Epigenetics in human disease and prospects for epigenetic therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-05

AUTHORS

Gerda Egger, Gangning Liang, Ana Aparicio, Peter A Jones

ABSTRACT

Epigenetic mechanisms, which involve DNA and histone modifications, result in the heritable silencing of genes without a change in their coding sequence. The study of human disease has focused on genetic mechanisms, but disruption of the balance of epigenetic networks can cause several major pathologies, including cancer, syndromes involving chromosomal instabilities, and mental retardation. The development of new diagnostic tools might reveal other diseases that are caused by epigenetic alterations. Great potential lies in the development of 'epigenetic therapies'--several inhibitors of enzymes controlling epigenetic modifications, specifically DNA methyltransferases and histone deacetylases, have shown promising anti-tumorigenic effects for some malignancies. More... »

PAGES

457-463

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature02625

    DOI

    http://dx.doi.org/10.1038/nature02625

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019871284

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15164071


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