A transcription factor response element for gene expression during circadian night View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-08

AUTHORS

Hiroki R. Ueda, Wenbin Chen, Akihito Adachi, Hisanori Wakamatsu, Satoko Hayashi, Tomohiro Takasugi, Mamoru Nagano, Ken-ichi Nakahama, Yutaka Suzuki, Sumio Sugano, Masamitsu Iino, Yasufumi Shigeyoshi, Seiichi Hashimoto

ABSTRACT

Mammalian circadian clocks consist of complex integrated feedback loops1,2,3,4,5,6,7,8,9,10 that cannot be elucidated without comprehensive measurement of system dynamics and determination of network structures11. To dissect such a complicated system, we took a systems-biological approach based on genomic, molecular and cell biological techniques. We profiled suprachiasmatic nuclei and liver genome-wide expression patterns under light/dark cycles and constant darkness. We determined transcription start sites of human orthologues for newly identified cycling genes and then performed bioinformatical searches for relationships between time-of-day specific expression and transcription factor response elements around transcription start sites. Here we demonstrate the role of the Rev-ErbA/ROR response element in gene expression during circadian night, which is in phase with Bmal1 and in antiphase to Per2 oscillations. This role was verified using an in vitro validation system, in which cultured fibroblasts transiently transfected with clock-controlled reporter vectors exhibited robust circadian bioluminescence12. More... »

PAGES

534-539

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nature00906

DOI

http://dx.doi.org/10.1038/nature00906

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026677705

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12152080


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35 schema:description Mammalian circadian clocks consist of complex integrated feedback loops1,2,3,4,5,6,7,8,9,10 that cannot be elucidated without comprehensive measurement of system dynamics and determination of network structures11. To dissect such a complicated system, we took a systems-biological approach based on genomic, molecular and cell biological techniques. We profiled suprachiasmatic nuclei and liver genome-wide expression patterns under light/dark cycles and constant darkness. We determined transcription start sites of human orthologues for newly identified cycling genes and then performed bioinformatical searches for relationships between time-of-day specific expression and transcription factor response elements around transcription start sites. Here we demonstrate the role of the Rev-ErbA/ROR response element in gene expression during circadian night, which is in phase with Bmal1 and in antiphase to Per2 oscillations. This role was verified using an in vitro validation system, in which cultured fibroblasts transiently transfected with clock-controlled reporter vectors exhibited robust circadian bioluminescence12.
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43 Per2 oscillation
44 ROR response elements
45 antiphase
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47 biological techniques
48 cell biological techniques
49 circadian clock
50 circadian night
51 clock
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54 constant darkness
55 cycle
56 cycling genes
57 dark cycle
58 darkness
59 determination
60 dynamics
61 elements
62 expression
63 expression patterns
64 feedback
65 fibroblasts
66 gene expression
67 genes
68 human orthologue
69 integrated feedback
70 liver
71 mammalian circadian clock
72 measurements
73 night
74 nucleus
75 orthologues
76 oscillations
77 patterns
78 phase
79 relationship
80 reporter vector
81 response element
82 role
83 search
84 sites
85 specific expression
86 start site
87 suprachiasmatic nucleus
88 system
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