Active genes are tri-methylated at K4 of histone H3 View Full Text


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Article Info

DATE

2002-09

AUTHORS

Helena Santos-Rosa, Robert Schneider, Andrew J. Bannister, Julia Sherriff, Bradley E. Bernstein, N. C. Tolga Emre, Stuart L. Schreiber, Jane Mellor, Tony Kouzarides

ABSTRACT

Lysine methylation of histones in vivo occurs in three states: mono-, di- and tri-methyl. Histone H3 has been found to be di-methylated at lysine 4 (K4) in active euchromatic regions but not in silent heterochromatic sites. Here we show that the Saccharomyces cerevisiae Set1 protein can catalyse di- and tri-methylation of K4 and stimulate the activity of many genes. Using antibodies that discriminate between the di- and tri-methylated state of K4 we show that di-methylation occurs at both inactive and active euchromatic genes, whereas tri-methylation is present exclusively at active genes. It is therefore the presence of a tri-methylated K4 that defines an active state of gene expression. These findings establish the concept of methyl status as a determinant for gene activity and thus extend considerably the complexity of histone modifications. More... »

PAGES

407

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature01080

DOI

http://dx.doi.org/10.1038/nature01080

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https://app.dimensions.ai/details/publication/pub.1005406259

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12353038


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