Dec1 and Dec2 are regulators of the mammalian molecular clock View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-10

AUTHORS

Sato Honma, Takeshi Kawamoto, Yumiko Takagi, Katsumi Fujimoto, Fuyuki Sato, Mitsuhide Noshiro, Yukio Kato, Ken-ichi Honma

ABSTRACT

The circadian rhythms in mammals are regulated by a pacemaker located in the suprachiasmatic nucleus of the hypothalamus. Four clock-gene families have been found to be involved in a transcription-translation feedback loop that generates the circadian rhythm at the intracellular level. The proteins Clock and Bmal1 form a heterodimer which activates the transcription of the Per gene from the E-box elements in its promoter region. Protein products of Per act together with Cry proteins to inhibit Per transcription, thus closing the autoregulatory feedback loop. We found that Dec1 and Dec2, basic helix-loop-helix transcription factors, repressed Clock/Bmal1-induced transactivation of the mouse Per1 promoter through direct protein-protein interactions with Bmal1 and/or competition for E-box elements. Dec1 and Dec2 are expressed in the suprachiasmic nucleus in a circadian fashion, with a peak in the subjective day. A brief light pulse induced Dec1 but not Dec2 expression in the suprachiasmic nucleus in a phase-dependent manner. Dec1 and Dec2 are regulators of the mammalian molecular clock, and form a fifth clock-gene family. More... »

PAGES

841

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature01123

DOI

http://dx.doi.org/10.1038/nature01123

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009996468

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12397359


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