Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-12

AUTHORS

Cyrille De Joussineau, Jonathan Soulé, Marianne Martin, Christelle Anguille, Philippe Montcourrier, Daniel Alexandre

ABSTRACT

Drosophila thoracic mechanosensory bristles originate from cells that are singled out from 'proneural' groups of competent epithelial cells. Neural competence is restricted to individual sensory organ precursors (SOPs) by Delta/Notch-mediated 'lateral inhibition', whereas other cells in the proneural field adopt an epidermal fate. The precursors of the large macrochaetes differentiate separately from individual proneural clusters that comprise about 20-30 cells or as heterochronic pairs from groups of more than 100 cells, whereas the precursors of the small regularly spaced microchaetes emerge from even larger proneural fields. This indicates that lateral inhibition might act over several cell diameters; it was difficult to reconcile with the fact that the inhibitory ligand Delta is membrane-bound until the observation that SOPs frequently extend thin processes offered an attractive hypothesis. Here we show that the extension of these planar filopodia--a common attribute of wing imaginal disc cells--is promoted by Delta and that their experimental suppression reduces Notch signalling in distant cells and increases bristle density in large proneural groups, showing that these membrane specializations mediate long-range lateral inhibition. More... »

PAGES

555

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature02157

DOI

http://dx.doi.org/10.1038/nature02157

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030324601

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14654840


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeletal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drosophila melanogaster", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ligands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neurons", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pseudopodia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Notch", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stem Cells", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Montpellier", 
          "id": "https://www.grid.ac/institutes/grid.121334.6", 
          "name": [
            "Laboratoire Dynamique Mol\u00e9culaire des Interactions Membranaires, CNRS UMR 5539, Universit\u00e9 Montpellier II C.C. 107, Place Eug\u00e8ne Bataillon, 34095 Montpellier cedex 5, France [corrected]"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Joussineau", 
        "givenName": "Cyrille", 
        "id": "sg:person.01005021405.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005021405.10"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Soul\u00e9", 
        "givenName": "Jonathan", 
        "id": "sg:person.0747603600.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747603600.74"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Martin", 
        "givenName": "Marianne", 
        "id": "sg:person.0704671377.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704671377.18"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Anguille", 
        "givenName": "Christelle", 
        "id": "sg:person.01257713115.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257713115.81"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Montcourrier", 
        "givenName": "Philippe", 
        "id": "sg:person.067232656.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.067232656.75"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Alexandre", 
        "givenName": "Daniel", 
        "id": "sg:person.01200260600.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200260600.75"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1091/mbc.8.8.1543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010864116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm882", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013550011", 
          "https://doi.org/10.1038/nrm882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm882", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013550011", 
          "https://doi.org/10.1038/nrm882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/293733a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018065618", 
          "https://doi.org/10.1038/293733a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.128.6.1081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023121887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0925-4773(94)90099-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026322236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0925-4773(94)90099-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026322236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35050558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026856978", 
          "https://doi.org/10.1038/35050558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35050558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026856978", 
          "https://doi.org/10.1038/35050558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(90)90534-l", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028531813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(02)00839-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028554421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(00)80701-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028662449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.9.21.2598", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029243517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81015-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032456826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80771-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032522347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.2001.0482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034489829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1098/rstb.1952.0012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037923414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200203117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041490994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.2000.0124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043845962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(94)90174-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044053018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00489-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044152247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(06)00295-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044357811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00365054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049004630", 
          "https://doi.org/10.1007/bf00365054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.1993.1151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049166866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.12.8.1086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049967056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.283.5398.91", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062563727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077726423", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082522972", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082532388", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082760179", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082816470", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083096743", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-12", 
    "datePublishedReg": "2003-12-01", 
    "description": "Drosophila thoracic mechanosensory bristles originate from cells that are singled out from 'proneural' groups of competent epithelial cells. Neural competence is restricted to individual sensory organ precursors (SOPs) by Delta/Notch-mediated 'lateral inhibition', whereas other cells in the proneural field adopt an epidermal fate. The precursors of the large macrochaetes differentiate separately from individual proneural clusters that comprise about 20-30 cells or as heterochronic pairs from groups of more than 100 cells, whereas the precursors of the small regularly spaced microchaetes emerge from even larger proneural fields. This indicates that lateral inhibition might act over several cell diameters; it was difficult to reconcile with the fact that the inhibitory ligand Delta is membrane-bound until the observation that SOPs frequently extend thin processes offered an attractive hypothesis. Here we show that the extension of these planar filopodia--a common attribute of wing imaginal disc cells--is promoted by Delta and that their experimental suppression reduces Notch signalling in distant cells and increases bristle density in large proneural groups, showing that these membrane specializations mediate long-range lateral inhibition.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature02157", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6966", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "426"
      }
    ], 
    "name": "Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila", 
    "pagination": "555", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9075a424325520934042ded899a2233a0918da3266165ee10cb0cdb266df1c64"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14654840"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature02157"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030324601"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature02157", 
      "https://app.dimensions.ai/details/publication/pub.1030324601"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53977_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature02157"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature02157'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature02157'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature02157'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature02157'


 

This table displays all metadata directly associated to this object as RDF triples.

244 TRIPLES      21 PREDICATES      73 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature02157 schema:about N07074acbb7fd484fb554504769b2468f
2 N12a2f6a5cc6446058d64448839632059
3 N1fa6d7e2b63a46a99a3d3787eec3c69d
4 N2ab89d05dc194aefaa603d421c947ad4
5 N3c730711b4f64e579293ee92b1385c27
6 N4a7bf0044ca34f4ea8ae342c0c2844a7
7 N6421166829a74a8caeb8143fc87ecbd0
8 N9a053cc85c5a447392e86931945ac96d
9 Na3f546fa396c4ac2a72f6217dc1831c4
10 Na8e2849ba7fd4799803ce2e47a3bbd5d
11 Naec9df9cef20493d82d61723178639b7
12 Nb8dbf1120b1547549154186047ee127c
13 Nd131df2b4e8449b7b76be660817caaf4
14 Ne9bdbf0194c4423b8cda42c6cdc13d04
15 Nfb57d224c5fd4a5ca5f12aee9392b8fa
16 anzsrc-for:06
17 anzsrc-for:0601
18 schema:author N582fa26a9b0641c8ab786bc10fc89ae1
19 schema:citation sg:pub.10.1007/bf00365054
20 sg:pub.10.1038/293733a0
21 sg:pub.10.1038/35050558
22 sg:pub.10.1038/nrm882
23 https://app.dimensions.ai/details/publication/pub.1077726423
24 https://app.dimensions.ai/details/publication/pub.1082522972
25 https://app.dimensions.ai/details/publication/pub.1082532388
26 https://app.dimensions.ai/details/publication/pub.1082760179
27 https://app.dimensions.ai/details/publication/pub.1082816470
28 https://app.dimensions.ai/details/publication/pub.1083096743
29 https://doi.org/10.1006/dbio.1993.1151
30 https://doi.org/10.1006/dbio.2000.0124
31 https://doi.org/10.1006/dbio.2001.0482
32 https://doi.org/10.1016/0092-8674(90)90534-l
33 https://doi.org/10.1016/0092-8674(94)90174-0
34 https://doi.org/10.1016/0925-4773(94)90099-x
35 https://doi.org/10.1016/s0092-8674(00)80771-0
36 https://doi.org/10.1016/s0092-8674(00)81015-6
37 https://doi.org/10.1016/s0092-8674(01)00489-5
38 https://doi.org/10.1016/s0896-6273(00)80701-1
39 https://doi.org/10.1016/s0960-9822(02)00839-4
40 https://doi.org/10.1016/s0960-9822(06)00295-8
41 https://doi.org/10.1083/jcb.128.6.1081
42 https://doi.org/10.1083/jcb.200203117
43 https://doi.org/10.1091/mbc.8.8.1543
44 https://doi.org/10.1098/rstb.1952.0012
45 https://doi.org/10.1101/gad.12.8.1086
46 https://doi.org/10.1101/gad.9.21.2598
47 https://doi.org/10.1126/science.283.5398.91
48 schema:datePublished 2003-12
49 schema:datePublishedReg 2003-12-01
50 schema:description Drosophila thoracic mechanosensory bristles originate from cells that are singled out from 'proneural' groups of competent epithelial cells. Neural competence is restricted to individual sensory organ precursors (SOPs) by Delta/Notch-mediated 'lateral inhibition', whereas other cells in the proneural field adopt an epidermal fate. The precursors of the large macrochaetes differentiate separately from individual proneural clusters that comprise about 20-30 cells or as heterochronic pairs from groups of more than 100 cells, whereas the precursors of the small regularly spaced microchaetes emerge from even larger proneural fields. This indicates that lateral inhibition might act over several cell diameters; it was difficult to reconcile with the fact that the inhibitory ligand Delta is membrane-bound until the observation that SOPs frequently extend thin processes offered an attractive hypothesis. Here we show that the extension of these planar filopodia--a common attribute of wing imaginal disc cells--is promoted by Delta and that their experimental suppression reduces Notch signalling in distant cells and increases bristle density in large proneural groups, showing that these membrane specializations mediate long-range lateral inhibition.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree false
54 schema:isPartOf N5e866f6a885343a89b8a162b3bda4ad0
55 Ndd52c5992fc74000bc2df62636d8c855
56 sg:journal.1018957
57 schema:name Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila
58 schema:pagination 555
59 schema:productId N18e29577851f40df9be5d9d3980c19c1
60 N338fd7ecebc848c6aae5f9d5014784cf
61 N470b9668d7824857a33650d461753e79
62 N7498bf121a19466b83c1b743000335f2
63 Ne301ebc807fb4e98a7f67b37cde65d15
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030324601
65 https://doi.org/10.1038/nature02157
66 schema:sdDatePublished 2019-04-11T12:10
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher N04874934948144e3872be925b835fc7c
69 schema:url https://www.nature.com/articles/nature02157
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N04874934948144e3872be925b835fc7c schema:name Springer Nature - SN SciGraph project
74 rdf:type schema:Organization
75 N07074acbb7fd484fb554504769b2468f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Pseudopodia
77 rdf:type schema:DefinedTerm
78 N10d10997d5004d05b8872c7a67a4ed65 rdf:first sg:person.0704671377.18
79 rdf:rest N9b2713af8fff4558b2bcfabade6ffd30
80 N12a2f6a5cc6446058d64448839632059 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Receptors, Notch
82 rdf:type schema:DefinedTerm
83 N18e29577851f40df9be5d9d3980c19c1 schema:name pubmed_id
84 schema:value 14654840
85 rdf:type schema:PropertyValue
86 N1fa6d7e2b63a46a99a3d3787eec3c69d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Animals
88 rdf:type schema:DefinedTerm
89 N2ab89d05dc194aefaa603d421c947ad4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Signal Transduction
91 rdf:type schema:DefinedTerm
92 N338fd7ecebc848c6aae5f9d5014784cf schema:name readcube_id
93 schema:value 9075a424325520934042ded899a2233a0918da3266165ee10cb0cdb266df1c64
94 rdf:type schema:PropertyValue
95 N3c730711b4f64e579293ee92b1385c27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Phosphoproteins
97 rdf:type schema:DefinedTerm
98 N470b9668d7824857a33650d461753e79 schema:name dimensions_id
99 schema:value pub.1030324601
100 rdf:type schema:PropertyValue
101 N4a7bf0044ca34f4ea8ae342c0c2844a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Neurons
103 rdf:type schema:DefinedTerm
104 N582fa26a9b0641c8ab786bc10fc89ae1 rdf:first sg:person.01005021405.10
105 rdf:rest N9bd9cee114e54ae2b31a3802b14cf191
106 N5e866f6a885343a89b8a162b3bda4ad0 schema:volumeNumber 426
107 rdf:type schema:PublicationVolume
108 N6421166829a74a8caeb8143fc87ecbd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Drosophila Proteins
110 rdf:type schema:DefinedTerm
111 N7498bf121a19466b83c1b743000335f2 schema:name nlm_unique_id
112 schema:value 0410462
113 rdf:type schema:PropertyValue
114 N837a526d54e04ecab38b2cc37c19415d rdf:first sg:person.01200260600.75
115 rdf:rest rdf:nil
116 N9a053cc85c5a447392e86931945ac96d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Phenotype
118 rdf:type schema:DefinedTerm
119 N9b2713af8fff4558b2bcfabade6ffd30 rdf:first sg:person.01257713115.81
120 rdf:rest Na30d2876653b4603aea94e0bdd41b37a
121 N9bd9cee114e54ae2b31a3802b14cf191 rdf:first sg:person.0747603600.74
122 rdf:rest N10d10997d5004d05b8872c7a67a4ed65
123 Na30d2876653b4603aea94e0bdd41b37a rdf:first sg:person.067232656.75
124 rdf:rest N837a526d54e04ecab38b2cc37c19415d
125 Na3f546fa396c4ac2a72f6217dc1831c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Cytoskeletal Proteins
127 rdf:type schema:DefinedTerm
128 Na8e2849ba7fd4799803ce2e47a3bbd5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Ligands
130 rdf:type schema:DefinedTerm
131 Naec9df9cef20493d82d61723178639b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Membrane Proteins
133 rdf:type schema:DefinedTerm
134 Nb8dbf1120b1547549154186047ee127c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Stem Cells
136 rdf:type schema:DefinedTerm
137 Nd131df2b4e8449b7b76be660817caaf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Drosophila melanogaster
139 rdf:type schema:DefinedTerm
140 Ndd52c5992fc74000bc2df62636d8c855 schema:issueNumber 6966
141 rdf:type schema:PublicationIssue
142 Ne301ebc807fb4e98a7f67b37cde65d15 schema:name doi
143 schema:value 10.1038/nature02157
144 rdf:type schema:PropertyValue
145 Ne9bdbf0194c4423b8cda42c6cdc13d04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Intracellular Signaling Peptides and Proteins
147 rdf:type schema:DefinedTerm
148 Nfb57d224c5fd4a5ca5f12aee9392b8fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Cell Differentiation
150 rdf:type schema:DefinedTerm
151 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
152 schema:name Biological Sciences
153 rdf:type schema:DefinedTerm
154 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
155 schema:name Biochemistry and Cell Biology
156 rdf:type schema:DefinedTerm
157 sg:journal.1018957 schema:issn 0090-0028
158 1476-4687
159 schema:name Nature
160 rdf:type schema:Periodical
161 sg:person.01005021405.10 schema:affiliation https://www.grid.ac/institutes/grid.121334.6
162 schema:familyName De Joussineau
163 schema:givenName Cyrille
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005021405.10
165 rdf:type schema:Person
166 sg:person.01200260600.75 schema:familyName Alexandre
167 schema:givenName Daniel
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200260600.75
169 rdf:type schema:Person
170 sg:person.01257713115.81 schema:familyName Anguille
171 schema:givenName Christelle
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257713115.81
173 rdf:type schema:Person
174 sg:person.067232656.75 schema:familyName Montcourrier
175 schema:givenName Philippe
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.067232656.75
177 rdf:type schema:Person
178 sg:person.0704671377.18 schema:familyName Martin
179 schema:givenName Marianne
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704671377.18
181 rdf:type schema:Person
182 sg:person.0747603600.74 schema:familyName Soulé
183 schema:givenName Jonathan
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747603600.74
185 rdf:type schema:Person
186 sg:pub.10.1007/bf00365054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049004630
187 https://doi.org/10.1007/bf00365054
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/293733a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018065618
190 https://doi.org/10.1038/293733a0
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/35050558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026856978
193 https://doi.org/10.1038/35050558
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/nrm882 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013550011
196 https://doi.org/10.1038/nrm882
197 rdf:type schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1077726423 schema:CreativeWork
199 https://app.dimensions.ai/details/publication/pub.1082522972 schema:CreativeWork
200 https://app.dimensions.ai/details/publication/pub.1082532388 schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1082760179 schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1082816470 schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1083096743 schema:CreativeWork
204 https://doi.org/10.1006/dbio.1993.1151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049166866
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1006/dbio.2000.0124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043845962
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1006/dbio.2001.0482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034489829
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/0092-8674(90)90534-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1028531813
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/0092-8674(94)90174-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044053018
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/0925-4773(94)90099-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026322236
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/s0092-8674(00)80771-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032522347
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/s0092-8674(00)81015-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032456826
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/s0092-8674(01)00489-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044152247
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/s0896-6273(00)80701-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028662449
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/s0960-9822(02)00839-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028554421
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/s0960-9822(06)00295-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044357811
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1083/jcb.128.6.1081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023121887
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1083/jcb.200203117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041490994
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1091/mbc.8.8.1543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010864116
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1098/rstb.1952.0012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037923414
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1101/gad.12.8.1086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049967056
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1101/gad.9.21.2598 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029243517
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1126/science.283.5398.91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062563727
241 rdf:type schema:CreativeWork
242 https://www.grid.ac/institutes/grid.121334.6 schema:alternateName University of Montpellier
243 schema:name Laboratoire Dynamique Moléculaire des Interactions Membranaires, CNRS UMR 5539, Université Montpellier II C.C. 107, Place Eugène Bataillon, 34095 Montpellier cedex 5, France [corrected]
244 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...