STAT3 signalling is required for leptin regulation of energy balance but not reproduction View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-02

AUTHORS

Sarah H. Bates, Walter H. Stearns, Trevor A. Dundon, Markus Schubert, Annette W. K. Tso, Yongping Wang, Alexander S. Banks, Hugh J. Lavery, Asma K. Haq, Eleftheria Maratos-Flier, Benjamin G. Neel, Michael W. Schwartz, Martin G. Myers

ABSTRACT

Secretion of leptin from adipocytes communicates body energy status to the brain by activating the leptin receptor long form (LRb). LRb regulates energy homeostasis and neuroendocrine function; the absence of LRb in db/db mice results in obesity, impaired growth, infertility and diabetes. Tyr 1138 of LRb mediates activation of the transcription factor STAT3 during leptin action. To investigate the contribution of STAT3 signalling to leptin action in vivo, we replaced the gene encoding the leptin receptor (lepr) in mice with an allele coding for a replacement of Tyr 1138 in LRb with a serine residue (lepr(S1138)) that specifically disrupts the LRb-STAT3 signal. Here we show that, like db/db mice, lepr(S1138) homozygotes (s/s) are hyperphagic and obese. However, whereas db/db mice are infertile, short and diabetic, s/s mice are fertile, long and less hyperglycaemic. Furthermore, hypothalamic expression of neuropeptide Y (NPY) is elevated in db/db mice but not s/s mice, whereas the hypothalamic melanocortin system is suppressed in both db/db and s/s mice. LRb-STAT3 signalling thus mediates the effects of leptin on melanocortin production and body energy homeostasis, whereas distinct LRb signals regulate NPY and the control of fertility, growth and glucose homeostasis. More... »

PAGES

856

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature01388

DOI

http://dx.doi.org/10.1038/nature01388

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004717905

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12594516


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