A proteomic view of the Plasmodium falciparum life cycle View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-10

AUTHORS

Laurence Florens, Michael P. Washburn, J. Dale Raine, Robert M. Anthony, Munira Grainger, J. David Haynes, J. Kathleen Moch, Nemone Muster, John B. Sacci, David L. Tabb, Adam A. Witney, Dirk Wolters, Yimin Wu, Malcolm J. Gardner, Anthony A. Holder, Robert E. Sinden, John R. Yates, Daniel J. Carucci

ABSTRACT

The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which to conduct comparative proteomics studies of this human pathogen. Here, we applied a high-throughput proteomics approach to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite. We characterized four stages of the parasite life cycle (sporozoites, merozoites, trophozoites and gametocytes) by multidimensional protein identification technology. Functional profiling of over 2,400 proteins agreed with the physiology of each stage. Unexpectedly, the antigenically variant proteins of var and rif genes, defined as molecules on the surface of infected erythrocytes, were also largely expressed in sporozoites. The detection of chromosomal clusters encoding co-expressed proteins suggested a potential mechanism for controlling gene expression. More... »

PAGES

520

References to SciGraph publications

  • 1983-12. Isolate-specific S-antigen of Plasmodium falciparum contains a repeated sequence of eleven amino acids in NATURE
  • 2001-04. A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax in NATURE
  • 2002-06-28. Erythrocytic Malaria Growth or Invasion Inhibition Assays with Emphasis on Suspension Culture GIA in MALARIA METHODS AND PROTOCOLS
  • 1993-08-11. The Culture and Preparation of Gametocytes of Plasmodium falciparum for Immunochemical, Molecular, and Mosquito Infectivity Studies in PROTOCOLS IN MOLECULAR PARASITOLOGY
  • 2002-10. Genome sequence of the human malaria parasite Plasmodium falciparum in NATURE
  • 2002-10. Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii in NATURE
  • 2000-06. Genomics, gene expression and DNA arrays in NATURE
  • 1998-03. Identification of xanthurenic acid as the putative inducer of malaria development in the mosquito in NATURE
  • 2000-10. A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression in NATURE GENETICS
  • 2002-06. Clustering of housekeeping genes provides a unified model of gene order in the human genome in NATURE GENETICS
  • 2002-06-28. Automated Synchronization of Plasmodium falciparum Parasites by Culture in a Temperature-Cycling Incubator in MALARIA METHODS AND PROTOCOLS
  • 2001-03. Large-scale analysis of the yeast proteome by multidimensional protein identification technology in NATURE BIOTECHNOLOGY
  • 1994-11. An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database in JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature01107

    DOI

    http://dx.doi.org/10.1038/nature01107

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053547571

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12368866


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