Ontology type: schema:ScholarlyArticle
2004-03
AUTHORSHarith Rajagopalan, Prasad V. Jallepalli, Carlo Rago, Victor E. Velculescu, Kenneth W. Kinzler, Bert Vogelstein, Christoph Lengauer
ABSTRACTAneuploidy, an abnormal chromosome number, has been recognized as a hallmark of human cancer for nearly a century; however, the mechanisms responsible for this abnormality have remained elusive. Here we report the identification of mutations in hCDC4 (also known as Fbw7 or Archipelago) in both human colorectal cancers and their precursor lesions. We show that genetic inactivation of hCDC4, by means of targeted disruption of the gene in karyotypically stable colorectal cancer cells, results in a striking phenotype associated with micronuclei and chromosomal instability. This phenotype can be traced to a defect in the execution of metaphase and subsequent transmission of chromosomes, and is dependent on cyclin E--a protein that is regulated by hCDC4 (refs 2-4). Our data suggest that chromosomal instability is caused by specific genetic alterations in a large fraction of human cancers and can occur before malignant conversion. More... »
PAGES77
http://scigraph.springernature.com/pub.10.1038/nature02313
DOIhttp://dx.doi.org/10.1038/nature02313
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1016242812
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/14999283
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aneuploidy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Cycle Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Colorectal Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cyclin E",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "F-Box Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "F-Box-WD Repeat-Containing Protein 7",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Deletion",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genomic Instability",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "In Situ Hybridization, Fluorescence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Micronuclei, Chromosome-Defective",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Models, Molecular",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mutation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein Conformation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA, Messenger",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ubiquitin-Protein Ligases",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA"
],
"type": "Organization"
},
"familyName": "Rajagopalan",
"givenName": "Harith",
"id": "sg:person.01021532664.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021532664.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Memorial Sloan Kettering Cancer Center",
"id": "https://www.grid.ac/institutes/grid.51462.34",
"name": [
"The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA",
"Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA"
],
"type": "Organization"
},
"familyName": "Jallepalli",
"givenName": "Prasad V.",
"id": "sg:person.01242004170.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242004170.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA"
],
"type": "Organization"
},
"familyName": "Rago",
"givenName": "Carlo",
"id": "sg:person.01175107436.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175107436.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA"
],
"type": "Organization"
},
"familyName": "Velculescu",
"givenName": "Victor E.",
"id": "sg:person.010354303077.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010354303077.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA"
],
"type": "Organization"
},
"familyName": "Kinzler",
"givenName": "Kenneth W.",
"id": "sg:person.0620642630.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620642630.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA",
"Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA"
],
"type": "Organization"
},
"familyName": "Vogelstein",
"givenName": "Bert",
"id": "sg:person.011173760757.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011173760757.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Johns Hopkins University",
"id": "https://www.grid.ac/institutes/grid.21107.35",
"name": [
"The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA"
],
"type": "Organization"
},
"familyName": "Lengauer",
"givenName": "Christoph",
"id": "sg:person.01066520346.94",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066520346.94"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/0165-7992(89)90115-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001690688"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/45836",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005965021",
"https://doi.org/10.1038/45836"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/45836",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005965021",
"https://doi.org/10.1038/45836"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35095157",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011521007",
"https://doi.org/10.1038/35095157"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35095157",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011521007",
"https://doi.org/10.1038/35095157"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/32688",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011887818",
"https://doi.org/10.1038/32688"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/32688",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011887818",
"https://doi.org/10.1038/32688"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1165",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014080321",
"https://doi.org/10.1038/nrc1165"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1165",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014080321",
"https://doi.org/10.1038/nrc1165"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.012679099",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019457405"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35107009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020206735",
"https://doi.org/10.1038/35107009"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35107009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020206735",
"https://doi.org/10.1038/35107009"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.19.8.5512",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020895672"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1065203",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021494973"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/25292",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033871070",
"https://doi.org/10.1038/25292"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/25292",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033871070",
"https://doi.org/10.1038/25292"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1097-0142(19810801)48:3<745::aid-cncr2820480314>3.0.co;2-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034615945"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-9822(98)70156-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035164628"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(01)00340-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036118549"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/386623a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036879517",
"https://doi.org/10.1038/386623a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng0796-343",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040980709",
"https://doi.org/10.1038/ng0796-343"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.202617399",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041206234"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(03)00034-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042253200"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1170",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044830086",
"https://doi.org/10.1038/nrc1170"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrc1170",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044830086",
"https://doi.org/10.1038/nrc1170"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1066237",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045037599"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35095076",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046432237",
"https://doi.org/10.1038/35095076"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35095076",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046432237",
"https://doi.org/10.1038/35095076"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35095068",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048326031",
"https://doi.org/10.1038/35095068"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/35095068",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048326031",
"https://doi.org/10.1038/35095068"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-9822(00)80021-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048399549"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/elps.1150181505",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049714182"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/elps.1150181505",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049714182"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1082596",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062447944"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074775077",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075108909",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083314335",
"type": "CreativeWork"
}
],
"datePublished": "2004-03",
"datePublishedReg": "2004-03-01",
"description": "Aneuploidy, an abnormal chromosome number, has been recognized as a hallmark of human cancer for nearly a century; however, the mechanisms responsible for this abnormality have remained elusive. Here we report the identification of mutations in hCDC4 (also known as Fbw7 or Archipelago) in both human colorectal cancers and their precursor lesions. We show that genetic inactivation of hCDC4, by means of targeted disruption of the gene in karyotypically stable colorectal cancer cells, results in a striking phenotype associated with micronuclei and chromosomal instability. This phenotype can be traced to a defect in the execution of metaphase and subsequent transmission of chromosomes, and is dependent on cyclin E--a protein that is regulated by hCDC4 (refs 2-4). Our data suggest that chromosomal instability is caused by specific genetic alterations in a large fraction of human cancers and can occur before malignant conversion.",
"genre": "research_article",
"id": "sg:pub.10.1038/nature02313",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0090-0028",
"1476-4687"
],
"name": "Nature",
"type": "Periodical"
},
{
"issueNumber": "6978",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "428"
}
],
"name": "Inactivation of hCDC4 can cause chromosomal instability",
"pagination": "77",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"4d64bd0625ef9a82cadf59e6233d1971dc2e7ba9bd65799ef82574bfd8b34a79"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"14999283"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0410462"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/nature02313"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1016242812"
]
}
],
"sameAs": [
"https://doi.org/10.1038/nature02313",
"https://app.dimensions.ai/details/publication/pub.1016242812"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T12:22",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87088_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/nature02313"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature02313'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature02313'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature02313'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature02313'
This table displays all metadata directly associated to this object as RDF triples.
273 TRIPLES
21 PREDICATES
73 URIs
38 LITERALS
26 BLANK NODES