Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-09

AUTHORS

Javier Di Noia, Michael S. Neuberger

ABSTRACT

A functional immune system depends on the production of a wide range of immunoglobulin molecules. Immunoglobulin variable region (IgV) genes are diversified after gene rearrangement by hypermutation. In the DNA deamination model, we have proposed that deamination of dC residues to dU by activation-induced deaminase (AID) triggers this diversification. In hypermutating chicken DT40 B cells, most IgV mutations are dC --> dG/dA or dG --> dC/dT transversions, which are proposed to result from replication over sites of base loss produced by the excision activity of uracil-DNA glycosylase. Blocking the activity of uracil-DNA glycosylase should instead lead to replication over the dU lesion, resulting in dC --> dT (and dG --> dA) transitions. Here we show that expression in DT40 cells of a bacteriophage-encoded protein that inhibits uracil-DNA glycosylase shifts the pattern of IgV gene mutations from transversion dominance to transition dominance. This is good evidence that antibody diversification involves dC --> dU deamination within the immunoglobulin locus itself. More... »

PAGES

43

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature00981

DOI

http://dx.doi.org/10.1038/nature00981

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012417517

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12214226


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibody Diversity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chickens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytidine Deaminase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Glycosylases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repair", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Immunoglobulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutagenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "N-Glycosyl Hydrolases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Somatic Hypermutation, Immunoglobulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Uracil-DNA Glycosidase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "MRC Laboratory of Molecular Biology", 
          "id": "https://www.grid.ac/institutes/grid.42475.30", 
          "name": [
            "*Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Noia", 
        "givenName": "Javier", 
        "id": "sg:person.0713467760.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713467760.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "MRC Laboratory of Molecular Biology", 
          "id": "https://www.grid.ac/institutes/grid.42475.30", 
          "name": [
            "*Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neuberger", 
        "givenName": "Michael S.", 
        "id": "sg:person.01043211662.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043211662.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1128/mcb.21.8.2858-2866.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003825698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m011166200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006251793"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1383-5742(00)00024-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009175915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.75.21.10488-10492.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009948039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90467-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014213722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80271-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015856254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0042-6822(85)90312-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016969577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35091100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019110575", 
          "https://doi.org/10.1038/35091100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35091100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019110575", 
          "https://doi.org/10.1038/35091100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/362709a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019428971", 
          "https://doi.org/10.1038/362709a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.71.9.3649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020851135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0921-8777(00)00025-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027591868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0921-8777(00)00040-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030400444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.26.18470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034823954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/20.15.4278", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036694578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039993406", 
          "https://doi.org/10.1038/nature00862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039993406", 
          "https://doi.org/10.1038/nature00862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(99)80087-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042956165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(02)00717-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043343086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00524a027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055179403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jb.170.3.1082-1091.1988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062716746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1990.tb08190.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078394112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082640773", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2002-09", 
    "datePublishedReg": "2002-09-01", 
    "description": "A functional immune system depends on the production of a wide range of immunoglobulin molecules. Immunoglobulin variable region (IgV) genes are diversified after gene rearrangement by hypermutation. In the DNA deamination model, we have proposed that deamination of dC residues to dU by activation-induced deaminase (AID) triggers this diversification. In hypermutating chicken DT40 B cells, most IgV mutations are dC --> dG/dA or dG --> dC/dT transversions, which are proposed to result from replication over sites of base loss produced by the excision activity of uracil-DNA glycosylase. Blocking the activity of uracil-DNA glycosylase should instead lead to replication over the dU lesion, resulting in dC --> dT (and dG --> dA) transitions. Here we show that expression in DT40 cells of a bacteriophage-encoded protein that inhibits uracil-DNA glycosylase shifts the pattern of IgV gene mutations from transversion dominance to transition dominance. This is good evidence that antibody diversification involves dC --> dU deamination within the immunoglobulin locus itself.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nature00981", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6902", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "419"
      }
    ], 
    "name": "Altering the pathway of immunoglobulin hypermutation by inhibiting\n      uracil-DNA glycosylase", 
    "pagination": "43", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3b28e88311d16e60e4cf9cc5e5eb7ef5c31eed5f318efab86b3b2d1bada49722"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12214226"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nature00981"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012417517"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nature00981", 
      "https://app.dimensions.ai/details/publication/pub.1012417517"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000359_0000000359/records_29183_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nature00981"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nature00981'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nature00981'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nature00981'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nature00981'


 

This table displays all metadata directly associated to this object as RDF triples.

225 TRIPLES      21 PREDICATES      71 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nature00981 schema:about N26c2d9cbfd1b47a6bbefbfa30ee1ad55
2 N2bc6fb65c76b45c8a44b63165c7cfe29
3 N2e09c068d15c440e86c55083f66b09c2
4 N5d8fdae8214c40f78d0b08a41cecf16b
5 N6358383f6cbc43a1aefc52a59ba7bd1c
6 N79dcd10c671446dc8bc08c149f931818
7 N7e624233d7ad45b399baf12b4c5fe0b6
8 N92ca5115f0044110a30737209b7b5c8a
9 N930e58b4a420460b85a159ecfed50dfa
10 N94ffd2d3fff14f8182e74cedf629af98
11 N9f49eff4ecad41beac8ec8a1bb8651b3
12 Na2f95151591e46d780aa80dd1421a7d7
13 Na9efbcd72d8a4e72a2d3e539fb2eed31
14 Nb237ef54c8e04535b3ca69f9fca8f493
15 Nb2bd6cea850f478a9005d651ff29e5fe
16 Nbe574cfa93b749e2be15f1280049046e
17 Nc495768fca18417096e32ff2784a6d1f
18 Nc6c2c5cc3e144eaa8e6fa9ca3e86d507
19 Ne6b5c9c875f746dfb14fec3d7956f966
20 Nea37bafe45194c8b9272e6894d90c168
21 Nf4bb1e321ce14a0ab9412c3bfceacf6a
22 anzsrc-for:06
23 anzsrc-for:0604
24 schema:author N4a1f4be1bf0a4e2c84adbd52433b0784
25 schema:citation sg:pub.10.1038/35091100
26 sg:pub.10.1038/362709a0
27 sg:pub.10.1038/nature00862
28 https://app.dimensions.ai/details/publication/pub.1082640773
29 https://doi.org/10.1002/j.1460-2075.1990.tb08190.x
30 https://doi.org/10.1016/0042-6822(85)90312-5
31 https://doi.org/10.1016/0092-8674(95)90467-0
32 https://doi.org/10.1016/s0921-8777(00)00025-2
33 https://doi.org/10.1016/s0921-8777(00)00040-9
34 https://doi.org/10.1016/s0960-9822(02)00717-0
35 https://doi.org/10.1016/s0960-9822(99)80087-6
36 https://doi.org/10.1016/s1097-2765(00)80271-3
37 https://doi.org/10.1016/s1383-5742(00)00024-7
38 https://doi.org/10.1021/bi00524a027
39 https://doi.org/10.1073/pnas.71.9.3649
40 https://doi.org/10.1074/jbc.274.26.18470
41 https://doi.org/10.1074/jbc.m011166200
42 https://doi.org/10.1093/emboj/20.15.4278
43 https://doi.org/10.1128/jb.170.3.1082-1091.1988
44 https://doi.org/10.1128/jvi.75.21.10488-10492.2001
45 https://doi.org/10.1128/mcb.21.8.2858-2866.2001
46 schema:datePublished 2002-09
47 schema:datePublishedReg 2002-09-01
48 schema:description A functional immune system depends on the production of a wide range of immunoglobulin molecules. Immunoglobulin variable region (IgV) genes are diversified after gene rearrangement by hypermutation. In the DNA deamination model, we have proposed that deamination of dC residues to dU by activation-induced deaminase (AID) triggers this diversification. In hypermutating chicken DT40 B cells, most IgV mutations are dC --> dG/dA or dG --> dC/dT transversions, which are proposed to result from replication over sites of base loss produced by the excision activity of uracil-DNA glycosylase. Blocking the activity of uracil-DNA glycosylase should instead lead to replication over the dU lesion, resulting in dC --> dT (and dG --> dA) transitions. Here we show that expression in DT40 cells of a bacteriophage-encoded protein that inhibits uracil-DNA glycosylase shifts the pattern of IgV gene mutations from transversion dominance to transition dominance. This is good evidence that antibody diversification involves dC --> dU deamination within the immunoglobulin locus itself.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree false
52 schema:isPartOf N82e594dfc6824b918b77f73a7d56bada
53 Nd1b24fe2a88042c3a27c2eec1160ae8c
54 sg:journal.1018957
55 schema:name Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
56 schema:pagination 43
57 schema:productId N4676b02a12784bdc83774f03a5a35ba5
58 N847214a9b24f4e4c89826a875f3eef8f
59 Na7cdbf370740419e88f8822e7d00b04e
60 Nc8ce8972b1234a29ab64d283917ff04b
61 Nd1c26db7e0aa4c029035104d4203e667
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012417517
63 https://doi.org/10.1038/nature00981
64 schema:sdDatePublished 2019-04-11T11:51
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher N6ac63f952ad94284a07036c2d2e6a408
67 schema:url https://www.nature.com/articles/nature00981
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N26c2d9cbfd1b47a6bbefbfa30ee1ad55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Antibody Diversity
73 rdf:type schema:DefinedTerm
74 N2bc6fb65c76b45c8a44b63165c7cfe29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Somatic Hypermutation, Immunoglobulin
76 rdf:type schema:DefinedTerm
77 N2e09c068d15c440e86c55083f66b09c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Gene Deletion
79 rdf:type schema:DefinedTerm
80 N4676b02a12784bdc83774f03a5a35ba5 schema:name nlm_unique_id
81 schema:value 0410462
82 rdf:type schema:PropertyValue
83 N4a1f4be1bf0a4e2c84adbd52433b0784 rdf:first sg:person.0713467760.41
84 rdf:rest Nfa1d1328a28a4fc7911c59e72b19ae60
85 N5d8fdae8214c40f78d0b08a41cecf16b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Fibroblasts
87 rdf:type schema:DefinedTerm
88 N6358383f6cbc43a1aefc52a59ba7bd1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Mutagenesis
90 rdf:type schema:DefinedTerm
91 N6ac63f952ad94284a07036c2d2e6a408 schema:name Springer Nature - SN SciGraph project
92 rdf:type schema:Organization
93 N79dcd10c671446dc8bc08c149f931818 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Genes, Immunoglobulin
95 rdf:type schema:DefinedTerm
96 N7e624233d7ad45b399baf12b4c5fe0b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Cytidine Deaminase
98 rdf:type schema:DefinedTerm
99 N82e594dfc6824b918b77f73a7d56bada schema:issueNumber 6902
100 rdf:type schema:PublicationIssue
101 N847214a9b24f4e4c89826a875f3eef8f schema:name doi
102 schema:value 10.1038/nature00981
103 rdf:type schema:PropertyValue
104 N92ca5115f0044110a30737209b7b5c8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Chickens
106 rdf:type schema:DefinedTerm
107 N930e58b4a420460b85a159ecfed50dfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Viral Proteins
109 rdf:type schema:DefinedTerm
110 N94ffd2d3fff14f8182e74cedf629af98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name DNA Repair
112 rdf:type schema:DefinedTerm
113 N9f49eff4ecad41beac8ec8a1bb8651b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name N-Glycosyl Hydrolases
115 rdf:type schema:DefinedTerm
116 Na2f95151591e46d780aa80dd1421a7d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name RNA, Messenger
118 rdf:type schema:DefinedTerm
119 Na7cdbf370740419e88f8822e7d00b04e schema:name pubmed_id
120 schema:value 12214226
121 rdf:type schema:PropertyValue
122 Na9efbcd72d8a4e72a2d3e539fb2eed31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name DNA-Binding Proteins
124 rdf:type schema:DefinedTerm
125 Nb237ef54c8e04535b3ca69f9fca8f493 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Mice
127 rdf:type schema:DefinedTerm
128 Nb2bd6cea850f478a9005d651ff29e5fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Base Sequence
130 rdf:type schema:DefinedTerm
131 Nbe574cfa93b749e2be15f1280049046e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name B-Lymphocytes
133 rdf:type schema:DefinedTerm
134 Nc495768fca18417096e32ff2784a6d1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name DNA Glycosylases
136 rdf:type schema:DefinedTerm
137 Nc6c2c5cc3e144eaa8e6fa9ca3e86d507 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Uracil-DNA Glycosidase
139 rdf:type schema:DefinedTerm
140 Nc8ce8972b1234a29ab64d283917ff04b schema:name readcube_id
141 schema:value 3b28e88311d16e60e4cf9cc5e5eb7ef5c31eed5f318efab86b3b2d1bada49722
142 rdf:type schema:PropertyValue
143 Nd1b24fe2a88042c3a27c2eec1160ae8c schema:volumeNumber 419
144 rdf:type schema:PublicationVolume
145 Nd1c26db7e0aa4c029035104d4203e667 schema:name dimensions_id
146 schema:value pub.1012417517
147 rdf:type schema:PropertyValue
148 Ne6b5c9c875f746dfb14fec3d7956f966 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Transfection
150 rdf:type schema:DefinedTerm
151 Nea37bafe45194c8b9272e6894d90c168 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Cell Line
153 rdf:type schema:DefinedTerm
154 Nf4bb1e321ce14a0ab9412c3bfceacf6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Animals
156 rdf:type schema:DefinedTerm
157 Nfa1d1328a28a4fc7911c59e72b19ae60 rdf:first sg:person.01043211662.37
158 rdf:rest rdf:nil
159 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
160 schema:name Biological Sciences
161 rdf:type schema:DefinedTerm
162 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
163 schema:name Genetics
164 rdf:type schema:DefinedTerm
165 sg:journal.1018957 schema:issn 0090-0028
166 1476-4687
167 schema:name Nature
168 rdf:type schema:Periodical
169 sg:person.01043211662.37 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
170 schema:familyName Neuberger
171 schema:givenName Michael S.
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043211662.37
173 rdf:type schema:Person
174 sg:person.0713467760.41 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
175 schema:familyName Di Noia
176 schema:givenName Javier
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713467760.41
178 rdf:type schema:Person
179 sg:pub.10.1038/35091100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019110575
180 https://doi.org/10.1038/35091100
181 rdf:type schema:CreativeWork
182 sg:pub.10.1038/362709a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019428971
183 https://doi.org/10.1038/362709a0
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/nature00862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039993406
186 https://doi.org/10.1038/nature00862
187 rdf:type schema:CreativeWork
188 https://app.dimensions.ai/details/publication/pub.1082640773 schema:CreativeWork
189 https://doi.org/10.1002/j.1460-2075.1990.tb08190.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1078394112
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/0042-6822(85)90312-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016969577
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/0092-8674(95)90467-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014213722
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/s0921-8777(00)00025-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027591868
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/s0921-8777(00)00040-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030400444
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/s0960-9822(02)00717-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043343086
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/s0960-9822(99)80087-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042956165
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/s1097-2765(00)80271-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015856254
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/s1383-5742(00)00024-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009175915
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1021/bi00524a027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055179403
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1073/pnas.71.9.3649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020851135
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1074/jbc.274.26.18470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034823954
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1074/jbc.m011166200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006251793
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1093/emboj/20.15.4278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036694578
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1128/jb.170.3.1082-1091.1988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062716746
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1128/jvi.75.21.10488-10492.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009948039
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1128/mcb.21.8.2858-2866.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003825698
222 rdf:type schema:CreativeWork
223 https://www.grid.ac/institutes/grid.42475.30 schema:alternateName MRC Laboratory of Molecular Biology
224 schema:name *Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
225 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...