Smad-dependent and Smad-independent pathways in TGF-β family signalling View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-10

AUTHORS

Rik Derynck, Ying E. Zhang

ABSTRACT

Transforming growth factor-beta (TGF-beta) proteins regulate cell function, and have key roles in development and carcinogenesis. The intracellular effectors of TGF-beta signalling, the Smad proteins, are activated by receptors and translocate into the nucleus, where they regulate transcription. Although this pathway is inherently simple, combinatorial interactions in the heteromeric receptor and Smad complexes, receptor-interacting and Smad-interacting proteins, and cooperation with sequence-specific transcription factors allow substantial versatility and diversification of TGF-beta family responses. Other signalling pathways further regulate Smad activation and function. In addition, TGF-beta receptors activate Smad-independent pathways that not only regulate Smad signalling, but also allow Smad-independent TGF-beta responses. More... »

PAGES

577

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature02006

    DOI

    http://dx.doi.org/10.1038/nature02006

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1009326672

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14534577


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