Viral infection switches non-plasmacytoid dendritic cells into high interferon producers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-07

AUTHORS

Sandra S. Diebold, Maria Montoya, Hermann Unger, Lena Alexopoulou, Polly Roy, Linsey E. Haswell, Aymen Al-Shamkhani, Richard Flavell, Persephone Borrow, Caetano Reis e Sousa

ABSTRACT

Type I interferons (IFN-I) are important cytokines linking innate and adaptive immunity. Plasmacytoid dendritic cells make high levels of IFN-I in response to viral infection and are thought to be the major source of the cytokines in vivo. Here, we show that conventional non-plasmacytoid dendritic cells taken from mice infected with a dendritic-cell-tropic strain of lymphocytic choriomeningitis virus make similarly high levels of IFN-I on subsequent culture. Similarly, non-plasmacytoid dendritic cells secrete high levels of IFN-I in response to double-stranded RNA (dsRNA), a major viral signature, when the latter is introduced into the cytoplasm to mimic direct viral infection. This response is partially dependent on the cytosolic dsRNA-binding enzyme protein kinase R and does not require signalling through toll-like receptor (TLR) 3, a surface receptor for dsRNA. Furthermore, we show that sequestration of dsRNA by viral NS1 (refs 6, 7) explains the inability of conventional dendritic cells to produce IFN-I on infection with influenza. Our results suggest that multiple dendritic cell types, not just plasmacytoid cells, can act as specialized interferon-producing cells in certain viral infections, and reveal the existence of a TLR-independent pathway for dendritic cell activation that can be the target of viral interference. More... »

PAGES

324

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature01783

DOI

http://dx.doi.org/10.1038/nature01783

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017298472

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12819664


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "3T3 Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CpG Islands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dendritic Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon Type I", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocytic Choriomeningitis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocytic choriomeningitis virus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Glycoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Double-Stranded", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Cell Surface", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Toll-Like Receptor 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Toll-Like Receptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "eIF-2 Kinase", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "*Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Diebold", 
        "givenName": "Sandra S.", 
        "id": "sg:person.015365610407.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015365610407.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jenner Institute", 
          "id": "https://www.grid.ac/institutes/grid.418731.8", 
          "name": [
            "\u2020Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Montoya", 
        "givenName": "Maria", 
        "id": "sg:person.01037174111.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037174111.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Veterinary Medicine Vienna", 
          "id": "https://www.grid.ac/institutes/grid.6583.8", 
          "name": [
            "\u2021Institute for Virology, University of Veterinary Medicine, Vienna A-1210, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Unger", 
        "givenName": "Hermann", 
        "id": "sg:person.0762745347.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762745347.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "\u00a7Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alexopoulou", 
        "givenName": "Lena", 
        "id": "sg:person.01054146505.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054146505.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "London School of Hygiene & Tropical Medicine", 
          "id": "https://www.grid.ac/institutes/grid.8991.9", 
          "name": [
            "\u2016London School of Hygiene & Tropical Medicine, London WC1A 7HT, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roy", 
        "givenName": "Polly", 
        "id": "sg:person.01000752176.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000752176.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Southampton General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.123047.3", 
          "name": [
            "\u00b6Tenovus Research Laboratory, Cancer Sciences Division, The School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haswell", 
        "givenName": "Linsey E.", 
        "id": "sg:person.0702775630.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702775630.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Southampton General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.123047.3", 
          "name": [
            "\u00b6Tenovus Research Laboratory, Cancer Sciences Division, The School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Al-Shamkhani", 
        "givenName": "Aymen", 
        "id": "sg:person.01337474107.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337474107.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "\u00a7Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Flavell", 
        "givenName": "Richard", 
        "id": "sg:person.013636762157.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013636762157.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jenner Institute", 
          "id": "https://www.grid.ac/institutes/grid.418731.8", 
          "name": [
            "\u2020Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Borrow", 
        "givenName": "Persephone", 
        "id": "sg:person.01245346746.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245346746.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "*Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reis e Sousa", 
        "givenName": "Caetano", 
        "id": "sg:person.01252465034.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252465034.71"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nri888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004545980", 
          "https://doi.org/10.1038/nri888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004545980", 
          "https://doi.org/10.1038/nri888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri888", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004545980", 
          "https://doi.org/10.1038/nri888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006881973", 
          "https://doi.org/10.1038/ni736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006881973", 
          "https://doi.org/10.1038/ni736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.284.5421.1835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007458822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.2.634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009691745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/viro.1996.0259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023749972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/11360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025050169", 
          "https://doi.org/10.1038/11360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/11360", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025050169", 
          "https://doi.org/10.1038/11360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m008717200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025106387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.194.8.1171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028310627"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80596-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028440125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)00014-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028489999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35099560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031094923", 
          "https://doi.org/10.1038/35099560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35099560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031094923", 
          "https://doi.org/10.1038/35099560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.192.2.219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031439553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.192.2.219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031439553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1521-4141(200111)31:11<3403::aid-immu3403>3.0.co;2-t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033394915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0952-7915(02)00354-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033642276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.22.6660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034519279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni0901-835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037156244", 
          "https://doi.org/10.1038/ni0901-835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni0901-835", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037156244", 
          "https://doi.org/10.1038/ni0901-835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200323797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037859595"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20021031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040384409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.74.13.6203-6206.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044020720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0952-7915(02)00349-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046004579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/viro.1998.9508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047191810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20011672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051006171"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1099/0022-1317-69-7-1637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060356804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3281258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062604283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/stke.2001.89.re2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062690615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.166.9.5448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074802017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.169.7.3652", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075128325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082520365", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082845827", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1995.tb00300.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082858090"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-07", 
    "datePublishedReg": "2003-07-01", 
    "description": "Type I interferons (IFN-I) are important cytokines linking innate and adaptive immunity. Plasmacytoid dendritic cells make high levels of IFN-I in response to viral infection and are thought to be the major source of the cytokines in vivo. Here, we show that conventional non-plasmacytoid dendritic cells taken from mice infected with a dendritic-cell-tropic strain of lymphocytic choriomeningitis virus make similarly high levels of IFN-I on subsequent culture. Similarly, non-plasmacytoid dendritic cells secrete high levels of IFN-I in response to double-stranded RNA (dsRNA), a major viral signature, when the latter is introduced into the cytoplasm to mimic direct viral infection. This response is partially dependent on the cytosolic dsRNA-binding enzyme protein kinase R and does not require signalling through toll-like receptor (TLR) 3, a surface receptor for dsRNA. Furthermore, we show that sequestration of dsRNA by viral NS1 (refs 6, 7) explains the inability of conventional dendritic cells to produce IFN-I on infection with influenza. Our results suggest that multiple dendritic cell types, not just plasmacytoid cells, can act as specialized interferon-producing cells in certain viral infections, and reveal the existence of a TLR-independent pathway for dendritic cell activation that can be the target of viral interference.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature01783", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6946", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "424"
      }
    ], 
    "name": "Viral infection switches non-plasmacytoid dendritic cells into high interferon producers", 
    "pagination": "324", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "526abadd30bcc458e1d6ddbfe3ffaa9470a98ef68732b366022d624d35edeb79"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12819664"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature01783"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017298472"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature01783", 
      "https://app.dimensions.ai/details/publication/pub.1017298472"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87083_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature01783"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature01783'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature01783'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature01783'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature01783'


 

This table displays all metadata directly associated to this object as RDF triples.

313 TRIPLES      21 PREDICATES      77 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature01783 schema:about N14afa92961ee45a2a3b54c4f85919040
2 N16a208dac1264f9089ef955f8f84a2de
3 N190474646fe94982a63ba8f65bc82f86
4 N34213bec465244c8b3bd5fea93e1b5c5
5 N5c081d4674124aa4abe2a467ccf8fa31
6 N64527d5ce823418089c2366b600d2121
7 N6b80b7b45e064c55b15dd9d364b14207
8 N6c436f19432b4426bc13b45dda798211
9 N7a32c37391534c48aa7f991befe417dc
10 N8b8c3a2ebc51419fb32bec07bbe9c7bc
11 N8d24b5210d4741e0863663e1e6dae96b
12 Nb39598aba3cd4e27968d22c8468335c9
13 Nb599f6575e14492385a68fff02c8ab4f
14 Nc20a75355bcb4a8884eb33573f90c7a4
15 Nc8aa6204bbc049459db19f95422c7542
16 Necd1ac7a657f4a6e943a5b3fca74e913
17 Nf374a58a8ba64965b874ac5b978db643
18 Nfb48513a6c9b4f19a73d1fb7d75f28e8
19 anzsrc-for:11
20 anzsrc-for:1107
21 schema:author N3c0f55dbdfc944e2bf1e14d3aebf79f2
22 schema:citation sg:pub.10.1038/11360
23 sg:pub.10.1038/35099560
24 sg:pub.10.1038/ni0901-835
25 sg:pub.10.1038/ni736
26 sg:pub.10.1038/nri888
27 https://app.dimensions.ai/details/publication/pub.1082520365
28 https://app.dimensions.ai/details/publication/pub.1082845827
29 https://doi.org/10.1002/1521-4141(200111)31:11<3403::aid-immu3403>3.0.co;2-t
30 https://doi.org/10.1002/eji.200323797
31 https://doi.org/10.1002/j.1460-2075.1995.tb00300.x
32 https://doi.org/10.1006/viro.1996.0259
33 https://doi.org/10.1006/viro.1998.9508
34 https://doi.org/10.1016/s0952-7915(02)00349-7
35 https://doi.org/10.1016/s0952-7915(02)00354-0
36 https://doi.org/10.1016/s1074-7613(00)00014-5
37 https://doi.org/10.1016/s1074-7613(00)80596-8
38 https://doi.org/10.1073/pnas.94.2.634
39 https://doi.org/10.1074/jbc.m008717200
40 https://doi.org/10.1084/jem.192.2.219
41 https://doi.org/10.1084/jem.194.8.1171
42 https://doi.org/10.1084/jem.20011672
43 https://doi.org/10.1084/jem.20021031
44 https://doi.org/10.1093/emboj/17.22.6660
45 https://doi.org/10.1099/0022-1317-69-7-1637
46 https://doi.org/10.1126/science.284.5421.1835
47 https://doi.org/10.1126/science.3281258
48 https://doi.org/10.1126/stke.2001.89.re2
49 https://doi.org/10.1128/jvi.74.13.6203-6206.2000
50 https://doi.org/10.4049/jimmunol.166.9.5448
51 https://doi.org/10.4049/jimmunol.169.7.3652
52 schema:datePublished 2003-07
53 schema:datePublishedReg 2003-07-01
54 schema:description Type I interferons (IFN-I) are important cytokines linking innate and adaptive immunity. Plasmacytoid dendritic cells make high levels of IFN-I in response to viral infection and are thought to be the major source of the cytokines in vivo. Here, we show that conventional non-plasmacytoid dendritic cells taken from mice infected with a dendritic-cell-tropic strain of lymphocytic choriomeningitis virus make similarly high levels of IFN-I on subsequent culture. Similarly, non-plasmacytoid dendritic cells secrete high levels of IFN-I in response to double-stranded RNA (dsRNA), a major viral signature, when the latter is introduced into the cytoplasm to mimic direct viral infection. This response is partially dependent on the cytosolic dsRNA-binding enzyme protein kinase R and does not require signalling through toll-like receptor (TLR) 3, a surface receptor for dsRNA. Furthermore, we show that sequestration of dsRNA by viral NS1 (refs 6, 7) explains the inability of conventional dendritic cells to produce IFN-I on infection with influenza. Our results suggest that multiple dendritic cell types, not just plasmacytoid cells, can act as specialized interferon-producing cells in certain viral infections, and reveal the existence of a TLR-independent pathway for dendritic cell activation that can be the target of viral interference.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree false
58 schema:isPartOf N3bea6dccb76a4f1b8a2debad7e387923
59 Nb7310e66072c42fa8c620bf648246258
60 sg:journal.1018957
61 schema:name Viral infection switches non-plasmacytoid dendritic cells into high interferon producers
62 schema:pagination 324
63 schema:productId N0dd2ac5e03e24a7fbf718f33dffb82db
64 N119333c1a37843a59f681b8a792ee801
65 N2cb9274df4924ee7af2ecddc90594fab
66 Neec69c5ed47b4fc0b57b4aee7fb28e69
67 Nf6cfe3fdd5d9444d9e62aac73264cb5e
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017298472
69 https://doi.org/10.1038/nature01783
70 schema:sdDatePublished 2019-04-11T12:22
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher N819ee2410e904c349cd3ea042a82c6f5
73 schema:url https://www.nature.com/articles/nature01783
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N0cba074d34454d218df0ecc927396ed2 schema:name *Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
78 rdf:type schema:Organization
79 N0dd2ac5e03e24a7fbf718f33dffb82db schema:name dimensions_id
80 schema:value pub.1017298472
81 rdf:type schema:PropertyValue
82 N119333c1a37843a59f681b8a792ee801 schema:name readcube_id
83 schema:value 526abadd30bcc458e1d6ddbfe3ffaa9470a98ef68732b366022d624d35edeb79
84 rdf:type schema:PropertyValue
85 N14afa92961ee45a2a3b54c4f85919040 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name eIF-2 Kinase
87 rdf:type schema:DefinedTerm
88 N16a208dac1264f9089ef955f8f84a2de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Mice, Inbred BALB C
90 rdf:type schema:DefinedTerm
91 N190474646fe94982a63ba8f65bc82f86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Interferon Type I
93 rdf:type schema:DefinedTerm
94 N2cb9274df4924ee7af2ecddc90594fab schema:name nlm_unique_id
95 schema:value 0410462
96 rdf:type schema:PropertyValue
97 N34213bec465244c8b3bd5fea93e1b5c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Lymphocytic choriomeningitis virus
99 rdf:type schema:DefinedTerm
100 N3bea6dccb76a4f1b8a2debad7e387923 schema:volumeNumber 424
101 rdf:type schema:PublicationVolume
102 N3c0f55dbdfc944e2bf1e14d3aebf79f2 rdf:first sg:person.015365610407.34
103 rdf:rest N746829dfeb26420eb4701cb6d160942f
104 N491227fbdd5d44fa825235c99f6a666d rdf:first sg:person.0762745347.20
105 rdf:rest Na082801abfef4eba96e2a464bbe33c3c
106 N51b0c940bc5b4a5780af478b74bc083b rdf:first sg:person.01245346746.30
107 rdf:rest N6685ea22369d4631a02444aa042ca250
108 N5c081d4674124aa4abe2a467ccf8fa31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Signal Transduction
110 rdf:type schema:DefinedTerm
111 N64527d5ce823418089c2366b600d2121 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Toll-Like Receptor 3
113 rdf:type schema:DefinedTerm
114 N6543e2351b7c469baff19ac0a10a78c6 rdf:first sg:person.01000752176.11
115 rdf:rest N84ed718beebc4035a2975b3ea801bff3
116 N6685ea22369d4631a02444aa042ca250 rdf:first sg:person.01252465034.71
117 rdf:rest rdf:nil
118 N67166f3bd9694a1392e0102f693e8742 rdf:first sg:person.013636762157.29
119 rdf:rest N51b0c940bc5b4a5780af478b74bc083b
120 N6b80b7b45e064c55b15dd9d364b14207 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name 3T3 Cells
122 rdf:type schema:DefinedTerm
123 N6c436f19432b4426bc13b45dda798211 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Mice
125 rdf:type schema:DefinedTerm
126 N746829dfeb26420eb4701cb6d160942f rdf:first sg:person.01037174111.79
127 rdf:rest N491227fbdd5d44fa825235c99f6a666d
128 N7a32c37391534c48aa7f991befe417dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Membrane Glycoproteins
130 rdf:type schema:DefinedTerm
131 N819ee2410e904c349cd3ea042a82c6f5 schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 N84ed718beebc4035a2975b3ea801bff3 rdf:first sg:person.0702775630.05
134 rdf:rest Nfd3aa184d44d440c89971ef07fadbaaa
135 N8b8c3a2ebc51419fb32bec07bbe9c7bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name CpG Islands
137 rdf:type schema:DefinedTerm
138 N8d24b5210d4741e0863663e1e6dae96b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Lymphocytic Choriomeningitis
140 rdf:type schema:DefinedTerm
141 Na082801abfef4eba96e2a464bbe33c3c rdf:first sg:person.01054146505.33
142 rdf:rest N6543e2351b7c469baff19ac0a10a78c6
143 Nb39598aba3cd4e27968d22c8468335c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Toll-Like Receptors
145 rdf:type schema:DefinedTerm
146 Nb599f6575e14492385a68fff02c8ab4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name RNA, Double-Stranded
148 rdf:type schema:DefinedTerm
149 Nb7310e66072c42fa8c620bf648246258 schema:issueNumber 6946
150 rdf:type schema:PublicationIssue
151 Nc20a75355bcb4a8884eb33573f90c7a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Mice, Inbred C57BL
153 rdf:type schema:DefinedTerm
154 Nc8aa6204bbc049459db19f95422c7542 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Interferon-alpha
156 rdf:type schema:DefinedTerm
157 Ne4b526c2700b4591a4818dad64a842d9 schema:name *Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
158 rdf:type schema:Organization
159 Necd1ac7a657f4a6e943a5b3fca74e913 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Receptors, Cell Surface
161 rdf:type schema:DefinedTerm
162 Neec69c5ed47b4fc0b57b4aee7fb28e69 schema:name pubmed_id
163 schema:value 12819664
164 rdf:type schema:PropertyValue
165 Nf374a58a8ba64965b874ac5b978db643 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Animals
167 rdf:type schema:DefinedTerm
168 Nf6cfe3fdd5d9444d9e62aac73264cb5e schema:name doi
169 schema:value 10.1038/nature01783
170 rdf:type schema:PropertyValue
171 Nfb48513a6c9b4f19a73d1fb7d75f28e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Dendritic Cells
173 rdf:type schema:DefinedTerm
174 Nfd3aa184d44d440c89971ef07fadbaaa rdf:first sg:person.01337474107.00
175 rdf:rest N67166f3bd9694a1392e0102f693e8742
176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical and Health Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
180 schema:name Immunology
181 rdf:type schema:DefinedTerm
182 sg:journal.1018957 schema:issn 0090-0028
183 1476-4687
184 schema:name Nature
185 rdf:type schema:Periodical
186 sg:person.01000752176.11 schema:affiliation https://www.grid.ac/institutes/grid.8991.9
187 schema:familyName Roy
188 schema:givenName Polly
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000752176.11
190 rdf:type schema:Person
191 sg:person.01037174111.79 schema:affiliation https://www.grid.ac/institutes/grid.418731.8
192 schema:familyName Montoya
193 schema:givenName Maria
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037174111.79
195 rdf:type schema:Person
196 sg:person.01054146505.33 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
197 schema:familyName Alexopoulou
198 schema:givenName Lena
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054146505.33
200 rdf:type schema:Person
201 sg:person.01245346746.30 schema:affiliation https://www.grid.ac/institutes/grid.418731.8
202 schema:familyName Borrow
203 schema:givenName Persephone
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245346746.30
205 rdf:type schema:Person
206 sg:person.01252465034.71 schema:affiliation Ne4b526c2700b4591a4818dad64a842d9
207 schema:familyName Reis e Sousa
208 schema:givenName Caetano
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252465034.71
210 rdf:type schema:Person
211 sg:person.01337474107.00 schema:affiliation https://www.grid.ac/institutes/grid.123047.3
212 schema:familyName Al-Shamkhani
213 schema:givenName Aymen
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337474107.00
215 rdf:type schema:Person
216 sg:person.013636762157.29 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
217 schema:familyName Flavell
218 schema:givenName Richard
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013636762157.29
220 rdf:type schema:Person
221 sg:person.015365610407.34 schema:affiliation N0cba074d34454d218df0ecc927396ed2
222 schema:familyName Diebold
223 schema:givenName Sandra S.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015365610407.34
225 rdf:type schema:Person
226 sg:person.0702775630.05 schema:affiliation https://www.grid.ac/institutes/grid.123047.3
227 schema:familyName Haswell
228 schema:givenName Linsey E.
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702775630.05
230 rdf:type schema:Person
231 sg:person.0762745347.20 schema:affiliation https://www.grid.ac/institutes/grid.6583.8
232 schema:familyName Unger
233 schema:givenName Hermann
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762745347.20
235 rdf:type schema:Person
236 sg:pub.10.1038/11360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025050169
237 https://doi.org/10.1038/11360
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/35099560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031094923
240 https://doi.org/10.1038/35099560
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/ni0901-835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037156244
243 https://doi.org/10.1038/ni0901-835
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/ni736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006881973
246 https://doi.org/10.1038/ni736
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/nri888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004545980
249 https://doi.org/10.1038/nri888
250 rdf:type schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1082520365 schema:CreativeWork
252 https://app.dimensions.ai/details/publication/pub.1082845827 schema:CreativeWork
253 https://doi.org/10.1002/1521-4141(200111)31:11<3403::aid-immu3403>3.0.co;2-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1033394915
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1002/eji.200323797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037859595
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1002/j.1460-2075.1995.tb00300.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082858090
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1006/viro.1996.0259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023749972
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1006/viro.1998.9508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047191810
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/s0952-7915(02)00349-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046004579
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/s0952-7915(02)00354-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033642276
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/s1074-7613(00)00014-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028489999
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/s1074-7613(00)80596-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028440125
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1073/pnas.94.2.634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009691745
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1074/jbc.m008717200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025106387
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1084/jem.192.2.219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031439553
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1084/jem.194.8.1171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028310627
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1084/jem.20011672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051006171
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1084/jem.20021031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040384409
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1093/emboj/17.22.6660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034519279
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1099/0022-1317-69-7-1637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060356804
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1126/science.284.5421.1835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007458822
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1126/science.3281258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062604283
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1126/stke.2001.89.re2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062690615
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1128/jvi.74.13.6203-6206.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044020720
294 rdf:type schema:CreativeWork
295 https://doi.org/10.4049/jimmunol.166.9.5448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074802017
296 rdf:type schema:CreativeWork
297 https://doi.org/10.4049/jimmunol.169.7.3652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075128325
298 rdf:type schema:CreativeWork
299 https://www.grid.ac/institutes/grid.123047.3 schema:alternateName Southampton General Hospital
300 schema:name ¶Tenovus Research Laboratory, Cancer Sciences Division, The School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
301 rdf:type schema:Organization
302 https://www.grid.ac/institutes/grid.418731.8 schema:alternateName Jenner Institute
303 schema:name †Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, UK
304 rdf:type schema:Organization
305 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
306 schema:name §Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
307 rdf:type schema:Organization
308 https://www.grid.ac/institutes/grid.6583.8 schema:alternateName University of Veterinary Medicine Vienna
309 schema:name ‡Institute for Virology, University of Veterinary Medicine, Vienna A-1210, Austria
310 rdf:type schema:Organization
311 https://www.grid.ac/institutes/grid.8991.9 schema:alternateName London School of Hygiene & Tropical Medicine
312 schema:name ‖London School of Hygiene & Tropical Medicine, London WC1A 7HT, UK
313 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...