Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-07

AUTHORS

K. S. Li, Y. Guan, J. Wang, G. J. D. Smith, K. M. Xu, L. Duan, A. P. Rahardjo, P. Puthavathana, C. Buranathai, T. D. Nguyen, A. T. S. Estoepangestie, A. Chaisingh, P. Auewarakul, H. T. Long, N. T. H. Hanh, R. J. Webby, L. L. M. Poon, H. Chen, K. F. Shortridge, K. Y. Yuen, R. G. Webster, J. S. M. Peiris

ABSTRACT

A highly pathogenic avian influenza virus, H5N1, caused disease outbreaks in poultry in China and seven other east Asian countries between late 2003 and early 2004; the same virus was fatal to humans in Thailand and Vietnam1. Here we demonstrate a series of genetic reassortment events traceable to the precursor of the H5N1 viruses that caused the initial human outbreak in Hong Kong in 1997 (refs 2–4) and subsequent avian outbreaks in 2001 and 2002 (refs 5, 6). These events gave rise to a dominant H5N1 genotype (Z) in chickens and ducks that was responsible for the regional outbreak in 2003–04. Our findings indicate that domestic ducks in southern China had a central role in the generation and maintenance of this virus, and that wild birds may have contributed to the increasingly wide spread of the virus in Asia. Our results suggest that H5N1 viruses with pandemic potential have become endemic in the region and are not easily eradicable. These developments pose a threat to public and veterinary health in the region and potentially the world, and suggest that long-term control measures are required. More... »

PAGES

209-213

Journal

TITLE

Nature

ISSUE

6996

VOLUME

430

Related Patents

  • Influenza Hemagglutinin And Neuraminidase Variants
  • Influenza Virus Replication For Vaccine Development
  • High Titer Recombinant Influenza Viruses With Enhanced Replication In Vero Cells
  • Vaccines Against Multiple Subtypes Of Influenza Virus
  • Novel Vaccines Against Multiple Subtypes Of Influenza Virus
  • Functional Influenza Virus-Like Particles (Vlps)
  • Influenza Hemagglutinin And Neuraminidase Variants
  • Modified Influenza Virus For Monitoring And Improving Vaccine Efficiency
  • High Titer Recombinant Influenza Viruses For Vaccines
  • High Titer Recombinant Influenza Viruses With Enhanced Replication In Mdck Or Vero Cells Or Eggs
  • Functional Influenza Virus Like Particles (Vlps)
  • Modified Influenza Virus For Monitoring And Improving Vaccine Efficiency
  • Influenza M2 Protein Mutant Viruses As Live Influenza Attenuated Vaccines
  • Functional Influenza Virus Like Particles (Vlps)
  • Functional Influenza Virus-Like Particles (Vlps)
  • Functional Influenza Virus Like Particles (Vlps)
  • High Titer Recombinant Influenza Viruses With Enhanced Replication In Mdck Or Vero Cells Or Eggs
  • Functional Influenza Virus-Like Particles (Vlps)
  • Highly Efficient Influenza Matrix (M1) Proteins
  • Functional Influenza Virus-Like Particles (Vlps)
  • Mutations That Confer Genetic Stability To Additional Genes In Influenza Viruses
  • Mutations That Confer Genetic Stability To Additional Genes In Influenza Viruses
  • High Titer Recombinant Influenza Viruses With Enhanced Replication In Vero Cells
  • Functional Influenza Virus-Like Particles (Vlps)
  • High Titer Recombinant Influenza Viruses With Enhanced Replication In Vero Cells
  • Functional Influenza Virus-Like Particles (Vlps)
  • Influenza Virus Replication For Vaccine Development
  • Modified Influenza Virus For Monitoring And Improving Vaccine Efficiency
  • Vaccines Against Multiple Subtypes Of Influenza Virus
  • Highly Efficient Influenza Matrix (M1) Proteins
  • Influenza Hemagglutinin And Neuraminidase Variants
  • Functional Influenza Virus Like Particles (Vlps)
  • Functional Influenza Virus-Like Particles (Vlps)
  • Functional Influenza Virus-Like Particles (Vlps)
  • Vaccines Comprising Mutant Attenuated Influenza Viruses
  • Influenza Hemagglutinin And Neuraminidase Variants
  • Highly Efficient Influenza Matrix (M1) Proteins
  • Influenza Hemagglutinin And Neuraminidase Variants
  • Influenza Hemagglutinin And Neuraminidase Variants
  • Modified Influenza Virus For Monitoring And Improving Vaccine Efficiency
  • Avian Influenza Viruses, Vaccines, Compositions, Formulations, And Methods
  • Highly Efficient Influenza Matrix (M1) Proteins
  • High Titer Recombinant Influenza Viruses With Enhanced Replication In Vero Cells
  • Functional Influenza Virus Like Particles (Vlps)
  • Functional Influenza Virus-Like Particles (Vlps)
  • Influenza Hemagglutinin And Neuraminidase Variants
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature02746

    DOI

    http://dx.doi.org/10.1038/nature02746

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023946802

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15241415


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Birds", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Evolution, Molecular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Far East", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes, Viral", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Influenza, Human", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Orthomyxoviridae", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phylogeny", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reassortant Viruses", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Time Factors", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Joint Influenza Research Centre (SUMC & HKU), Shantou University Medical College, 515031, Shantou, Guangdong, China", 
              "id": "http://www.grid.ac/institutes/grid.411679.c", 
              "name": [
                "Joint Influenza Research Centre (SUMC & HKU), Shantou University Medical College, 515031, Shantou, Guangdong, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "K. S.", 
            "id": "sg:person.01103266565.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103266565.67"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong", 
              "id": "http://www.grid.ac/institutes/grid.194645.b", 
              "name": [
                "Joint Influenza Research Centre (SUMC & HKU), Shantou University Medical College, 515031, Shantou, Guangdong, China", 
                "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Guan", 
            "givenName": "Y.", 
            "id": "sg:person.0726247752.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726247752.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong", 
              "id": "http://www.grid.ac/institutes/grid.194645.b", 
              "name": [
                "Joint Influenza Research Centre (SUMC & HKU), Shantou University Medical College, 515031, Shantou, Guangdong, China", 
                "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "J.", 
            "id": "sg:person.012357752614.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012357752614.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong", 
              "id": "http://www.grid.ac/institutes/grid.194645.b", 
              "name": [
                "Joint Influenza Research Centre (SUMC & HKU), Shantou University Medical College, 515031, Shantou, Guangdong, China", 
                "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Smith", 
            "givenName": "G. J. D.", 
            "id": "sg:person.016356542404.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016356542404.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong", 
              "id": "http://www.grid.ac/institutes/grid.194645.b", 
              "name": [
                "Joint Influenza Research Centre (SUMC & HKU), Shantou University Medical College, 515031, Shantou, Guangdong, China", 
                "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Xu", 
            "givenName": "K. M.", 
            "id": "sg:person.01036531750.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036531750.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong", 
              "id": "http://www.grid.ac/institutes/grid.194645.b", 
              "name": [
                "Joint Influenza Research Centre (SUMC & HKU), Shantou University Medical College, 515031, Shantou, Guangdong, China", 
                "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Duan", 
            "givenName": "L.", 
            "id": "sg:person.01372276757.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372276757.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Fakultas Kedokteran Hewan, Universitas Airlangga, 60115, Surabaya, Indonesia", 
              "id": "http://www.grid.ac/institutes/grid.440745.6", 
              "name": [
                "Fakultas Kedokteran Hewan, Universitas Airlangga, 60115, Surabaya, Indonesia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rahardjo", 
            "givenName": "A. P.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, Sriraj Hospital, 10700, Bangkok, Thailand", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Microbiology, Sriraj Hospital, 10700, Bangkok, Thailand"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Puthavathana", 
            "givenName": "P.", 
            "id": "sg:person.016263714337.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016263714337.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Livestock Development, National Institute of Animal Health, 10900, Bangkok, Thailand", 
              "id": "http://www.grid.ac/institutes/grid.494092.2", 
              "name": [
                "Department of Livestock Development, National Institute of Animal Health, 10900, Bangkok, Thailand"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Buranathai", 
            "givenName": "C.", 
            "id": "sg:person.01360150677.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360150677.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Virology, National Institute of Veterinary Research, Ministry of Agriculture and Rural Development, Hanoi, Vietnam", 
              "id": "http://www.grid.ac/institutes/grid.419675.8", 
              "name": [
                "Department of Virology, National Institute of Veterinary Research, Ministry of Agriculture and Rural Development, Hanoi, Vietnam"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nguyen", 
            "givenName": "T. D.", 
            "id": "sg:person.07616542067.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07616542067.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Fakultas Kedokteran Hewan, Universitas Airlangga, 60115, Surabaya, Indonesia", 
              "id": "http://www.grid.ac/institutes/grid.440745.6", 
              "name": [
                "Fakultas Kedokteran Hewan, Universitas Airlangga, 60115, Surabaya, Indonesia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Estoepangestie", 
            "givenName": "A. T. S.", 
            "id": "sg:person.016517006560.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016517006560.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Livestock Development, National Institute of Animal Health, 10900, Bangkok, Thailand", 
              "id": "http://www.grid.ac/institutes/grid.494092.2", 
              "name": [
                "Department of Livestock Development, National Institute of Animal Health, 10900, Bangkok, Thailand"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chaisingh", 
            "givenName": "A.", 
            "id": "sg:person.0575514447.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575514447.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, Sriraj Hospital, 10700, Bangkok, Thailand", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Microbiology, Sriraj Hospital, 10700, Bangkok, Thailand"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Auewarakul", 
            "givenName": "P.", 
            "id": "sg:person.0677304045.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677304045.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Virology Department, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam", 
              "id": "http://www.grid.ac/institutes/grid.419597.7", 
              "name": [
                "Virology Department, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Long", 
            "givenName": "H. T.", 
            "id": "sg:person.011321503072.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011321503072.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Virology Department, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam", 
              "id": "http://www.grid.ac/institutes/grid.419597.7", 
              "name": [
                "Virology Department, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hanh", 
            "givenName": "N. T. H.", 
            "id": "sg:person.016126703003.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016126703003.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Virology Division, Department of Infectious Diseases, St Jude Children's Research Hospital, 38105, Memphis, Tennessee, USA", 
              "id": "http://www.grid.ac/institutes/grid.240871.8", 
              "name": [
                "Virology Division, Department of Infectious Diseases, St Jude Children's Research Hospital, 38105, Memphis, Tennessee, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Webby", 
            "givenName": "R. J.", 
            "id": "sg:person.07474250137.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07474250137.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong", 
              "id": "http://www.grid.ac/institutes/grid.194645.b", 
              "name": [
                "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Poon", 
            "givenName": "L. L. M.", 
            "id": "sg:person.014333042622.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014333042622.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong", 
              "id": "http://www.grid.ac/institutes/grid.194645.b", 
              "name": [
                "Joint Influenza Research Centre (SUMC & HKU), Shantou University Medical College, 515031, Shantou, Guangdong, China", 
                "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "H.", 
            "id": "sg:person.013531143517.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013531143517.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong", 
              "id": "http://www.grid.ac/institutes/grid.194645.b", 
              "name": [
                "Joint Influenza Research Centre (SUMC & HKU), Shantou University Medical College, 515031, Shantou, Guangdong, China", 
                "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shortridge", 
            "givenName": "K. F.", 
            "id": "sg:person.013003156324.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013003156324.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong", 
              "id": "http://www.grid.ac/institutes/grid.194645.b", 
              "name": [
                "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yuen", 
            "givenName": "K. Y.", 
            "id": "sg:person.012312344764.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012312344764.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Virology Division, Department of Infectious Diseases, St Jude Children's Research Hospital, 38105, Memphis, Tennessee, USA", 
              "id": "http://www.grid.ac/institutes/grid.240871.8", 
              "name": [
                "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong", 
                "Virology Division, Department of Infectious Diseases, St Jude Children's Research Hospital, 38105, Memphis, Tennessee, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Webster", 
            "givenName": "R. G.", 
            "id": "sg:person.011634667077.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011634667077.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong", 
              "id": "http://www.grid.ac/institutes/grid.194645.b", 
              "name": [
                "Joint Influenza Research Centre (SUMC & HKU), Shantou University Medical College, 515031, Shantou, Guangdong, China", 
                "Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peiris", 
            "givenName": "J. S. M.", 
            "id": "sg:person.015115705164.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015115705164.25"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature01679", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020073694", 
              "https://doi.org/10.1038/nature01679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038677764", 
              "https://doi.org/10.1038/nm757"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2004-07", 
        "datePublishedReg": "2004-07-01", 
        "description": "A highly pathogenic avian influenza virus, H5N1, caused disease outbreaks in poultry in China and seven other east Asian countries between late 2003 and early 2004; the same virus was fatal to humans in Thailand and Vietnam1. Here we demonstrate a series of genetic reassortment events traceable to the precursor of the H5N1 viruses that caused the initial human outbreak in Hong Kong in 1997 (refs 2\u20134) and subsequent avian outbreaks in 2001 and 2002 (refs 5, 6). These events gave rise to a dominant H5N1 genotype (Z) in chickens and ducks that was responsible for the regional outbreak in 2003\u201304. Our findings indicate that domestic ducks in southern China had a central role in the generation and maintenance of this virus, and that wild birds may have contributed to the increasingly wide spread of the virus in Asia. Our results suggest that H5N1 viruses with pandemic potential have become endemic in the region and are not easily eradicable. These developments pose a threat to public and veterinary health in the region and potentially the world, and suggest that long-term control measures are required.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nature02746", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6996", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "430"
          }
        ], 
        "keywords": [
          "pathogenic avian influenza virus", 
          "long-term control measures", 
          "avian influenza viruses", 
          "genetic reassortment events", 
          "influenza virus", 
          "avian outbreaks", 
          "veterinary health", 
          "wild birds", 
          "disease outbreaks", 
          "domestic ducks", 
          "regional outbreaks", 
          "H5N1 virus", 
          "human outbreaks", 
          "control measures", 
          "reassortment events", 
          "southern China", 
          "pandemic potential", 
          "outbreak", 
          "same virus", 
          "ducks", 
          "eastern Asia", 
          "poultry", 
          "virus", 
          "Asian countries", 
          "Asia", 
          "H5N1", 
          "genotypes", 
          "chickens", 
          "wide spread", 
          "East Asian countries", 
          "Vietnam1", 
          "China", 
          "birds", 
          "threat", 
          "Thailand", 
          "spread", 
          "region", 
          "potential", 
          "countries", 
          "health", 
          "world", 
          "humans", 
          "maintenance", 
          "development", 
          "measures", 
          "generation", 
          "results", 
          "central role", 
          "role", 
          "events", 
          "findings", 
          "rise", 
          "series", 
          "Hong Kong", 
          "Kong", 
          "precursors", 
          "genesis", 
          "initial human outbreak", 
          "subsequent avian outbreaks", 
          "dominant H5N1 genotype", 
          "H5N1 genotype"
        ], 
        "name": "Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia", 
        "pagination": "209-213", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1023946802"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature02746"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "15241415"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature02746", 
          "https://app.dimensions.ai/details/publication/pub.1023946802"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-11-01T18:07", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_383.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nature02746"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature02746'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature02746'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature02746'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature02746'


     

    This table displays all metadata directly associated to this object as RDF triples.

    356 TRIPLES      22 PREDICATES      104 URIs      94 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature02746 schema:about N013f02cd8aa74aaeb94e44d1448d92c6
    2 N115a5f9b991c4abab686435bfeb3b704
    3 N38a8e67396f44f09bb5b5c2fa4dcbc94
    4 N40f0af4d5df442dc821c3e2699d09612
    5 N5af190a94f084a7ca5db5d3d9a4184dd
    6 N60f1d64961bd4f188b531792df49acb5
    7 N71e5f158a6fd4e17a0a2d0ee955846d9
    8 N74f00784682940eda1297097bfee3777
    9 N971fcb135b8d4283af978fe3d8c440e2
    10 N9e4d01a63ac4443f8dd11a2256eb0dd7
    11 Nbf718eca567940be9b22b0cda38335a2
    12 Ncedaf006d5be4df9ad3b52b251d9f0be
    13 Nec4b9a8aad474e45bbbeab97ad3e047d
    14 Nf08e1a6ec72042949cfd609a25e5b5c3
    15 anzsrc-for:11
    16 anzsrc-for:1108
    17 schema:author Nbaf6f966e29a4d4092e2d54271e4c9ea
    18 schema:citation sg:pub.10.1038/nature01679
    19 sg:pub.10.1038/nm757
    20 schema:datePublished 2004-07
    21 schema:datePublishedReg 2004-07-01
    22 schema:description A highly pathogenic avian influenza virus, H5N1, caused disease outbreaks in poultry in China and seven other east Asian countries between late 2003 and early 2004; the same virus was fatal to humans in Thailand and Vietnam1. Here we demonstrate a series of genetic reassortment events traceable to the precursor of the H5N1 viruses that caused the initial human outbreak in Hong Kong in 1997 (refs 2–4) and subsequent avian outbreaks in 2001 and 2002 (refs 5, 6). These events gave rise to a dominant H5N1 genotype (Z) in chickens and ducks that was responsible for the regional outbreak in 2003–04. Our findings indicate that domestic ducks in southern China had a central role in the generation and maintenance of this virus, and that wild birds may have contributed to the increasingly wide spread of the virus in Asia. Our results suggest that H5N1 viruses with pandemic potential have become endemic in the region and are not easily eradicable. These developments pose a threat to public and veterinary health in the region and potentially the world, and suggest that long-term control measures are required.
    23 schema:genre article
    24 schema:inLanguage en
    25 schema:isAccessibleForFree false
    26 schema:isPartOf N2d390d9bfa35427cad2dd0f9cef45330
    27 N8330938373a749ffa25de2065b1f5789
    28 sg:journal.1018957
    29 schema:keywords Asia
    30 Asian countries
    31 China
    32 East Asian countries
    33 H5N1
    34 H5N1 genotype
    35 H5N1 virus
    36 Hong Kong
    37 Kong
    38 Thailand
    39 Vietnam1
    40 avian influenza viruses
    41 avian outbreaks
    42 birds
    43 central role
    44 chickens
    45 control measures
    46 countries
    47 development
    48 disease outbreaks
    49 domestic ducks
    50 dominant H5N1 genotype
    51 ducks
    52 eastern Asia
    53 events
    54 findings
    55 generation
    56 genesis
    57 genetic reassortment events
    58 genotypes
    59 health
    60 human outbreaks
    61 humans
    62 influenza virus
    63 initial human outbreak
    64 long-term control measures
    65 maintenance
    66 measures
    67 outbreak
    68 pandemic potential
    69 pathogenic avian influenza virus
    70 potential
    71 poultry
    72 precursors
    73 reassortment events
    74 region
    75 regional outbreaks
    76 results
    77 rise
    78 role
    79 same virus
    80 series
    81 southern China
    82 spread
    83 subsequent avian outbreaks
    84 threat
    85 veterinary health
    86 virus
    87 wide spread
    88 wild birds
    89 world
    90 schema:name Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia
    91 schema:pagination 209-213
    92 schema:productId N373dcf90aa8b4e4da470f204863d52e2
    93 N75b4009021a144e1bb062056300654d1
    94 Ncb35e80cfc504e0599af2720c921600f
    95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023946802
    96 https://doi.org/10.1038/nature02746
    97 schema:sdDatePublished 2021-11-01T18:07
    98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    99 schema:sdPublisher N785dc0064439445995d3b149fde23e76
    100 schema:url https://doi.org/10.1038/nature02746
    101 sgo:license sg:explorer/license/
    102 sgo:sdDataset articles
    103 rdf:type schema:ScholarlyArticle
    104 N013f02cd8aa74aaeb94e44d1448d92c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Time Factors
    106 rdf:type schema:DefinedTerm
    107 N018469a81a7547f79e560df77c2c2f28 rdf:first sg:person.011321503072.47
    108 rdf:rest Na09c78b96a2743d59e08dcec97f3501b
    109 N0ef22cfcd0f542d89310dd68b45ad337 rdf:first sg:person.015115705164.25
    110 rdf:rest rdf:nil
    111 N115a5f9b991c4abab686435bfeb3b704 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Animals
    113 rdf:type schema:DefinedTerm
    114 N198c81c9f61a4c42b664b590db077c29 rdf:first sg:person.013003156324.94
    115 rdf:rest N56d619201ce747d4b4e95d2fc3e170de
    116 N2d390d9bfa35427cad2dd0f9cef45330 schema:issueNumber 6996
    117 rdf:type schema:PublicationIssue
    118 N2f52069460f7484da4a8c5661c7711b7 rdf:first sg:person.01360150677.53
    119 rdf:rest Nc5395b0c24644fda8baccb4ab5fc74b7
    120 N373dcf90aa8b4e4da470f204863d52e2 schema:name pubmed_id
    121 schema:value 15241415
    122 rdf:type schema:PropertyValue
    123 N38a8e67396f44f09bb5b5c2fa4dcbc94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Influenza, Human
    125 rdf:type schema:DefinedTerm
    126 N39a7edca98c2419181a5b8d64a051659 rdf:first sg:person.01372276757.99
    127 rdf:rest N3a21b2c04e1640e68eadb45d8ecc50e2
    128 N3a21b2c04e1640e68eadb45d8ecc50e2 rdf:first Nc03dad4fd1df4b25bd3b5d959214771b
    129 rdf:rest N9ed17dd595e04a8298f4170859f7a040
    130 N40f0af4d5df442dc821c3e2699d09612 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Genes, Viral
    132 rdf:type schema:DefinedTerm
    133 N56d619201ce747d4b4e95d2fc3e170de rdf:first sg:person.012312344764.63
    134 rdf:rest N578fa8e1c1e34538b5f9e42b1e60f050
    135 N578fa8e1c1e34538b5f9e42b1e60f050 rdf:first sg:person.011634667077.27
    136 rdf:rest N0ef22cfcd0f542d89310dd68b45ad337
    137 N5af190a94f084a7ca5db5d3d9a4184dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Reassortant Viruses
    139 rdf:type schema:DefinedTerm
    140 N60f1d64961bd4f188b531792df49acb5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Birds
    142 rdf:type schema:DefinedTerm
    143 N6653820ad70d4367995242b2d7a87b7e rdf:first sg:person.0677304045.32
    144 rdf:rest N018469a81a7547f79e560df77c2c2f28
    145 N71e5f158a6fd4e17a0a2d0ee955846d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Mutation
    147 rdf:type schema:DefinedTerm
    148 N74f00784682940eda1297097bfee3777 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Evolution, Molecular
    150 rdf:type schema:DefinedTerm
    151 N75b4009021a144e1bb062056300654d1 schema:name dimensions_id
    152 schema:value pub.1023946802
    153 rdf:type schema:PropertyValue
    154 N785dc0064439445995d3b149fde23e76 schema:name Springer Nature - SN SciGraph project
    155 rdf:type schema:Organization
    156 N7a81c1e4ff48491fa01f2ba432aa336e rdf:first sg:person.0575514447.11
    157 rdf:rest N6653820ad70d4367995242b2d7a87b7e
    158 N8330938373a749ffa25de2065b1f5789 schema:volumeNumber 430
    159 rdf:type schema:PublicationVolume
    160 N836853fa742e4f3295c9aff07077edaa rdf:first sg:person.013531143517.04
    161 rdf:rest N198c81c9f61a4c42b664b590db077c29
    162 N8911affe605445858f48adffc99de6df rdf:first sg:person.016356542404.96
    163 rdf:rest Nd30b8b4dedc74f5d9734301a0cf70026
    164 N8a5d1f6185a6450abe3786dfd2c5b34e rdf:first sg:person.0726247752.75
    165 rdf:rest Nf039cfa6d8134fe0ad2d421a4fd644e2
    166 N971fcb135b8d4283af978fe3d8c440e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Genotype
    168 rdf:type schema:DefinedTerm
    169 N9e4d01a63ac4443f8dd11a2256eb0dd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Humans
    171 rdf:type schema:DefinedTerm
    172 N9ed17dd595e04a8298f4170859f7a040 rdf:first sg:person.016263714337.68
    173 rdf:rest N2f52069460f7484da4a8c5661c7711b7
    174 Na09c78b96a2743d59e08dcec97f3501b rdf:first sg:person.016126703003.50
    175 rdf:rest Nd212b1c631204602b73ef5cf121a7654
    176 Nbaf6f966e29a4d4092e2d54271e4c9ea rdf:first sg:person.01103266565.67
    177 rdf:rest N8a5d1f6185a6450abe3786dfd2c5b34e
    178 Nbf718eca567940be9b22b0cda38335a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Phylogeny
    180 rdf:type schema:DefinedTerm
    181 Nc03dad4fd1df4b25bd3b5d959214771b schema:affiliation grid-institutes:grid.440745.6
    182 schema:familyName Rahardjo
    183 schema:givenName A. P.
    184 rdf:type schema:Person
    185 Nc0c5b1a206414d9093db6ec36aa006a3 rdf:first sg:person.014333042622.05
    186 rdf:rest N836853fa742e4f3295c9aff07077edaa
    187 Nc5395b0c24644fda8baccb4ab5fc74b7 rdf:first sg:person.07616542067.42
    188 rdf:rest Nf95a3af7da084ba8aadd4cf52cadac53
    189 Ncb35e80cfc504e0599af2720c921600f schema:name doi
    190 schema:value 10.1038/nature02746
    191 rdf:type schema:PropertyValue
    192 Ncedaf006d5be4df9ad3b52b251d9f0be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Far East
    194 rdf:type schema:DefinedTerm
    195 Nd212b1c631204602b73ef5cf121a7654 rdf:first sg:person.07474250137.77
    196 rdf:rest Nc0c5b1a206414d9093db6ec36aa006a3
    197 Nd30b8b4dedc74f5d9734301a0cf70026 rdf:first sg:person.01036531750.33
    198 rdf:rest N39a7edca98c2419181a5b8d64a051659
    199 Nec4b9a8aad474e45bbbeab97ad3e047d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Molecular Sequence Data
    201 rdf:type schema:DefinedTerm
    202 Nf039cfa6d8134fe0ad2d421a4fd644e2 rdf:first sg:person.012357752614.68
    203 rdf:rest N8911affe605445858f48adffc99de6df
    204 Nf08e1a6ec72042949cfd609a25e5b5c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Orthomyxoviridae
    206 rdf:type schema:DefinedTerm
    207 Nf95a3af7da084ba8aadd4cf52cadac53 rdf:first sg:person.016517006560.19
    208 rdf:rest N7a81c1e4ff48491fa01f2ba432aa336e
    209 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    210 schema:name Medical and Health Sciences
    211 rdf:type schema:DefinedTerm
    212 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
    213 schema:name Medical Microbiology
    214 rdf:type schema:DefinedTerm
    215 sg:journal.1018957 schema:issn 0028-0836
    216 1476-4687
    217 schema:name Nature
    218 schema:publisher Springer Nature
    219 rdf:type schema:Periodical
    220 sg:person.01036531750.33 schema:affiliation grid-institutes:grid.194645.b
    221 schema:familyName Xu
    222 schema:givenName K. M.
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036531750.33
    224 rdf:type schema:Person
    225 sg:person.01103266565.67 schema:affiliation grid-institutes:grid.411679.c
    226 schema:familyName Li
    227 schema:givenName K. S.
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103266565.67
    229 rdf:type schema:Person
    230 sg:person.011321503072.47 schema:affiliation grid-institutes:grid.419597.7
    231 schema:familyName Long
    232 schema:givenName H. T.
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011321503072.47
    234 rdf:type schema:Person
    235 sg:person.011634667077.27 schema:affiliation grid-institutes:grid.240871.8
    236 schema:familyName Webster
    237 schema:givenName R. G.
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011634667077.27
    239 rdf:type schema:Person
    240 sg:person.012312344764.63 schema:affiliation grid-institutes:grid.194645.b
    241 schema:familyName Yuen
    242 schema:givenName K. Y.
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012312344764.63
    244 rdf:type schema:Person
    245 sg:person.012357752614.68 schema:affiliation grid-institutes:grid.194645.b
    246 schema:familyName Wang
    247 schema:givenName J.
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012357752614.68
    249 rdf:type schema:Person
    250 sg:person.013003156324.94 schema:affiliation grid-institutes:grid.194645.b
    251 schema:familyName Shortridge
    252 schema:givenName K. F.
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013003156324.94
    254 rdf:type schema:Person
    255 sg:person.013531143517.04 schema:affiliation grid-institutes:grid.194645.b
    256 schema:familyName Chen
    257 schema:givenName H.
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013531143517.04
    259 rdf:type schema:Person
    260 sg:person.01360150677.53 schema:affiliation grid-institutes:grid.494092.2
    261 schema:familyName Buranathai
    262 schema:givenName C.
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360150677.53
    264 rdf:type schema:Person
    265 sg:person.01372276757.99 schema:affiliation grid-institutes:grid.194645.b
    266 schema:familyName Duan
    267 schema:givenName L.
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372276757.99
    269 rdf:type schema:Person
    270 sg:person.014333042622.05 schema:affiliation grid-institutes:grid.194645.b
    271 schema:familyName Poon
    272 schema:givenName L. L. M.
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014333042622.05
    274 rdf:type schema:Person
    275 sg:person.015115705164.25 schema:affiliation grid-institutes:grid.194645.b
    276 schema:familyName Peiris
    277 schema:givenName J. S. M.
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015115705164.25
    279 rdf:type schema:Person
    280 sg:person.016126703003.50 schema:affiliation grid-institutes:grid.419597.7
    281 schema:familyName Hanh
    282 schema:givenName N. T. H.
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016126703003.50
    284 rdf:type schema:Person
    285 sg:person.016263714337.68 schema:affiliation grid-institutes:None
    286 schema:familyName Puthavathana
    287 schema:givenName P.
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016263714337.68
    289 rdf:type schema:Person
    290 sg:person.016356542404.96 schema:affiliation grid-institutes:grid.194645.b
    291 schema:familyName Smith
    292 schema:givenName G. J. D.
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016356542404.96
    294 rdf:type schema:Person
    295 sg:person.016517006560.19 schema:affiliation grid-institutes:grid.440745.6
    296 schema:familyName Estoepangestie
    297 schema:givenName A. T. S.
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016517006560.19
    299 rdf:type schema:Person
    300 sg:person.0575514447.11 schema:affiliation grid-institutes:grid.494092.2
    301 schema:familyName Chaisingh
    302 schema:givenName A.
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575514447.11
    304 rdf:type schema:Person
    305 sg:person.0677304045.32 schema:affiliation grid-institutes:None
    306 schema:familyName Auewarakul
    307 schema:givenName P.
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677304045.32
    309 rdf:type schema:Person
    310 sg:person.0726247752.75 schema:affiliation grid-institutes:grid.194645.b
    311 schema:familyName Guan
    312 schema:givenName Y.
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726247752.75
    314 rdf:type schema:Person
    315 sg:person.07474250137.77 schema:affiliation grid-institutes:grid.240871.8
    316 schema:familyName Webby
    317 schema:givenName R. J.
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07474250137.77
    319 rdf:type schema:Person
    320 sg:person.07616542067.42 schema:affiliation grid-institutes:grid.419675.8
    321 schema:familyName Nguyen
    322 schema:givenName T. D.
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07616542067.42
    324 rdf:type schema:Person
    325 sg:pub.10.1038/nature01679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020073694
    326 https://doi.org/10.1038/nature01679
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/nm757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038677764
    329 https://doi.org/10.1038/nm757
    330 rdf:type schema:CreativeWork
    331 grid-institutes:None schema:alternateName Department of Microbiology, Sriraj Hospital, 10700, Bangkok, Thailand
    332 schema:name Department of Microbiology, Sriraj Hospital, 10700, Bangkok, Thailand
    333 rdf:type schema:Organization
    334 grid-institutes:grid.194645.b schema:alternateName Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong
    335 schema:name Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong
    336 Joint Influenza Research Centre (SUMC & HKU), Shantou University Medical College, 515031, Shantou, Guangdong, China
    337 rdf:type schema:Organization
    338 grid-institutes:grid.240871.8 schema:alternateName Virology Division, Department of Infectious Diseases, St Jude Children's Research Hospital, 38105, Memphis, Tennessee, USA
    339 schema:name Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, SAR, China, Hong Kong
    340 Virology Division, Department of Infectious Diseases, St Jude Children's Research Hospital, 38105, Memphis, Tennessee, USA
    341 rdf:type schema:Organization
    342 grid-institutes:grid.411679.c schema:alternateName Joint Influenza Research Centre (SUMC & HKU), Shantou University Medical College, 515031, Shantou, Guangdong, China
    343 schema:name Joint Influenza Research Centre (SUMC & HKU), Shantou University Medical College, 515031, Shantou, Guangdong, China
    344 rdf:type schema:Organization
    345 grid-institutes:grid.419597.7 schema:alternateName Virology Department, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
    346 schema:name Virology Department, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
    347 rdf:type schema:Organization
    348 grid-institutes:grid.419675.8 schema:alternateName Department of Virology, National Institute of Veterinary Research, Ministry of Agriculture and Rural Development, Hanoi, Vietnam
    349 schema:name Department of Virology, National Institute of Veterinary Research, Ministry of Agriculture and Rural Development, Hanoi, Vietnam
    350 rdf:type schema:Organization
    351 grid-institutes:grid.440745.6 schema:alternateName Fakultas Kedokteran Hewan, Universitas Airlangga, 60115, Surabaya, Indonesia
    352 schema:name Fakultas Kedokteran Hewan, Universitas Airlangga, 60115, Surabaya, Indonesia
    353 rdf:type schema:Organization
    354 grid-institutes:grid.494092.2 schema:alternateName Department of Livestock Development, National Institute of Animal Health, 10900, Bangkok, Thailand
    355 schema:name Department of Livestock Development, National Institute of Animal Health, 10900, Bangkok, Thailand
    356 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...