Dec1 and Dec2 are regulators of the mammalian molecular clock View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-10

AUTHORS

Sato Honma, Takeshi Kawamoto, Yumiko Takagi, Katsumi Fujimoto, Fuyuki Sato, Mitsuhide Noshiro, Yukio Kato, Ken-ichi Honma

ABSTRACT

The circadian rhythms in mammals are regulated by a pacemaker located in the suprachiasmatic nucleus of the hypothalamus. Four clock-gene families have been found to be involved in a transcription-translation feedback loop that generates the circadian rhythm at the intracellular level. The proteins Clock and Bmal1 form a heterodimer which activates the transcription of the Per gene from the E-box elements in its promoter region. Protein products of Per act together with Cry proteins to inhibit Per transcription, thus closing the autoregulatory feedback loop. We found that Dec1 and Dec2, basic helix-loop-helix transcription factors, repressed Clock/Bmal1-induced transactivation of the mouse Per1 promoter through direct protein-protein interactions with Bmal1 and/or competition for E-box elements. Dec1 and Dec2 are expressed in the suprachiasmic nucleus in a circadian fashion, with a peak in the subjective day. A brief light pulse induced Dec1 but not Dec2 expression in the suprachiasmic nucleus in a phase-dependent manner. Dec1 and Dec2 are regulators of the mammalian molecular clock, and form a fifth clock-gene family. More... »

PAGES

841

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature01123

DOI

http://dx.doi.org/10.1038/nature01123

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009996468

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12397359


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ARNTL Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Basic Helix-Loop-Helix Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Clocks", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CLOCK Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Circadian Rhythm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophoretic Mobility Shift Assay", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feedback, Physiological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Reporter", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homeodomain Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Period Circadian Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Response Elements", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Activators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hokkaido University", 
          "id": "https://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "*Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Honma", 
        "givenName": "Sato", 
        "id": "sg:person.01252732677.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252732677.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hiroshima University", 
          "id": "https://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "\u2020Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawamoto", 
        "givenName": "Takeshi", 
        "id": "sg:person.0620144770.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620144770.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University", 
          "id": "https://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "*Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takagi", 
        "givenName": "Yumiko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hiroshima University", 
          "id": "https://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "\u2020Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujimoto", 
        "givenName": "Katsumi", 
        "id": "sg:person.015344054402.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015344054402.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hiroshima University", 
          "id": "https://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "\u2020Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Fuyuki", 
        "id": "sg:person.01010730730.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010730730.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hiroshima University", 
          "id": "https://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "\u2020Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Noshiro", 
        "givenName": "Mitsuhide", 
        "id": "sg:person.01017332403.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017332403.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hiroshima University", 
          "id": "https://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "\u2020Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kato", 
        "givenName": "Yukio", 
        "id": "sg:person.0713513601.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713513601.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University", 
          "id": "https://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "*Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Honma", 
        "givenName": "Ken-ichi", 
        "id": "sg:person.01257077237.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257077237.20"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2000.01313.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001407384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/mcne.1997.0640", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001493197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2170/jjphysiol.35.643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002342316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2001.6300", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002962555"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.2000.6166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007786047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.physiol.63.1.647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008497566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80494-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011821238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.54.6.1521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018735692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1200912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021565851", 
          "https://doi.org/10.1038/sj.onc.1200912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1200912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021565851", 
          "https://doi.org/10.1038/sj.onc.1200912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00722-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023441279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81014-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023562195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2000.4133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027113787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1985.tb11805.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028115130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(00)80492-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029466308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.873501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035116914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1998.9275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037090482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.11.16.2052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039426845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(72)90054-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039688439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-8993(72)90054-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039688439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.102075599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044545587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.288.5466.682", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045623895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.10.6519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046893850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.288.5468.1013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047586371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80566-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047627332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.10.6043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048866301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1997.6960", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049013375"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1460-9568.2000.01313.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056741113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.jbchem.a002869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059959546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.280.5369.1564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062561333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.280.5369.1599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062561341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074648218", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-10", 
    "datePublishedReg": "2002-10-01", 
    "description": "The circadian rhythms in mammals are regulated by a pacemaker located in the suprachiasmatic nucleus of the hypothalamus. Four clock-gene families have been found to be involved in a transcription-translation feedback loop that generates the circadian rhythm at the intracellular level. The proteins Clock and Bmal1 form a heterodimer which activates the transcription of the Per gene from the E-box elements in its promoter region. Protein products of Per act together with Cry proteins to inhibit Per transcription, thus closing the autoregulatory feedback loop. We found that Dec1 and Dec2, basic helix-loop-helix transcription factors, repressed Clock/Bmal1-induced transactivation of the mouse Per1 promoter through direct protein-protein interactions with Bmal1 and/or competition for E-box elements. Dec1 and Dec2 are expressed in the suprachiasmic nucleus in a circadian fashion, with a peak in the subjective day. A brief light pulse induced Dec1 but not Dec2 expression in the suprachiasmic nucleus in a phase-dependent manner. Dec1 and Dec2 are regulators of the mammalian molecular clock, and form a fifth clock-gene family.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature01123", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6909", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "419"
      }
    ], 
    "name": "Dec1 and Dec2 are regulators of the mammalian molecular clock", 
    "pagination": "841", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2f9f7a4c8ad0e6085107e1cdeecc87d91402ae26c3622b3f7b799c457db08c3d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12397359"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature01123"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009996468"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature01123", 
      "https://app.dimensions.ai/details/publication/pub.1009996468"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29194_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature01123"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature01123'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature01123'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature01123'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature01123'


 

This table displays all metadata directly associated to this object as RDF triples.

318 TRIPLES      21 PREDICATES      86 URIs      48 LITERALS      36 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature01123 schema:about N0ee95f85e41a420494bb0a3439fd4803
2 N2a4294b4c3de4b5a950866bbce7ff7ae
3 N40d8aed01a09416f89a462e9ff754b5f
4 N46c418a62c734edd9c8a0848e5631278
5 N47692a28093a4b1683ef63385ff25438
6 N612f7c6ac4d84a8986ec190c43ce2706
7 N632689b02af54c13b51f415e486690a2
8 N7b2f1a9ca83f4265aa1c6a0f36e96db8
9 N7c852e7c68254d5589a4ad6ddeea8b7b
10 N7d28b9cbe0eb475d8499c593424dd146
11 N8883e66d356f48e1a1f9522db27e81da
12 N8e9cf749a423437f8eb03c350405da3e
13 N8eaaea77149f4bc0967ca3da83b788fa
14 N93b8f121fa894f15ae82dbe260d13cb1
15 N9537316cbcc84f97968dc6764041a76f
16 N98dfc352adaa4873a13cbe10fd652a3b
17 Nb3193050250a4a8c9b75c228593a240d
18 Nba013c443bbd4e4d95bc8d514a187995
19 Nba41278ad92d470d90f804f9273eb168
20 Nbb06cd71463e4415900e2e6e5b589697
21 Nc3f462ca4c0640a297f0ebe7101d886a
22 Ncb54c5fdce3e48d98cd16490a0ad0a27
23 Ncc12afb61f7446e4a808d3b8ae78da1a
24 Ncdbd0614e1554eb9b22579b65bbb2bb9
25 Nd1502fbef3984b358dc4e010f8de834b
26 Nd6c2c5b0d44a40d897d389919c540dea
27 Nfe0468ea51294e609b54dc738e027041
28 anzsrc-for:06
29 anzsrc-for:0601
30 schema:author N0de06515ee3e4da5891ec1c8f508cc60
31 schema:citation sg:pub.10.1038/sj.onc.1200912
32 https://app.dimensions.ai/details/publication/pub.1074648218
33 https://doi.org/10.1006/bbrc.1997.6960
34 https://doi.org/10.1006/bbrc.1998.9275
35 https://doi.org/10.1006/bbrc.2000.4133
36 https://doi.org/10.1006/bbrc.2001.6300
37 https://doi.org/10.1006/geno.2000.6166
38 https://doi.org/10.1006/mcne.1997.0640
39 https://doi.org/10.1016/0006-8993(72)90054-6
40 https://doi.org/10.1016/s0092-8674(00)80494-8
41 https://doi.org/10.1016/s0092-8674(00)80566-8
42 https://doi.org/10.1016/s0092-8674(00)81014-4
43 https://doi.org/10.1016/s0092-8674(02)00722-5
44 https://doi.org/10.1016/s0896-6273(00)80492-4
45 https://doi.org/10.1046/j.1460-9568.2000.01313.x
46 https://doi.org/10.1073/pnas.102075599
47 https://doi.org/10.1073/pnas.54.6.1521
48 https://doi.org/10.1074/jbc.274.10.6043
49 https://doi.org/10.1074/jbc.274.10.6519
50 https://doi.org/10.1093/oxfordjournals.jbchem.a002869
51 https://doi.org/10.1101/gad.11.16.2052
52 https://doi.org/10.1101/gad.873501
53 https://doi.org/10.1111/j.1460-9568.2000.01313.x
54 https://doi.org/10.1111/j.1749-6632.1985.tb11805.x
55 https://doi.org/10.1126/science.280.5369.1564
56 https://doi.org/10.1126/science.280.5369.1599
57 https://doi.org/10.1126/science.288.5466.682
58 https://doi.org/10.1126/science.288.5468.1013
59 https://doi.org/10.1146/annurev.physiol.63.1.647
60 https://doi.org/10.2170/jjphysiol.35.643
61 schema:datePublished 2002-10
62 schema:datePublishedReg 2002-10-01
63 schema:description The circadian rhythms in mammals are regulated by a pacemaker located in the suprachiasmatic nucleus of the hypothalamus. Four clock-gene families have been found to be involved in a transcription-translation feedback loop that generates the circadian rhythm at the intracellular level. The proteins Clock and Bmal1 form a heterodimer which activates the transcription of the Per gene from the E-box elements in its promoter region. Protein products of Per act together with Cry proteins to inhibit Per transcription, thus closing the autoregulatory feedback loop. We found that Dec1 and Dec2, basic helix-loop-helix transcription factors, repressed Clock/Bmal1-induced transactivation of the mouse Per1 promoter through direct protein-protein interactions with Bmal1 and/or competition for E-box elements. Dec1 and Dec2 are expressed in the suprachiasmic nucleus in a circadian fashion, with a peak in the subjective day. A brief light pulse induced Dec1 but not Dec2 expression in the suprachiasmic nucleus in a phase-dependent manner. Dec1 and Dec2 are regulators of the mammalian molecular clock, and form a fifth clock-gene family.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree false
67 schema:isPartOf Nc3fa14a583d445819f3dace44654951f
68 Nd17881d09f62412a83e06a870d23e703
69 sg:journal.1018957
70 schema:name Dec1 and Dec2 are regulators of the mammalian molecular clock
71 schema:pagination 841
72 schema:productId N286236fe7afb4494a1cbe1d1a1082bfe
73 N3a1bce9497374b679b1ade09acdef798
74 N78034a8a524c4c27923b9af7b88bb6dd
75 N978bfc3f296d46d1a5af814093f358ba
76 Ndd61d4075a1e498b9d4094a3f07da61f
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009996468
78 https://doi.org/10.1038/nature01123
79 schema:sdDatePublished 2019-04-11T11:52
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N1747136cb4bc4b16a7ebb7eef5842afb
82 schema:url https://www.nature.com/articles/nature01123
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N02fb3e432ca44777a3eea651647fee4e rdf:first sg:person.01017332403.68
87 rdf:rest N562bef905d974dd38220e032ada63641
88 N0579639c273d46f5af1d2d156dc39a28 rdf:first sg:person.01257077237.20
89 rdf:rest rdf:nil
90 N0de06515ee3e4da5891ec1c8f508cc60 rdf:first sg:person.01252732677.99
91 rdf:rest N82840aa106404517bdc3ace8f8fdf6de
92 N0ee95f85e41a420494bb0a3439fd4803 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Genes, Reporter
94 rdf:type schema:DefinedTerm
95 N1747136cb4bc4b16a7ebb7eef5842afb schema:name Springer Nature - SN SciGraph project
96 rdf:type schema:Organization
97 N286236fe7afb4494a1cbe1d1a1082bfe schema:name pubmed_id
98 schema:value 12397359
99 rdf:type schema:PropertyValue
100 N2a4294b4c3de4b5a950866bbce7ff7ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Nuclear Proteins
102 rdf:type schema:DefinedTerm
103 N3a1bce9497374b679b1ade09acdef798 schema:name dimensions_id
104 schema:value pub.1009996468
105 rdf:type schema:PropertyValue
106 N40d8aed01a09416f89a462e9ff754b5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Transcription Factors
108 rdf:type schema:DefinedTerm
109 N46c418a62c734edd9c8a0848e5631278 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Cell Cycle Proteins
111 rdf:type schema:DefinedTerm
112 N47692a28093a4b1683ef63385ff25438 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Homeodomain Proteins
114 rdf:type schema:DefinedTerm
115 N562bef905d974dd38220e032ada63641 rdf:first sg:person.0713513601.18
116 rdf:rest N0579639c273d46f5af1d2d156dc39a28
117 N612f7c6ac4d84a8986ec190c43ce2706 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Response Elements
119 rdf:type schema:DefinedTerm
120 N632689b02af54c13b51f415e486690a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Feedback, Physiological
122 rdf:type schema:DefinedTerm
123 N6782de6854314f208398a8af256291a0 rdf:first N909c0a3dd2f34069b19339dd6229332e
124 rdf:rest Nff0a47400a09446b8416d793668ad52a
125 N69c62321661246299cbe29204e948a10 rdf:first sg:person.01010730730.42
126 rdf:rest N02fb3e432ca44777a3eea651647fee4e
127 N78034a8a524c4c27923b9af7b88bb6dd schema:name nlm_unique_id
128 schema:value 0410462
129 rdf:type schema:PropertyValue
130 N7b2f1a9ca83f4265aa1c6a0f36e96db8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Protein Binding
132 rdf:type schema:DefinedTerm
133 N7c852e7c68254d5589a4ad6ddeea8b7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Basic Helix-Loop-Helix Transcription Factors
135 rdf:type schema:DefinedTerm
136 N7d28b9cbe0eb475d8499c593424dd146 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Biological Clocks
138 rdf:type schema:DefinedTerm
139 N82840aa106404517bdc3ace8f8fdf6de rdf:first sg:person.0620144770.20
140 rdf:rest N6782de6854314f208398a8af256291a0
141 N8883e66d356f48e1a1f9522db27e81da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Rats, Wistar
143 rdf:type schema:DefinedTerm
144 N8e9cf749a423437f8eb03c350405da3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Promoter Regions, Genetic
146 rdf:type schema:DefinedTerm
147 N8eaaea77149f4bc0967ca3da83b788fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name DNA
149 rdf:type schema:DefinedTerm
150 N909c0a3dd2f34069b19339dd6229332e schema:affiliation https://www.grid.ac/institutes/grid.39158.36
151 schema:familyName Takagi
152 schema:givenName Yumiko
153 rdf:type schema:Person
154 N93b8f121fa894f15ae82dbe260d13cb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name CLOCK Proteins
156 rdf:type schema:DefinedTerm
157 N9537316cbcc84f97968dc6764041a76f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Period Circadian Proteins
159 rdf:type schema:DefinedTerm
160 N978bfc3f296d46d1a5af814093f358ba schema:name doi
161 schema:value 10.1038/nature01123
162 rdf:type schema:PropertyValue
163 N98dfc352adaa4873a13cbe10fd652a3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Mice
165 rdf:type schema:DefinedTerm
166 Nb3193050250a4a8c9b75c228593a240d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Trans-Activators
168 rdf:type schema:DefinedTerm
169 Nba013c443bbd4e4d95bc8d514a187995 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Molecular Sequence Data
171 rdf:type schema:DefinedTerm
172 Nba41278ad92d470d90f804f9273eb168 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Circadian Rhythm
174 rdf:type schema:DefinedTerm
175 Nbb06cd71463e4415900e2e6e5b589697 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Animals
177 rdf:type schema:DefinedTerm
178 Nc3f462ca4c0640a297f0ebe7101d886a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Electrophoretic Mobility Shift Assay
180 rdf:type schema:DefinedTerm
181 Nc3fa14a583d445819f3dace44654951f schema:issueNumber 6909
182 rdf:type schema:PublicationIssue
183 Ncb54c5fdce3e48d98cd16490a0ad0a27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Rats
185 rdf:type schema:DefinedTerm
186 Ncc12afb61f7446e4a808d3b8ae78da1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name ARNTL Transcription Factors
188 rdf:type schema:DefinedTerm
189 Ncdbd0614e1554eb9b22579b65bbb2bb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name RNA, Messenger
191 rdf:type schema:DefinedTerm
192 Nd1502fbef3984b358dc4e010f8de834b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name In Situ Hybridization
194 rdf:type schema:DefinedTerm
195 Nd17881d09f62412a83e06a870d23e703 schema:volumeNumber 419
196 rdf:type schema:PublicationVolume
197 Nd6c2c5b0d44a40d897d389919c540dea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Humans
199 rdf:type schema:DefinedTerm
200 Ndd61d4075a1e498b9d4094a3f07da61f schema:name readcube_id
201 schema:value 2f9f7a4c8ad0e6085107e1cdeecc87d91402ae26c3622b3f7b799c457db08c3d
202 rdf:type schema:PropertyValue
203 Nfe0468ea51294e609b54dc738e027041 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Gene Expression Regulation
205 rdf:type schema:DefinedTerm
206 Nff0a47400a09446b8416d793668ad52a rdf:first sg:person.015344054402.71
207 rdf:rest N69c62321661246299cbe29204e948a10
208 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
209 schema:name Biological Sciences
210 rdf:type schema:DefinedTerm
211 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
212 schema:name Biochemistry and Cell Biology
213 rdf:type schema:DefinedTerm
214 sg:journal.1018957 schema:issn 0090-0028
215 1476-4687
216 schema:name Nature
217 rdf:type schema:Periodical
218 sg:person.01010730730.42 schema:affiliation https://www.grid.ac/institutes/grid.257022.0
219 schema:familyName Sato
220 schema:givenName Fuyuki
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010730730.42
222 rdf:type schema:Person
223 sg:person.01017332403.68 schema:affiliation https://www.grid.ac/institutes/grid.257022.0
224 schema:familyName Noshiro
225 schema:givenName Mitsuhide
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017332403.68
227 rdf:type schema:Person
228 sg:person.01252732677.99 schema:affiliation https://www.grid.ac/institutes/grid.39158.36
229 schema:familyName Honma
230 schema:givenName Sato
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252732677.99
232 rdf:type schema:Person
233 sg:person.01257077237.20 schema:affiliation https://www.grid.ac/institutes/grid.39158.36
234 schema:familyName Honma
235 schema:givenName Ken-ichi
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257077237.20
237 rdf:type schema:Person
238 sg:person.015344054402.71 schema:affiliation https://www.grid.ac/institutes/grid.257022.0
239 schema:familyName Fujimoto
240 schema:givenName Katsumi
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015344054402.71
242 rdf:type schema:Person
243 sg:person.0620144770.20 schema:affiliation https://www.grid.ac/institutes/grid.257022.0
244 schema:familyName Kawamoto
245 schema:givenName Takeshi
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620144770.20
247 rdf:type schema:Person
248 sg:person.0713513601.18 schema:affiliation https://www.grid.ac/institutes/grid.257022.0
249 schema:familyName Kato
250 schema:givenName Yukio
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713513601.18
252 rdf:type schema:Person
253 sg:pub.10.1038/sj.onc.1200912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021565851
254 https://doi.org/10.1038/sj.onc.1200912
255 rdf:type schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1074648218 schema:CreativeWork
257 https://doi.org/10.1006/bbrc.1997.6960 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049013375
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1006/bbrc.1998.9275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037090482
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1006/bbrc.2000.4133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027113787
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1006/bbrc.2001.6300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002962555
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1006/geno.2000.6166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007786047
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1006/mcne.1997.0640 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001493197
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/0006-8993(72)90054-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039688439
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0092-8674(00)80494-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011821238
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0092-8674(00)80566-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047627332
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0092-8674(00)81014-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023562195
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0092-8674(02)00722-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023441279
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s0896-6273(00)80492-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029466308
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1046/j.1460-9568.2000.01313.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1056741113
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1073/pnas.102075599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044545587
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1073/pnas.54.6.1521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018735692
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1074/jbc.274.10.6043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048866301
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1074/jbc.274.10.6519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046893850
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1093/oxfordjournals.jbchem.a002869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059959546
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1101/gad.11.16.2052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039426845
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1101/gad.873501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035116914
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1111/j.1460-9568.2000.01313.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001407384
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1111/j.1749-6632.1985.tb11805.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028115130
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1126/science.280.5369.1564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062561333
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1126/science.280.5369.1599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062561341
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1126/science.288.5466.682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045623895
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1126/science.288.5468.1013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047586371
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1146/annurev.physiol.63.1.647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008497566
310 rdf:type schema:CreativeWork
311 https://doi.org/10.2170/jjphysiol.35.643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002342316
312 rdf:type schema:CreativeWork
313 https://www.grid.ac/institutes/grid.257022.0 schema:alternateName Hiroshima University
314 schema:name †Department of Dental and Medical Biochemistry, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8553, Japan
315 rdf:type schema:Organization
316 https://www.grid.ac/institutes/grid.39158.36 schema:alternateName Hokkaido University
317 schema:name *Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan
318 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...