Computational approaches to cellular rhythms View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-11

AUTHORS

Albert Goldbeter

ABSTRACT

Oscillations arise in genetic and metabolic networks as a result of various modes of cellular regulation. In view of the large number of variables involved and of the complexity of feedback processes that generate oscillations, mathematical models and numerical simulations are needed to fully grasp the molecular mechanisms and functions of biological rhythms. Models are also necessary to comprehend the transition from simple to complex oscillatory behaviour and to delineate the conditions under which they arise. Examples ranging from calcium oscillations to pulsatile intercellular communication and circadian rhythms illustrate how computational biology contributes to clarify the molecular and dynamical bases of cellular rhythms. More... »

PAGES

238-245

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature01259

DOI

http://dx.doi.org/10.1038/nature01259

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031369938

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12432409


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