Genetic Risk for Schizophrenia and Psychosis in Alzheimer Disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-05-02

AUTHORS

Mary Ann A. DeMichele-Sweet, Elise A. Weamer, Lambertus Klei, Dylan T. Vrana, Deborah J. Hollingshead, Howard J. Seltman, Rebecca Sims, Tatiana Foroud, Isabel Hernandez, Sonia Moreno-Grau, Lluís Tárraga, Mercè Boada, Agustin Ruiz, Julie Williams, Richard Mayeux, Oscar L. Lopez, Etienne L. Sibille, M. Ilyas Kamboh, Bernie Devlin, Robert A. Sweet

ABSTRACT

Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD), affecting ~40 to 60% of individuals with AD (AD with psychosis (AD+P)). In comparison with AD subjects without psychosis, AD+P subjects have more rapid cognitive decline and poor outcomes. Prior studies have estimated the heritability of psychosis in AD at 61%, but the underlying genetic sources of this risk are not known. We evaluated a Discovery Cohort of 2876 AD subjects with (N=1761) or without psychosis (N=1115). All subjects were genotyped using a custom genotyping array designed to evaluate single-nucleotide polymorphisms (SNPs) with evidence of genetic association with AD+P and include SNPs affecting or putatively affecting risk for schizophrenia and AD. Results were replicated in an independent cohort of 2194 AD subjects with (N=734) or without psychosis (N=1460). We found that AD+P is associated with polygenic risk for a set of novel loci and inversely associated with polygenic risk for schizophrenia. Among the biologic pathways identified by the associations of schizophrenia SNPs with AD+P are endosomal trafficking, autophagy and calcium channel signaling. To the best of our knowledge, these findings provide the first clear demonstration that AD+P is associated with common genetic variation. In addition, they provide an unbiased link between polygenic risk for schizophrenia and a lower risk of psychosis in AD. This provides an opportunity to leverage progress made in identifying the biologic effects of schizophrenia alleles to identify novel mechanisms protecting against more rapid cognitive decline and psychosis risk in AD. More... »

PAGES

963-972

References to SciGraph publications

  • 2016-09-26. Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia in NATURE NEUROSCIENCE
  • 2009-07-01. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder in NATURE
  • 2014-01-22. A polygenic burden of rare disruptive mutations in schizophrenia in NATURE
  • 2011-09-18. Genome-wide association study identifies five new schizophrenia loci in NATURE GENETICS
  • 2013-09-08. Systematic identification of trans eQTLs as putative drivers of known disease associations in NATURE GENETICS
  • 2016-01-27. Schizophrenia risk from complex variation of complement component 4 in NATURE
  • 2012-09-30. Autophagy-receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome in NATURE CELL BIOLOGY
  • 2011-10-18. Genome-wide Association Study of Alzheimer’s disease with Psychotic Symptoms in MOLECULAR PSYCHIATRY
  • 2013-10-27. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease in NATURE GENETICS
  • 2011-04-03. Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease in NATURE GENETICS
  • 2016-05-09. A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus in NATURE MEDICINE
  • 2016-10-19. A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity in SCIENTIFIC REPORTS
  • 2013-12-24. Autophagy has a key role in the pathophysiology of schizophrenia in MOLECULAR PSYCHIATRY
  • 2003-04. Psychotic symptoms in Alzheimer disease: evidence for a distinct phenotype in MOLECULAR PSYCHIATRY
  • 2014-07-22. Biological Insights From 108 Schizophrenia-Associated Genetic Loci in NATURE
  • Journal

    TITLE

    Molecular Psychiatry

    ISSUE

    4

    VOLUME

    23

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/mp.2017.81

    DOI

    http://dx.doi.org/10.1038/mp.2017.81

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085105472

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28461698


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