The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-06

AUTHORS

Helen Skaletsky, Tomoko Kuroda-Kawaguchi, Patrick J. Minx, Holland S. Cordum, LaDeana Hillier, Laura G. Brown, Sjoerd Repping, Tatyana Pyntikova, Johar Ali, Tamberlyn Bieri, Asif Chinwalla, Andrew Delehaunty, Kim Delehaunty, Hui Du, Ginger Fewell, Lucinda Fulton, Robert Fulton, Tina Graves, Shun-Fang Hou, Philip Latrielle, Shawn Leonard, Elaine Mardis, Rachel Maupin, John McPherson, Tracie Miner, William Nash, Christine Nguyen, Philip Ozersky, Kymberlie Pepin, Susan Rock, Tracy Rohlfing, Kelsi Scott, Brian Schultz, Cindy Strong, Aye Tin-Wollam, Shiaw-Pyng Yang, Robert H. Waterston, Richard K. Wilson, Steve Rozen, David C. Page

ABSTRACT

The male-specific region of the Y chromosome, the MSY, differentiates the sexes and comprises 95% of the chromosome's length. Here, we report that the MSY is a mosaic of heterochromatic sequences and three classes of euchromatic sequences: X-transposed, X-degenerate and ampliconic. These classes contain all 156 known transcription units, which include 78 protein-coding genes that collectively encode 27 distinct proteins. The X-transposed sequences exhibit 99% identity to the X chromosome. The X-degenerate sequences are remnants of ancient autosomes from which the modern X and Y chromosomes evolved. The ampliconic class includes large regions (about 30% of the MSY euchromatin) where sequence pairs show greater than 99.9% identity, which is maintained by frequent gene conversion (non-reciprocal transfer). The most prominent features here are eight massive palindromes, at least six of which contain testis genes. More... »

PAGES

825-837

References to SciGraph publications

  • 2001-02-15. Initial sequencing and analysis of the human genome in NATURE
  • 1967. Sex Chromosomes and Sex-Linked Genes in NONE
  • 1996-11. The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned in NATURE GENETICS
  • 1999-07. RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene in NATURE GENETICS
  • 2002-12. Initial sequencing and comparative analysis of the mouse genome in NATURE
  • 1997-05. Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome in NATURE GENETICS
  • 2001-10-22. The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men in NATURE GENETICS
  • 2000-11. Y chromosome sequence variation and the history of human populations in NATURE GENETICS
  • 2001-02-15. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms in NATURE
  • 1959-01. A Case of Human Intersexuality Having a Possible XXY Sex-Determining Mechanism in NATURE
  • 1999-07. The candidate spermatogenesis gene RBMY has a homologue on the human X chromosome in NATURE GENETICS
  • 1981-07. Gene conversion between duplicated genetic elements in yeast in NATURE
  • 1998-08. A proposed path by which genes common to mammalian X and Y chromosomes evolve to become X inactivated in NATURE
  • 1993-12. Localization of DNA sequences required for human centromere function through an analysis of rearranged Y chromosomes in NATURE GENETICS
  • 1984-09. Occurrence of a transposition from the X-chromosome long arm to the Y-chromosome short arm during human evolution in NATURE
  • 2001-02-15. A physical map of the human Y chromosome in NATURE
  • 2003-06. Abundant gene conversion between arms of palindromes in human and ape Y chromosomes in NATURE
  • 1999-04. Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome in NATURE GENETICS
  • 1999-12. An azoospermic man with a de novo point mutation in the Y-chromosomal gene USP9Y in NATURE GENETICS
  • Journal

    TITLE

    Nature

    ISSUE

    6942

    VOLUME

    423

    Related Patents

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature01722

    DOI

    http://dx.doi.org/10.1038/nature01722

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032168678

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12815422


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomes, Human, X", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomes, Human, Y", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Crossing Over, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Transposable Elements", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Euchromatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Evolution, Molecular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Amplification", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Conversion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heterochromatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "In Situ Hybridization, Fluorescence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multigene Family", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Organ Specificity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pseudogenes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Homology, Nucleic Acid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sex Characteristics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sex Determination Processes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Species Specificity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Testis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transducin", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Skaletsky", 
            "givenName": "Helen", 
            "id": "sg:person.01266753034.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266753034.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kuroda-Kawaguchi", 
            "givenName": "Tomoko", 
            "id": "sg:person.0702641052.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702641052.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Minx", 
            "givenName": "Patrick J.", 
            "id": "sg:person.015337230467.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015337230467.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cordum", 
            "givenName": "Holland S.", 
            "id": "sg:person.01017067452.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017067452.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hillier", 
            "givenName": "LaDeana", 
            "id": "sg:person.01014313442.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014313442.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Brown", 
            "givenName": "Laura G.", 
            "id": "sg:person.012271742572.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012271742572.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Reproductive Medicine, Department of Gynaecology and Obstetrics, Academic Medical Centre, 1105 AZ, Amsterdam, the Netherlands", 
              "id": "http://www.grid.ac/institutes/grid.5650.6", 
              "name": [
                "Center for Reproductive Medicine, Department of Gynaecology and Obstetrics, Academic Medical Centre, 1105 AZ, Amsterdam, the Netherlands"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Repping", 
            "givenName": "Sjoerd", 
            "id": "sg:person.01072732504.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072732504.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pyntikova", 
            "givenName": "Tatyana", 
            "id": "sg:person.01224563513.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224563513.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ali", 
            "givenName": "Johar", 
            "id": "sg:person.01272506051.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272506051.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bieri", 
            "givenName": "Tamberlyn", 
            "id": "sg:person.0772622770.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772622770.84"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chinwalla", 
            "givenName": "Asif", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Delehaunty", 
            "givenName": "Andrew", 
            "id": "sg:person.01152430577.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152430577.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Delehaunty", 
            "givenName": "Kim", 
            "id": "sg:person.0761455636.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761455636.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Du", 
            "givenName": "Hui", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fewell", 
            "givenName": "Ginger", 
            "id": "sg:person.0603501634.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603501634.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fulton", 
            "givenName": "Lucinda", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fulton", 
            "givenName": "Robert", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Graves", 
            "givenName": "Tina", 
            "id": "sg:person.01123736653.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123736653.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hou", 
            "givenName": "Shun-Fang", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Latrielle", 
            "givenName": "Philip", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Leonard", 
            "givenName": "Shawn", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mardis", 
            "givenName": "Elaine", 
            "id": "sg:person.01023627236.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023627236.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Maupin", 
            "givenName": "Rachel", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McPherson", 
            "givenName": "John", 
            "id": "sg:person.0650216531.95", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650216531.95"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miner", 
            "givenName": "Tracie", 
            "id": "sg:person.01344004151.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344004151.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nash", 
            "givenName": "William", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nguyen", 
            "givenName": "Christine", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ozersky", 
            "givenName": "Philip", 
            "id": "sg:person.0605620467.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605620467.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pepin", 
            "givenName": "Kymberlie", 
            "id": "sg:person.0717134061.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717134061.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rock", 
            "givenName": "Susan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rohlfing", 
            "givenName": "Tracy", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Scott", 
            "givenName": "Kelsi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schultz", 
            "givenName": "Brian", 
            "id": "sg:person.0745605505.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745605505.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Strong", 
            "givenName": "Cindy", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tin-Wollam", 
            "givenName": "Aye", 
            "id": "sg:person.01220514306.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220514306.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Shiaw-Pyng", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Waterston", 
            "givenName": "Robert H.", 
            "id": "sg:person.0772724136.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772724136.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.4367.6", 
              "name": [
                "Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wilson", 
            "givenName": "Richard K.", 
            "id": "sg:person.013076541047.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013076541047.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rozen", 
            "givenName": "Steve", 
            "id": "sg:person.013130175037.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013130175037.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA", 
              "id": "http://www.grid.ac/institutes/grid.270301.7", 
              "name": [
                "Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Page", 
            "givenName": "David C.", 
            "id": "sg:person.01224407762.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224407762.64"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature01723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002596939", 
              "https://doi.org/10.1038/nature01723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/29522", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052618075", 
              "https://doi.org/10.1038/29522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/7771", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017350084", 
              "https://doi.org/10.1038/7771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/10279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043333106", 
              "https://doi.org/10.1038/10279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/10282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022822883", 
              "https://doi.org/10.1038/10282"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/70539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017222001", 
              "https://doi.org/10.1038/70539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35057062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042854081", 
              "https://doi.org/10.1038/35057062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/292306a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016316617", 
              "https://doi.org/10.1038/292306a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35057149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046153445", 
              "https://doi.org/10.1038/35057149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0597-54", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014547772", 
              "https://doi.org/10.1038/ng0597-54"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/311119a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020641144", 
              "https://doi.org/10.1038/311119a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/81685", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005509970", 
              "https://doi.org/10.1038/81685"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1293-368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025716934", 
              "https://doi.org/10.1038/ng1293-368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-88178-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017975083", 
              "https://doi.org/10.1007/978-3-642-88178-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/183302a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039307308", 
              "https://doi.org/10.1038/183302a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35057170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039691728", 
              "https://doi.org/10.1038/35057170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1196-292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012147825", 
              "https://doi.org/10.1038/ng1196-292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng757", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040986528", 
              "https://doi.org/10.1038/ng757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039854529", 
              "https://doi.org/10.1038/nature01262"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2003-06", 
        "datePublishedReg": "2003-06-01", 
        "description": "The male-specific region of the Y chromosome, the MSY, differentiates the sexes and comprises 95% of the chromosome's length. Here, we report that the MSY is a mosaic of heterochromatic sequences and three classes of euchromatic sequences: X-transposed, X-degenerate and ampliconic. These classes contain all 156 known transcription units, which include 78 protein-coding genes that collectively encode 27 distinct proteins. The X-transposed sequences exhibit 99% identity to the X chromosome. The X-degenerate sequences are remnants of ancient autosomes from which the modern X and Y chromosomes evolved. The ampliconic class includes large regions (about 30% of the MSY euchromatin) where sequence pairs show greater than 99.9% identity, which is maintained by frequent gene conversion (non-reciprocal transfer). The most prominent features here are eight massive palindromes, at least six of which contain testis genes.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nature01722", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6942", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "423"
          }
        ], 
        "keywords": [
          "male-specific region", 
          "Y chromosome", 
          "protein-coding genes", 
          "frequent gene conversion", 
          "human Y chromosome", 
          "ancient autosomes", 
          "heterochromatic sequences", 
          "euchromatic sequences", 
          "transcription unit", 
          "gene conversion", 
          "chromosome length", 
          "distinct proteins", 
          "X chromosome", 
          "massive palindromes", 
          "testis genes", 
          "chromosomes", 
          "degenerate sequence", 
          "sequence classes", 
          "genes", 
          "sequence", 
          "MSY", 
          "autosomes", 
          "sequence pairs", 
          "palindromes", 
          "protein", 
          "region", 
          "large regions", 
          "identity", 
          "prominent feature", 
          "length", 
          "class", 
          "remnants", 
          "pairs", 
          "conversion", 
          "sex", 
          "features", 
          "units"
        ], 
        "name": "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes", 
        "pagination": "825-837", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1032168678"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature01722"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "12815422"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature01722", 
          "https://app.dimensions.ai/details/publication/pub.1032168678"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T15:51", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_373.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nature01722"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature01722'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature01722'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature01722'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature01722'


     

    This table displays all metadata directly associated to this object as RDF triples.

    538 TRIPLES      21 PREDICATES      107 URIs      80 LITERALS      32 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature01722 schema:about N1f7b3f1b242e4777832445f25c5a9afe
    2 N27c3fa364d9e4b7aaa2f70b4ac89821e
    3 N39dbd86cff10410c87a363999805ac0f
    4 N48955ccab16d498d8116c9db589c564e
    5 N574488438d304c86b5c7b9c2e6eb036f
    6 N59646f301f1542ac82c98e2c92c4a51c
    7 N5e4169c7fed945129298bb3b80cbb648
    8 N6be70c114ca8454bb52621b283e70077
    9 N7922e768d18e49169890949dbb5b5b53
    10 N7e163e1141424997a6e8591b0dabea1a
    11 N991de0588d3e4cad884325a00128fda2
    12 Nb33fbba362c244b398ed6a6d6491daf1
    13 Nb3fda81d3a7c41d89314f5c32d4d5aee
    14 Nb76f60cbad004b1bb5298a63c0f65a7b
    15 Nc31e9b767d89498a82a3f8662695830d
    16 Nd7054e8cfc7646a2bae1461a68b92d31
    17 Nde506d5ba1bf4c93a1683aa058526e6b
    18 Ne0e7f435c4fd4c13babb1541097f5800
    19 Ne12b6ca0ebc649528ddba46c6df7d94c
    20 Ne133d1160d424df199456f76cc469910
    21 Ne1a5022642704b7fbf295ce1c49bdcd0
    22 Ne23ef9c883c945d39c23cc15e5bf8f5f
    23 Ne899109ab7c641f5b8b1a243d0205ed4
    24 Nf02f9c2a8a0c44cdab2b09c34b799140
    25 Nf7dc2411ca2347dbb7ca6694e668033d
    26 anzsrc-for:06
    27 anzsrc-for:0604
    28 schema:author N575662c5a06a4df8a22f4efe73c39bea
    29 schema:citation sg:pub.10.1007/978-3-642-88178-7
    30 sg:pub.10.1038/10279
    31 sg:pub.10.1038/10282
    32 sg:pub.10.1038/183302a0
    33 sg:pub.10.1038/292306a0
    34 sg:pub.10.1038/29522
    35 sg:pub.10.1038/311119a0
    36 sg:pub.10.1038/35057062
    37 sg:pub.10.1038/35057149
    38 sg:pub.10.1038/35057170
    39 sg:pub.10.1038/70539
    40 sg:pub.10.1038/7771
    41 sg:pub.10.1038/81685
    42 sg:pub.10.1038/nature01262
    43 sg:pub.10.1038/nature01723
    44 sg:pub.10.1038/ng0597-54
    45 sg:pub.10.1038/ng1196-292
    46 sg:pub.10.1038/ng1293-368
    47 sg:pub.10.1038/ng757
    48 schema:datePublished 2003-06
    49 schema:datePublishedReg 2003-06-01
    50 schema:description The male-specific region of the Y chromosome, the MSY, differentiates the sexes and comprises 95% of the chromosome's length. Here, we report that the MSY is a mosaic of heterochromatic sequences and three classes of euchromatic sequences: X-transposed, X-degenerate and ampliconic. These classes contain all 156 known transcription units, which include 78 protein-coding genes that collectively encode 27 distinct proteins. The X-transposed sequences exhibit 99% identity to the X chromosome. The X-degenerate sequences are remnants of ancient autosomes from which the modern X and Y chromosomes evolved. The ampliconic class includes large regions (about 30% of the MSY euchromatin) where sequence pairs show greater than 99.9% identity, which is maintained by frequent gene conversion (non-reciprocal transfer). The most prominent features here are eight massive palindromes, at least six of which contain testis genes.
    51 schema:genre article
    52 schema:isAccessibleForFree true
    53 schema:isPartOf N14d9eb0dc14243ef988018a7b880f0ef
    54 N57d72331ec1e45e2a7ecd1f5800d7066
    55 sg:journal.1018957
    56 schema:keywords MSY
    57 X chromosome
    58 Y chromosome
    59 ancient autosomes
    60 autosomes
    61 chromosome length
    62 chromosomes
    63 class
    64 conversion
    65 degenerate sequence
    66 distinct proteins
    67 euchromatic sequences
    68 features
    69 frequent gene conversion
    70 gene conversion
    71 genes
    72 heterochromatic sequences
    73 human Y chromosome
    74 identity
    75 large regions
    76 length
    77 male-specific region
    78 massive palindromes
    79 pairs
    80 palindromes
    81 prominent feature
    82 protein
    83 protein-coding genes
    84 region
    85 remnants
    86 sequence
    87 sequence classes
    88 sequence pairs
    89 sex
    90 testis genes
    91 transcription unit
    92 units
    93 schema:name The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes
    94 schema:pagination 825-837
    95 schema:productId N14becbd6c8da4dfb86e9cf83c998fce4
    96 N2e62237e99604ec68d6e69743737bedf
    97 Nd73b309df48345e289247bf750156884
    98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032168678
    99 https://doi.org/10.1038/nature01722
    100 schema:sdDatePublished 2022-09-02T15:51
    101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    102 schema:sdPublisher N75ea5ee76f414ec6b47f0855c4b4b0b8
    103 schema:url https://doi.org/10.1038/nature01722
    104 sgo:license sg:explorer/license/
    105 sgo:sdDataset articles
    106 rdf:type schema:ScholarlyArticle
    107 N00c7829fc9b44b898b55540c0b714d53 rdf:first N72aaefba22f3465dab922e1ca89e3c62
    108 rdf:rest Nee04994b20bd47ab95adf19d06778afa
    109 N0d598335bee9401b892c6eeb60394a52 schema:affiliation grid-institutes:grid.4367.6
    110 schema:familyName Latrielle
    111 schema:givenName Philip
    112 rdf:type schema:Person
    113 N12c5d9bbda2c467ca1b451387dd5c0d3 schema:affiliation grid-institutes:grid.4367.6
    114 schema:familyName Nash
    115 schema:givenName William
    116 rdf:type schema:Person
    117 N14becbd6c8da4dfb86e9cf83c998fce4 schema:name doi
    118 schema:value 10.1038/nature01722
    119 rdf:type schema:PropertyValue
    120 N14d9eb0dc14243ef988018a7b880f0ef schema:issueNumber 6942
    121 rdf:type schema:PublicationIssue
    122 N156e069c72af47eb847784070e0d5af4 rdf:first N2233480a10014706ba8292083ff08aa6
    123 rdf:rest N662ea3fdbba0408ea94e0a72697c70a4
    124 N1e07a872f174481d89a44a85dda9c672 rdf:first sg:person.0702641052.21
    125 rdf:rest N6a361364c6664404bde8e2ec8daedb3b
    126 N1ec6f52d5e064524a89b94b736bb1f7a rdf:first sg:person.01017067452.18
    127 rdf:rest Ndaa2bab44e7b4daa9103b1e376b6421d
    128 N1f7b3f1b242e4777832445f25c5a9afe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Species Specificity
    130 rdf:type schema:DefinedTerm
    131 N2233480a10014706ba8292083ff08aa6 schema:affiliation grid-institutes:grid.4367.6
    132 schema:familyName Hou
    133 schema:givenName Shun-Fang
    134 rdf:type schema:Person
    135 N27c3fa364d9e4b7aaa2f70b4ac89821e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Gene Amplification
    137 rdf:type schema:DefinedTerm
    138 N2e62237e99604ec68d6e69743737bedf schema:name pubmed_id
    139 schema:value 12815422
    140 rdf:type schema:PropertyValue
    141 N337cfc8fefd145b1925dca3ae20c55e4 schema:affiliation grid-institutes:grid.4367.6
    142 schema:familyName Chinwalla
    143 schema:givenName Asif
    144 rdf:type schema:Person
    145 N39dbd86cff10410c87a363999805ac0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Testis
    147 rdf:type schema:DefinedTerm
    148 N3c9bef1730154686bf45eb5949b386ff rdf:first N7e3d04b4818647d4bc73e07440d926e2
    149 rdf:rest Na443101c023441428bd136df32e831bd
    150 N3feb1b5b081e402992e0e9e1f89e7c29 rdf:first N505b7f748c73485184aa3cfc707a3096
    151 rdf:rest N7e5894c4666a4c20bedced380f65e614
    152 N48955ccab16d498d8116c9db589c564e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Euchromatin
    154 rdf:type schema:DefinedTerm
    155 N505b7f748c73485184aa3cfc707a3096 schema:affiliation grid-institutes:grid.4367.6
    156 schema:familyName Leonard
    157 schema:givenName Shawn
    158 rdf:type schema:Person
    159 N574488438d304c86b5c7b9c2e6eb036f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Gene Conversion
    161 rdf:type schema:DefinedTerm
    162 N575662c5a06a4df8a22f4efe73c39bea rdf:first sg:person.01266753034.97
    163 rdf:rest N1e07a872f174481d89a44a85dda9c672
    164 N57d72331ec1e45e2a7ecd1f5800d7066 schema:volumeNumber 423
    165 rdf:type schema:PublicationVolume
    166 N59646f301f1542ac82c98e2c92c4a51c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Chromosomes, Human, X
    168 rdf:type schema:DefinedTerm
    169 N5abf4e9b6ce84f448a5a874e2cf7c75d rdf:first N75114dc414394d369b8652d8557793e9
    170 rdf:rest N9f1f048f189549808ac28a7b641c9114
    171 N5da4f69237ea4b6ab20c230da8a11656 rdf:first sg:person.01220514306.97
    172 rdf:rest N6d5f53cd4adf4e14b590f63187658304
    173 N5e4169c7fed945129298bb3b80cbb648 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Pseudogenes
    175 rdf:type schema:DefinedTerm
    176 N662ea3fdbba0408ea94e0a72697c70a4 rdf:first N0d598335bee9401b892c6eeb60394a52
    177 rdf:rest N3feb1b5b081e402992e0e9e1f89e7c29
    178 N67a3025eb754423a9ee5622c3524ba15 rdf:first sg:person.01224407762.64
    179 rdf:rest rdf:nil
    180 N6a361364c6664404bde8e2ec8daedb3b rdf:first sg:person.015337230467.68
    181 rdf:rest N1ec6f52d5e064524a89b94b736bb1f7a
    182 N6be70c114ca8454bb52621b283e70077 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Heterochromatin
    184 rdf:type schema:DefinedTerm
    185 N6d5f53cd4adf4e14b590f63187658304 rdf:first Nef48178dfcbf41f99d8775a385fcdc62
    186 rdf:rest N8277e52a281e44d688edfc76c99340e5
    187 N71951ddfde14498795d18ac005696184 rdf:first sg:person.013076541047.38
    188 rdf:rest Nbf6ddc82ab1347328224d1356fdd5277
    189 N72aaefba22f3465dab922e1ca89e3c62 schema:affiliation grid-institutes:grid.4367.6
    190 schema:familyName Maupin
    191 schema:givenName Rachel
    192 rdf:type schema:Person
    193 N75114dc414394d369b8652d8557793e9 schema:affiliation grid-institutes:grid.4367.6
    194 schema:familyName Fulton
    195 schema:givenName Robert
    196 rdf:type schema:Person
    197 N75ea5ee76f414ec6b47f0855c4b4b0b8 schema:name Springer Nature - SN SciGraph project
    198 rdf:type schema:Organization
    199 N7922e768d18e49169890949dbb5b5b53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Male
    201 rdf:type schema:DefinedTerm
    202 N7a8951ef736f4942801d61ffa7ad3199 rdf:first sg:person.01272506051.90
    203 rdf:rest Nf5792db6e1674e91830fa1c721b619ae
    204 N7e163e1141424997a6e8591b0dabea1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    205 schema:name Genes
    206 rdf:type schema:DefinedTerm
    207 N7e3d04b4818647d4bc73e07440d926e2 schema:affiliation grid-institutes:grid.4367.6
    208 schema:familyName Nguyen
    209 schema:givenName Christine
    210 rdf:type schema:Person
    211 N7e5894c4666a4c20bedced380f65e614 rdf:first sg:person.01023627236.33
    212 rdf:rest N00c7829fc9b44b898b55540c0b714d53
    213 N8277e52a281e44d688edfc76c99340e5 rdf:first sg:person.0772724136.39
    214 rdf:rest N71951ddfde14498795d18ac005696184
    215 N82e514ce92d24f5bb9a318e3beefc021 rdf:first sg:person.01224563513.92
    216 rdf:rest N7a8951ef736f4942801d61ffa7ad3199
    217 N8540b0cd46c547819290008dbd0f2ec7 schema:affiliation grid-institutes:grid.4367.6
    218 schema:familyName Scott
    219 schema:givenName Kelsi
    220 rdf:type schema:Person
    221 N907d5f09e61e496c8591c58e3f086771 rdf:first Nce9e57bb0bb04745bcadbe9255a57b2d
    222 rdf:rest Nbcd42c36fb734ff6b2bde9cd54a7e4ab
    223 N91aa1db50eb6444d9190d4853d44d639 rdf:first N12c5d9bbda2c467ca1b451387dd5c0d3
    224 rdf:rest N3c9bef1730154686bf45eb5949b386ff
    225 N991de0588d3e4cad884325a00128fda2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    226 schema:name Organ Specificity
    227 rdf:type schema:DefinedTerm
    228 N9f1f048f189549808ac28a7b641c9114 rdf:first sg:person.01123736653.38
    229 rdf:rest N156e069c72af47eb847784070e0d5af4
    230 Na3af27c8746944dfbbeccb8312112223 rdf:first sg:person.0717134061.36
    231 rdf:rest Nf29616efb8f146dabb764d5d4be19a44
    232 Na443101c023441428bd136df32e831bd rdf:first sg:person.0605620467.64
    233 rdf:rest Na3af27c8746944dfbbeccb8312112223
    234 Naef8f5e9bbeb41d698d8beae8dbf3a16 schema:affiliation grid-institutes:grid.4367.6
    235 schema:familyName Rock
    236 schema:givenName Susan
    237 rdf:type schema:Person
    238 Nafa669454f1f49d4801a77607fd436b0 rdf:first sg:person.01344004151.06
    239 rdf:rest N91aa1db50eb6444d9190d4853d44d639
    240 Nb33fbba362c244b398ed6a6d6491daf1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    241 schema:name Multigene Family
    242 rdf:type schema:DefinedTerm
    243 Nb39d938151ca446dbdbf7d07417453a8 rdf:first N337cfc8fefd145b1925dca3ae20c55e4
    244 rdf:rest Ned2a4df661f34a189c3bc0170b0931a8
    245 Nb3fda81d3a7c41d89314f5c32d4d5aee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    246 schema:name Sex Determination Processes
    247 rdf:type schema:DefinedTerm
    248 Nb76f60cbad004b1bb5298a63c0f65a7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    249 schema:name Chromosomes, Human, Y
    250 rdf:type schema:DefinedTerm
    251 Nbcd42c36fb734ff6b2bde9cd54a7e4ab rdf:first N8540b0cd46c547819290008dbd0f2ec7
    252 rdf:rest Nc129958f8d604339b99f3e625292f5b0
    253 Nbf6ddc82ab1347328224d1356fdd5277 rdf:first sg:person.013130175037.28
    254 rdf:rest N67a3025eb754423a9ee5622c3524ba15
    255 Nc129958f8d604339b99f3e625292f5b0 rdf:first sg:person.0745605505.21
    256 rdf:rest Ne84941d564c44fbbbfa8e35d60d2fda2
    257 Nc31e9b767d89498a82a3f8662695830d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    258 schema:name Sequence Homology, Nucleic Acid
    259 rdf:type schema:DefinedTerm
    260 Ncb52b7ba23a648f6820ea4daf1759a52 schema:affiliation grid-institutes:grid.4367.6
    261 schema:familyName Du
    262 schema:givenName Hui
    263 rdf:type schema:Person
    264 Nce9e57bb0bb04745bcadbe9255a57b2d schema:affiliation grid-institutes:grid.4367.6
    265 schema:familyName Rohlfing
    266 schema:givenName Tracy
    267 rdf:type schema:Person
    268 Nd0b29aadf3884af7979dc601b221bc9c rdf:first Nfbbd5ae702954f2cb54c0571512ad5f6
    269 rdf:rest N5abf4e9b6ce84f448a5a874e2cf7c75d
    270 Nd66fc03c242d4668bab9dad7a94c9846 rdf:first sg:person.0761455636.11
    271 rdf:rest Ne96b96edbeb643c096cbe246cad68c31
    272 Nd7054e8cfc7646a2bae1461a68b92d31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    273 schema:name DNA Transposable Elements
    274 rdf:type schema:DefinedTerm
    275 Nd73b309df48345e289247bf750156884 schema:name dimensions_id
    276 schema:value pub.1032168678
    277 rdf:type schema:PropertyValue
    278 Nd795b026c3f24426a3f0aecf23c91788 rdf:first sg:person.0603501634.38
    279 rdf:rest Nd0b29aadf3884af7979dc601b221bc9c
    280 Ndaa2bab44e7b4daa9103b1e376b6421d rdf:first sg:person.01014313442.46
    281 rdf:rest Nf8334be2acd74272ad2ba855b0a77154
    282 Nde506d5ba1bf4c93a1683aa058526e6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    283 schema:name Models, Genetic
    284 rdf:type schema:DefinedTerm
    285 Ne0e7f435c4fd4c13babb1541097f5800 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    286 schema:name In Situ Hybridization, Fluorescence
    287 rdf:type schema:DefinedTerm
    288 Ne12b6ca0ebc649528ddba46c6df7d94c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    289 schema:name Sex Characteristics
    290 rdf:type schema:DefinedTerm
    291 Ne133d1160d424df199456f76cc469910 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    292 schema:name Transducin
    293 rdf:type schema:DefinedTerm
    294 Ne1a5022642704b7fbf295ce1c49bdcd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    295 schema:name Female
    296 rdf:type schema:DefinedTerm
    297 Ne23ef9c883c945d39c23cc15e5bf8f5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    298 schema:name Humans
    299 rdf:type schema:DefinedTerm
    300 Ne5b79a6db8b0473084a1ed18a278d609 schema:affiliation grid-institutes:grid.4367.6
    301 schema:familyName Strong
    302 schema:givenName Cindy
    303 rdf:type schema:Person
    304 Ne84941d564c44fbbbfa8e35d60d2fda2 rdf:first Ne5b79a6db8b0473084a1ed18a278d609
    305 rdf:rest N5da4f69237ea4b6ab20c230da8a11656
    306 Ne899109ab7c641f5b8b1a243d0205ed4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    307 schema:name Crossing Over, Genetic
    308 rdf:type schema:DefinedTerm
    309 Ne96b96edbeb643c096cbe246cad68c31 rdf:first Ncb52b7ba23a648f6820ea4daf1759a52
    310 rdf:rest Nd795b026c3f24426a3f0aecf23c91788
    311 Ned2a4df661f34a189c3bc0170b0931a8 rdf:first sg:person.01152430577.92
    312 rdf:rest Nd66fc03c242d4668bab9dad7a94c9846
    313 Nee04994b20bd47ab95adf19d06778afa rdf:first sg:person.0650216531.95
    314 rdf:rest Nafa669454f1f49d4801a77607fd436b0
    315 Nef48178dfcbf41f99d8775a385fcdc62 schema:affiliation grid-institutes:grid.4367.6
    316 schema:familyName Yang
    317 schema:givenName Shiaw-Pyng
    318 rdf:type schema:Person
    319 Nf02f9c2a8a0c44cdab2b09c34b799140 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    320 schema:name Evolution, Molecular
    321 rdf:type schema:DefinedTerm
    322 Nf29616efb8f146dabb764d5d4be19a44 rdf:first Naef8f5e9bbeb41d698d8beae8dbf3a16
    323 rdf:rest N907d5f09e61e496c8591c58e3f086771
    324 Nf36f6b11ca0a47248004c0da4adc9d1c rdf:first sg:person.01072732504.52
    325 rdf:rest N82e514ce92d24f5bb9a318e3beefc021
    326 Nf5792db6e1674e91830fa1c721b619ae rdf:first sg:person.0772622770.84
    327 rdf:rest Nb39d938151ca446dbdbf7d07417453a8
    328 Nf7dc2411ca2347dbb7ca6694e668033d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    329 schema:name Transcription, Genetic
    330 rdf:type schema:DefinedTerm
    331 Nf8334be2acd74272ad2ba855b0a77154 rdf:first sg:person.012271742572.52
    332 rdf:rest Nf36f6b11ca0a47248004c0da4adc9d1c
    333 Nfbbd5ae702954f2cb54c0571512ad5f6 schema:affiliation grid-institutes:grid.4367.6
    334 schema:familyName Fulton
    335 schema:givenName Lucinda
    336 rdf:type schema:Person
    337 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    338 schema:name Biological Sciences
    339 rdf:type schema:DefinedTerm
    340 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    341 schema:name Genetics
    342 rdf:type schema:DefinedTerm
    343 sg:journal.1018957 schema:issn 0028-0836
    344 1476-4687
    345 schema:name Nature
    346 schema:publisher Springer Nature
    347 rdf:type schema:Periodical
    348 sg:person.01014313442.46 schema:affiliation grid-institutes:grid.4367.6
    349 schema:familyName Hillier
    350 schema:givenName LaDeana
    351 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014313442.46
    352 rdf:type schema:Person
    353 sg:person.01017067452.18 schema:affiliation grid-institutes:grid.4367.6
    354 schema:familyName Cordum
    355 schema:givenName Holland S.
    356 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017067452.18
    357 rdf:type schema:Person
    358 sg:person.01023627236.33 schema:affiliation grid-institutes:grid.4367.6
    359 schema:familyName Mardis
    360 schema:givenName Elaine
    361 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023627236.33
    362 rdf:type schema:Person
    363 sg:person.01072732504.52 schema:affiliation grid-institutes:grid.5650.6
    364 schema:familyName Repping
    365 schema:givenName Sjoerd
    366 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072732504.52
    367 rdf:type schema:Person
    368 sg:person.01123736653.38 schema:affiliation grid-institutes:grid.4367.6
    369 schema:familyName Graves
    370 schema:givenName Tina
    371 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123736653.38
    372 rdf:type schema:Person
    373 sg:person.01152430577.92 schema:affiliation grid-institutes:grid.4367.6
    374 schema:familyName Delehaunty
    375 schema:givenName Andrew
    376 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152430577.92
    377 rdf:type schema:Person
    378 sg:person.01220514306.97 schema:affiliation grid-institutes:grid.4367.6
    379 schema:familyName Tin-Wollam
    380 schema:givenName Aye
    381 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220514306.97
    382 rdf:type schema:Person
    383 sg:person.01224407762.64 schema:affiliation grid-institutes:grid.270301.7
    384 schema:familyName Page
    385 schema:givenName David C.
    386 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224407762.64
    387 rdf:type schema:Person
    388 sg:person.01224563513.92 schema:affiliation grid-institutes:grid.270301.7
    389 schema:familyName Pyntikova
    390 schema:givenName Tatyana
    391 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224563513.92
    392 rdf:type schema:Person
    393 sg:person.012271742572.52 schema:affiliation grid-institutes:grid.270301.7
    394 schema:familyName Brown
    395 schema:givenName Laura G.
    396 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012271742572.52
    397 rdf:type schema:Person
    398 sg:person.01266753034.97 schema:affiliation grid-institutes:grid.270301.7
    399 schema:familyName Skaletsky
    400 schema:givenName Helen
    401 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266753034.97
    402 rdf:type schema:Person
    403 sg:person.01272506051.90 schema:affiliation grid-institutes:grid.4367.6
    404 schema:familyName Ali
    405 schema:givenName Johar
    406 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272506051.90
    407 rdf:type schema:Person
    408 sg:person.013076541047.38 schema:affiliation grid-institutes:grid.4367.6
    409 schema:familyName Wilson
    410 schema:givenName Richard K.
    411 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013076541047.38
    412 rdf:type schema:Person
    413 sg:person.013130175037.28 schema:affiliation grid-institutes:grid.270301.7
    414 schema:familyName Rozen
    415 schema:givenName Steve
    416 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013130175037.28
    417 rdf:type schema:Person
    418 sg:person.01344004151.06 schema:affiliation grid-institutes:grid.4367.6
    419 schema:familyName Miner
    420 schema:givenName Tracie
    421 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344004151.06
    422 rdf:type schema:Person
    423 sg:person.015337230467.68 schema:affiliation grid-institutes:grid.4367.6
    424 schema:familyName Minx
    425 schema:givenName Patrick J.
    426 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015337230467.68
    427 rdf:type schema:Person
    428 sg:person.0603501634.38 schema:affiliation grid-institutes:grid.4367.6
    429 schema:familyName Fewell
    430 schema:givenName Ginger
    431 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603501634.38
    432 rdf:type schema:Person
    433 sg:person.0605620467.64 schema:affiliation grid-institutes:grid.4367.6
    434 schema:familyName Ozersky
    435 schema:givenName Philip
    436 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605620467.64
    437 rdf:type schema:Person
    438 sg:person.0650216531.95 schema:affiliation grid-institutes:grid.4367.6
    439 schema:familyName McPherson
    440 schema:givenName John
    441 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650216531.95
    442 rdf:type schema:Person
    443 sg:person.0702641052.21 schema:affiliation grid-institutes:grid.270301.7
    444 schema:familyName Kuroda-Kawaguchi
    445 schema:givenName Tomoko
    446 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702641052.21
    447 rdf:type schema:Person
    448 sg:person.0717134061.36 schema:affiliation grid-institutes:grid.4367.6
    449 schema:familyName Pepin
    450 schema:givenName Kymberlie
    451 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717134061.36
    452 rdf:type schema:Person
    453 sg:person.0745605505.21 schema:affiliation grid-institutes:grid.4367.6
    454 schema:familyName Schultz
    455 schema:givenName Brian
    456 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745605505.21
    457 rdf:type schema:Person
    458 sg:person.0761455636.11 schema:affiliation grid-institutes:grid.4367.6
    459 schema:familyName Delehaunty
    460 schema:givenName Kim
    461 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761455636.11
    462 rdf:type schema:Person
    463 sg:person.0772622770.84 schema:affiliation grid-institutes:grid.4367.6
    464 schema:familyName Bieri
    465 schema:givenName Tamberlyn
    466 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772622770.84
    467 rdf:type schema:Person
    468 sg:person.0772724136.39 schema:affiliation grid-institutes:grid.4367.6
    469 schema:familyName Waterston
    470 schema:givenName Robert H.
    471 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772724136.39
    472 rdf:type schema:Person
    473 sg:pub.10.1007/978-3-642-88178-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017975083
    474 https://doi.org/10.1007/978-3-642-88178-7
    475 rdf:type schema:CreativeWork
    476 sg:pub.10.1038/10279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043333106
    477 https://doi.org/10.1038/10279
    478 rdf:type schema:CreativeWork
    479 sg:pub.10.1038/10282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022822883
    480 https://doi.org/10.1038/10282
    481 rdf:type schema:CreativeWork
    482 sg:pub.10.1038/183302a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039307308
    483 https://doi.org/10.1038/183302a0
    484 rdf:type schema:CreativeWork
    485 sg:pub.10.1038/292306a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016316617
    486 https://doi.org/10.1038/292306a0
    487 rdf:type schema:CreativeWork
    488 sg:pub.10.1038/29522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052618075
    489 https://doi.org/10.1038/29522
    490 rdf:type schema:CreativeWork
    491 sg:pub.10.1038/311119a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020641144
    492 https://doi.org/10.1038/311119a0
    493 rdf:type schema:CreativeWork
    494 sg:pub.10.1038/35057062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042854081
    495 https://doi.org/10.1038/35057062
    496 rdf:type schema:CreativeWork
    497 sg:pub.10.1038/35057149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046153445
    498 https://doi.org/10.1038/35057149
    499 rdf:type schema:CreativeWork
    500 sg:pub.10.1038/35057170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039691728
    501 https://doi.org/10.1038/35057170
    502 rdf:type schema:CreativeWork
    503 sg:pub.10.1038/70539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017222001
    504 https://doi.org/10.1038/70539
    505 rdf:type schema:CreativeWork
    506 sg:pub.10.1038/7771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017350084
    507 https://doi.org/10.1038/7771
    508 rdf:type schema:CreativeWork
    509 sg:pub.10.1038/81685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005509970
    510 https://doi.org/10.1038/81685
    511 rdf:type schema:CreativeWork
    512 sg:pub.10.1038/nature01262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039854529
    513 https://doi.org/10.1038/nature01262
    514 rdf:type schema:CreativeWork
    515 sg:pub.10.1038/nature01723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002596939
    516 https://doi.org/10.1038/nature01723
    517 rdf:type schema:CreativeWork
    518 sg:pub.10.1038/ng0597-54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014547772
    519 https://doi.org/10.1038/ng0597-54
    520 rdf:type schema:CreativeWork
    521 sg:pub.10.1038/ng1196-292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012147825
    522 https://doi.org/10.1038/ng1196-292
    523 rdf:type schema:CreativeWork
    524 sg:pub.10.1038/ng1293-368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025716934
    525 https://doi.org/10.1038/ng1293-368
    526 rdf:type schema:CreativeWork
    527 sg:pub.10.1038/ng757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040986528
    528 https://doi.org/10.1038/ng757
    529 rdf:type schema:CreativeWork
    530 grid-institutes:grid.270301.7 schema:alternateName Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA
    531 schema:name Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, 02142, Cambridge, Massachusetts, USA
    532 rdf:type schema:Organization
    533 grid-institutes:grid.4367.6 schema:alternateName Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA
    534 schema:name Genome Sequencing Center, Washington University School of Medicine, 4444 Forest Park Boulevard, 63108, St Louis, Missouri, USA
    535 rdf:type schema:Organization
    536 grid-institutes:grid.5650.6 schema:alternateName Center for Reproductive Medicine, Department of Gynaecology and Obstetrics, Academic Medical Centre, 1105 AZ, Amsterdam, the Netherlands
    537 schema:name Center for Reproductive Medicine, Department of Gynaecology and Obstetrics, Academic Medical Centre, 1105 AZ, Amsterdam, the Netherlands
    538 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...