CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity View Full Text


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Article Info

DATE

2002-12

AUTHORS

Yasmine Belkaid, Ciriaco A. Piccirillo, Susana Mendez, Ethan M. Shevach, David L. Sacks

ABSTRACT

The long-term persistence of pathogens in a host that is also able to maintain strong resistance to reinfection, referred to as concomitant immunity, is a hallmark of certain infectious diseases, including tuberculosis and leishmaniasis. The ability of pathogens to establish latency in immune individuals often has severe consequences for disease reactivation. Here we show that the persistence of Leishmania major in the skin after healing in resistant C57BL/6 mice is controlled by an endogenous population of CD4+CD25+ regulatory T cells. These cells constitute 5-10% of peripheral CD4+ T cells in naive mice and humans, and suppress several potentially pathogenic responses in vivo, particularly T-cell responses directed against self-antigens. During infection by L. major, CD4+CD25+ T cells accumulate in the dermis, where they suppress-by both interleukin-10-dependent and interleukin-10-independent mechanisms-the ability of CD4+CD25- effector T cells to eliminate the parasite from the site. The sterilizing immunity achieved in mice with impaired IL-10 activity is followed by the loss of immunity to reinfection, indicating that the equilibrium established between effector and regulatory T cells in sites of chronic infection might reflect both parasite and host survival strategies. More... »

PAGES

502

References to SciGraph publications

  • 2002-06. CD4+CD25+ suppressor T cells: more questions than answers in NATURE REVIEWS IMMUNOLOGY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1038/nature01152

    DOI

    http://dx.doi.org/10.1038/nature01152

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001196109

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12466842


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