Tools for translation: non-viral materials for therapeutic mRNA delivery View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-09-12

AUTHORS

Khalid A. Hajj, Kathryn A. Whitehead

ABSTRACT

In recent years, messenger RNA (mRNA) has come into the spotlight as a versatile therapeutic with the potential to prevent and treat a staggering range of diseases. Billions of dollars have been invested in the commercial development of mRNA drugs, with ongoing clinical trials focused on vaccines (for example, influenza and Zika viruses) and cancer immunotherapy (for example, myeloma, leukaemia and glioblastoma). Although significant progress has been made in the design of in vitro-transcribed mRNA that retains potency while minimizing unwanted immune responses, the widespread use of mRNA drugs requires the development of safe and effective drug delivery vehicles. In this Review, we provide an overview of the field of mRNA therapeutics and describe recent advances in the development of synthetic materials that encapsulate and deliver mRNA payloads. More... »

PAGES

17056

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    http://scigraph.springernature.com/pub.10.1038/natrevmats.2017.56

    DOI

    http://dx.doi.org/10.1038/natrevmats.2017.56

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    https://app.dimensions.ai/details/publication/pub.1091578628


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