Identification of the haematopoietic stem cell niche and control of the niche size View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-10

AUTHORS

Jiwang Zhang, Chao Niu, Ling Ye, Haiyang Huang, Xi He, Wei-Gang Tong, Jason Ross, Jeff Haug, Teri Johnson, Jian Q. Feng, Stephen Harris, Leanne M. Wiedemann, Yuji Mishina, Linheng Li

ABSTRACT

Haematopoietic stem cells (HSCs) are a subset of bone marrow cells that are capable of self-renewal and of forming all types of blood cells (multi-potential). However, the HSC 'niche'--the in vivo regulatory microenvironment where HSCs reside--and the mechanisms involved in controlling the number of adult HSCs remain largely unknown. The bone morphogenetic protein (BMP) signal has an essential role in inducing haematopoietic tissue during embryogenesis. We investigated the roles of the BMP signalling pathway in regulating adult HSC development in vivo by analysing mutant mice with conditional inactivation of BMP receptor type IA (BMPRIA). Here we show that an increase in the number of spindle-shaped N-cadherin+CD45- osteoblastic (SNO) cells correlates with an increase in the number of HSCs. The long-term HSCs are found attached to SNO cells. Two adherens junction molecules, N-cadherin and beta-catenin, are asymmetrically localized between the SNO cells and the long-term HSCs. We conclude that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of HSCs by regulating niche size. More... »

PAGES

836

Journal

TITLE

Nature

ISSUE

6960

VOLUME

425

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature02041

DOI

http://dx.doi.org/10.1038/nature02041

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033616640

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14574412


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Morphogenetic Protein Receptors, Type I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Morphogenetic Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone and Bones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cadherins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Count", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukocyte Common Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Osteoblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Stowers Institute for Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.250820.d", 
          "name": [
            "Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jiwang", 
        "id": "sg:person.010350532507.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010350532507.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stowers Institute for Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.250820.d", 
          "name": [
            "Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niu", 
        "givenName": "Chao", 
        "id": "sg:person.0603312324.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603312324.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Missouri\u2013Kansas City", 
          "id": "https://www.grid.ac/institutes/grid.266756.6", 
          "name": [
            "Department of Oral Biology, School of Dentistry, University of Missouri\u2013Kansas City, 650 East 25th Street, Kansas City, Missouri 64108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ye", 
        "givenName": "Ling", 
        "id": "sg:person.0627331640.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627331640.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Missouri\u2013Kansas City", 
          "id": "https://www.grid.ac/institutes/grid.266756.6", 
          "name": [
            "Department of Oral Biology, School of Dentistry, University of Missouri\u2013Kansas City, 650 East 25th Street, Kansas City, Missouri 64108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Haiyang", 
        "id": "sg:person.01277236034.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277236034.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stowers Institute for Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.250820.d", 
          "name": [
            "Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Xi", 
        "id": "sg:person.01307234144.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307234144.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stowers Institute for Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.250820.d", 
          "name": [
            "Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tong", 
        "givenName": "Wei-Gang", 
        "id": "sg:person.01355347344.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355347344.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stowers Institute for Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.250820.d", 
          "name": [
            "Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ross", 
        "givenName": "Jason", 
        "id": "sg:person.0674404401.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674404401.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stowers Institute for Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.250820.d", 
          "name": [
            "Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haug", 
        "givenName": "Jeff", 
        "id": "sg:person.01157136704.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157136704.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stowers Institute for Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.250820.d", 
          "name": [
            "Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnson", 
        "givenName": "Teri", 
        "id": "sg:person.01302072351.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302072351.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Missouri\u2013Kansas City", 
          "id": "https://www.grid.ac/institutes/grid.266756.6", 
          "name": [
            "Department of Oral Biology, School of Dentistry, University of Missouri\u2013Kansas City, 650 East 25th Street, Kansas City, Missouri 64108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Feng", 
        "givenName": "Jian Q.", 
        "id": "sg:person.012530220247.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012530220247.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Missouri\u2013Kansas City", 
          "id": "https://www.grid.ac/institutes/grid.266756.6", 
          "name": [
            "Department of Oral Biology, School of Dentistry, University of Missouri\u2013Kansas City, 650 East 25th Street, Kansas City, Missouri 64108, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harris", 
        "givenName": "Stephen", 
        "id": "sg:person.015162155612.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015162155612.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kansas Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412016.0", 
          "name": [
            "Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA", 
            "Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, Kansas 66160, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wiedemann", 
        "givenName": "Leanne M.", 
        "id": "sg:person.01046656335.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046656335.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute of Environmental Health Sciences", 
          "id": "https://www.grid.ac/institutes/grid.280664.e", 
          "name": [
            "Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mishina", 
        "givenName": "Yuji", 
        "id": "sg:person.0615064135.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615064135.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Kansas Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412016.0", 
          "name": [
            "Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA", 
            "Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, Kansas 66160, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Linheng", 
        "id": "sg:person.0746360701.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746360701.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.m011265200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002669803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003509222", 
          "https://doi.org/10.1038/nature02040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003509222", 
          "https://doi.org/10.1038/nature02040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.142.1.295", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004825297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-4652(200004)183:1<117::aid-jcp14>3.0.co;2-#", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006605938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(94)90329-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008438994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-06-1780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017875743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood.v97.8.2293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020150776"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gene.10038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020773016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)00050-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021046695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35102160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021584545", 
          "https://doi.org/10.1038/35102160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35102160", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021584545", 
          "https://doi.org/10.1038/35102160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.20-6-501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023148533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80453-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023618914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.290.5490.328", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023854286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.232389399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031494614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35004599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036639289", 
          "https://doi.org/10.1038/35004599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35004599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036639289", 
          "https://doi.org/10.1038/35004599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1040910303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036776047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1074-7613(94)90037-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041252447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10245332.1999.11746468", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041821002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1359/jbmr.2001.16.12.2222", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047731615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.6.3120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051052670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0070-2153(00)50003-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052184750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(01)00123-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052461671"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2898810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062571086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7660125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062648331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074793193", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074945344", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082377481", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082965992", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083214824", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-10", 
    "datePublishedReg": "2003-10-01", 
    "description": "Haematopoietic stem cells (HSCs) are a subset of bone marrow cells that are capable of self-renewal and of forming all types of blood cells (multi-potential). However, the HSC 'niche'--the in vivo regulatory microenvironment where HSCs reside--and the mechanisms involved in controlling the number of adult HSCs remain largely unknown. The bone morphogenetic protein (BMP) signal has an essential role in inducing haematopoietic tissue during embryogenesis. We investigated the roles of the BMP signalling pathway in regulating adult HSC development in vivo by analysing mutant mice with conditional inactivation of BMP receptor type IA (BMPRIA). Here we show that an increase in the number of spindle-shaped N-cadherin+CD45- osteoblastic (SNO) cells correlates with an increase in the number of HSCs. The long-term HSCs are found attached to SNO cells. Two adherens junction molecules, N-cadherin and beta-catenin, are asymmetrically localized between the SNO cells and the long-term HSCs. We conclude that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of HSCs by regulating niche size.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature02041", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2717563", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6960", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "425"
      }
    ], 
    "name": "Identification of the haematopoietic stem cell niche and control of the niche size", 
    "pagination": "836", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a02348018e576f019ca956ffa0b6a791da9dc67f916928de9c6019c164bdb392"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14574412"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature02041"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033616640"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature02041", 
      "https://app.dimensions.ai/details/publication/pub.1033616640"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:26", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87112_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature02041"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature02041'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature02041'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature02041'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature02041'


 

This table displays all metadata directly associated to this object as RDF triples.

317 TRIPLES      21 PREDICATES      73 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature02041 schema:about N05023e52cf1847b98aa7ea86d7acac89
2 N4751ad99c83946f3a53fd4158ddb9259
3 N515d68f633534dff815be4a2329edc15
4 N53508558e27b4396ae053faed4d80f14
5 N58cfa44b80614af0b69c8ce848cae6de
6 N79f32885a6da4f3485ed183b6c4ffff0
7 N8219a1c1bbf2481ea49034d4a3d55be5
8 Naf2bafee6a084384b7bbc876142b4cc4
9 Nb2e4cda73c124c6dbba0cece4db6ec49
10 Nb633d3bef6ec45e485f89d06f2a1afe4
11 Nb81f580e61544f50ad4458e4f8920234
12 Nc2b9d85c40154c86b9c18fb21385c3ab
13 Nf1df3928452d4ab4a1aa52374887b4ee
14 Nf4dae0a9ba7940978d2d949a9dbba27d
15 Nf5f6e5712fb04187bc5c3f5ff9c51e0d
16 anzsrc-for:06
17 anzsrc-for:0601
18 schema:author N958322a7ccc049539b733c0362068dde
19 schema:citation sg:pub.10.1038/35004599
20 sg:pub.10.1038/35102160
21 sg:pub.10.1038/nature02040
22 https://app.dimensions.ai/details/publication/pub.1074793193
23 https://app.dimensions.ai/details/publication/pub.1074945344
24 https://app.dimensions.ai/details/publication/pub.1082377481
25 https://app.dimensions.ai/details/publication/pub.1082965992
26 https://app.dimensions.ai/details/publication/pub.1083214824
27 https://doi.org/10.1002/(sici)1097-4652(200004)183:1<117::aid-jcp14>3.0.co;2-#
28 https://doi.org/10.1002/gene.10038
29 https://doi.org/10.1002/jcp.1040910303
30 https://doi.org/10.1016/0092-8674(94)90329-8
31 https://doi.org/10.1016/1074-7613(94)90037-x
32 https://doi.org/10.1016/s0070-2153(00)50003-9
33 https://doi.org/10.1016/s0092-8674(00)00050-7
34 https://doi.org/10.1016/s0092-8674(00)80453-5
35 https://doi.org/10.1016/s1074-7613(01)00123-6
36 https://doi.org/10.1073/pnas.232389399
37 https://doi.org/10.1073/pnas.96.6.3120
38 https://doi.org/10.1074/jbc.m011265200
39 https://doi.org/10.1080/10245332.1999.11746468
40 https://doi.org/10.1083/jcb.142.1.295
41 https://doi.org/10.1126/science.2898810
42 https://doi.org/10.1126/science.290.5490.328
43 https://doi.org/10.1126/science.7660125
44 https://doi.org/10.1182/blood-2002-06-1780
45 https://doi.org/10.1182/blood.v97.8.2293
46 https://doi.org/10.1359/jbmr.2001.16.12.2222
47 https://doi.org/10.1634/stemcells.20-6-501
48 schema:datePublished 2003-10
49 schema:datePublishedReg 2003-10-01
50 schema:description Haematopoietic stem cells (HSCs) are a subset of bone marrow cells that are capable of self-renewal and of forming all types of blood cells (multi-potential). However, the HSC 'niche'--the in vivo regulatory microenvironment where HSCs reside--and the mechanisms involved in controlling the number of adult HSCs remain largely unknown. The bone morphogenetic protein (BMP) signal has an essential role in inducing haematopoietic tissue during embryogenesis. We investigated the roles of the BMP signalling pathway in regulating adult HSC development in vivo by analysing mutant mice with conditional inactivation of BMP receptor type IA (BMPRIA). Here we show that an increase in the number of spindle-shaped N-cadherin+CD45- osteoblastic (SNO) cells correlates with an increase in the number of HSCs. The long-term HSCs are found attached to SNO cells. Two adherens junction molecules, N-cadherin and beta-catenin, are asymmetrically localized between the SNO cells and the long-term HSCs. We conclude that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of HSCs by regulating niche size.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree true
54 schema:isPartOf N014674b0b22746c69c81dd27744cefbb
55 N21ad696c662b452187dc16e3e2e4a3e4
56 sg:journal.1018957
57 schema:name Identification of the haematopoietic stem cell niche and control of the niche size
58 schema:pagination 836
59 schema:productId N2ff63ecc79e44ee7a4de892bc98e40fd
60 N43049dfecd3b4ad78b110eb0bbddc830
61 N5729b18e6b6b48ad9fd702b2084f017d
62 Nb97149b020ff4bbb8face0aac7e6051b
63 Nf6b746bd0b164d0588d0eb6fd4420809
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033616640
65 https://doi.org/10.1038/nature02041
66 schema:sdDatePublished 2019-04-11T12:26
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher Nb7310651b05749e79ec2a9e57f480002
69 schema:url https://www.nature.com/articles/nature02041
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N014674b0b22746c69c81dd27744cefbb schema:issueNumber 6960
74 rdf:type schema:PublicationIssue
75 N05023e52cf1847b98aa7ea86d7acac89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Protein-Serine-Threonine Kinases
77 rdf:type schema:DefinedTerm
78 N14526615d9b54c5ea04ee19f9ffdd4c4 rdf:first sg:person.01046656335.50
79 rdf:rest N8356deaeee344bdcbd8c02112c23d9b2
80 N21ad696c662b452187dc16e3e2e4a3e4 schema:volumeNumber 425
81 rdf:type schema:PublicationVolume
82 N2befbf76ddc342cc8deb3a160c2fe171 rdf:first sg:person.0674404401.19
83 rdf:rest Neeb2bb7d73ef4d858c34a870cddd5c50
84 N2ff63ecc79e44ee7a4de892bc98e40fd schema:name nlm_unique_id
85 schema:value 0410462
86 rdf:type schema:PropertyValue
87 N305749b077cd48e182d319b22dd423c8 rdf:first sg:person.0746360701.12
88 rdf:rest rdf:nil
89 N387c30da3f794d798bd8cc13d2b28c25 rdf:first sg:person.012530220247.33
90 rdf:rest Ndd178a1c292a4b778b0fcae672015b93
91 N43049dfecd3b4ad78b110eb0bbddc830 schema:name readcube_id
92 schema:value a02348018e576f019ca956ffa0b6a791da9dc67f916928de9c6019c164bdb392
93 rdf:type schema:PropertyValue
94 N46b0c1859a8b40aea24c4693daf497ae rdf:first sg:person.0603312324.45
95 rdf:rest Nf2cc502bbe3449e395028fe3afc4bff2
96 N4751ad99c83946f3a53fd4158ddb9259 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Hematopoietic Stem Cells
98 rdf:type schema:DefinedTerm
99 N515d68f633534dff815be4a2329edc15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Receptors, Growth Factor
101 rdf:type schema:DefinedTerm
102 N53508558e27b4396ae053faed4d80f14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Mice
104 rdf:type schema:DefinedTerm
105 N55721fba219d4bb09362613cb6100323 rdf:first sg:person.01355347344.72
106 rdf:rest N2befbf76ddc342cc8deb3a160c2fe171
107 N5729b18e6b6b48ad9fd702b2084f017d schema:name dimensions_id
108 schema:value pub.1033616640
109 rdf:type schema:PropertyValue
110 N58cfa44b80614af0b69c8ce848cae6de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Bone Morphogenetic Proteins
112 rdf:type schema:DefinedTerm
113 N655a235cddba42c589be4de0f34f2bbc rdf:first sg:person.01302072351.53
114 rdf:rest N387c30da3f794d798bd8cc13d2b28c25
115 N79f32885a6da4f3485ed183b6c4ffff0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Cell Count
117 rdf:type schema:DefinedTerm
118 N8219a1c1bbf2481ea49034d4a3d55be5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Bone Morphogenetic Protein Receptors, Type I
120 rdf:type schema:DefinedTerm
121 N8356deaeee344bdcbd8c02112c23d9b2 rdf:first sg:person.0615064135.46
122 rdf:rest N305749b077cd48e182d319b22dd423c8
123 N958322a7ccc049539b733c0362068dde rdf:first sg:person.010350532507.24
124 rdf:rest N46b0c1859a8b40aea24c4693daf497ae
125 Na55c152e5f1f4ac88c053d39f0847a01 rdf:first sg:person.01307234144.49
126 rdf:rest N55721fba219d4bb09362613cb6100323
127 Naf2bafee6a084384b7bbc876142b4cc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Mutation
129 rdf:type schema:DefinedTerm
130 Nb2e4cda73c124c6dbba0cece4db6ec49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Bone and Bones
132 rdf:type schema:DefinedTerm
133 Nb633d3bef6ec45e485f89d06f2a1afe4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cell Adhesion
135 rdf:type schema:DefinedTerm
136 Nb7310651b05749e79ec2a9e57f480002 schema:name Springer Nature - SN SciGraph project
137 rdf:type schema:Organization
138 Nb81f580e61544f50ad4458e4f8920234 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Animals
140 rdf:type schema:DefinedTerm
141 Nb97149b020ff4bbb8face0aac7e6051b schema:name doi
142 schema:value 10.1038/nature02041
143 rdf:type schema:PropertyValue
144 Nc2b9d85c40154c86b9c18fb21385c3ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Leukocyte Common Antigens
146 rdf:type schema:DefinedTerm
147 Nd83c9f8ae3ab426ba0b303c2537fc2b5 rdf:first sg:person.01277236034.39
148 rdf:rest Na55c152e5f1f4ac88c053d39f0847a01
149 Ndd178a1c292a4b778b0fcae672015b93 rdf:first sg:person.015162155612.18
150 rdf:rest N14526615d9b54c5ea04ee19f9ffdd4c4
151 Neeb2bb7d73ef4d858c34a870cddd5c50 rdf:first sg:person.01157136704.27
152 rdf:rest N655a235cddba42c589be4de0f34f2bbc
153 Nf1df3928452d4ab4a1aa52374887b4ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Signal Transduction
155 rdf:type schema:DefinedTerm
156 Nf2cc502bbe3449e395028fe3afc4bff2 rdf:first sg:person.0627331640.67
157 rdf:rest Nd83c9f8ae3ab426ba0b303c2537fc2b5
158 Nf4dae0a9ba7940978d2d949a9dbba27d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Cadherins
160 rdf:type schema:DefinedTerm
161 Nf5f6e5712fb04187bc5c3f5ff9c51e0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Osteoblasts
163 rdf:type schema:DefinedTerm
164 Nf6b746bd0b164d0588d0eb6fd4420809 schema:name pubmed_id
165 schema:value 14574412
166 rdf:type schema:PropertyValue
167 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
168 schema:name Biological Sciences
169 rdf:type schema:DefinedTerm
170 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
171 schema:name Biochemistry and Cell Biology
172 rdf:type schema:DefinedTerm
173 sg:grant.2717563 http://pending.schema.org/fundedItem sg:pub.10.1038/nature02041
174 rdf:type schema:MonetaryGrant
175 sg:journal.1018957 schema:issn 0090-0028
176 1476-4687
177 schema:name Nature
178 rdf:type schema:Periodical
179 sg:person.010350532507.24 schema:affiliation https://www.grid.ac/institutes/grid.250820.d
180 schema:familyName Zhang
181 schema:givenName Jiwang
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010350532507.24
183 rdf:type schema:Person
184 sg:person.01046656335.50 schema:affiliation https://www.grid.ac/institutes/grid.412016.0
185 schema:familyName Wiedemann
186 schema:givenName Leanne M.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046656335.50
188 rdf:type schema:Person
189 sg:person.01157136704.27 schema:affiliation https://www.grid.ac/institutes/grid.250820.d
190 schema:familyName Haug
191 schema:givenName Jeff
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157136704.27
193 rdf:type schema:Person
194 sg:person.012530220247.33 schema:affiliation https://www.grid.ac/institutes/grid.266756.6
195 schema:familyName Feng
196 schema:givenName Jian Q.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012530220247.33
198 rdf:type schema:Person
199 sg:person.01277236034.39 schema:affiliation https://www.grid.ac/institutes/grid.266756.6
200 schema:familyName Huang
201 schema:givenName Haiyang
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277236034.39
203 rdf:type schema:Person
204 sg:person.01302072351.53 schema:affiliation https://www.grid.ac/institutes/grid.250820.d
205 schema:familyName Johnson
206 schema:givenName Teri
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302072351.53
208 rdf:type schema:Person
209 sg:person.01307234144.49 schema:affiliation https://www.grid.ac/institutes/grid.250820.d
210 schema:familyName He
211 schema:givenName Xi
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307234144.49
213 rdf:type schema:Person
214 sg:person.01355347344.72 schema:affiliation https://www.grid.ac/institutes/grid.250820.d
215 schema:familyName Tong
216 schema:givenName Wei-Gang
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355347344.72
218 rdf:type schema:Person
219 sg:person.015162155612.18 schema:affiliation https://www.grid.ac/institutes/grid.266756.6
220 schema:familyName Harris
221 schema:givenName Stephen
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015162155612.18
223 rdf:type schema:Person
224 sg:person.0603312324.45 schema:affiliation https://www.grid.ac/institutes/grid.250820.d
225 schema:familyName Niu
226 schema:givenName Chao
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603312324.45
228 rdf:type schema:Person
229 sg:person.0615064135.46 schema:affiliation https://www.grid.ac/institutes/grid.280664.e
230 schema:familyName Mishina
231 schema:givenName Yuji
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0615064135.46
233 rdf:type schema:Person
234 sg:person.0627331640.67 schema:affiliation https://www.grid.ac/institutes/grid.266756.6
235 schema:familyName Ye
236 schema:givenName Ling
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627331640.67
238 rdf:type schema:Person
239 sg:person.0674404401.19 schema:affiliation https://www.grid.ac/institutes/grid.250820.d
240 schema:familyName Ross
241 schema:givenName Jason
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674404401.19
243 rdf:type schema:Person
244 sg:person.0746360701.12 schema:affiliation https://www.grid.ac/institutes/grid.412016.0
245 schema:familyName Li
246 schema:givenName Linheng
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746360701.12
248 rdf:type schema:Person
249 sg:pub.10.1038/35004599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036639289
250 https://doi.org/10.1038/35004599
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/35102160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021584545
253 https://doi.org/10.1038/35102160
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/nature02040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003509222
256 https://doi.org/10.1038/nature02040
257 rdf:type schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1074793193 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1074945344 schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1082377481 schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1082965992 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1083214824 schema:CreativeWork
263 https://doi.org/10.1002/(sici)1097-4652(200004)183:1<117::aid-jcp14>3.0.co;2-# schema:sameAs https://app.dimensions.ai/details/publication/pub.1006605938
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1002/gene.10038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020773016
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1002/jcp.1040910303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036776047
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/0092-8674(94)90329-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008438994
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/1074-7613(94)90037-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041252447
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0070-2153(00)50003-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052184750
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0092-8674(00)00050-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021046695
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0092-8674(00)80453-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023618914
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s1074-7613(01)00123-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052461671
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1073/pnas.232389399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031494614
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1073/pnas.96.6.3120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051052670
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1074/jbc.m011265200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002669803
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1080/10245332.1999.11746468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041821002
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1083/jcb.142.1.295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004825297
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1126/science.2898810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062571086
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1126/science.290.5490.328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023854286
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1126/science.7660125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062648331
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1182/blood-2002-06-1780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017875743
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1182/blood.v97.8.2293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020150776
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1359/jbmr.2001.16.12.2222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047731615
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1634/stemcells.20-6-501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023148533
304 rdf:type schema:CreativeWork
305 https://www.grid.ac/institutes/grid.250820.d schema:alternateName Stowers Institute for Medical Research
306 schema:name Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
307 rdf:type schema:Organization
308 https://www.grid.ac/institutes/grid.266756.6 schema:alternateName University of Missouri–Kansas City
309 schema:name Department of Oral Biology, School of Dentistry, University of Missouri–Kansas City, 650 East 25th Street, Kansas City, Missouri 64108, USA
310 rdf:type schema:Organization
311 https://www.grid.ac/institutes/grid.280664.e schema:alternateName National Institute of Environmental Health Sciences
312 schema:name Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
313 rdf:type schema:Organization
314 https://www.grid.ac/institutes/grid.412016.0 schema:alternateName University of Kansas Medical Center
315 schema:name Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, Kansas 66160, USA
316 Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
317 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...