Inflammation and cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-12

AUTHORS

Lisa M. Coussens, Zena Werb

ABSTRACT

Recent data have expanded the concept that inflammation is a critical component of tumour progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration. In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. These insights are fostering new anti-inflammatory therapeutic approaches to cancer development. More... »

PAGES

860-867

Journal

TITLE

Nature

ISSUE

6917

VOLUME

420

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature01322

    DOI

    http://dx.doi.org/10.1038/nature01322

    DIMENSIONS

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    PUBMED

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