Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-01

AUTHORS

Hanna K. A. Mikkola, Jenny Klintman, Haidi Yang, Hanno Hock, Thorsten M. Schlaeger, Yuko Fujiwara, Stuart H. Orkin

ABSTRACT

The production of blood cells is sustained throughout the lifetime of an individual by haematopoietic stem cells (HSCs). Specification of HSCs from mesoderm during embryonic development requires the stem cell leukaemia SCL/tal-1 gene product. Forced expression of SCL/tal-1 strongly induces blood formation in embryos, indicating that this gene has a dominant role in commitment to haematopoiesis. In the adult haematopoietic system, expression of SCL/tal-1 is enriched in HSCs and multipotent progenitors, and in erythroid and megakaryocytic lineages, consistent with roles for this factor in adult haematopoiesis. Here we assess by conditional gene targeting whether SCL/tal-1 is required continuously for the identity and function of HSCs. We find that SCL/tal-1 is dispensable for HSC engraftment, self-renewal and differentiation into myeloid and lymphoid lineages; however, the proper differentiation of erythroid and megakaryocytic precursors is dependent on SCL/tal-1. Thus, SCL/tal-1 is essential for the genesis of HSCs, but its continued expression is not essential for HSC functions. These findings contrast with lineage choice mechanisms, in which the identity of haematopoietic lineages requires continuous transcription factor expression. More... »

PAGES

547

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature01345

DOI

http://dx.doi.org/10.1038/nature01345

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035194300

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12540851


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Basic Helix-Loop-Helix Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematopoietic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphopoiesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multipotent Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myelopoiesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Cell Acute Lymphocytic Leukemia Protein 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Dana\u2013Farber Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "*Department of Pediatric Oncology, Children's Hospital and the Dana Farber Cancer Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mikkola", 
        "givenName": "Hanna K. A.", 
        "id": "sg:person.014445503627.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014445503627.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dana\u2013Farber Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "*Department of Pediatric Oncology, Children's Hospital and the Dana Farber Cancer Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klintman", 
        "givenName": "Jenny", 
        "id": "sg:person.0733465711.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733465711.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dana\u2013Farber Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "*Department of Pediatric Oncology, Children's Hospital and the Dana Farber Cancer Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "Haidi", 
        "id": "sg:person.01250416207.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250416207.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dana\u2013Farber Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "*Department of Pediatric Oncology, Children's Hospital and the Dana Farber Cancer Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hock", 
        "givenName": "Hanno", 
        "id": "sg:person.0621072231.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621072231.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dana\u2013Farber Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "*Department of Pediatric Oncology, Children's Hospital and the Dana Farber Cancer Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schlaeger", 
        "givenName": "Thorsten M.", 
        "id": "sg:person.0764576306.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764576306.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dana\u2013Farber Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "*Department of Pediatric Oncology, Children's Hospital and the Dana Farber Cancer Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujiwara", 
        "givenName": "Yuko", 
        "id": "sg:person.0672324456.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672324456.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dana\u2013Farber Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "*Department of Pediatric Oncology, Children's Hospital and the Dana Farber Cancer Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orkin", 
        "givenName": "Stuart H.", 
        "id": "sg:person.0610537173.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610537173.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1182/blood.v98.12.3261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003730781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.20.11897", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003970642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature730", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017087327", 
          "https://doi.org/10.1038/nature730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature730", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017087327", 
          "https://doi.org/10.1038/nature730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.11.3145", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017509311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80076-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017594997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/373432a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019482424", 
          "https://doi.org/10.1038/373432a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.15.7075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019671936"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.14.4029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023319920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.7.3890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024384782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.12.4268-4279.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026330558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35004599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036639289", 
          "https://doi.org/10.1038/35004599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35004599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036639289", 
          "https://doi.org/10.1038/35004599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1072530", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037567645"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.287.5457.1442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040886078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35049577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047214085", 
          "https://doi.org/10.1038/35049577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35049577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047214085", 
          "https://doi.org/10.1038/35049577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050743069", 
          "https://doi.org/10.1038/nature729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050743069", 
          "https://doi.org/10.1038/nature729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1067518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062445716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7660125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062648331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8016642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062651964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074525952", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074618081", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074637358", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074860851", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1996.tb00787.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082979336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083199537", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-01", 
    "datePublishedReg": "2003-01-01", 
    "description": "The production of blood cells is sustained throughout the lifetime of an individual by haematopoietic stem cells (HSCs). Specification of HSCs from mesoderm during embryonic development requires the stem cell leukaemia SCL/tal-1 gene product. Forced expression of SCL/tal-1 strongly induces blood formation in embryos, indicating that this gene has a dominant role in commitment to haematopoiesis. In the adult haematopoietic system, expression of SCL/tal-1 is enriched in HSCs and multipotent progenitors, and in erythroid and megakaryocytic lineages, consistent with roles for this factor in adult haematopoiesis. Here we assess by conditional gene targeting whether SCL/tal-1 is required continuously for the identity and function of HSCs. We find that SCL/tal-1 is dispensable for HSC engraftment, self-renewal and differentiation into myeloid and lymphoid lineages; however, the proper differentiation of erythroid and megakaryocytic precursors is dependent on SCL/tal-1. Thus, SCL/tal-1 is essential for the genesis of HSCs, but its continued expression is not essential for HSC functions. These findings contrast with lineage choice mechanisms, in which the identity of haematopoietic lineages requires continuous transcription factor expression.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature01345", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6922", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "421"
      }
    ], 
    "name": "Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene", 
    "pagination": "547", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a7a6551cd590cf6b29b1631eda256639178159cd9a605c3379dd967df0b53c3e"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12540851"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature01345"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035194300"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature01345", 
      "https://app.dimensions.ai/details/publication/pub.1035194300"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87117_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature01345"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature01345'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature01345'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature01345'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature01345'


 

This table displays all metadata directly associated to this object as RDF triples.

239 TRIPLES      21 PREDICATES      67 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature01345 schema:about N2a191266f5464b3dac406eb34845a4fa
2 N2b6f732f9d2b4993ad6b472da7affd99
3 N3709b4e07a2148b2937c940ec7468c55
4 N7602f98075314caeb9cc5ff82aa7b823
5 N9a87531745054dfc919ccd0a58593e85
6 Na8d482dc3862466099ca9a3882fba8ec
7 Nafa54f1b7b894b15bb6d3ee188ec48de
8 Nb7e2ae924d5947d1b9ddee701fa90016
9 Nbfa1ac4d48764768ae42f3137eb749d2
10 Ncab5187142bf496589368a602ca8d87e
11 Ndd4abd5bb0674cafbd904146a938b332
12 Ne7b78a69f87a4a088e3f25a5ad740c37
13 Nfe37c5c2518549a9bddceb8b5896825e
14 Nfe519cbf904a4a00a902dfd53cbc7c70
15 anzsrc-for:06
16 anzsrc-for:0604
17 schema:author N54fe8440f8da405ebca71110e45861ce
18 schema:citation sg:pub.10.1038/35004599
19 sg:pub.10.1038/35049577
20 sg:pub.10.1038/373432a0
21 sg:pub.10.1038/nature729
22 sg:pub.10.1038/nature730
23 https://app.dimensions.ai/details/publication/pub.1074525952
24 https://app.dimensions.ai/details/publication/pub.1074618081
25 https://app.dimensions.ai/details/publication/pub.1074637358
26 https://app.dimensions.ai/details/publication/pub.1074860851
27 https://app.dimensions.ai/details/publication/pub.1083199537
28 https://doi.org/10.1002/j.1460-2075.1996.tb00787.x
29 https://doi.org/10.1016/s0092-8674(00)80076-8
30 https://doi.org/10.1073/pnas.92.15.7075
31 https://doi.org/10.1073/pnas.95.20.11897
32 https://doi.org/10.1073/pnas.95.7.3890
33 https://doi.org/10.1093/emboj/16.11.3145
34 https://doi.org/10.1093/emboj/17.14.4029
35 https://doi.org/10.1126/science.1067518
36 https://doi.org/10.1126/science.1072530
37 https://doi.org/10.1126/science.287.5457.1442
38 https://doi.org/10.1126/science.7660125
39 https://doi.org/10.1126/science.8016642
40 https://doi.org/10.1128/mcb.22.12.4268-4279.2002
41 https://doi.org/10.1182/blood.v98.12.3261
42 schema:datePublished 2003-01
43 schema:datePublishedReg 2003-01-01
44 schema:description The production of blood cells is sustained throughout the lifetime of an individual by haematopoietic stem cells (HSCs). Specification of HSCs from mesoderm during embryonic development requires the stem cell leukaemia SCL/tal-1 gene product. Forced expression of SCL/tal-1 strongly induces blood formation in embryos, indicating that this gene has a dominant role in commitment to haematopoiesis. In the adult haematopoietic system, expression of SCL/tal-1 is enriched in HSCs and multipotent progenitors, and in erythroid and megakaryocytic lineages, consistent with roles for this factor in adult haematopoiesis. Here we assess by conditional gene targeting whether SCL/tal-1 is required continuously for the identity and function of HSCs. We find that SCL/tal-1 is dispensable for HSC engraftment, self-renewal and differentiation into myeloid and lymphoid lineages; however, the proper differentiation of erythroid and megakaryocytic precursors is dependent on SCL/tal-1. Thus, SCL/tal-1 is essential for the genesis of HSCs, but its continued expression is not essential for HSC functions. These findings contrast with lineage choice mechanisms, in which the identity of haematopoietic lineages requires continuous transcription factor expression.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf N26e1796845ad44f7bc1e2968d83f0979
49 N8be7fc85a4134fe4a97a04db78d0c262
50 sg:journal.1018957
51 schema:name Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene
52 schema:pagination 547
53 schema:productId N015f28da731a4837b91ff5bb1da18aab
54 N38e3a999534f4aa9b7d8596107d6fc2e
55 N3ea78270b59346279a53b8053fe64104
56 N41811dfda4114f02aa9a3405b0957607
57 Nfbd89b2e74484b438d11b3490099b16e
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035194300
59 https://doi.org/10.1038/nature01345
60 schema:sdDatePublished 2019-04-11T12:27
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N667fd577c64a4a6388a172a4b31df1b0
63 schema:url https://www.nature.com/articles/nature01345
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N015f28da731a4837b91ff5bb1da18aab schema:name dimensions_id
68 schema:value pub.1035194300
69 rdf:type schema:PropertyValue
70 N03711042e8ef4b36acd16ff85ceeb8ee rdf:first sg:person.0733465711.29
71 rdf:rest Na88a69801d744a478eed498379014b25
72 N26e1796845ad44f7bc1e2968d83f0979 schema:issueNumber 6922
73 rdf:type schema:PublicationIssue
74 N2a191266f5464b3dac406eb34845a4fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Hematopoietic Stem Cells
76 rdf:type schema:DefinedTerm
77 N2b6f732f9d2b4993ad6b472da7affd99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Lymphopoiesis
79 rdf:type schema:DefinedTerm
80 N3709b4e07a2148b2937c940ec7468c55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Cell Division
82 rdf:type schema:DefinedTerm
83 N38e3a999534f4aa9b7d8596107d6fc2e schema:name nlm_unique_id
84 schema:value 0410462
85 rdf:type schema:PropertyValue
86 N3ea78270b59346279a53b8053fe64104 schema:name doi
87 schema:value 10.1038/nature01345
88 rdf:type schema:PropertyValue
89 N41811dfda4114f02aa9a3405b0957607 schema:name pubmed_id
90 schema:value 12540851
91 rdf:type schema:PropertyValue
92 N54fe8440f8da405ebca71110e45861ce rdf:first sg:person.014445503627.07
93 rdf:rest N03711042e8ef4b36acd16ff85ceeb8ee
94 N597301bf24f54585bccf11c9b7702f37 rdf:first sg:person.0610537173.51
95 rdf:rest rdf:nil
96 N5b0940647e7442ee850735e9af4e80db rdf:first sg:person.0621072231.24
97 rdf:rest N9aca4c035fc147608cc0ea56f82d3d42
98 N667fd577c64a4a6388a172a4b31df1b0 schema:name Springer Nature - SN SciGraph project
99 rdf:type schema:Organization
100 N7602f98075314caeb9cc5ff82aa7b823 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name DNA-Binding Proteins
102 rdf:type schema:DefinedTerm
103 N8be7fc85a4134fe4a97a04db78d0c262 schema:volumeNumber 421
104 rdf:type schema:PublicationVolume
105 N9a87531745054dfc919ccd0a58593e85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Animals
107 rdf:type schema:DefinedTerm
108 N9aca4c035fc147608cc0ea56f82d3d42 rdf:first sg:person.0764576306.77
109 rdf:rest Nce22766806f44c2a840da6fcf6bccea9
110 Na88a69801d744a478eed498379014b25 rdf:first sg:person.01250416207.60
111 rdf:rest N5b0940647e7442ee850735e9af4e80db
112 Na8d482dc3862466099ca9a3882fba8ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Transcription Factors
114 rdf:type schema:DefinedTerm
115 Nafa54f1b7b894b15bb6d3ee188ec48de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Basic Helix-Loop-Helix Transcription Factors
117 rdf:type schema:DefinedTerm
118 Nb7e2ae924d5947d1b9ddee701fa90016 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Myelopoiesis
120 rdf:type schema:DefinedTerm
121 Nbfa1ac4d48764768ae42f3137eb749d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Mice
123 rdf:type schema:DefinedTerm
124 Ncab5187142bf496589368a602ca8d87e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Cell Differentiation
126 rdf:type schema:DefinedTerm
127 Nce22766806f44c2a840da6fcf6bccea9 rdf:first sg:person.0672324456.29
128 rdf:rest N597301bf24f54585bccf11c9b7702f37
129 Ndd4abd5bb0674cafbd904146a938b332 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Proto-Oncogene Proteins
131 rdf:type schema:DefinedTerm
132 Ne7b78a69f87a4a088e3f25a5ad740c37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name T-Cell Acute Lymphocytic Leukemia Protein 1
134 rdf:type schema:DefinedTerm
135 Nfbd89b2e74484b438d11b3490099b16e schema:name readcube_id
136 schema:value a7a6551cd590cf6b29b1631eda256639178159cd9a605c3379dd967df0b53c3e
137 rdf:type schema:PropertyValue
138 Nfe37c5c2518549a9bddceb8b5896825e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Mice, Knockout
140 rdf:type schema:DefinedTerm
141 Nfe519cbf904a4a00a902dfd53cbc7c70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Multipotent Stem Cells
143 rdf:type schema:DefinedTerm
144 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
145 schema:name Biological Sciences
146 rdf:type schema:DefinedTerm
147 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
148 schema:name Genetics
149 rdf:type schema:DefinedTerm
150 sg:journal.1018957 schema:issn 0090-0028
151 1476-4687
152 schema:name Nature
153 rdf:type schema:Periodical
154 sg:person.01250416207.60 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
155 schema:familyName Yang
156 schema:givenName Haidi
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250416207.60
158 rdf:type schema:Person
159 sg:person.014445503627.07 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
160 schema:familyName Mikkola
161 schema:givenName Hanna K. A.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014445503627.07
163 rdf:type schema:Person
164 sg:person.0610537173.51 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
165 schema:familyName Orkin
166 schema:givenName Stuart H.
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610537173.51
168 rdf:type schema:Person
169 sg:person.0621072231.24 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
170 schema:familyName Hock
171 schema:givenName Hanno
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621072231.24
173 rdf:type schema:Person
174 sg:person.0672324456.29 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
175 schema:familyName Fujiwara
176 schema:givenName Yuko
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672324456.29
178 rdf:type schema:Person
179 sg:person.0733465711.29 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
180 schema:familyName Klintman
181 schema:givenName Jenny
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733465711.29
183 rdf:type schema:Person
184 sg:person.0764576306.77 schema:affiliation https://www.grid.ac/institutes/grid.65499.37
185 schema:familyName Schlaeger
186 schema:givenName Thorsten M.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764576306.77
188 rdf:type schema:Person
189 sg:pub.10.1038/35004599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036639289
190 https://doi.org/10.1038/35004599
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/35049577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047214085
193 https://doi.org/10.1038/35049577
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/373432a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019482424
196 https://doi.org/10.1038/373432a0
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/nature729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050743069
199 https://doi.org/10.1038/nature729
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/nature730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017087327
202 https://doi.org/10.1038/nature730
203 rdf:type schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1074525952 schema:CreativeWork
205 https://app.dimensions.ai/details/publication/pub.1074618081 schema:CreativeWork
206 https://app.dimensions.ai/details/publication/pub.1074637358 schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1074860851 schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1083199537 schema:CreativeWork
209 https://doi.org/10.1002/j.1460-2075.1996.tb00787.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082979336
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/s0092-8674(00)80076-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017594997
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1073/pnas.92.15.7075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019671936
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1073/pnas.95.20.11897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003970642
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1073/pnas.95.7.3890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024384782
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1093/emboj/16.11.3145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017509311
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1093/emboj/17.14.4029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023319920
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1126/science.1067518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445716
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1126/science.1072530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037567645
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1126/science.287.5457.1442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040886078
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1126/science.7660125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062648331
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1126/science.8016642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062651964
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1128/mcb.22.12.4268-4279.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026330558
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1182/blood.v98.12.3261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003730781
236 rdf:type schema:CreativeWork
237 https://www.grid.ac/institutes/grid.65499.37 schema:alternateName Dana–Farber Cancer Institute
238 schema:name *Department of Pediatric Oncology, Children's Hospital and the Dana Farber Cancer Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
239 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...