RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-09

AUTHORS

Carsten Hoege, Boris Pfander, George-Lucian Moldovan, George Pyrowolakis, Stefan Jentsch

ABSTRACT

The RAD6 pathway is central to post-replicative DNA repair in eukaryotic cells; however, the machinery and its regulation remain poorly understood. Two principal elements of this pathway are the ubiquitin-conjugating enzymes RAD6 and the MMS2-UBC13 heterodimer, which are recruited to chromatin by the RING-finger proteins RAD18 and RAD5, respectively. Here we show that UBC9, a small ubiquitin-related modifier (SUMO)-conjugating enzyme, is also affiliated with this pathway and that proliferating cell nuclear antigen (PCNA) -- a DNA-polymerase sliding clamp involved in DNA synthesis and repair -- is a substrate. PCNA is mono-ubiquitinated through RAD6 and RAD18, modified by lysine-63-linked multi-ubiquitination--which additionally requires MMS2, UBC13 and RAD5--and is conjugated to SUMO by UBC9. All three modifications affect the same lysine residue of PCNA, suggesting that they label PCNA for alternative functions. We demonstrate that these modifications differentially affect resistance to DNA damage, and that damage-induced PCNA ubiquitination is elementary for DNA repair and occurs at the same conserved residue in yeast and humans. More... »

PAGES

135

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature00991

DOI

http://dx.doi.org/10.1038/nature00991

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008683677

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12226657


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Conserved Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repair", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Fungal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HeLa Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ligases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Biological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proliferating Cell Nuclear Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Small Ubiquitin-Related Modifier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ubiquitin-Conjugating Enzymes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Biochemistry", 
          "id": "https://www.grid.ac/institutes/grid.418615.f", 
          "name": [
            "*Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, 82152 Martinsried, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hoege", 
        "givenName": "Carsten", 
        "id": "sg:person.0713144071.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713144071.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Biochemistry", 
          "id": "https://www.grid.ac/institutes/grid.418615.f", 
          "name": [
            "*Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, 82152 Martinsried, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pfander", 
        "givenName": "Boris", 
        "id": "sg:person.01073275017.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073275017.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Biochemistry", 
          "id": "https://www.grid.ac/institutes/grid.418615.f", 
          "name": [
            "*Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, 82152 Martinsried, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moldovan", 
        "givenName": "George-Lucian", 
        "id": "sg:person.01157374103.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157374103.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Biochemistry", 
          "id": "https://www.grid.ac/institutes/grid.418615.f", 
          "name": [
            "*Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, 82152 Martinsried, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pyrowolakis", 
        "givenName": "George", 
        "id": "sg:person.01153055521.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153055521.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute of Biochemistry", 
          "id": "https://www.grid.ac/institutes/grid.418615.f", 
          "name": [
            "*Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, 82152 Martinsried, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jentsch", 
        "givenName": "Stefan", 
        "id": "sg:person.01133324361.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133324361.32"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/90373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000226640", 
          "https://doi.org/10.1038/90373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/329131a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000508335", 
          "https://doi.org/10.1038/329131a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/329131a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000508335", 
          "https://doi.org/10.1038/329131a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(00)01681-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000580121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35041601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005473668", 
          "https://doi.org/10.1038/35041601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35041601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005473668", 
          "https://doi.org/10.1038/35041601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/18457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005715451", 
          "https://doi.org/10.1038/18457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/18457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005715451", 
          "https://doi.org/10.1038/18457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.15.3.1265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008236081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0921-8777(99)00034-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010471638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.062047799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010981511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80133-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012793429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35085597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015156454", 
          "https://doi.org/10.1038/35085597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35085597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015156454", 
          "https://doi.org/10.1038/35085597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1994.tb52825.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016089960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/373078a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016819296", 
          "https://doi.org/10.1038/373078a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)00126-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019416384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.10.5678", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021382970"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.18.9676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023362968"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cellbio.16.1.591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023791975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/18.2.261", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024308065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/ec.1.1.1-10.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024911566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmbi.1994.1495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026150519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)00011-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026446134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35077232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027480321", 
          "https://doi.org/10.1038/35077232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35077232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027480321", 
          "https://doi.org/10.1038/35077232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/19.13.3388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028186220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)00077-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028832754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(94)90502-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029225789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/30.3.732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029697975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00387-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032063520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.8.7.811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032797483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80575-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036121644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1521-1878(200011)22:11<997::aid-bies6>3.0.co;2-#", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036459202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00630-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039487934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.14.7927", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039511320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.275.18.13321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041552428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.11.6367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041661901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002940050515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042026136", 
          "https://doi.org/10.1007/s002940050515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002940050515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042026136", 
          "https://doi.org/10.1007/s002940050515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.19.5847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043833594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/16.19.5847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043833594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.7.2419-2426.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045152932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.ge.27.120193.000341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047320352"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00491-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047459960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.147.5.981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048852700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.12.9.3807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049206495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.15.8.4420", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049302129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35056591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049389948", 
          "https://doi.org/10.1038/35056591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35056591", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049389948", 
          "https://doi.org/10.1038/35056591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(02)00486-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050076762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0061(199907)15:10b<963::aid-yea399>3.0.co;2-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050374223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/29.17.3487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052193380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2741/a469", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070917252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074678883", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074960343", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078433341", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079980941", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082988296", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-09", 
    "datePublishedReg": "2002-09-01", 
    "description": "The RAD6 pathway is central to post-replicative DNA repair in eukaryotic cells; however, the machinery and its regulation remain poorly understood. Two principal elements of this pathway are the ubiquitin-conjugating enzymes RAD6 and the MMS2-UBC13 heterodimer, which are recruited to chromatin by the RING-finger proteins RAD18 and RAD5, respectively. Here we show that UBC9, a small ubiquitin-related modifier (SUMO)-conjugating enzyme, is also affiliated with this pathway and that proliferating cell nuclear antigen (PCNA) -- a DNA-polymerase sliding clamp involved in DNA synthesis and repair -- is a substrate. PCNA is mono-ubiquitinated through RAD6 and RAD18, modified by lysine-63-linked multi-ubiquitination--which additionally requires MMS2, UBC13 and RAD5--and is conjugated to SUMO by UBC9. All three modifications affect the same lysine residue of PCNA, suggesting that they label PCNA for alternative functions. We demonstrate that these modifications differentially affect resistance to DNA damage, and that damage-induced PCNA ubiquitination is elementary for DNA repair and occurs at the same conserved residue in yeast and humans.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature00991", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6903", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "419"
      }
    ], 
    "name": "RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO", 
    "pagination": "135", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "295f0792d4014766b631d586bd12e8d4f4e08e31bd56e07dbc3867934f501da4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12226657"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature00991"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008683677"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature00991", 
      "https://app.dimensions.ai/details/publication/pub.1008683677"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29212_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature00991"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature00991'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature00991'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature00991'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature00991'


 

This table displays all metadata directly associated to this object as RDF triples.

330 TRIPLES      21 PREDICATES      99 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature00991 schema:about N06b1cfbb501d4739ad869d84857ff66c
2 N0b93310db20d4578bf4b97aad986a38f
3 N19721a20b9be40d7b67e9e01cd4b3007
4 N208f8354ed31495e8677942e4cf06df8
5 N24decfde254c4e8e98b9582885a66fff
6 N2a4920483ef548299348b9e55632599c
7 N33c45fdceee547eb990c801381f63735
8 N4984402d63e44725a8f0958088f49016
9 N52ebc4f06ffa44b4aeb7bd7c9f98dba4
10 N794c0b934fc7486ab21ddc52539326b1
11 N7dbf9d992da1433081513dbeed5b0f71
12 N8071c0b32bc34a6b82e31759b54a08a0
13 N9b4ea0784ca7422193a8353ef355bca3
14 Na933a2ab81984fc8ae8f44c6af38daec
15 Nb0116661de9a4b74bbb904a75dcd6484
16 Nc8746c8871664fe38b1621e53df3b5c1
17 Ne1fe22572a114e7b81f3f625758f6c60
18 Ne41497ca24f846e382af6841af5bc6d7
19 Nfa63fd02a5e54520993f430ba6b45c99
20 anzsrc-for:06
21 anzsrc-for:0601
22 schema:author N171aa1fbb31e4e3986345c58b1ffe90e
23 schema:citation sg:pub.10.1007/s002940050515
24 sg:pub.10.1038/18457
25 sg:pub.10.1038/329131a0
26 sg:pub.10.1038/35041601
27 sg:pub.10.1038/35056591
28 sg:pub.10.1038/35077232
29 sg:pub.10.1038/35085597
30 sg:pub.10.1038/373078a0
31 sg:pub.10.1038/90373
32 https://app.dimensions.ai/details/publication/pub.1074678883
33 https://app.dimensions.ai/details/publication/pub.1074960343
34 https://app.dimensions.ai/details/publication/pub.1078433341
35 https://app.dimensions.ai/details/publication/pub.1079980941
36 https://app.dimensions.ai/details/publication/pub.1082988296
37 https://doi.org/10.1002/(sici)1097-0061(199907)15:10b<963::aid-yea399>3.0.co;2-w
38 https://doi.org/10.1002/1521-1878(200011)22:11<997::aid-bies6>3.0.co;2-#
39 https://doi.org/10.1006/jmbi.1994.1495
40 https://doi.org/10.1016/s0092-8674(00)00011-8
41 https://doi.org/10.1016/s0092-8674(00)00077-5
42 https://doi.org/10.1016/s0092-8674(00)00126-4
43 https://doi.org/10.1016/s0092-8674(00)80575-9
44 https://doi.org/10.1016/s0092-8674(01)00387-7
45 https://doi.org/10.1016/s0092-8674(01)00491-3
46 https://doi.org/10.1016/s0092-8674(02)00630-x
47 https://doi.org/10.1016/s0092-8674(94)90502-9
48 https://doi.org/10.1016/s0921-8777(99)00034-8
49 https://doi.org/10.1016/s0968-0004(00)01681-9
50 https://doi.org/10.1016/s1097-2765(00)80133-1
51 https://doi.org/10.1016/s1097-2765(02)00486-0
52 https://doi.org/10.1073/pnas.062047799
53 https://doi.org/10.1073/pnas.93.18.9676
54 https://doi.org/10.1073/pnas.95.10.5678
55 https://doi.org/10.1073/pnas.97.14.7927
56 https://doi.org/10.1074/jbc.275.18.13321
57 https://doi.org/10.1083/jcb.147.5.981
58 https://doi.org/10.1093/emboj/16.19.5847
59 https://doi.org/10.1093/emboj/19.13.3388
60 https://doi.org/10.1093/nar/18.2.261
61 https://doi.org/10.1093/nar/29.17.3487
62 https://doi.org/10.1093/nar/30.3.732
63 https://doi.org/10.1101/gad.8.7.811
64 https://doi.org/10.1111/j.1749-6632.1994.tb52825.x
65 https://doi.org/10.1128/ec.1.1.1-10.2002
66 https://doi.org/10.1128/mcb.12.9.3807
67 https://doi.org/10.1128/mcb.15.3.1265
68 https://doi.org/10.1128/mcb.15.8.4420
69 https://doi.org/10.1128/mcb.17.11.6367
70 https://doi.org/10.1128/mcb.22.7.2419-2426.2002
71 https://doi.org/10.1146/annurev.cellbio.16.1.591
72 https://doi.org/10.1146/annurev.ge.27.120193.000341
73 https://doi.org/10.2741/a469
74 schema:datePublished 2002-09
75 schema:datePublishedReg 2002-09-01
76 schema:description The RAD6 pathway is central to post-replicative DNA repair in eukaryotic cells; however, the machinery and its regulation remain poorly understood. Two principal elements of this pathway are the ubiquitin-conjugating enzymes RAD6 and the MMS2-UBC13 heterodimer, which are recruited to chromatin by the RING-finger proteins RAD18 and RAD5, respectively. Here we show that UBC9, a small ubiquitin-related modifier (SUMO)-conjugating enzyme, is also affiliated with this pathway and that proliferating cell nuclear antigen (PCNA) -- a DNA-polymerase sliding clamp involved in DNA synthesis and repair -- is a substrate. PCNA is mono-ubiquitinated through RAD6 and RAD18, modified by lysine-63-linked multi-ubiquitination--which additionally requires MMS2, UBC13 and RAD5--and is conjugated to SUMO by UBC9. All three modifications affect the same lysine residue of PCNA, suggesting that they label PCNA for alternative functions. We demonstrate that these modifications differentially affect resistance to DNA damage, and that damage-induced PCNA ubiquitination is elementary for DNA repair and occurs at the same conserved residue in yeast and humans.
77 schema:genre research_article
78 schema:inLanguage en
79 schema:isAccessibleForFree false
80 schema:isPartOf N1f133f76074f44b1918fbf4f15b139ab
81 Nc5a7ff0a1b0b49c093b948fa0db45217
82 sg:journal.1018957
83 schema:name RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
84 schema:pagination 135
85 schema:productId N2c6a926a3aa1466793c7d675074da17f
86 N4a7333f6a127419695a238c7429cc501
87 N5e3a5311f9954b9d8382e2846adb9f2b
88 Nc3da6c7691e845aaa009b5ff514ad29a
89 Nccbef12bbd964a27a037d5f4fd7b5ce1
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008683677
91 https://doi.org/10.1038/nature00991
92 schema:sdDatePublished 2019-04-11T11:55
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher Nb65e8a7a3e604f63a93915450427d921
95 schema:url https://www.nature.com/articles/nature00991
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N05ca2f3a7bfc491f91b5c732ca567d47 rdf:first sg:person.01157374103.49
100 rdf:rest N0b9ca0440227447c966291ec2101449f
101 N06b1cfbb501d4739ad869d84857ff66c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Saccharomyces cerevisiae Proteins
103 rdf:type schema:DefinedTerm
104 N0b93310db20d4578bf4b97aad986a38f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Humans
106 rdf:type schema:DefinedTerm
107 N0b9ca0440227447c966291ec2101449f rdf:first sg:person.01153055521.55
108 rdf:rest Nd7d3890a1e63486da39c4ed43f73f2e2
109 N171aa1fbb31e4e3986345c58b1ffe90e rdf:first sg:person.0713144071.62
110 rdf:rest N5e8c4b2753204e428e7db1fdc7a7c29c
111 N19721a20b9be40d7b67e9e01cd4b3007 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name HeLa Cells
113 rdf:type schema:DefinedTerm
114 N1f133f76074f44b1918fbf4f15b139ab schema:volumeNumber 419
115 rdf:type schema:PublicationVolume
116 N208f8354ed31495e8677942e4cf06df8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Models, Biological
118 rdf:type schema:DefinedTerm
119 N24decfde254c4e8e98b9582885a66fff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name DNA Damage
121 rdf:type schema:DefinedTerm
122 N2a4920483ef548299348b9e55632599c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Ubiquitin-Conjugating Enzymes
124 rdf:type schema:DefinedTerm
125 N2c6a926a3aa1466793c7d675074da17f schema:name nlm_unique_id
126 schema:value 0410462
127 rdf:type schema:PropertyValue
128 N33c45fdceee547eb990c801381f63735 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Ubiquitin
130 rdf:type schema:DefinedTerm
131 N4984402d63e44725a8f0958088f49016 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Proliferating Cell Nuclear Antigen
133 rdf:type schema:DefinedTerm
134 N4a7333f6a127419695a238c7429cc501 schema:name doi
135 schema:value 10.1038/nature00991
136 rdf:type schema:PropertyValue
137 N52ebc4f06ffa44b4aeb7bd7c9f98dba4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Saccharomyces cerevisiae
139 rdf:type schema:DefinedTerm
140 N5e3a5311f9954b9d8382e2846adb9f2b schema:name readcube_id
141 schema:value 295f0792d4014766b631d586bd12e8d4f4e08e31bd56e07dbc3867934f501da4
142 rdf:type schema:PropertyValue
143 N5e8c4b2753204e428e7db1fdc7a7c29c rdf:first sg:person.01073275017.12
144 rdf:rest N05ca2f3a7bfc491f91b5c732ca567d47
145 N794c0b934fc7486ab21ddc52539326b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Cell Cycle
147 rdf:type schema:DefinedTerm
148 N7dbf9d992da1433081513dbeed5b0f71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name DNA Repair
150 rdf:type schema:DefinedTerm
151 N8071c0b32bc34a6b82e31759b54a08a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Protein Binding
153 rdf:type schema:DefinedTerm
154 N9b4ea0784ca7422193a8353ef355bca3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Genes, Fungal
156 rdf:type schema:DefinedTerm
157 Na933a2ab81984fc8ae8f44c6af38daec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Conserved Sequence
159 rdf:type schema:DefinedTerm
160 Nb0116661de9a4b74bbb904a75dcd6484 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name DNA-Binding Proteins
162 rdf:type schema:DefinedTerm
163 Nb65e8a7a3e604f63a93915450427d921 schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 Nc3da6c7691e845aaa009b5ff514ad29a schema:name pubmed_id
166 schema:value 12226657
167 rdf:type schema:PropertyValue
168 Nc5a7ff0a1b0b49c093b948fa0db45217 schema:issueNumber 6903
169 rdf:type schema:PublicationIssue
170 Nc8746c8871664fe38b1621e53df3b5c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Ligases
172 rdf:type schema:DefinedTerm
173 Nccbef12bbd964a27a037d5f4fd7b5ce1 schema:name dimensions_id
174 schema:value pub.1008683677
175 rdf:type schema:PropertyValue
176 Nd7d3890a1e63486da39c4ed43f73f2e2 rdf:first sg:person.01133324361.32
177 rdf:rest rdf:nil
178 Ne1fe22572a114e7b81f3f625758f6c60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name DNA
180 rdf:type schema:DefinedTerm
181 Ne41497ca24f846e382af6841af5bc6d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Small Ubiquitin-Related Modifier Proteins
183 rdf:type schema:DefinedTerm
184 Nfa63fd02a5e54520993f430ba6b45c99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Mutation
186 rdf:type schema:DefinedTerm
187 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
188 schema:name Biological Sciences
189 rdf:type schema:DefinedTerm
190 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
191 schema:name Biochemistry and Cell Biology
192 rdf:type schema:DefinedTerm
193 sg:journal.1018957 schema:issn 0090-0028
194 1476-4687
195 schema:name Nature
196 rdf:type schema:Periodical
197 sg:person.01073275017.12 schema:affiliation https://www.grid.ac/institutes/grid.418615.f
198 schema:familyName Pfander
199 schema:givenName Boris
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073275017.12
201 rdf:type schema:Person
202 sg:person.01133324361.32 schema:affiliation https://www.grid.ac/institutes/grid.418615.f
203 schema:familyName Jentsch
204 schema:givenName Stefan
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133324361.32
206 rdf:type schema:Person
207 sg:person.01153055521.55 schema:affiliation https://www.grid.ac/institutes/grid.418615.f
208 schema:familyName Pyrowolakis
209 schema:givenName George
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153055521.55
211 rdf:type schema:Person
212 sg:person.01157374103.49 schema:affiliation https://www.grid.ac/institutes/grid.418615.f
213 schema:familyName Moldovan
214 schema:givenName George-Lucian
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157374103.49
216 rdf:type schema:Person
217 sg:person.0713144071.62 schema:affiliation https://www.grid.ac/institutes/grid.418615.f
218 schema:familyName Hoege
219 schema:givenName Carsten
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713144071.62
221 rdf:type schema:Person
222 sg:pub.10.1007/s002940050515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042026136
223 https://doi.org/10.1007/s002940050515
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/18457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005715451
226 https://doi.org/10.1038/18457
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/329131a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000508335
229 https://doi.org/10.1038/329131a0
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/35041601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005473668
232 https://doi.org/10.1038/35041601
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/35056591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049389948
235 https://doi.org/10.1038/35056591
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/35077232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027480321
238 https://doi.org/10.1038/35077232
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/35085597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015156454
241 https://doi.org/10.1038/35085597
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/373078a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016819296
244 https://doi.org/10.1038/373078a0
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/90373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000226640
247 https://doi.org/10.1038/90373
248 rdf:type schema:CreativeWork
249 https://app.dimensions.ai/details/publication/pub.1074678883 schema:CreativeWork
250 https://app.dimensions.ai/details/publication/pub.1074960343 schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1078433341 schema:CreativeWork
252 https://app.dimensions.ai/details/publication/pub.1079980941 schema:CreativeWork
253 https://app.dimensions.ai/details/publication/pub.1082988296 schema:CreativeWork
254 https://doi.org/10.1002/(sici)1097-0061(199907)15:10b<963::aid-yea399>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1050374223
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1002/1521-1878(200011)22:11<997::aid-bies6>3.0.co;2-# schema:sameAs https://app.dimensions.ai/details/publication/pub.1036459202
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1006/jmbi.1994.1495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026150519
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/s0092-8674(00)00011-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026446134
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/s0092-8674(00)00077-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028832754
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/s0092-8674(00)00126-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019416384
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/s0092-8674(00)80575-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036121644
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/s0092-8674(01)00387-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032063520
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/s0092-8674(01)00491-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047459960
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s0092-8674(02)00630-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039487934
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/s0092-8674(94)90502-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029225789
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s0921-8777(99)00034-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010471638
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/s0968-0004(00)01681-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000580121
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/s1097-2765(00)80133-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012793429
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/s1097-2765(02)00486-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050076762
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1073/pnas.062047799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010981511
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1073/pnas.93.18.9676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023362968
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1073/pnas.95.10.5678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021382970
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1073/pnas.97.14.7927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039511320
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1074/jbc.275.18.13321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041552428
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1083/jcb.147.5.981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048852700
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1093/emboj/16.19.5847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043833594
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1093/emboj/19.13.3388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028186220
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1093/nar/18.2.261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024308065
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1093/nar/29.17.3487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052193380
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1093/nar/30.3.732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029697975
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1101/gad.8.7.811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032797483
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1111/j.1749-6632.1994.tb52825.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016089960
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1128/ec.1.1.1-10.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024911566
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1128/mcb.12.9.3807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049206495
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1128/mcb.15.3.1265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008236081
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1128/mcb.15.8.4420 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049302129
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1128/mcb.17.11.6367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041661901
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1128/mcb.22.7.2419-2426.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045152932
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1146/annurev.cellbio.16.1.591 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023791975
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1146/annurev.ge.27.120193.000341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047320352
325 rdf:type schema:CreativeWork
326 https://doi.org/10.2741/a469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070917252
327 rdf:type schema:CreativeWork
328 https://www.grid.ac/institutes/grid.418615.f schema:alternateName Max Planck Institute of Biochemistry
329 schema:name *Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, 82152 Martinsried, Germany
330 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...