A positive-feedback-based bistable ‘memory module’ that governs a cell fate decision View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-11

AUTHORS

Wen Xiong, James E. Ferrell

ABSTRACT

The maturation of Xenopus oocytes can be thought of as a process of cell fate induction, with the immature oocyte representing the default fate and the mature oocyte representing the induced fate. Crucial mediators of Xenopus oocyte maturation, including the p42 mitogen-activated protein kinase (MAPK) and the cell-division cycle protein kinase Cdc2, are known to be organized into positive feedback loops. In principle, such positive feedback loops could produce an actively maintained 'memory' of a transient inductive stimulus and could explain the irreversibility of maturation. Here we show that the p42 MAPK and Cdc2 system normally generates an irreversible biochemical response from a transient stimulus, but the response becomes transient when positive feedback is blocked. Our results explain how a group of intrinsically reversible signal transducers can generate an irreversible response at a systems level, and show how a cell fate can be maintained by a self-sustaining pattern of protein kinase activation. More... »

PAGES

460

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature02089

DOI

http://dx.doi.org/10.1038/nature02089

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026655503

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14647386


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