Design, clinical translation and immunological response of biomaterials in regenerative medicine View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-07

AUTHORS

Kaitlyn Sadtler, Anirudha Singh, Matthew T. Wolf, Xiaokun Wang, Drew M. Pardoll, Jennifer H. Elisseeff

ABSTRACT

The field of regenerative medicine aims to replace tissues lost as a consequence of disease, trauma or congenital abnormalities. Biomaterials serve as scaffolds for regenerative medicine to deliver cells, provide biological signals and physical support, and mobilize endogenous cells to repair tissues. Sophisticated chemistries are used to synthesize materials that mimic and modulate native tissue microenvironments, to replace form and to elucidate structure–function relationships of cell–material interactions. The therapeutic relevance of these biomaterial properties can only be studied after clinical translation, whereby key parameters for efficacy can be defined and then used for future design. In this Review, we present the development and translation of biomaterials for two tissue engineering targets, cartilage and cornea, both of which lack the ability to self-repair. Finally, looking to the future, we discuss the role of the immune system in regeneration and the potential for biomaterial scaffolds to modulate immune signalling to create a pro-regenerative environment. More... »

PAGES

natrevmats201640

Journal

TITLE

Nature Reviews Materials

ISSUE

7

VOLUME

1

Author Affiliations

From Grant

  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/natrevmats.2016.40

    DOI

    http://dx.doi.org/10.1038/natrevmats.2016.40

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003008911


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