Identification of the haematopoietic stem cell niche and control of the niche size View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-10

AUTHORS

Jiwang Zhang, Chao Niu, Ling Ye, Haiyang Huang, Xi He, Wei-Gang Tong, Jason Ross, Jeff Haug, Teri Johnson, Jian Q. Feng, Stephen Harris, Leanne M. Wiedemann, Yuji Mishina, Linheng Li

ABSTRACT

Haematopoietic stem cells (HSCs) are a subset of bone marrow cells that are capable of self-renewal and of forming all types of blood cells (multi-potential). However, the HSC 'niche'--the in vivo regulatory microenvironment where HSCs reside--and the mechanisms involved in controlling the number of adult HSCs remain largely unknown. The bone morphogenetic protein (BMP) signal has an essential role in inducing haematopoietic tissue during embryogenesis. We investigated the roles of the BMP signalling pathway in regulating adult HSC development in vivo by analysing mutant mice with conditional inactivation of BMP receptor type IA (BMPRIA). Here we show that an increase in the number of spindle-shaped N-cadherin+CD45- osteoblastic (SNO) cells correlates with an increase in the number of HSCs. The long-term HSCs are found attached to SNO cells. Two adherens junction molecules, N-cadherin and beta-catenin, are asymmetrically localized between the SNO cells and the long-term HSCs. We conclude that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of HSCs by regulating niche size. More... »

PAGES

836

Journal

TITLE

Nature

ISSUE

6960

VOLUME

425

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature02041

DOI

http://dx.doi.org/10.1038/nature02041

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033616640

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14574412


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature02041'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature02041'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature02041'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature02041'


 

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317 rdf:type schema:Organization
 




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