Systematic functional analysis of the Caenorhabditis elegans genome using RNAi View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-01

AUTHORS

Ravi S. Kamath, Andrew G. Fraser, Yan Dong, Gino Poulin, Richard Durbin, Monica Gotta, Alexander Kanapin, Nathalie Le Bot, Sergio Moreno, Marc Sohrmann, David P. Welchman, Peder Zipperlen, Julie Ahringer

ABSTRACT

A principal challenge currently facing biologists is how to connect the complete DNA sequence of an organism to its development and behaviour. Large-scale targeted-deletions have been successful in defining gene functions in the single-celled yeast Saccharomyces cerevisiae, but comparable analyses have yet to be performed in an animal. Here we describe the use of RNA interference to inhibit the function of approximately 86% of the 19,427 predicted genes of C. elegans. We identified mutant phenotypes for 1,722 genes, about two-thirds of which were not previously associated with a phenotype. We find that genes of similar functions are clustered in distinct, multi-megabase regions of individual chromosomes; genes in these regions tend to share transcriptional profiles. Our resulting data set and reusable RNAi library of 16,757 bacterial clones will facilitate systematic analyses of the connections among gene sequence, chromosomal location and gene function in C. elegans. More... »

PAGES

231

References to SciGraph publications

  • 2001-02. Initial sequencing and analysis of the human genome in NATURE
  • 1998-02. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans in NATURE
  • 2000-11. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III in NATURE
  • 2000-01. Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans in GENOME BIOLOGY
  • 2002-05. Effective expression of small interfering RNA in human cells in NATURE BIOTECHNOLOGY
  • 2000-12. Analysis of the genome sequence of the flowering plant Arabidopsis thaliana in NATURE
  • 2000-10. A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression in NATURE GENETICS
  • 2002-06. Clustering of housekeeping genes provides a unified model of gene order in the human genome in NATURE GENETICS
  • 2002-02. The genome sequence of Schizosaccharomyces pombe in NATURE
  • 1998-10. Specific interference by ingested dsRNA in NATURE
  • 2002-06. Evidence for large domains of similarly expressed genes in the Drosophila genome in BMC BIOLOGY
  • 2000-02. Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes in NATURE GENETICS
  • 2002-08. Chromosomal clustering of muscle-expressed genes in Caenorhabditis elegans in NATURE
  • 2000-11. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference in NATURE
  • 2002-05. U6 promoter–driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells in NATURE BIOTECHNOLOGY
  • Journal

    TITLE

    Nature

    ISSUE

    6920

    VOLUME

    421

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature01278

    DOI

    http://dx.doi.org/10.1038/nature01278

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031657596

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12529635


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