A proteomic view of the Plasmodium falciparum life cycle View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-10

AUTHORS

Laurence Florens, Michael P. Washburn, J. Dale Raine, Robert M. Anthony, Munira Grainger, J. David Haynes, J. Kathleen Moch, Nemone Muster, John B. Sacci, David L. Tabb, Adam A. Witney, Dirk Wolters, Yimin Wu, Malcolm J. Gardner, Anthony A. Holder, Robert E. Sinden, John R. Yates, Daniel J. Carucci

ABSTRACT

The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which to conduct comparative proteomics studies of this human pathogen. Here, we applied a high-throughput proteomics approach to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite. We characterized four stages of the parasite life cycle (sporozoites, merozoites, trophozoites and gametocytes) by multidimensional protein identification technology. Functional profiling of over 2,400 proteins agreed with the physiology of each stage. Unexpectedly, the antigenically variant proteins of var and rif genes, defined as molecules on the surface of infected erythrocytes, were also largely expressed in sporozoites. The detection of chromosomal clusters encoding co-expressed proteins suggested a potential mechanism for controlling gene expression. More... »

PAGES

520

References to SciGraph publications

  • 1983-12. Isolate-specific S-antigen of Plasmodium falciparum contains a repeated sequence of eleven amino acids in NATURE
  • 2001-04. A superfamily of variant genes encoded in the subtelomeric region of Plasmodium vivax in NATURE
  • 2002-06-28. Erythrocytic Malaria Growth or Invasion Inhibition Assays with Emphasis on Suspension Culture GIA in MALARIA METHODS AND PROTOCOLS
  • 1993-08-11. The Culture and Preparation of Gametocytes of Plasmodium falciparum for Immunochemical, Molecular, and Mosquito Infectivity Studies in PROTOCOLS IN MOLECULAR PARASITOLOGY
  • 2002-10. Genome sequence of the human malaria parasite Plasmodium falciparum in NATURE
  • 2002-10. Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii in NATURE
  • 2000-06. Genomics, gene expression and DNA arrays in NATURE
  • 1998-03. Identification of xanthurenic acid as the putative inducer of malaria development in the mosquito in NATURE
  • 2000-10. A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression in NATURE GENETICS
  • 2002-06. Clustering of housekeeping genes provides a unified model of gene order in the human genome in NATURE GENETICS
  • 2002-06-28. Automated Synchronization of Plasmodium falciparum Parasites by Culture in a Temperature-Cycling Incubator in MALARIA METHODS AND PROTOCOLS
  • 2001-03. Large-scale analysis of the yeast proteome by multidimensional protein identification technology in NATURE BIOTECHNOLOGY
  • 1994-11. An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database in JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nature01107

    DOI

    http://dx.doi.org/10.1038/nature01107

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053547571

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12368866


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antimalarials", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Erythrocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome, Protozoan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Germ Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Life Cycle Stages", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Malaria Vaccines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Plasmodium falciparum", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proteome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protozoan Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Scripps Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.214007.0", 
              "name": [
                "*Department of Cell Biology, The Scripps Research Institute, SR-11, 10550 North Torrey Pines Road, La Jolla, California 92037, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Florens", 
            "givenName": "Laurence", 
            "id": "sg:person.01174555024.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174555024.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Syngenta (United States)", 
              "id": "https://www.grid.ac/institutes/grid.420134.0", 
              "name": [
                "\u2020Department of Proteomics and Metabolomics, Torrey Mesa Research Institute, Syngenta Research & Technology, 3115 Merryfield Row, San Diego, California 92121-1125, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Washburn", 
            "givenName": "Michael P.", 
            "id": "sg:person.0612316474.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612316474.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Imperial College London", 
              "id": "https://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "\u2021Infection and Immunity Section, Department of Biological Sciences, Imperial College of Science, Technology & Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Raine", 
            "givenName": "J. Dale", 
            "id": "sg:person.0750111344.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750111344.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "\u00a7Naval Medical Research Center, Malaria Program (IDD), 503 Robert Grant Avenue, Room 3A40, Silver Spring, Maryland 20910-7500, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Anthony", 
            "givenName": "Robert M.", 
            "id": "sg:person.01353055306.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353055306.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Francis Crick Institute", 
              "id": "https://www.grid.ac/institutes/grid.451388.3", 
              "name": [
                "\u2016The Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Grainger", 
            "givenName": "Munira", 
            "id": "sg:person.012645107707.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012645107707.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "United States Army Medical Research and Materiel Command", 
              "id": "https://www.grid.ac/institutes/grid.420210.5", 
              "name": [
                "\u00a7Naval Medical Research Center, Malaria Program (IDD), 503 Robert Grant Avenue, Room 3A40, Silver Spring, Maryland 20910-7500, USA", 
                "\u00b6Department of Immunology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910-7500, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Haynes", 
            "givenName": "J. David", 
            "id": "sg:person.014510037362.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014510037362.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "\u00a7Naval Medical Research Center, Malaria Program (IDD), 503 Robert Grant Avenue, Room 3A40, Silver Spring, Maryland 20910-7500, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Moch", 
            "givenName": "J. Kathleen", 
            "id": "sg:person.0723471026.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723471026.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Scripps Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.214007.0", 
              "name": [
                "*Department of Cell Biology, The Scripps Research Institute, SR-11, 10550 North Torrey Pines Road, La Jolla, California 92037, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Muster", 
            "givenName": "Nemone", 
            "id": "sg:person.01022033703.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022033703.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "\u00a7Naval Medical Research Center, Malaria Program (IDD), 503 Robert Grant Avenue, Room 3A40, Silver Spring, Maryland 20910-7500, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sacci", 
            "givenName": "John B.", 
            "id": "sg:person.0733373014.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733373014.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Washington", 
              "id": "https://www.grid.ac/institutes/grid.34477.33", 
              "name": [
                "*Department of Cell Biology, The Scripps Research Institute, SR-11, 10550 North Torrey Pines Road, La Jolla, California 92037, USA", 
                "\u2606Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tabb", 
            "givenName": "David L.", 
            "id": "sg:person.01055750403.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055750403.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "\u00a7Naval Medical Research Center, Malaria Program (IDD), 503 Robert Grant Avenue, Room 3A40, Silver Spring, Maryland 20910-7500, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Witney", 
            "givenName": "Adam A.", 
            "id": "sg:person.01113367443.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113367443.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Syngenta (United States)", 
              "id": "https://www.grid.ac/institutes/grid.420134.0", 
              "name": [
                "\u2020Department of Proteomics and Metabolomics, Torrey Mesa Research Institute, Syngenta Research & Technology, 3115 Merryfield Row, San Diego, California 92121-1125, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wolters", 
            "givenName": "Dirk", 
            "id": "sg:person.01064524156.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064524156.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "American Type Culture Collection", 
              "id": "https://www.grid.ac/institutes/grid.281196.5", 
              "name": [
                "**Malaria Research and Reference Reagent Resource Center, American Type Culture Collection, 10801 University Boulevard, Manassas, Virginia 20110-2209, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "Yimin", 
            "id": "sg:person.01262004625.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262004625.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "J. Craig Venter Institute", 
              "id": "https://www.grid.ac/institutes/grid.469946.0", 
              "name": [
                "\u2020\u2020The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gardner", 
            "givenName": "Malcolm J.", 
            "id": "sg:person.01103576600.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103576600.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Francis Crick Institute", 
              "id": "https://www.grid.ac/institutes/grid.451388.3", 
              "name": [
                "\u2016The Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Holder", 
            "givenName": "Anthony A.", 
            "id": "sg:person.01171476745.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171476745.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Imperial College London", 
              "id": "https://www.grid.ac/institutes/grid.7445.2", 
              "name": [
                "\u2021Infection and Immunity Section, Department of Biological Sciences, Imperial College of Science, Technology & Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sinden", 
            "givenName": "Robert E.", 
            "id": "sg:person.01002545174.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002545174.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Syngenta (United States)", 
              "id": "https://www.grid.ac/institutes/grid.420134.0", 
              "name": [
                "*Department of Cell Biology, The Scripps Research Institute, SR-11, 10550 North Torrey Pines Road, La Jolla, California 92037, USA", 
                "\u2020Department of Proteomics and Metabolomics, Torrey Mesa Research Institute, Syngenta Research & Technology, 3115 Merryfield Row, San Diego, California 92121-1125, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yates", 
            "givenName": "John R.", 
            "id": "sg:person.01104567247.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104567247.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "\u00a7Naval Medical Research Center, Malaria Program (IDD), 503 Robert Grant Avenue, Room 3A40, Silver Spring, Maryland 20910-7500, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carucci", 
            "givenName": "Daniel J.", 
            "id": "sg:person.01267237007.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267237007.12"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1093/protein/10.1.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001804651"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/306751a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002257464", 
              "https://doi.org/10.1038/306751a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1051/parasite/2000071019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008064719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/30.1.31", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009221125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2958.2000.01730.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011767272"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/1-59259-271-6:535", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014150728", 
              "https://doi.org/10.1385/1-59259-271-6:535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2958.2001.02222.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014477350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-308x(08)60033-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016188834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/iai.69.6.3635-3645.2001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016623132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.2000.4315", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018016237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/1044-0305(94)80016-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018629105", 
              "https://doi.org/10.1016/1044-0305(94)80016-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/1044-0305(94)80016-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018629105", 
              "https://doi.org/10.1016/1044-0305(94)80016-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.171185198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018824999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1056794", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019683539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.287.5461.2185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019737566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/79896", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020624693", 
              "https://doi.org/10.1038/79896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/79896", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020624693", 
              "https://doi.org/10.1038/79896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025111270", 
              "https://doi.org/10.1038/nature01099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025111270", 
              "https://doi.org/10.1038/nature01099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/18.22.6221", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025552451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/protein/11.12.1155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026117307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35015701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028135585", 
              "https://doi.org/10.1038/35015701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35015701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028135585", 
              "https://doi.org/10.1038/35015701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030736656", 
              "https://doi.org/10.1038/nature01097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01097", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030736656", 
              "https://doi.org/10.1038/nature01097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0091-679x(08)61853-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037295256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.biochem.71.090501.145453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039214028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.17.2.604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039764228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.19.2.967", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040723006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1522-2683(19991201)20:18<3603::aid-elps3603>3.0.co;2-v", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042049812"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0166-6851(95)02575-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044181941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/0-89603-239-6:67", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044199310", 
              "https://doi.org/10.1385/0-89603-239-6:67"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0166-6851(01)00391-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044525688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.16.9333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045274124"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.022630099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046411131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/32667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047956353", 
              "https://doi.org/10.1038/32667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/32667", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047956353", 
              "https://doi.org/10.1038/32667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.274.45.32411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048278758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.040561197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049036597"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35071118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049668505", 
              "https://doi.org/10.1038/35071118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35071118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049668505", 
              "https://doi.org/10.1038/35071118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1385/1-59259-271-6:489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049729428", 
              "https://doi.org/10.1385/1-59259-271-6:489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/85686", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050637706", 
              "https://doi.org/10.1038/85686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/85686", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050637706", 
              "https://doi.org/10.1038/85686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng887", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050756839", 
              "https://doi.org/10.1038/ng887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng887", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050756839", 
              "https://doi.org/10.1038/ng887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/pr015504q", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056290126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.282.5391.1126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062563116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1381612023394197", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069164664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2307/3280286", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070252344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075088180", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075088188", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078243467", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078997899", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083277601", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2002-10", 
        "datePublishedReg": "2002-10-01", 
        "description": "The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which to conduct comparative proteomics studies of this human pathogen. Here, we applied a high-throughput proteomics approach to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite. We characterized four stages of the parasite life cycle (sporozoites, merozoites, trophozoites and gametocytes) by multidimensional protein identification technology. Functional profiling of over 2,400 proteins agreed with the physiology of each stage. Unexpectedly, the antigenically variant proteins of var and rif genes, defined as molecules on the surface of infected erythrocytes, were also largely expressed in sporozoites. The detection of chromosomal clusters encoding co-expressed proteins suggested a potential mechanism for controlling gene expression.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nature01107", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2771650", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6906", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "419"
          }
        ], 
        "name": "A proteomic view of the Plasmodium falciparum life cycle", 
        "pagination": "520", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "ff0d9ac275a567da720d8366172ea957e40381f4dec141ca66be48f89fb7467f"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "12368866"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nature01107"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1053547571"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nature01107", 
          "https://app.dimensions.ai/details/publication/pub.1053547571"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T11:51", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29182_00000002.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nature01107"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature01107'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature01107'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature01107'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature01107'


     

    This table displays all metadata directly associated to this object as RDF triples.

    426 TRIPLES      21 PREDICATES      89 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nature01107 schema:about N19157434c93648dc9a5329bb7ab3c89d
    2 N195373c4eb704b99a771b9440f0cf6cf
    3 N1f2539a148c740ce9171add99ba9aa29
    4 N3281531a6aea4e82a6c978572b8b7160
    5 N6db3643906d94f25805e5c7c6866e502
    6 N6e12c182002844f1ba7a3bff021998d0
    7 N7a7c4bac034445a795c90411a3f5fc2f
    8 N8070e3f0d7964e4a811aa7df629f65f4
    9 N8198427c30c5427ebd88f2d612c90eaa
    10 N8b5a07ee5dda4923beddba06611688db
    11 Nb864de67f43c49439ace210ac0bef4b0
    12 Nca4dfd36a80349eea54c4974c34d17be
    13 Ncce3c792ba1d43b2865bd95ee3f83103
    14 Ncdee6ce9ae9f43ee8877b8c80330260b
    15 anzsrc-for:06
    16 anzsrc-for:0601
    17 schema:author Nf5c04930b8dc47b69131bb3bcf507937
    18 schema:citation sg:pub.10.1016/1044-0305(94)80016-2
    19 sg:pub.10.1038/306751a0
    20 sg:pub.10.1038/32667
    21 sg:pub.10.1038/35015701
    22 sg:pub.10.1038/35071118
    23 sg:pub.10.1038/79896
    24 sg:pub.10.1038/85686
    25 sg:pub.10.1038/nature01097
    26 sg:pub.10.1038/nature01099
    27 sg:pub.10.1038/ng887
    28 sg:pub.10.1385/0-89603-239-6:67
    29 sg:pub.10.1385/1-59259-271-6:489
    30 sg:pub.10.1385/1-59259-271-6:535
    31 https://app.dimensions.ai/details/publication/pub.1075088180
    32 https://app.dimensions.ai/details/publication/pub.1075088188
    33 https://app.dimensions.ai/details/publication/pub.1078243467
    34 https://app.dimensions.ai/details/publication/pub.1078997899
    35 https://app.dimensions.ai/details/publication/pub.1083277601
    36 https://doi.org/10.1002/(sici)1522-2683(19991201)20:18<3603::aid-elps3603>3.0.co;2-v
    37 https://doi.org/10.1006/jmbi.2000.4315
    38 https://doi.org/10.1016/0166-6851(95)02575-8
    39 https://doi.org/10.1016/s0065-308x(08)60033-0
    40 https://doi.org/10.1016/s0091-679x(08)61853-1
    41 https://doi.org/10.1016/s0166-6851(01)00391-7
    42 https://doi.org/10.1021/pr015504q
    43 https://doi.org/10.1046/j.1365-2958.2000.01730.x
    44 https://doi.org/10.1046/j.1365-2958.2001.02222.x
    45 https://doi.org/10.1051/parasite/2000071019
    46 https://doi.org/10.1073/pnas.022630099
    47 https://doi.org/10.1073/pnas.040561197
    48 https://doi.org/10.1073/pnas.171185198
    49 https://doi.org/10.1073/pnas.96.16.9333
    50 https://doi.org/10.1074/jbc.274.45.32411
    51 https://doi.org/10.1093/emboj/18.22.6221
    52 https://doi.org/10.1093/nar/30.1.31
    53 https://doi.org/10.1093/protein/10.1.1
    54 https://doi.org/10.1093/protein/11.12.1155
    55 https://doi.org/10.1126/science.1056794
    56 https://doi.org/10.1126/science.282.5391.1126
    57 https://doi.org/10.1126/science.287.5461.2185
    58 https://doi.org/10.1128/iai.69.6.3635-3645.2001
    59 https://doi.org/10.1128/mcb.17.2.604
    60 https://doi.org/10.1128/mcb.19.2.967
    61 https://doi.org/10.1146/annurev.biochem.71.090501.145453
    62 https://doi.org/10.2174/1381612023394197
    63 https://doi.org/10.2307/3280286
    64 schema:datePublished 2002-10
    65 schema:datePublishedReg 2002-10-01
    66 schema:description The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which to conduct comparative proteomics studies of this human pathogen. Here, we applied a high-throughput proteomics approach to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite. We characterized four stages of the parasite life cycle (sporozoites, merozoites, trophozoites and gametocytes) by multidimensional protein identification technology. Functional profiling of over 2,400 proteins agreed with the physiology of each stage. Unexpectedly, the antigenically variant proteins of var and rif genes, defined as molecules on the surface of infected erythrocytes, were also largely expressed in sporozoites. The detection of chromosomal clusters encoding co-expressed proteins suggested a potential mechanism for controlling gene expression.
    67 schema:genre research_article
    68 schema:inLanguage en
    69 schema:isAccessibleForFree false
    70 schema:isPartOf N1b934d302aea49149ee71d3e4fcaac79
    71 N799552ee0af94083ba505614c43d6d62
    72 sg:journal.1018957
    73 schema:name A proteomic view of the Plasmodium falciparum life cycle
    74 schema:pagination 520
    75 schema:productId N03886961de1e4ef4bd863f5a6fe3a9c6
    76 N25dbf00c890b49cc9520b9957371f935
    77 N84e14c1f18954c0a8cd3934d0f912bc1
    78 Nb4fdd80d56764bf8b3b44b04daa86af7
    79 Nc18d153a91b34cba97c93510c4537d6f
    80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053547571
    81 https://doi.org/10.1038/nature01107
    82 schema:sdDatePublished 2019-04-11T11:51
    83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    84 schema:sdPublisher N502d3e623ac14d13acc209fa0ff561cd
    85 schema:url https://www.nature.com/articles/nature01107
    86 sgo:license sg:explorer/license/
    87 sgo:sdDataset articles
    88 rdf:type schema:ScholarlyArticle
    89 N0340fdf608b84a5ca86e7b2ba3de69a6 rdf:first sg:person.012645107707.83
    90 rdf:rest Nd98d2b1c11f748fe836b8b2b2c574645
    91 N03886961de1e4ef4bd863f5a6fe3a9c6 schema:name pubmed_id
    92 schema:value 12368866
    93 rdf:type schema:PropertyValue
    94 N0bf949b613844164a294d6fa26b3b08f rdf:first sg:person.01262004625.51
    95 rdf:rest N6690f2e8d399435c8bee545f63a49a9f
    96 N1069b6f10ab046a3a85d8faa60b627bc rdf:first sg:person.0750111344.65
    97 rdf:rest Ndc5345f9de034aa88ae678b3a61b31f5
    98 N19157434c93648dc9a5329bb7ab3c89d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Genome, Protozoan
    100 rdf:type schema:DefinedTerm
    101 N195373c4eb704b99a771b9440f0cf6cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Male
    103 rdf:type schema:DefinedTerm
    104 N1b934d302aea49149ee71d3e4fcaac79 schema:volumeNumber 419
    105 rdf:type schema:PublicationVolume
    106 N1f2539a148c740ce9171add99ba9aa29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Life Cycle Stages
    108 rdf:type schema:DefinedTerm
    109 N2325832546ad4c96a9419ad3f1d8446b rdf:first sg:person.01267237007.12
    110 rdf:rest rdf:nil
    111 N250650af6ea34de2bb5f711a8b7105fc rdf:first sg:person.01064524156.31
    112 rdf:rest N0bf949b613844164a294d6fa26b3b08f
    113 N25dbf00c890b49cc9520b9957371f935 schema:name readcube_id
    114 schema:value ff0d9ac275a567da720d8366172ea957e40381f4dec141ca66be48f89fb7467f
    115 rdf:type schema:PropertyValue
    116 N3276be5b604b4caba5f730ec7413f06a rdf:first sg:person.01113367443.26
    117 rdf:rest N250650af6ea34de2bb5f711a8b7105fc
    118 N3281531a6aea4e82a6c978572b8b7160 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Erythrocytes
    120 rdf:type schema:DefinedTerm
    121 N490c1f8e39f648a7a1ccdd1ee5ef6585 schema:name §Naval Medical Research Center, Malaria Program (IDD), 503 Robert Grant Avenue, Room 3A40, Silver Spring, Maryland 20910-7500, USA
    122 rdf:type schema:Organization
    123 N4fc153efad4b4ea39fb7c984f8966c09 schema:name §Naval Medical Research Center, Malaria Program (IDD), 503 Robert Grant Avenue, Room 3A40, Silver Spring, Maryland 20910-7500, USA
    124 rdf:type schema:Organization
    125 N502d3e623ac14d13acc209fa0ff561cd schema:name Springer Nature - SN SciGraph project
    126 rdf:type schema:Organization
    127 N5a042ec172404995be0fcb0065d11844 rdf:first sg:person.0612316474.10
    128 rdf:rest N1069b6f10ab046a3a85d8faa60b627bc
    129 N6690f2e8d399435c8bee545f63a49a9f rdf:first sg:person.01103576600.88
    130 rdf:rest Ncb294cfbed3c48d8b2e32e1fb8e53a90
    131 N6db3643906d94f25805e5c7c6866e502 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Animals
    133 rdf:type schema:DefinedTerm
    134 N6e12c182002844f1ba7a3bff021998d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Humans
    136 rdf:type schema:DefinedTerm
    137 N738f1c6ceeef4faa8eaa824588b2ee08 schema:name §Naval Medical Research Center, Malaria Program (IDD), 503 Robert Grant Avenue, Room 3A40, Silver Spring, Maryland 20910-7500, USA
    138 rdf:type schema:Organization
    139 N799552ee0af94083ba505614c43d6d62 schema:issueNumber 6906
    140 rdf:type schema:PublicationIssue
    141 N7a7c4bac034445a795c90411a3f5fc2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Proteome
    143 rdf:type schema:DefinedTerm
    144 N7b2735a3318f4bde8a3d94c9d29808b5 rdf:first sg:person.01022033703.50
    145 rdf:rest Ne2c9fee9519041f0854099dd78139b8a
    146 N8070e3f0d7964e4a811aa7df629f65f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Malaria Vaccines
    148 rdf:type schema:DefinedTerm
    149 N8198427c30c5427ebd88f2d612c90eaa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Antimalarials
    151 rdf:type schema:DefinedTerm
    152 N84e14c1f18954c0a8cd3934d0f912bc1 schema:name dimensions_id
    153 schema:value pub.1053547571
    154 rdf:type schema:PropertyValue
    155 N8b5a07ee5dda4923beddba06611688db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Plasmodium falciparum
    157 rdf:type schema:DefinedTerm
    158 N90b451e8a4c64837adbff2c9b58eb598 rdf:first sg:person.01002545174.02
    159 rdf:rest Naa167ae561464a779bfed0e00047be58
    160 Naa167ae561464a779bfed0e00047be58 rdf:first sg:person.01104567247.41
    161 rdf:rest N2325832546ad4c96a9419ad3f1d8446b
    162 Nb4fdd80d56764bf8b3b44b04daa86af7 schema:name nlm_unique_id
    163 schema:value 0410462
    164 rdf:type schema:PropertyValue
    165 Nb864de67f43c49439ace210ac0bef4b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Female
    167 rdf:type schema:DefinedTerm
    168 Nc18d153a91b34cba97c93510c4537d6f schema:name doi
    169 schema:value 10.1038/nature01107
    170 rdf:type schema:PropertyValue
    171 Nc55205ca74fc481791cef106934f6028 rdf:first sg:person.0723471026.80
    172 rdf:rest N7b2735a3318f4bde8a3d94c9d29808b5
    173 Nc7f16034b20546568cca9092fab4504d rdf:first sg:person.01055750403.43
    174 rdf:rest N3276be5b604b4caba5f730ec7413f06a
    175 Nca4dfd36a80349eea54c4974c34d17be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Protozoan Proteins
    177 rdf:type schema:DefinedTerm
    178 Ncb294cfbed3c48d8b2e32e1fb8e53a90 rdf:first sg:person.01171476745.37
    179 rdf:rest N90b451e8a4c64837adbff2c9b58eb598
    180 Ncce3c792ba1d43b2865bd95ee3f83103 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Chromosomes
    182 rdf:type schema:DefinedTerm
    183 Ncdee6ce9ae9f43ee8877b8c80330260b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Germ Cells
    185 rdf:type schema:DefinedTerm
    186 Nd98d2b1c11f748fe836b8b2b2c574645 rdf:first sg:person.014510037362.91
    187 rdf:rest Nc55205ca74fc481791cef106934f6028
    188 Ndc5345f9de034aa88ae678b3a61b31f5 rdf:first sg:person.01353055306.80
    189 rdf:rest N0340fdf608b84a5ca86e7b2ba3de69a6
    190 Ne0b9a7655b71455daaaab6a8d498389c schema:name §Naval Medical Research Center, Malaria Program (IDD), 503 Robert Grant Avenue, Room 3A40, Silver Spring, Maryland 20910-7500, USA
    191 rdf:type schema:Organization
    192 Ne2c9fee9519041f0854099dd78139b8a rdf:first sg:person.0733373014.75
    193 rdf:rest Nc7f16034b20546568cca9092fab4504d
    194 Nef242ff3ffe340dca84c947716173fb5 schema:name §Naval Medical Research Center, Malaria Program (IDD), 503 Robert Grant Avenue, Room 3A40, Silver Spring, Maryland 20910-7500, USA
    195 rdf:type schema:Organization
    196 Nf5c04930b8dc47b69131bb3bcf507937 rdf:first sg:person.01174555024.14
    197 rdf:rest N5a042ec172404995be0fcb0065d11844
    198 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    199 schema:name Biological Sciences
    200 rdf:type schema:DefinedTerm
    201 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    202 schema:name Biochemistry and Cell Biology
    203 rdf:type schema:DefinedTerm
    204 sg:grant.2771650 http://pending.schema.org/fundedItem sg:pub.10.1038/nature01107
    205 rdf:type schema:MonetaryGrant
    206 sg:journal.1018957 schema:issn 0090-0028
    207 1476-4687
    208 schema:name Nature
    209 rdf:type schema:Periodical
    210 sg:person.01002545174.02 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
    211 schema:familyName Sinden
    212 schema:givenName Robert E.
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002545174.02
    214 rdf:type schema:Person
    215 sg:person.01022033703.50 schema:affiliation https://www.grid.ac/institutes/grid.214007.0
    216 schema:familyName Muster
    217 schema:givenName Nemone
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022033703.50
    219 rdf:type schema:Person
    220 sg:person.01055750403.43 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
    221 schema:familyName Tabb
    222 schema:givenName David L.
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055750403.43
    224 rdf:type schema:Person
    225 sg:person.01064524156.31 schema:affiliation https://www.grid.ac/institutes/grid.420134.0
    226 schema:familyName Wolters
    227 schema:givenName Dirk
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064524156.31
    229 rdf:type schema:Person
    230 sg:person.01103576600.88 schema:affiliation https://www.grid.ac/institutes/grid.469946.0
    231 schema:familyName Gardner
    232 schema:givenName Malcolm J.
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103576600.88
    234 rdf:type schema:Person
    235 sg:person.01104567247.41 schema:affiliation https://www.grid.ac/institutes/grid.420134.0
    236 schema:familyName Yates
    237 schema:givenName John R.
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104567247.41
    239 rdf:type schema:Person
    240 sg:person.01113367443.26 schema:affiliation N738f1c6ceeef4faa8eaa824588b2ee08
    241 schema:familyName Witney
    242 schema:givenName Adam A.
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113367443.26
    244 rdf:type schema:Person
    245 sg:person.01171476745.37 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
    246 schema:familyName Holder
    247 schema:givenName Anthony A.
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171476745.37
    249 rdf:type schema:Person
    250 sg:person.01174555024.14 schema:affiliation https://www.grid.ac/institutes/grid.214007.0
    251 schema:familyName Florens
    252 schema:givenName Laurence
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174555024.14
    254 rdf:type schema:Person
    255 sg:person.01262004625.51 schema:affiliation https://www.grid.ac/institutes/grid.281196.5
    256 schema:familyName Wu
    257 schema:givenName Yimin
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262004625.51
    259 rdf:type schema:Person
    260 sg:person.012645107707.83 schema:affiliation https://www.grid.ac/institutes/grid.451388.3
    261 schema:familyName Grainger
    262 schema:givenName Munira
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012645107707.83
    264 rdf:type schema:Person
    265 sg:person.01267237007.12 schema:affiliation N4fc153efad4b4ea39fb7c984f8966c09
    266 schema:familyName Carucci
    267 schema:givenName Daniel J.
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267237007.12
    269 rdf:type schema:Person
    270 sg:person.01353055306.80 schema:affiliation Ne0b9a7655b71455daaaab6a8d498389c
    271 schema:familyName Anthony
    272 schema:givenName Robert M.
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353055306.80
    274 rdf:type schema:Person
    275 sg:person.014510037362.91 schema:affiliation https://www.grid.ac/institutes/grid.420210.5
    276 schema:familyName Haynes
    277 schema:givenName J. David
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014510037362.91
    279 rdf:type schema:Person
    280 sg:person.0612316474.10 schema:affiliation https://www.grid.ac/institutes/grid.420134.0
    281 schema:familyName Washburn
    282 schema:givenName Michael P.
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0612316474.10
    284 rdf:type schema:Person
    285 sg:person.0723471026.80 schema:affiliation N490c1f8e39f648a7a1ccdd1ee5ef6585
    286 schema:familyName Moch
    287 schema:givenName J. Kathleen
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723471026.80
    289 rdf:type schema:Person
    290 sg:person.0733373014.75 schema:affiliation Nef242ff3ffe340dca84c947716173fb5
    291 schema:familyName Sacci
    292 schema:givenName John B.
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733373014.75
    294 rdf:type schema:Person
    295 sg:person.0750111344.65 schema:affiliation https://www.grid.ac/institutes/grid.7445.2
    296 schema:familyName Raine
    297 schema:givenName J. Dale
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750111344.65
    299 rdf:type schema:Person
    300 sg:pub.10.1016/1044-0305(94)80016-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018629105
    301 https://doi.org/10.1016/1044-0305(94)80016-2
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1038/306751a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002257464
    304 https://doi.org/10.1038/306751a0
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1038/32667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047956353
    307 https://doi.org/10.1038/32667
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/35015701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028135585
    310 https://doi.org/10.1038/35015701
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/35071118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049668505
    313 https://doi.org/10.1038/35071118
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/79896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020624693
    316 https://doi.org/10.1038/79896
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/85686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050637706
    319 https://doi.org/10.1038/85686
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/nature01097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030736656
    322 https://doi.org/10.1038/nature01097
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/nature01099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025111270
    325 https://doi.org/10.1038/nature01099
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/ng887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050756839
    328 https://doi.org/10.1038/ng887
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1385/0-89603-239-6:67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044199310
    331 https://doi.org/10.1385/0-89603-239-6:67
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1385/1-59259-271-6:489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049729428
    334 https://doi.org/10.1385/1-59259-271-6:489
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1385/1-59259-271-6:535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014150728
    337 https://doi.org/10.1385/1-59259-271-6:535
    338 rdf:type schema:CreativeWork
    339 https://app.dimensions.ai/details/publication/pub.1075088180 schema:CreativeWork
    340 https://app.dimensions.ai/details/publication/pub.1075088188 schema:CreativeWork
    341 https://app.dimensions.ai/details/publication/pub.1078243467 schema:CreativeWork
    342 https://app.dimensions.ai/details/publication/pub.1078997899 schema:CreativeWork
    343 https://app.dimensions.ai/details/publication/pub.1083277601 schema:CreativeWork
    344 https://doi.org/10.1002/(sici)1522-2683(19991201)20:18<3603::aid-elps3603>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1042049812
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1006/jmbi.2000.4315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018016237
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1016/0166-6851(95)02575-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044181941
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1016/s0065-308x(08)60033-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016188834
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1016/s0091-679x(08)61853-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037295256
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1016/s0166-6851(01)00391-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044525688
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1021/pr015504q schema:sameAs https://app.dimensions.ai/details/publication/pub.1056290126
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1046/j.1365-2958.2000.01730.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011767272
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1046/j.1365-2958.2001.02222.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014477350
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1051/parasite/2000071019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008064719
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1073/pnas.022630099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046411131
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1073/pnas.040561197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049036597
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1073/pnas.171185198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018824999
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1073/pnas.96.16.9333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045274124
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1074/jbc.274.45.32411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048278758
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1093/emboj/18.22.6221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025552451
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1093/nar/30.1.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009221125
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1093/protein/10.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001804651
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1093/protein/11.12.1155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026117307
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1126/science.1056794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019683539
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1126/science.282.5391.1126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062563116
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1126/science.287.5461.2185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019737566
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1128/iai.69.6.3635-3645.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016623132
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1128/mcb.17.2.604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039764228
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1128/mcb.19.2.967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040723006
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1146/annurev.biochem.71.090501.145453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039214028
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.2174/1381612023394197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069164664
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.2307/3280286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070252344
    399 rdf:type schema:CreativeWork
    400 https://www.grid.ac/institutes/grid.214007.0 schema:alternateName Scripps Research Institute
    401 schema:name *Department of Cell Biology, The Scripps Research Institute, SR-11, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    402 rdf:type schema:Organization
    403 https://www.grid.ac/institutes/grid.281196.5 schema:alternateName American Type Culture Collection
    404 schema:name **Malaria Research and Reference Reagent Resource Center, American Type Culture Collection, 10801 University Boulevard, Manassas, Virginia 20110-2209, USA
    405 rdf:type schema:Organization
    406 https://www.grid.ac/institutes/grid.34477.33 schema:alternateName University of Washington
    407 schema:name *Department of Cell Biology, The Scripps Research Institute, SR-11, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    408 ☆Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    409 rdf:type schema:Organization
    410 https://www.grid.ac/institutes/grid.420134.0 schema:alternateName Syngenta (United States)
    411 schema:name *Department of Cell Biology, The Scripps Research Institute, SR-11, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    412 †Department of Proteomics and Metabolomics, Torrey Mesa Research Institute, Syngenta Research & Technology, 3115 Merryfield Row, San Diego, California 92121-1125, USA
    413 rdf:type schema:Organization
    414 https://www.grid.ac/institutes/grid.420210.5 schema:alternateName United States Army Medical Research and Materiel Command
    415 schema:name §Naval Medical Research Center, Malaria Program (IDD), 503 Robert Grant Avenue, Room 3A40, Silver Spring, Maryland 20910-7500, USA
    416 ¶Department of Immunology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910-7500, USA
    417 rdf:type schema:Organization
    418 https://www.grid.ac/institutes/grid.451388.3 schema:alternateName The Francis Crick Institute
    419 schema:name ‖The Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    420 rdf:type schema:Organization
    421 https://www.grid.ac/institutes/grid.469946.0 schema:alternateName J. Craig Venter Institute
    422 schema:name ††The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    423 rdf:type schema:Organization
    424 https://www.grid.ac/institutes/grid.7445.2 schema:alternateName Imperial College London
    425 schema:name ‡Infection and Immunity Section, Department of Biological Sciences, Imperial College of Science, Technology & Medicine, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, UK
    426 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...