Susceptibility to leprosy is associated with PARK2 and PACRG View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-02

AUTHORS

Marcelo T. Mira, Alexandre Alcaïs, Nguyen Van Thuc, Milton O. Moraes, Celestino Di Flumeri, Vu Hong Thai, Mai Chi Phuong, Nguyen Thu Huong, Nguyen Ngoc Ba, Pham Xuan Khoa, Euzenir N. Sarno, Andrea Alter, Alexandre Montpetit, Maria E. Moraes, José R. Moraes, Carole Doré, Caroline J. Gallant, Pierre Lepage, Andrei Verner, Esther van de Vosse, Thomas J. Hudson, Laurent Abel, Erwin Schurr

ABSTRACT

Leprosy is caused by Mycobacterium leprae and affects about 700,000 individuals each year. It has long been thought that leprosy has a strong genetic component, and recently we mapped a leprosy susceptibility locus to chromosome 6 region q25-q26 (ref. 3). Here we investigate this region further by using a systematic association scan of the chromosomal interval most likely to harbour this leprosy susceptibility locus. In 197 Vietnamese families we found a significant association between leprosy and 17 markers located in a block of approx. 80 kilobases overlapping the 5' regulatory region shared by the Parkinson's disease gene PARK2 and the co-regulated gene PACRG. Possession of as few as two of the 17 risk alleles was highly predictive of leprosy. This was confirmed in a sample of 975 unrelated leprosy cases and controls from Brazil in whom the same alleles were strongly associated with leprosy. Variants in the regulatory region shared by PARK2 and PACRG therefore act as common risk factors for leprosy. More... »

PAGES

636

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature02326

DOI

http://dx.doi.org/10.1038/nature02326

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010170785

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14737177


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