Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-01

AUTHORS

Golam M. I. Chowdhury, Jie Zhang, Monique Thomas, Mounira Banasr, Xiaoxian Ma, Brian Pittman, Linda Bristow, Eric Schaeffer, Ronald Duman, Douglas Rothman, Kevin Behar, Gerard Sanacora

ABSTRACT

Several drugs have recently been reported to induce rapid antidepressant effects in clinical trials and rodent models. Although the cellular mechanisms involved remain unclear, reports suggest that increased glutamate transmission contributes to these effects. Here, we demonstrate that the antidepressant-like efficacy of three unique drugs, with reported rapid onset antidepressant properties, is coupled with a rapid transient rise in glutamate cycling in the medial prefronal cortex (mPFC) of awake rats as measured by ex vivo 1H-[13C]-nuclear magnetic resonance spectroscopy. Rats were acutely pretreated by intraperitoneal injection with a single dose of ketamine (1, 3, 10, 30 and 80 mg kg-1), Ro 25-6981 (1, 3 and 10 mg kg-1), scopolamine (5, 25 and 100 μg kg-1) or vehicle (controls). At fixed times after drug injection, animals received an intravenous infusion of [1,6-13C2]glucose for 8 min to enrich the amino-acid pools of the brain with 13C, followed by rapid euthanasia. The mPFC was dissected, extracted with ethanol and metabolite 13C enrichments were measured. We found a clear dose-dependent effect of ketamine and Ro 25-6981 on behavior and the percentage of 13C enrichment of glutamate, glutamine and GABA (γ-aminobutyric acid). Further, we also found an effect of scopolamine on both cycling and behavior. These studies demonstrate that three pharmacologically distinct classes of drugs, clinically related through their reported rapid antidepressant actions, share the common ability to rapidly stimulate glutamate cycling at doses pertinent for their antidepressant-like efficacy. We conclude that increased cycling precedes the antidepressant action at behaviorally effective doses and suggest that the rapid change in cycling could be used to predict efficacy of novel agents or identify doses with antidepressant activity. More... »

PAGES

120

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/mp.2016.34

DOI

http://dx.doi.org/10.1038/mp.2016.34

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012359509

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27067013


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antidepressive Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutamic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutamine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ketamine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Spectroscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Piperidines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prefrontal Cortex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Scopolamine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "gamma-Aminobutyric Acid", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Psychiatry and Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, CT USA 06519"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chowdhury", 
        "givenName": "Golam M. I.", 
        "id": "sg:person.0705020477.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705020477.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shantou University Medical College", 
          "id": "https://www.grid.ac/institutes/grid.411679.c", 
          "name": [
            "Department of Psychiatry and the Ribicoff Research Facilities, Yale University School of Medicine, New Haven, CT USA 06519", 
            "Mental Health Centre, Shantou University Medical College, Shantou, Guangdong P. R. China 515065"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jie", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Psychiatry and Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, CT USA 06519"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thomas", 
        "givenName": "Monique", 
        "id": "sg:person.01067362277.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067362277.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Psychiatry and the Ribicoff Research Facilities, Yale University School of Medicine, New Haven, CT USA 06519"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Banasr", 
        "givenName": "Mounira", 
        "id": "sg:person.01122067247.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122067247.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Psychiatry and Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, CT USA 06519"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Xiaoxian", 
        "id": "sg:person.01047011365.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047011365.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Psychiatry and the Ribicoff Research Facilities, Yale University School of Medicine, New Haven, CT USA 06519"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pittman", 
        "givenName": "Brian", 
        "id": "sg:person.01171174407.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171174407.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bristow", 
        "givenName": "Linda", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Janssen (United States)", 
          "id": "https://www.grid.ac/institutes/grid.497530.c", 
          "name": [
            "Janssen Research & Development, 1125 Trenton-Harbourton Road, Titusville, NJ 08569"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schaeffer", 
        "givenName": "Eric", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Psychiatry and the Ribicoff Research Facilities, Yale University School of Medicine, New Haven, CT USA 06519"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Duman", 
        "givenName": "Ronald", 
        "id": "sg:person.014054607677.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014054607677.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Diagnostic Radiology and Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, CT USA 06520"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rothman", 
        "givenName": "Douglas", 
        "id": "sg:person.0660132734.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660132734.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Psychiatry and Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, CT USA 06519"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Behar", 
        "givenName": "Kevin", 
        "id": "sg:person.01310264210.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310264210.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Department of Psychiatry and the Ribicoff Research Facilities, Yale University School of Medicine, New Haven, CT USA 06519"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sanacora", 
        "givenName": "Gerard", 
        "id": "sg:person.0707247715.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707247715.69"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.biopsych.2010.12.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002048173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/jpet.114.216804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002779412"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2007.05.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003459895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mp.2013.130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004116360", 
          "https://doi.org/10.1038/mp.2013.130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropharm.2014.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005260759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropharm.2014.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005260759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jcp.0b013e31818a6cea", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008545018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jcp.0b013e31818a6cea", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008545018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/s0893-133x(99)00127-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009571672", 
          "https://doi.org/10.1016/s0893-133x(99)00127-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009968516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009968516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008877-199711000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014365112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008877-199711000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014365112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fbp.0b013e328343d7b2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015003643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fbp.0b013e328343d7b2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015003643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2012.09.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015141973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2011.11.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018919358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/npp.2015.298", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019582767", 
          "https://doi.org/10.1038/npp.2015.298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-007-1047-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019625062", 
          "https://doi.org/10.1007/s00213-007-1047-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-007-1047-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019625062", 
          "https://doi.org/10.1007/s00213-007-1047-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/mp.2013.55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020864419", 
          "https://doi.org/10.1038/mp.2013.55"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(93)90926-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023785705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(93)90926-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023785705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024585916", 
          "https://doi.org/10.1038/nature10130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(01)01991-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025345562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.2213-07.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025852264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026623238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.jcbfm.9600490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026623238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1222939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033173254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1222939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033173254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jn.00875.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033800247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(99)02426-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034080514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbr.2011.05.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035000884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/nbm.1385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035424072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/nbm.1385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035424072"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biopsych.2013.04.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036657701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(97)01390-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037650846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-006-0344-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041693149", 
          "https://doi.org/10.1007/s00213-006-0344-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00213-006-0344-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041693149", 
          "https://doi.org/10.1007/s00213-006-0344-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/00000539-198202000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043007958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1190287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052468979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1190287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052468979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/ajp.154.6.805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063485095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.162.2.394", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063496448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1176/appi.ajp.2015.15040465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063500640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.17-08-02921.1997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083068273"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-01", 
    "datePublishedReg": "2017-01-01", 
    "description": "Several drugs have recently been reported to induce rapid antidepressant effects in clinical trials and rodent models. Although the cellular mechanisms involved remain unclear, reports suggest that increased glutamate transmission contributes to these effects. Here, we demonstrate that the antidepressant-like efficacy of three unique drugs, with reported rapid onset antidepressant properties, is coupled with a rapid transient rise in glutamate cycling in the medial prefronal cortex (mPFC) of awake rats as measured by ex vivo 1H-[13C]-nuclear magnetic resonance spectroscopy. Rats were acutely pretreated by intraperitoneal injection with a single dose of ketamine (1, 3, 10, 30 and 80\u2009mg\u2009kg-1), Ro 25-6981 (1, 3 and 10\u2009mg\u2009kg-1), scopolamine (5, 25 and 100\u2009\u03bcg\u2009kg-1) or vehicle (controls). At fixed times after drug injection, animals received an intravenous infusion of [1,6-13C2]glucose for 8\u2009min to enrich the amino-acid pools of the brain with 13C, followed by rapid euthanasia. The mPFC was dissected, extracted with ethanol and metabolite 13C enrichments were measured. We found a clear dose-dependent effect of ketamine and Ro 25-6981 on behavior and the percentage of 13C enrichment of glutamate, glutamine and GABA (\u03b3-aminobutyric acid). Further, we also found an effect of scopolamine on both cycling and behavior. These studies demonstrate that three pharmacologically distinct classes of drugs, clinically related through their reported rapid antidepressant actions, share the common ability to rapidly stimulate glutamate cycling at doses pertinent for their antidepressant-like efficacy. We conclude that increased cycling precedes the antidepressant action at behaviorally effective doses and suggest that the rapid change in cycling could be used to predict efficacy of novel agents or identify doses with antidepressant activity.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/mp.2016.34", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2439476", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2551578", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2552529", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3803218", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1115540", 
        "issn": [
          "1359-4184", 
          "1476-5578"
        ], 
        "name": "Molecular Psychiatry", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "name": "Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects", 
    "pagination": "120", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/mp.2016.34"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3ae28a9e3e6bcdface10245c2db299037414ed957ef8cd9ab2118b7b9a09716f"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012359509"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9607835"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27067013"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/mp.2016.34", 
      "https://app.dimensions.ai/details/publication/pub.1012359509"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56171_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/mp201634"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/mp.2016.34'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/mp.2016.34'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/mp.2016.34'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/mp.2016.34'


 

This table displays all metadata directly associated to this object as RDF triples.

331 TRIPLES      21 PREDICATES      78 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/mp.2016.34 schema:about N0286ca02a50d4b459273b7eaccb3cc75
2 N1db2472399ab4f2ebce454f28a2ab59b
3 N1f9ac938dfbf4d89a53216e00408ea82
4 N1fc94379d49941e991fb50a0cf5a4bd2
5 N46a9b032a3bd45a2add0ffebae0c516f
6 N639315278b3d45e5a6d21e65659357aa
7 N74e5c6d42f114c579ff5f3b98cd01f97
8 Nb3fefe68fde143d08e2e10484afd7d2d
9 Nb4c96f07884347c99a1a46d24acb0b54
10 Nc70f3bf062894bd0aff3f3baec64fdca
11 Nc7bb9b634c44421d8ffef6d14fed10c6
12 Ncd5a80ac5ce9441c9dd1a81ab6388a17
13 Ne1d5c1b88ac641669e70e4dce8407e62
14 Ne28f69e4e94d47ff927725da7c6e2ee0
15 Ne61cb2689dc3412ea4899a00cc5ea840
16 anzsrc-for:11
17 anzsrc-for:1115
18 schema:author N27797c8b47a74c6e8be3d9c9e8bfcc74
19 schema:citation sg:pub.10.1007/s00213-006-0344-0
20 sg:pub.10.1007/s00213-007-1047-x
21 sg:pub.10.1016/s0893-133x(99)00127-x
22 sg:pub.10.1038/mp.2013.130
23 sg:pub.10.1038/mp.2013.55
24 sg:pub.10.1038/nature10130
25 sg:pub.10.1038/npp.2015.298
26 https://doi.org/10.1002/nbm.1385
27 https://doi.org/10.1016/0014-2999(93)90926-9
28 https://doi.org/10.1016/j.bbr.2011.05.035
29 https://doi.org/10.1016/j.biopsych.2007.05.028
30 https://doi.org/10.1016/j.biopsych.2010.12.015
31 https://doi.org/10.1016/j.biopsych.2011.11.006
32 https://doi.org/10.1016/j.biopsych.2012.09.031
33 https://doi.org/10.1016/j.biopsych.2013.04.025
34 https://doi.org/10.1016/j.neuropharm.2014.07.008
35 https://doi.org/10.1016/s0006-8993(01)01991-6
36 https://doi.org/10.1016/s0006-8993(97)01390-5
37 https://doi.org/10.1016/s0006-8993(99)02426-9
38 https://doi.org/10.1038/sj.jcbfm.9600263
39 https://doi.org/10.1038/sj.jcbfm.9600490
40 https://doi.org/10.1097/00008877-199711000-00010
41 https://doi.org/10.1097/fbp.0b013e328343d7b2
42 https://doi.org/10.1097/jcp.0b013e31818a6cea
43 https://doi.org/10.1124/jpet.114.216804
44 https://doi.org/10.1126/science.1190287
45 https://doi.org/10.1126/science.1222939
46 https://doi.org/10.1152/jn.00875.2004
47 https://doi.org/10.1176/ajp.154.6.805
48 https://doi.org/10.1176/appi.ajp.162.2.394
49 https://doi.org/10.1176/appi.ajp.2015.15040465
50 https://doi.org/10.1213/00000539-198202000-00004
51 https://doi.org/10.1523/jneurosci.17-08-02921.1997
52 https://doi.org/10.1523/jneurosci.2213-07.2007
53 schema:datePublished 2017-01
54 schema:datePublishedReg 2017-01-01
55 schema:description Several drugs have recently been reported to induce rapid antidepressant effects in clinical trials and rodent models. Although the cellular mechanisms involved remain unclear, reports suggest that increased glutamate transmission contributes to these effects. Here, we demonstrate that the antidepressant-like efficacy of three unique drugs, with reported rapid onset antidepressant properties, is coupled with a rapid transient rise in glutamate cycling in the medial prefronal cortex (mPFC) of awake rats as measured by ex vivo <sup>1</sup>H-[<sup>13</sup>C]-nuclear magnetic resonance spectroscopy. Rats were acutely pretreated by intraperitoneal injection with a single dose of ketamine (1, 3, 10, 30 and 80 mg kg<sup>-1</sup>), Ro 25-6981 (1, 3 and 10 mg kg<sup>-1</sup>), scopolamine (5, 25 and 100 μg kg<sup>-1</sup>) or vehicle (controls). At fixed times after drug injection, animals received an intravenous infusion of [1,6-<sup>13</sup>C<sub>2</sub>]glucose for 8 min to enrich the amino-acid pools of the brain with <sup>13</sup>C, followed by rapid euthanasia. The mPFC was dissected, extracted with ethanol and metabolite <sup>13</sup>C enrichments were measured. We found a clear dose-dependent effect of ketamine and Ro 25-6981 on behavior and the percentage of <sup>13</sup>C enrichment of glutamate, glutamine and GABA (γ-aminobutyric acid). Further, we also found an effect of scopolamine on both cycling and behavior. These studies demonstrate that three pharmacologically distinct classes of drugs, clinically related through their reported rapid antidepressant actions, share the common ability to rapidly stimulate glutamate cycling at doses pertinent for their antidepressant-like efficacy. We conclude that increased cycling precedes the antidepressant action at behaviorally effective doses and suggest that the rapid change in cycling could be used to predict efficacy of novel agents or identify doses with antidepressant activity.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree true
59 schema:isPartOf N298a0b824a4a485392dce4ac4f5df144
60 N5d7c6e50ea2c471ab8a8bc0cb24c192b
61 sg:journal.1115540
62 schema:name Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects
63 schema:pagination 120
64 schema:productId N42fd202a117c40cf8ad0c75da546470c
65 N620ab483bb914dd9b7804bad136ce856
66 N8077146ad9804891af7933e4ca7c5423
67 Na7b8035b832740d99b3314521c0a3086
68 Nd8b474de3ceb48708c6ccbb23acb863f
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012359509
70 https://doi.org/10.1038/mp.2016.34
71 schema:sdDatePublished 2019-04-15T09:15
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N808c473cff1d4b82b78e211caf58291a
74 schema:url https://www.nature.com/articles/mp201634
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N0286ca02a50d4b459273b7eaccb3cc75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Glutamine
80 rdf:type schema:DefinedTerm
81 N0b24a5990ce54479a77f0abaebecdf79 rdf:first sg:person.01047011365.11
82 rdf:rest N4bf18ab6c2084df28c80b2b7ddbbc757
83 N1db2472399ab4f2ebce454f28a2ab59b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Rats
85 rdf:type schema:DefinedTerm
86 N1f3e2d7ed59e46ba93c82ecbaa0b91fe schema:affiliation https://www.grid.ac/institutes/grid.497530.c
87 schema:familyName Schaeffer
88 schema:givenName Eric
89 rdf:type schema:Person
90 N1f9ac938dfbf4d89a53216e00408ea82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Brain
92 rdf:type schema:DefinedTerm
93 N1fc94379d49941e991fb50a0cf5a4bd2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Male
95 rdf:type schema:DefinedTerm
96 N2584d67140a24840a58378e18f4fd4f9 rdf:first sg:person.0707247715.69
97 rdf:rest rdf:nil
98 N27797c8b47a74c6e8be3d9c9e8bfcc74 rdf:first sg:person.0705020477.35
99 rdf:rest N9f65b1d189d04cb08f91d2eac4a63211
100 N27fd5e74dfc644409c781d2a4c7cdc85 schema:affiliation https://www.grid.ac/institutes/grid.411679.c
101 schema:familyName Zhang
102 schema:givenName Jie
103 rdf:type schema:Person
104 N298a0b824a4a485392dce4ac4f5df144 schema:issueNumber 1
105 rdf:type schema:PublicationIssue
106 N2dca4f8c51794fa6aa778be80345e070 schema:affiliation N465a5a5ec0354bacad04c5f7b2dcc960
107 schema:familyName Bristow
108 schema:givenName Linda
109 rdf:type schema:Person
110 N42fd202a117c40cf8ad0c75da546470c schema:name doi
111 schema:value 10.1038/mp.2016.34
112 rdf:type schema:PropertyValue
113 N465a5a5ec0354bacad04c5f7b2dcc960 schema:name Bristol-Myers Squibb, 5 Research Parkway, Wallingford, CT 06492
114 rdf:type schema:Organization
115 N46a9b032a3bd45a2add0ffebae0c516f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Prefrontal Cortex
117 rdf:type schema:DefinedTerm
118 N4bf18ab6c2084df28c80b2b7ddbbc757 rdf:first sg:person.01171174407.44
119 rdf:rest N85bfa96154a5412f8863a37a42432641
120 N5d7c6e50ea2c471ab8a8bc0cb24c192b schema:volumeNumber 22
121 rdf:type schema:PublicationVolume
122 N620ab483bb914dd9b7804bad136ce856 schema:name pubmed_id
123 schema:value 27067013
124 rdf:type schema:PropertyValue
125 N639315278b3d45e5a6d21e65659357aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Rats, Sprague-Dawley
127 rdf:type schema:DefinedTerm
128 N74e5c6d42f114c579ff5f3b98cd01f97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Phenols
130 rdf:type schema:DefinedTerm
131 N8026a1b0f0a148dbb5ebc49befd9d04f rdf:first sg:person.01310264210.91
132 rdf:rest N2584d67140a24840a58378e18f4fd4f9
133 N8077146ad9804891af7933e4ca7c5423 schema:name dimensions_id
134 schema:value pub.1012359509
135 rdf:type schema:PropertyValue
136 N808c473cff1d4b82b78e211caf58291a schema:name Springer Nature - SN SciGraph project
137 rdf:type schema:Organization
138 N85bfa96154a5412f8863a37a42432641 rdf:first N2dca4f8c51794fa6aa778be80345e070
139 rdf:rest Nbce095ba135346208c773b5f6bf952cd
140 N9f65b1d189d04cb08f91d2eac4a63211 rdf:first N27fd5e74dfc644409c781d2a4c7cdc85
141 rdf:rest Nb646efbf17e141a4aa16c80004cd4757
142 Na7b8035b832740d99b3314521c0a3086 schema:name nlm_unique_id
143 schema:value 9607835
144 rdf:type schema:PropertyValue
145 Nb3fefe68fde143d08e2e10484afd7d2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Piperidines
147 rdf:type schema:DefinedTerm
148 Nb4c96f07884347c99a1a46d24acb0b54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Glutamic Acid
150 rdf:type schema:DefinedTerm
151 Nb646efbf17e141a4aa16c80004cd4757 rdf:first sg:person.01067362277.15
152 rdf:rest Nbfc528687edb4637b77a458a877d05b0
153 Nbce095ba135346208c773b5f6bf952cd rdf:first N1f3e2d7ed59e46ba93c82ecbaa0b91fe
154 rdf:rest Nf43bc893d5db46b1834717b7316f64c5
155 Nbfc528687edb4637b77a458a877d05b0 rdf:first sg:person.01122067247.58
156 rdf:rest N0b24a5990ce54479a77f0abaebecdf79
157 Nc70f3bf062894bd0aff3f3baec64fdca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Magnetic Resonance Spectroscopy
159 rdf:type schema:DefinedTerm
160 Nc7bb9b634c44421d8ffef6d14fed10c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Antidepressive Agents
162 rdf:type schema:DefinedTerm
163 Ncd5a80ac5ce9441c9dd1a81ab6388a17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Scopolamine
165 rdf:type schema:DefinedTerm
166 Nd04512a6f54f4c00b60b528746a60bed rdf:first sg:person.0660132734.54
167 rdf:rest N8026a1b0f0a148dbb5ebc49befd9d04f
168 Nd8b474de3ceb48708c6ccbb23acb863f schema:name readcube_id
169 schema:value 3ae28a9e3e6bcdface10245c2db299037414ed957ef8cd9ab2118b7b9a09716f
170 rdf:type schema:PropertyValue
171 Ne1d5c1b88ac641669e70e4dce8407e62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name gamma-Aminobutyric Acid
173 rdf:type schema:DefinedTerm
174 Ne28f69e4e94d47ff927725da7c6e2ee0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Animals
176 rdf:type schema:DefinedTerm
177 Ne61cb2689dc3412ea4899a00cc5ea840 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Ketamine
179 rdf:type schema:DefinedTerm
180 Nf43bc893d5db46b1834717b7316f64c5 rdf:first sg:person.014054607677.68
181 rdf:rest Nd04512a6f54f4c00b60b528746a60bed
182 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
183 schema:name Medical and Health Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
186 schema:name Pharmacology and Pharmaceutical Sciences
187 rdf:type schema:DefinedTerm
188 sg:grant.2439476 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2016.34
189 rdf:type schema:MonetaryGrant
190 sg:grant.2551578 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2016.34
191 rdf:type schema:MonetaryGrant
192 sg:grant.2552529 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2016.34
193 rdf:type schema:MonetaryGrant
194 sg:grant.3803218 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2016.34
195 rdf:type schema:MonetaryGrant
196 sg:journal.1115540 schema:issn 1359-4184
197 1476-5578
198 schema:name Molecular Psychiatry
199 rdf:type schema:Periodical
200 sg:person.01047011365.11 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
201 schema:familyName Ma
202 schema:givenName Xiaoxian
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047011365.11
204 rdf:type schema:Person
205 sg:person.01067362277.15 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
206 schema:familyName Thomas
207 schema:givenName Monique
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067362277.15
209 rdf:type schema:Person
210 sg:person.01122067247.58 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
211 schema:familyName Banasr
212 schema:givenName Mounira
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122067247.58
214 rdf:type schema:Person
215 sg:person.01171174407.44 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
216 schema:familyName Pittman
217 schema:givenName Brian
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171174407.44
219 rdf:type schema:Person
220 sg:person.01310264210.91 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
221 schema:familyName Behar
222 schema:givenName Kevin
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310264210.91
224 rdf:type schema:Person
225 sg:person.014054607677.68 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
226 schema:familyName Duman
227 schema:givenName Ronald
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014054607677.68
229 rdf:type schema:Person
230 sg:person.0660132734.54 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
231 schema:familyName Rothman
232 schema:givenName Douglas
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660132734.54
234 rdf:type schema:Person
235 sg:person.0705020477.35 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
236 schema:familyName Chowdhury
237 schema:givenName Golam M. I.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705020477.35
239 rdf:type schema:Person
240 sg:person.0707247715.69 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
241 schema:familyName Sanacora
242 schema:givenName Gerard
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707247715.69
244 rdf:type schema:Person
245 sg:pub.10.1007/s00213-006-0344-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041693149
246 https://doi.org/10.1007/s00213-006-0344-0
247 rdf:type schema:CreativeWork
248 sg:pub.10.1007/s00213-007-1047-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019625062
249 https://doi.org/10.1007/s00213-007-1047-x
250 rdf:type schema:CreativeWork
251 sg:pub.10.1016/s0893-133x(99)00127-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009571672
252 https://doi.org/10.1016/s0893-133x(99)00127-x
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/mp.2013.130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004116360
255 https://doi.org/10.1038/mp.2013.130
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/mp.2013.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020864419
258 https://doi.org/10.1038/mp.2013.55
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/nature10130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024585916
261 https://doi.org/10.1038/nature10130
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/npp.2015.298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019582767
264 https://doi.org/10.1038/npp.2015.298
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1002/nbm.1385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035424072
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/0014-2999(93)90926-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023785705
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.bbr.2011.05.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035000884
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/j.biopsych.2007.05.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003459895
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.biopsych.2010.12.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002048173
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.biopsych.2011.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018919358
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.biopsych.2012.09.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015141973
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/j.biopsych.2013.04.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036657701
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.neuropharm.2014.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005260759
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s0006-8993(01)01991-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025345562
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/s0006-8993(97)01390-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037650846
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/s0006-8993(99)02426-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034080514
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1038/sj.jcbfm.9600263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009968516
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1038/sj.jcbfm.9600490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026623238
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1097/00008877-199711000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014365112
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1097/fbp.0b013e328343d7b2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015003643
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1097/jcp.0b013e31818a6cea schema:sameAs https://app.dimensions.ai/details/publication/pub.1008545018
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1124/jpet.114.216804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002779412
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1126/science.1190287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052468979
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1126/science.1222939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033173254
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1152/jn.00875.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033800247
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1176/ajp.154.6.805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063485095
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1176/appi.ajp.162.2.394 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063496448
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1176/appi.ajp.2015.15040465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063500640
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1213/00000539-198202000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043007958
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1523/jneurosci.17-08-02921.1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083068273
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1523/jneurosci.2213-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025852264
319 rdf:type schema:CreativeWork
320 https://www.grid.ac/institutes/grid.411679.c schema:alternateName Shantou University Medical College
321 schema:name Department of Psychiatry and the Ribicoff Research Facilities, Yale University School of Medicine, New Haven, CT USA 06519
322 Mental Health Centre, Shantou University Medical College, Shantou, Guangdong P. R. China 515065
323 rdf:type schema:Organization
324 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
325 schema:name Department of Psychiatry and Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, CT USA 06519
326 Department of Psychiatry and the Ribicoff Research Facilities, Yale University School of Medicine, New Haven, CT USA 06519
327 Diagnostic Radiology and Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, CT USA 06520
328 rdf:type schema:Organization
329 https://www.grid.ac/institutes/grid.497530.c schema:alternateName Janssen (United States)
330 schema:name Janssen Research & Development, 1125 Trenton-Harbourton Road, Titusville, NJ 08569
331 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...