Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-04

AUTHORS

Stefano Pluchino, Angelo Quattrini, Elena Brambilla, Angela Gritti, Giuliana Salani, Giorgia Dina, Rossella Galli, Ubaldo Del Carro, Stefano Amadio, Alessandra Bergami, Roberto Furlan, Giancarlo Comi, Angelo L. Vescovi, Gianvito Martino

ABSTRACT

Widespread demyelination and axonal loss are the pathological hallmarks of multiple sclerosis. The multifocal nature of this chronic inflammatory disease of the central nervous system complicates cellular therapy and puts emphasis on both the donor cell origin and the route of cell transplantation. We established syngenic adult neural stem cell cultures and injected them into an animal model of multiple sclerosis--experimental autoimmune encephalomyelitis (EAE) in the mouse--either intravenously or intracerebroventricularly. In both cases, significant numbers of donor cells entered into demyelinating areas of the central nervous system and differentiated into mature brain cells. Within these areas, oligodendrocyte progenitors markedly increased, with many of them being of donor origin and actively remyelinating axons. Furthermore, a significant reduction of astrogliosis and a marked decrease in the extent of demyelination and axonal loss were observed in transplanted animals. The functional impairment caused by EAE was almost abolished in transplanted mice, both clinically and neurophysiologically. Thus, adult neural precursor cells promote multifocal remyelination and functional recovery after intravenous or intrathecal injection in a chronic model of multiple sclerosis. More... »

PAGES

688

Journal

TITLE

Nature

ISSUE

6933

VOLUME

422

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature01552

    DOI

    http://dx.doi.org/10.1038/nature01552

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047241831

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12700753


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