Inflammation in atherosclerosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-12

AUTHORS

Peter Libby

ABSTRACT

Abundant data link hypercholesterolaemia to atherogenesis. However, only recently have we appreciated that inflammatory mechanisms couple dyslipidaemia to atheroma formation. Leukocyte recruitment and expression of pro-inflammatory cytokines characterize early atherogenesis, and malfunction of inflammatory mediators mutes atheroma formation in mice. Moreover, inflammatory pathways promote thrombosis, a late and dreaded complication of atherosclerosis responsible for myocardial infarctions and most strokes. The new appreciation of the role of inflammation in atherosclerosis provides a mechanistic framework for understanding the clinical benefits of lipid-lowering therapies. Identifying the triggers for inflammation and unravelling the details of inflammatory pathways may eventually furnish new therapeutic targets. More... »

PAGES

868-874

Journal

TITLE

Nature

ISSUE

6917

VOLUME

420

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature01323

    DOI

    http://dx.doi.org/10.1038/nature01323

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001371417

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12490960


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