 N370ed2d3ee6748919f361c7ef6376e52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Oligonucleotide Array Sequence Analysis
85 rdf:type schema:DefinedTerm
86 N40527ca2d373483e825073f9cd730f52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Alleles
88 rdf:type schema:DefinedTerm
89 N52c66d3c605c4c4ab44f684e36ea8571 rdf:first sg:person.0773436044.16
90 rdf:rest N34d5735da6cf49c39363b045a4b84e0b
91 N59db1f7a1a20464a9b15eda7d7d6fc0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Gene Expression Profiling
93 rdf:type schema:DefinedTerm
94 N765a0da8f210498b99459617a9e0b3fa schema:name pubmed_id
95 schema:value 15269782
96 rdf:type schema:PropertyValue
97 N78a0962f1a0641e8add0b91c187cc10a schema:name Department of Genetics, University of Pennsylvania
98 rdf:type schema:Organization
99 N7da0a8c090a14106a57872e5d74af091 schema:name Department of Genetics, University of Pennsylvania
100 rdf:type schema:Organization
101 N82a5090501c04db0b28a6a26f2ace9de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Genotype
103 rdf:type schema:DefinedTerm
104 N86f165a542f74e1f80819e50555139cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Genetic Variation
106 rdf:type schema:DefinedTerm
107 N870230b7b42a401c96becccddf6324e6 schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N8ace7e2e54ee4993972028bbd04d7eef schema:name Department of Genetics, University of Pennsylvania
110 rdf:type schema:Organization
111 N93ee074951484081a77345ce1501567b schema:volumeNumber 430
112 rdf:type schema:PublicationVolume
113 N94f34650d44149e495af942b5af937a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Genetic Linkage
115 rdf:type schema:DefinedTerm
116 N99613d1d1ac2475faade895be30a6f29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Genome, Human
118 rdf:type schema:DefinedTerm
119 N9d45eeeea6e04c60ab0a6844d8928933 schema:issueNumber 7001
120 rdf:type schema:PublicationIssue
121 N9d9392cfd04b426185872b9513fa9b71 schema:name doi
122 schema:value 10.1038/nature02797
123 rdf:type schema:PropertyValue
124 Na669a58e614d4ca2910b715f313d57ee rdf:first sg:person.01167127165.52
125 rdf:rest N339bf601f2fa49028e21f82960a92618
126 Nb19a278f1ff24b4fa0d0c8477b940b68 rdf:first sg:person.01247117763.17
127 rdf:rest rdf:nil
128 Nba6cf310eb1c417a9ddfd35b1593f567 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Polymorphism, Single Nucleotide
130 rdf:type schema:DefinedTerm
131 Nbb6498a11a02426aba83b324dacfe4b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Humans
133 rdf:type schema:DefinedTerm
134 Nd1481049d8a141489b57f710d5b0c571 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Transcription, Genetic
136 rdf:type schema:DefinedTerm
137 Nd3f8594d9dcb40aebceb421f65fe5370 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Genomics
139 rdf:type schema:DefinedTerm
140 Nddc3cbd5f2f4401caaedf8107efedd7d schema:name Department of Genetics, University of Pennsylvania
141 rdf:type schema:Organization
142 Ne65b0f8bdbf040a98e84952db0225d48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Phenotype
144 rdf:type schema:DefinedTerm
145 Nec31f3238cc54bf2a60df9e095bc2db2 rdf:first sg:person.0652035552.18
146 rdf:rest N18f5a1114cc84710a7042e20502a18c5
147 Nef8c306b97a24dd3aec80836662c480d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name B-Lymphocytes
149 rdf:type schema:DefinedTerm
150 Nf390528ccf164a10baf62e4759162b9d schema:name readcube_id
151 schema:value c9c6da8c608296fb98a709484102b24502c7346aeb134f322855265695a42761
152 rdf:type schema:PropertyValue
153 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
154 schema:name Biological Sciences
155 rdf:type schema:DefinedTerm
156 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
157 schema:name Genetics
158 rdf:type schema:DefinedTerm
159 sg:grant.2519750 http://pending.schema.org/fundedItem sg:pub.10.1038/nature02797
160 rdf:type schema:MonetaryGrant
161 sg:journal.1018957 schema:issn 0090-0028
162 1476-4687
163 schema:name Nature
164 rdf:type schema:Periodical
165 sg:person.01000715304.29 schema:affiliation N8ace7e2e54ee4993972028bbd04d7eef
166 schema:familyName Devlin
167 schema:givenName James L.
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000715304.29
169 rdf:type schema:Person
170 sg:person.01167127165.52 schema:affiliation N7da0a8c090a14106a57872e5d74af091
171 schema:familyName Ewens
172 schema:givenName Kathryn G.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167127165.52
174 rdf:type schema:Person
175 sg:person.01247117763.17 schema:affiliation https://www.grid.ac/institutes/grid.239552.a
176 schema:familyName Cheung
177 schema:givenName Vivian G.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247117763.17
179 rdf:type schema:Person
180 sg:person.01267777204.49 schema:affiliation N78a0962f1a0641e8add0b91c187cc10a
181 schema:familyName Spielman
182 schema:givenName Richard S.
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267777204.49
184 rdf:type schema:Person
185 sg:person.01270542375.51 schema:affiliation Nddc3cbd5f2f4401caaedf8107efedd7d
186 schema:familyName Molony
187 schema:givenName Cliona M.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270542375.51
189 rdf:type schema:Person
190 sg:person.0652035552.18 schema:affiliation https://www.grid.ac/institutes/grid.239552.a
191 schema:familyName Morley
192 schema:givenName Michael
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652035552.18
194 rdf:type schema:Person
195 sg:person.0773436044.16 schema:affiliation https://www.grid.ac/institutes/grid.239552.a
196 schema:familyName Weber
197 schema:givenName Teresa M.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773436044.16
199 rdf:type schema:Person
200 sg:pub.10.1007/bf01066731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023647884
201 https://doi.org/10.1007/bf01066731
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/79896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020624693
204 https://doi.org/10.1038/79896
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/nature01434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035744248
207 https://doi.org/10.1038/nature01434
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/ng1036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013881040
210 https://doi.org/10.1038/ng1036
211 rdf:type schema:CreativeWork
212 sg:pub.10.1038/ng1094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013710656
213 https://doi.org/10.1038/ng1094
214 rdf:type schema:CreativeWork
215 sg:pub.10.1038/ng1195-241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040726560
216 https://doi.org/10.1038/ng1195-241
217 rdf:type schema:CreativeWork
218 sg:pub.10.1038/ng1222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030965756
219 https://doi.org/10.1038/ng1222
220 rdf:type schema:CreativeWork
221 sg:pub.10.1038/ng786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041343500
222 https://doi.org/10.1038/ng786
223 rdf:type schema:CreativeWork
224 sg:pub.10.1038/ng983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044334187
225 https://doi.org/10.1038/ng983
226 rdf:type schema:CreativeWork
227 sg:pub.10.1186/1475-4924-1-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001591994
228 https://doi.org/10.1186/1475-4924-1-5
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/0888-7543(90)90491-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1046245784
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1073/pnas.112212199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016844565
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1086/302698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058610264
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1086/377137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058670231
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1093/hmg/10.10.1077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050135506
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1101/sqb.2003.68.403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060415984
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1126/science.1056794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019683539
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1126/science.1069516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017387178
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1126/science.1072545 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062446620
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1126/science.1088328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030171389
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1159/000072312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025736360
251 rdf:type schema:CreativeWork
252 https://www.grid.ac/institutes/grid.239552.a schema:alternateName Children's Hospital of Philadelphia
253 schema:name Department of Genetics, University of Pennsylvania
254 Department of Pediatrics, University of Pennsylvania
255 The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
256 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...