Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-07

AUTHORS

M A Labouesse, O Lassalle, J Richetto, J Iafrati, U Weber-Stadlbauer, T Notter, T Gschwind, L Pujadas, E Soriano, A C Reichelt, C Labouesse, W Langhans, P Chavis, U Meyer

ABSTRACT

Overconsumption of high-fat diets (HFDs) can critically affect synaptic and cognitive functions within telencephalic structures such as the medial prefrontal cortex (mPFC). The underlying mechanisms, however, remain largely unknown. Here we show that adolescence is a sensitive period for the emergence of prefrontal cognitive deficits in response to HFD. We establish that the synaptic modulator reelin (RELN) is a critical mediator of this vulnerability because (1) periadolescent HFD (pHFD) selectively downregulates prefrontal RELN+ cells and (2) augmenting mPFC RELN levels using transgenesis or prefrontal pharmacology prevents the pHFD-induced prefrontal cognitive deficits. We further identify N-methyl-d-aspartate-dependent long-term depression (NMDA-LTD) at prefrontal excitatory synapses as a synaptic signature of this association because pHFD abolishes NMDA-LTD, a function that is restored by RELN overexpression. We believe this study provides the first mechanistic insight into the vulnerability of the adolescent mPFC towards nutritional stress, such as HFDs. Our findings have primary relevance to obese individuals who are at an increased risk of developing neurological cognitive comorbidities, and may extend to multiple neuropsychiatric and neurological disorders in which RELN deficiency is a common feature. More... »

PAGES

961-971

References to SciGraph publications

  • 2014-12. Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer’s disease in NATURE COMMUNICATIONS
  • 2006-11. Reelin, lipoprotein receptors and synaptic plasticity in NATURE REVIEWS NEUROSCIENCE
  • 2014-04. Reelin, an extracellular matrix protein linked to early onset psychiatric diseases, drives postnatal development of the prefrontal cortex via GluN2B-NMDARs and the mTOR pathway in MOLECULAR PSYCHIATRY
  • 2011-11. Reelin, a Marker of Stress Resilience in Depression and Psychosis in NEUROPSYCHOPHARMACOLOGY
  • 1998-11. The sugar–fat relationship revisited: differences in consumption between men and women of varying BMI in INTERNATIONAL JOURNAL OF OBESITY
  • 2005-11. Critical period plasticity in local cortical circuits in NATURE REVIEWS NEUROSCIENCE
  • 2011-11. Overexpression of Reelin Prevents the Manifestation of Behavioral Phenotypes Related to Schizophrenia and Bipolar Disorder in NEUROPSYCHOPHARMACOLOGY
  • 2006-10. Is There Such Thing as a Schizophrenic Stomach? in NEUROPSYCHOPHARMACOLOGY
  • 2010-07. Long-term depression in the CNS in NATURE REVIEWS NEUROSCIENCE
  • 2013-01. The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders in NEUROPSYCHOPHARMACOLOGY
  • 2005-04. Cortical inhibitory neurons and schizophrenia in NATURE REVIEWS NEUROSCIENCE
  • 2013-06. The contextual brain: implications for fear conditioning, extinction and psychopathology in NATURE REVIEWS NEUROSCIENCE
  • 2011-06. Calcyon upregulation in adolescence impairs response inhibition and working memory in adulthood in MOLECULAR PSYCHIATRY
  • 2016-12. Multivariate synaptic and behavioral profiling reveals new developmental endophenotypes in the prefrontal cortex in SCIENTIFIC REPORTS
  • 2010-11. Preliminary evidence for brain complications in obese adolescents with type 2 diabetes mellitus in DIABETOLOGIA
  • 2006-11. Assessment of cognitive function in the heterozygous reeler mouse in PSYCHOPHARMACOLOGY
  • 2006-10. Food Intake and Reward Mechanisms in Patients with Schizophrenia: Implications for Metabolic Disturbances and Treatment with Second-Generation Antipsychotic Agents in NEUROPSYCHOPHARMACOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/mp.2016.193

    DOI

    http://dx.doi.org/10.1038/mp.2016.193

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035718436

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27843148


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Adhesion Molecules, Neuronal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diet, High-Fat", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Extracellular Matrix Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Malnutrition", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Inbred C57BL", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Transgenic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nerve Tissue Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neuronal Plasticity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prefrontal Cortex", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, N-Methyl-D-Aspartate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Serine Endopeptidases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Synapses", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Zurich", 
              "id": "https://www.grid.ac/institutes/grid.7400.3", 
              "name": [
                "Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.", 
                "Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Labouesse", 
            "givenName": "M A", 
            "id": "sg:person.01372072276.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372072276.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Aix-Marseille University", 
              "id": "https://www.grid.ac/institutes/grid.5399.6", 
              "name": [
                "INSERM, INMED UMR S 901, Aix-Marseille Universit\u00e9, Marseille, France."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lassalle", 
            "givenName": "O", 
            "id": "sg:person.0652617062.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652617062.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Zurich", 
              "id": "https://www.grid.ac/institutes/grid.7400.3", 
              "name": [
                "Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Richetto", 
            "givenName": "J", 
            "id": "sg:person.01221427306.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221427306.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Aix-Marseille University", 
              "id": "https://www.grid.ac/institutes/grid.5399.6", 
              "name": [
                "INSERM, INMED UMR S 901, Aix-Marseille Universit\u00e9, Marseille, France."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iafrati", 
            "givenName": "J", 
            "id": "sg:person.01226521400.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226521400.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Zurich", 
              "id": "https://www.grid.ac/institutes/grid.7400.3", 
              "name": [
                "Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.", 
                "Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weber-Stadlbauer", 
            "givenName": "U", 
            "id": "sg:person.01104642407.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104642407.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Zurich", 
              "id": "https://www.grid.ac/institutes/grid.7400.3", 
              "name": [
                "Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Notter", 
            "givenName": "T", 
            "id": "sg:person.01135105710.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135105710.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Zurich", 
              "id": "https://www.grid.ac/institutes/grid.7400.3", 
              "name": [
                "Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gschwind", 
            "givenName": "T", 
            "id": "sg:person.014010270771.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014010270771.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Vall d'Hebron Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.430994.3", 
              "name": [
                "Department of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona, Spain.", 
                "Centro de Investigaci\u00f3n en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.", 
                "Vall [Dacute ]Hebron Institut de Recerca (VHIR), Barcelona, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pujadas", 
            "givenName": "L", 
            "id": "sg:person.0716646337.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716646337.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats", 
              "id": "https://www.grid.ac/institutes/grid.425902.8", 
              "name": [
                "Department of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona, Spain.", 
                "Centro de Investigaci\u00f3n en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.", 
                "Vall [Dacute ]Hebron Institut de Recerca (VHIR), Barcelona, Spain.", 
                "Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats (ICREA Academia), Barcelona, Spain."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Soriano", 
            "givenName": "E", 
            "id": "sg:person.0645134356.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645134356.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "RMIT University", 
              "id": "https://www.grid.ac/institutes/grid.1017.7", 
              "name": [
                "School of Health and Biomedical Sciences, RMIT, Melbourne, VIC, Australia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Reichelt", 
            "givenName": "A C", 
            "id": "sg:person.01352637112.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352637112.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Wellcome / MRC Cambridge Stem Cell Institute", 
              "id": "https://www.grid.ac/institutes/grid.449973.4", 
              "name": [
                "Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.", 
                "Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Labouesse", 
            "givenName": "C", 
            "id": "sg:person.01310452433.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310452433.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Swiss Federal Institute of Technology in Zurich", 
              "id": "https://www.grid.ac/institutes/grid.5801.c", 
              "name": [
                "Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Langhans", 
            "givenName": "W", 
            "id": "sg:person.01174423374.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174423374.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Aix-Marseille University", 
              "id": "https://www.grid.ac/institutes/grid.5399.6", 
              "name": [
                "INSERM, INMED UMR S 901, Aix-Marseille Universit\u00e9, Marseille, France."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chavis", 
            "givenName": "P", 
            "id": "sg:person.0604271443.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604271443.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Zurich", 
              "id": "https://www.grid.ac/institutes/grid.7400.3", 
              "name": [
                "Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.", 
                "Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland.", 
                "Neuroscience Center Zurich (ZNZ), University of Zurich, Zurich, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Meyer", 
            "givenName": "U", 
            "id": "sg:person.01132120712.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132120712.04"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nrn1648", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000060878", 
              "https://doi.org/10.1038/nrn1648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn1648", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000060878", 
              "https://doi.org/10.1038/nrn1648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2011.14", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001673726", 
              "https://doi.org/10.1038/mp.2011.14"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/lm.038000.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004451710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2012.125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004667753", 
              "https://doi.org/10.1038/npp.2012.125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbi.2014.07.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005086844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.93.24.13473", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006661204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.psyneuen.2013.06.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006842484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep35504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007258616", 
              "https://doi.org/10.1038/srep35504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(14)60460-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007350540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2011.169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007946103", 
              "https://doi.org/10.1038/npp.2011.169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbi.2007.09.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008208329"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1772-07.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008384877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0402680101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008422748"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.57.1.65", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008952361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.112.252759", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010754345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.112.252759", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010754345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.112.252759", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010754345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2016.03.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010797599"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1037/0735-7044.120.4.984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011203772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2015.09.051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012658725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.psychres.2013.06.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012963959"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/dev.070151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014020757"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3945/ajcn.110.002758", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015397292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms4443", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016339312", 
              "https://doi.org/10.1038/ncomms4443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0800724", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017231570", 
              "https://doi.org/10.1038/sj.ijo.0800724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ijo.0800724", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017231570", 
              "https://doi.org/10.1038/sj.ijo.0800724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3945/jn.114.190447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020235966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.npp.1301051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021460190", 
              "https://doi.org/10.1038/sj.npp.1301051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.npp.1301051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021460190", 
              "https://doi.org/10.1038/sj.npp.1301051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2561-06.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023362810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1121251109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023544798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024822164", 
              "https://doi.org/10.1038/nrn2009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024822164", 
              "https://doi.org/10.1038/nrn2009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1476-5381.2011.01245.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026545796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2005.07.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027736275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2005.07.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027736275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0029665113003376", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028233539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn1787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029042036", 
              "https://doi.org/10.1038/nrn1787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn1787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029042036", 
              "https://doi.org/10.1038/nrn1787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2013.06.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030217610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/gbb.12191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031053055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031073156", 
              "https://doi.org/10.1038/nrn2867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031073156", 
              "https://doi.org/10.1038/nrn2867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbr.2014.04.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031083387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2013.04.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032066983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0149-7634(03)00005-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032711243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0149-7634(03)00005-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032711243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nlm.2005.11.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032742202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1951-05.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032854749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2011.153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033801597", 
              "https://doi.org/10.1038/npp.2011.153"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1511593112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034381350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/jcpp.12209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034421218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1542/peds.2005-2374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035796776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2014.03.038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035907005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.5284-09.2010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037299405"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biopsych.2013.02.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037387381"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nicl.2016.07.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037984385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s1461145714000121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038017430"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jand.2015.09.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038641969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jama.2015.5941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038851054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/oby.2011.15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039265975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/lm.2153511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039406042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.npp.1301141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040522188", 
              "https://doi.org/10.1038/sj.npp.1301141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.npp.1301141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040522188", 
              "https://doi.org/10.1038/sj.npp.1301141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biopsych.2012.09.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040786891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.10-171983", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041823291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hipo.22032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041831350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1934-15.2016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042013491"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nbd.2011.07.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043052015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2013.66", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043264819", 
              "https://doi.org/10.1038/mp.2013.66"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-010-1857-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043878313", 
              "https://doi.org/10.1007/s00125-010-1857-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00125-010-1857-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043878313", 
              "https://doi.org/10.1007/s00125-010-1857-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbr.2007.05.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045303889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/jn.91039.2008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048962840"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fendo.2014.00074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049401775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0005505", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050387861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.appet.2012.12.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050903522"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn3492", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051238593", 
              "https://doi.org/10.1038/nrn3492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2015.04.045", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052008591"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0149-7634(00)00014-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053135618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0269881112463468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053139755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0269881112463468", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053139755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropharm.2012.04.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053447192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00213-006-0530-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053625223", 
              "https://doi.org/10.1007/s00213-006-0530-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00213-006-0530-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053625223", 
              "https://doi.org/10.1007/s00213-006-0530-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.aaa6674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062685493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1403494813487449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064002236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1403494813487449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064002236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcn/70.3.560s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074518209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.18-19-07779.1998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083318032"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-07", 
        "datePublishedReg": "2017-07-01", 
        "description": "Overconsumption of high-fat diets (HFDs) can critically affect synaptic and cognitive functions within telencephalic structures such as the medial prefrontal cortex (mPFC). The underlying mechanisms, however, remain largely unknown. Here we show that adolescence is a sensitive period for the emergence of prefrontal cognitive deficits in response to HFD. We establish that the synaptic modulator reelin (RELN) is a critical mediator of this vulnerability because (1) periadolescent HFD (pHFD) selectively downregulates prefrontal RELN+ cells and (2) augmenting mPFC RELN levels using transgenesis or prefrontal pharmacology prevents the pHFD-induced prefrontal cognitive deficits. We further identify N-methyl-d-aspartate-dependent long-term depression (NMDA-LTD) at prefrontal excitatory synapses as a synaptic signature of this association because pHFD abolishes NMDA-LTD, a function that is restored by RELN overexpression. We believe this study provides the first mechanistic insight into the vulnerability of the adolescent mPFC towards nutritional stress, such as HFDs. Our findings have primary relevance to obese individuals who are at an increased risk of developing neurological cognitive comorbidities, and may extend to multiple neuropsychiatric and neurological disorders in which RELN deficiency is a common feature.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/mp.2016.193", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3782097", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3931722", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1115540", 
            "issn": [
              "1359-4184", 
              "1476-5578"
            ], 
            "name": "Molecular Psychiatry", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "22"
          }
        ], 
        "name": "Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency", 
        "pagination": "961-971", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "aa262eb98ef7bd726df4947380740c05fd9c0ecfcc5b2840a325db8ef478fd58"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "27843148"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9607835"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/mp.2016.193"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1035718436"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/mp.2016.193", 
          "https://app.dimensions.ai/details/publication/pub.1035718436"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:57", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000441.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/mp/journal/v22/n7/full/mp2016193a.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/mp.2016.193'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/mp.2016.193'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/mp.2016.193'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/mp.2016.193'


     

    This table displays all metadata directly associated to this object as RDF triples.

    496 TRIPLES      21 PREDICATES      120 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/mp.2016.193 schema:about N11fdfdd690654f43bf5b1c31322cb1f5
    2 N15a318876f784cbe99e07c861d2db1f3
    3 N170a3780ac1a4eba9240ab1afa2c0475
    4 N1bc4da1a83a348b99461f424bcb649e1
    5 N3639b5fb842548049940b84c822a3850
    6 N37704cef2dc349e6a2d689214763998f
    7 N49de993a69504d1ab97262b4cdeaa0b1
    8 N5809c86c5a044d0bb81d34656d809d54
    9 N6a36f37881344eddbe6cd12385c293d9
    10 N6d45fab7a674404daf7783c328452808
    11 N8218327dafbb4a5c84fb74d871fb9c2b
    12 N9fd9733facb7496abad93820943fcf0b
    13 Nabb7ad60bb7c40de9f8122030d1780a6
    14 Nc8f945d307df4ce7832b446f5eae95b9
    15 Ne56117d5d707469c95c6adef207a82df
    16 anzsrc-for:11
    17 anzsrc-for:1109
    18 schema:author Nd3262c7ae8284b65a5c3bdaeda37248e
    19 schema:citation sg:pub.10.1007/s00125-010-1857-y
    20 sg:pub.10.1007/s00213-006-0530-0
    21 sg:pub.10.1038/mp.2011.14
    22 sg:pub.10.1038/mp.2013.66
    23 sg:pub.10.1038/ncomms4443
    24 sg:pub.10.1038/npp.2011.153
    25 sg:pub.10.1038/npp.2011.169
    26 sg:pub.10.1038/npp.2012.125
    27 sg:pub.10.1038/nrn1648
    28 sg:pub.10.1038/nrn1787
    29 sg:pub.10.1038/nrn2009
    30 sg:pub.10.1038/nrn2867
    31 sg:pub.10.1038/nrn3492
    32 sg:pub.10.1038/sj.ijo.0800724
    33 sg:pub.10.1038/sj.npp.1301051
    34 sg:pub.10.1038/sj.npp.1301141
    35 sg:pub.10.1038/srep35504
    36 https://doi.org/10.1001/archpsyc.57.1.65
    37 https://doi.org/10.1001/jama.2015.5941
    38 https://doi.org/10.1002/hipo.22032
    39 https://doi.org/10.1016/j.appet.2012.12.018
    40 https://doi.org/10.1016/j.bbi.2007.09.012
    41 https://doi.org/10.1016/j.bbi.2014.07.005
    42 https://doi.org/10.1016/j.bbr.2007.05.004
    43 https://doi.org/10.1016/j.bbr.2014.04.016
    44 https://doi.org/10.1016/j.biopsych.2012.09.020
    45 https://doi.org/10.1016/j.biopsych.2013.02.021
    46 https://doi.org/10.1016/j.cell.2016.03.033
    47 https://doi.org/10.1016/j.jand.2015.09.020
    48 https://doi.org/10.1016/j.nbd.2011.07.008
    49 https://doi.org/10.1016/j.neurobiolaging.2014.03.038
    50 https://doi.org/10.1016/j.neuron.2005.07.007
    51 https://doi.org/10.1016/j.neuron.2013.06.028
    52 https://doi.org/10.1016/j.neuropharm.2012.04.013
    53 https://doi.org/10.1016/j.neuroscience.2013.04.042
    54 https://doi.org/10.1016/j.neuroscience.2015.04.045
    55 https://doi.org/10.1016/j.neuroscience.2015.09.051
    56 https://doi.org/10.1016/j.nicl.2016.07.005
    57 https://doi.org/10.1016/j.nlm.2005.11.001
    58 https://doi.org/10.1016/j.psychres.2013.06.020
    59 https://doi.org/10.1016/j.psyneuen.2013.06.003
    60 https://doi.org/10.1016/s0140-6736(14)60460-8
    61 https://doi.org/10.1016/s0149-7634(00)00014-2
    62 https://doi.org/10.1016/s0149-7634(03)00005-8
    63 https://doi.org/10.1017/s0029665113003376
    64 https://doi.org/10.1017/s1461145714000121
    65 https://doi.org/10.1037/0735-7044.120.4.984
    66 https://doi.org/10.1038/oby.2011.15
    67 https://doi.org/10.1073/pnas.0402680101
    68 https://doi.org/10.1073/pnas.1121251109
    69 https://doi.org/10.1073/pnas.1511593112
    70 https://doi.org/10.1073/pnas.93.24.13473
    71 https://doi.org/10.1093/ajcn/70.3.560s
    72 https://doi.org/10.1096/fj.10-171983
    73 https://doi.org/10.1101/lm.038000.114
    74 https://doi.org/10.1101/lm.2153511
    75 https://doi.org/10.1111/gbb.12191
    76 https://doi.org/10.1111/j.1476-5381.2011.01245.x
    77 https://doi.org/10.1111/jcpp.12209
    78 https://doi.org/10.1126/scisignal.aaa6674
    79 https://doi.org/10.1152/jn.91039.2008
    80 https://doi.org/10.1161/atvbaha.112.252759
    81 https://doi.org/10.1177/0269881112463468
    82 https://doi.org/10.1177/1403494813487449
    83 https://doi.org/10.1242/dev.070151
    84 https://doi.org/10.1371/journal.pone.0005505
    85 https://doi.org/10.1523/jneurosci.1772-07.2007
    86 https://doi.org/10.1523/jneurosci.18-19-07779.1998
    87 https://doi.org/10.1523/jneurosci.1934-15.2016
    88 https://doi.org/10.1523/jneurosci.1951-05.2005
    89 https://doi.org/10.1523/jneurosci.2561-06.2006
    90 https://doi.org/10.1523/jneurosci.5284-09.2010
    91 https://doi.org/10.1542/peds.2005-2374
    92 https://doi.org/10.3389/fendo.2014.00074
    93 https://doi.org/10.3945/ajcn.110.002758
    94 https://doi.org/10.3945/jn.114.190447
    95 schema:datePublished 2017-07
    96 schema:datePublishedReg 2017-07-01
    97 schema:description Overconsumption of high-fat diets (HFDs) can critically affect synaptic and cognitive functions within telencephalic structures such as the medial prefrontal cortex (mPFC). The underlying mechanisms, however, remain largely unknown. Here we show that adolescence is a sensitive period for the emergence of prefrontal cognitive deficits in response to HFD. We establish that the synaptic modulator reelin (RELN) is a critical mediator of this vulnerability because (1) periadolescent HFD (pHFD) selectively downregulates prefrontal RELN<sup>+</sup> cells and (2) augmenting mPFC RELN levels using transgenesis or prefrontal pharmacology prevents the pHFD-induced prefrontal cognitive deficits. We further identify N-methyl-d-aspartate-dependent long-term depression (NMDA-LTD) at prefrontal excitatory synapses as a synaptic signature of this association because pHFD abolishes NMDA-LTD, a function that is restored by RELN overexpression. We believe this study provides the first mechanistic insight into the vulnerability of the adolescent mPFC towards nutritional stress, such as HFDs. Our findings have primary relevance to obese individuals who are at an increased risk of developing neurological cognitive comorbidities, and may extend to multiple neuropsychiatric and neurological disorders in which RELN deficiency is a common feature.
    98 schema:genre research_article
    99 schema:inLanguage en
    100 schema:isAccessibleForFree false
    101 schema:isPartOf N590e968b5c5842dbbd880ed175c9bda8
    102 Na2a6b8a3b8c845e3ba89049ad03f3fe8
    103 sg:journal.1115540
    104 schema:name Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency
    105 schema:pagination 961-971
    106 schema:productId N85b8cfaadf5d41eabacbfc12306e4a89
    107 N96ab35ee21f54c93b89a22b9b00c6571
    108 Nbcd1ad869e0643ee851fe4a5c33d6a48
    109 Ncd7fb8e0961d4b21b50a173e79a7d22e
    110 Nd552e1d3f09b4f11a8206cb31313eb6f
    111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035718436
    112 https://doi.org/10.1038/mp.2016.193
    113 schema:sdDatePublished 2019-04-10T13:57
    114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    115 schema:sdPublisher N79db17b1cd7d489fb4f4e9decd6a1aef
    116 schema:url http://www.nature.com/mp/journal/v22/n7/full/mp2016193a.html
    117 sgo:license sg:explorer/license/
    118 sgo:sdDataset articles
    119 rdf:type schema:ScholarlyArticle
    120 N076db6ace6f1416c838a30af4c696a60 rdf:first sg:person.014010270771.91
    121 rdf:rest N62795eff8ddc4b0289d260bcf6dbd61b
    122 N0a58c259dc254abba76c280b8af92ffd rdf:first sg:person.01174423374.00
    123 rdf:rest N10576fcf303c4182b72624a6f557ec01
    124 N10576fcf303c4182b72624a6f557ec01 rdf:first sg:person.0604271443.26
    125 rdf:rest N69b74a39973e41d4bedab40c333f1da3
    126 N11fdfdd690654f43bf5b1c31322cb1f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Receptors, N-Methyl-D-Aspartate
    128 rdf:type schema:DefinedTerm
    129 N15a318876f784cbe99e07c861d2db1f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Nerve Tissue Proteins
    131 rdf:type schema:DefinedTerm
    132 N170a3780ac1a4eba9240ab1afa2c0475 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Mice, Transgenic
    134 rdf:type schema:DefinedTerm
    135 N1bc4da1a83a348b99461f424bcb649e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Extracellular Matrix Proteins
    137 rdf:type schema:DefinedTerm
    138 N235534c0f5ee4624bacef94c23eb060c rdf:first sg:person.01135105710.51
    139 rdf:rest N076db6ace6f1416c838a30af4c696a60
    140 N3639b5fb842548049940b84c822a3850 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Prefrontal Cortex
    142 rdf:type schema:DefinedTerm
    143 N37704cef2dc349e6a2d689214763998f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Serine Endopeptidases
    145 rdf:type schema:DefinedTerm
    146 N46deac1863f043f58c97020b3c480390 rdf:first sg:person.01221427306.18
    147 rdf:rest Nf790116acb7847dd9ae584dade39870f
    148 N49de993a69504d1ab97262b4cdeaa0b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Animals
    150 rdf:type schema:DefinedTerm
    151 N5809c86c5a044d0bb81d34656d809d54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Diet, High-Fat
    153 rdf:type schema:DefinedTerm
    154 N590e968b5c5842dbbd880ed175c9bda8 schema:issueNumber 7
    155 rdf:type schema:PublicationIssue
    156 N5dcf41a0b975442899a8012efb192e64 rdf:first sg:person.0645134356.50
    157 rdf:rest N75c0ff73a1544787a2117fb75a0a7d7c
    158 N62795eff8ddc4b0289d260bcf6dbd61b rdf:first sg:person.0716646337.49
    159 rdf:rest N5dcf41a0b975442899a8012efb192e64
    160 N69b74a39973e41d4bedab40c333f1da3 rdf:first sg:person.01132120712.04
    161 rdf:rest rdf:nil
    162 N6a36f37881344eddbe6cd12385c293d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Synapses
    164 rdf:type schema:DefinedTerm
    165 N6d45fab7a674404daf7783c328452808 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Male
    167 rdf:type schema:DefinedTerm
    168 N75c0ff73a1544787a2117fb75a0a7d7c rdf:first sg:person.01352637112.45
    169 rdf:rest Ndf9ff1897b7b41eabb87d19f15a57d3a
    170 N79db17b1cd7d489fb4f4e9decd6a1aef schema:name Springer Nature - SN SciGraph project
    171 rdf:type schema:Organization
    172 N8218327dafbb4a5c84fb74d871fb9c2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Cell Adhesion Molecules, Neuronal
    174 rdf:type schema:DefinedTerm
    175 N85b8cfaadf5d41eabacbfc12306e4a89 schema:name doi
    176 schema:value 10.1038/mp.2016.193
    177 rdf:type schema:PropertyValue
    178 N96ab35ee21f54c93b89a22b9b00c6571 schema:name dimensions_id
    179 schema:value pub.1035718436
    180 rdf:type schema:PropertyValue
    181 N9fd9733facb7496abad93820943fcf0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Malnutrition
    183 rdf:type schema:DefinedTerm
    184 Na2a6b8a3b8c845e3ba89049ad03f3fe8 schema:volumeNumber 22
    185 rdf:type schema:PublicationVolume
    186 Nabb7ad60bb7c40de9f8122030d1780a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Neuronal Plasticity
    188 rdf:type schema:DefinedTerm
    189 Naee2eb012dbc4686a79655d497f43547 rdf:first sg:person.0652617062.05
    190 rdf:rest N46deac1863f043f58c97020b3c480390
    191 Nbb689f485ac44632b7ab1f8b8ea38c39 rdf:first sg:person.01104642407.01
    192 rdf:rest N235534c0f5ee4624bacef94c23eb060c
    193 Nbcd1ad869e0643ee851fe4a5c33d6a48 schema:name readcube_id
    194 schema:value aa262eb98ef7bd726df4947380740c05fd9c0ecfcc5b2840a325db8ef478fd58
    195 rdf:type schema:PropertyValue
    196 Nc8f945d307df4ce7832b446f5eae95b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Mice, Inbred C57BL
    198 rdf:type schema:DefinedTerm
    199 Ncd7fb8e0961d4b21b50a173e79a7d22e schema:name nlm_unique_id
    200 schema:value 9607835
    201 rdf:type schema:PropertyValue
    202 Nd3262c7ae8284b65a5c3bdaeda37248e rdf:first sg:person.01372072276.55
    203 rdf:rest Naee2eb012dbc4686a79655d497f43547
    204 Nd552e1d3f09b4f11a8206cb31313eb6f schema:name pubmed_id
    205 schema:value 27843148
    206 rdf:type schema:PropertyValue
    207 Ndf9ff1897b7b41eabb87d19f15a57d3a rdf:first sg:person.01310452433.26
    208 rdf:rest N0a58c259dc254abba76c280b8af92ffd
    209 Ne56117d5d707469c95c6adef207a82df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Mice
    211 rdf:type schema:DefinedTerm
    212 Nf790116acb7847dd9ae584dade39870f rdf:first sg:person.01226521400.53
    213 rdf:rest Nbb689f485ac44632b7ab1f8b8ea38c39
    214 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    215 schema:name Medical and Health Sciences
    216 rdf:type schema:DefinedTerm
    217 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    218 schema:name Neurosciences
    219 rdf:type schema:DefinedTerm
    220 sg:grant.3782097 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2016.193
    221 rdf:type schema:MonetaryGrant
    222 sg:grant.3931722 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2016.193
    223 rdf:type schema:MonetaryGrant
    224 sg:journal.1115540 schema:issn 1359-4184
    225 1476-5578
    226 schema:name Molecular Psychiatry
    227 rdf:type schema:Periodical
    228 sg:person.01104642407.01 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
    229 schema:familyName Weber-Stadlbauer
    230 schema:givenName U
    231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104642407.01
    232 rdf:type schema:Person
    233 sg:person.01132120712.04 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
    234 schema:familyName Meyer
    235 schema:givenName U
    236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132120712.04
    237 rdf:type schema:Person
    238 sg:person.01135105710.51 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
    239 schema:familyName Notter
    240 schema:givenName T
    241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135105710.51
    242 rdf:type schema:Person
    243 sg:person.01174423374.00 schema:affiliation https://www.grid.ac/institutes/grid.5801.c
    244 schema:familyName Langhans
    245 schema:givenName W
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174423374.00
    247 rdf:type schema:Person
    248 sg:person.01221427306.18 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
    249 schema:familyName Richetto
    250 schema:givenName J
    251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221427306.18
    252 rdf:type schema:Person
    253 sg:person.01226521400.53 schema:affiliation https://www.grid.ac/institutes/grid.5399.6
    254 schema:familyName Iafrati
    255 schema:givenName J
    256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226521400.53
    257 rdf:type schema:Person
    258 sg:person.01310452433.26 schema:affiliation https://www.grid.ac/institutes/grid.449973.4
    259 schema:familyName Labouesse
    260 schema:givenName C
    261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310452433.26
    262 rdf:type schema:Person
    263 sg:person.01352637112.45 schema:affiliation https://www.grid.ac/institutes/grid.1017.7
    264 schema:familyName Reichelt
    265 schema:givenName A C
    266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352637112.45
    267 rdf:type schema:Person
    268 sg:person.01372072276.55 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
    269 schema:familyName Labouesse
    270 schema:givenName M A
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01372072276.55
    272 rdf:type schema:Person
    273 sg:person.014010270771.91 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
    274 schema:familyName Gschwind
    275 schema:givenName T
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014010270771.91
    277 rdf:type schema:Person
    278 sg:person.0604271443.26 schema:affiliation https://www.grid.ac/institutes/grid.5399.6
    279 schema:familyName Chavis
    280 schema:givenName P
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604271443.26
    282 rdf:type schema:Person
    283 sg:person.0645134356.50 schema:affiliation https://www.grid.ac/institutes/grid.425902.8
    284 schema:familyName Soriano
    285 schema:givenName E
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645134356.50
    287 rdf:type schema:Person
    288 sg:person.0652617062.05 schema:affiliation https://www.grid.ac/institutes/grid.5399.6
    289 schema:familyName Lassalle
    290 schema:givenName O
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652617062.05
    292 rdf:type schema:Person
    293 sg:person.0716646337.49 schema:affiliation https://www.grid.ac/institutes/grid.430994.3
    294 schema:familyName Pujadas
    295 schema:givenName L
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716646337.49
    297 rdf:type schema:Person
    298 sg:pub.10.1007/s00125-010-1857-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1043878313
    299 https://doi.org/10.1007/s00125-010-1857-y
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1007/s00213-006-0530-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053625223
    302 https://doi.org/10.1007/s00213-006-0530-0
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1038/mp.2011.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001673726
    305 https://doi.org/10.1038/mp.2011.14
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1038/mp.2013.66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043264819
    308 https://doi.org/10.1038/mp.2013.66
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1038/ncomms4443 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016339312
    311 https://doi.org/10.1038/ncomms4443
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1038/npp.2011.153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033801597
    314 https://doi.org/10.1038/npp.2011.153
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/npp.2011.169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007946103
    317 https://doi.org/10.1038/npp.2011.169
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/npp.2012.125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004667753
    320 https://doi.org/10.1038/npp.2012.125
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/nrn1648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000060878
    323 https://doi.org/10.1038/nrn1648
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/nrn1787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029042036
    326 https://doi.org/10.1038/nrn1787
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/nrn2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024822164
    329 https://doi.org/10.1038/nrn2009
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/nrn2867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031073156
    332 https://doi.org/10.1038/nrn2867
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/nrn3492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051238593
    335 https://doi.org/10.1038/nrn3492
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/sj.ijo.0800724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017231570
    338 https://doi.org/10.1038/sj.ijo.0800724
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/sj.npp.1301051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021460190
    341 https://doi.org/10.1038/sj.npp.1301051
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1038/sj.npp.1301141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040522188
    344 https://doi.org/10.1038/sj.npp.1301141
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1038/srep35504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007258616
    347 https://doi.org/10.1038/srep35504
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1001/archpsyc.57.1.65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008952361
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1001/jama.2015.5941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038851054
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1002/hipo.22032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041831350
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1016/j.appet.2012.12.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050903522
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1016/j.bbi.2007.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008208329
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1016/j.bbi.2014.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005086844
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1016/j.bbr.2007.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045303889
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1016/j.bbr.2014.04.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031083387
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1016/j.biopsych.2012.09.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040786891
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1016/j.biopsych.2013.02.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037387381
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1016/j.cell.2016.03.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010797599
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1016/j.jand.2015.09.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038641969
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1016/j.nbd.2011.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043052015
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1016/j.neurobiolaging.2014.03.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035907005
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1016/j.neuron.2005.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027736275
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1016/j.neuron.2013.06.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030217610
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1016/j.neuropharm.2012.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053447192
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1016/j.neuroscience.2013.04.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032066983
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1016/j.neuroscience.2015.04.045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052008591
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1016/j.neuroscience.2015.09.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012658725
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1016/j.nicl.2016.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037984385
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1016/j.nlm.2005.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032742202
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1016/j.psychres.2013.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012963959
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1016/j.psyneuen.2013.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006842484
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1016/s0140-6736(14)60460-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007350540
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1016/s0149-7634(00)00014-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053135618
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1016/s0149-7634(03)00005-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032711243
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1017/s0029665113003376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028233539
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1017/s1461145714000121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038017430
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1037/0735-7044.120.4.984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011203772
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1038/oby.2011.15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039265975
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1073/pnas.0402680101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008422748
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1073/pnas.1121251109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023544798
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1073/pnas.1511593112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034381350
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1073/pnas.93.24.13473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006661204
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1093/ajcn/70.3.560s schema:sameAs https://app.dimensions.ai/details/publication/pub.1074518209
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1096/fj.10-171983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041823291
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1101/lm.038000.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004451710
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1101/lm.2153511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039406042
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1111/gbb.12191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031053055
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1111/j.1476-5381.2011.01245.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026545796
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1111/jcpp.12209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034421218
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1126/scisignal.aaa6674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062685493
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1152/jn.91039.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048962840
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1161/atvbaha.112.252759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010754345
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1177/0269881112463468 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053139755
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1177/1403494813487449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064002236
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1242/dev.070151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014020757
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1371/journal.pone.0005505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050387861
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1523/jneurosci.1772-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008384877
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1523/jneurosci.18-19-07779.1998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083318032
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1523/jneurosci.1934-15.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042013491
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1523/jneurosci.1951-05.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032854749
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1523/jneurosci.2561-06.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023362810
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1523/jneurosci.5284-09.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037299405
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1542/peds.2005-2374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035796776
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.3389/fendo.2014.00074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049401775
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.3945/ajcn.110.002758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015397292
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.3945/jn.114.190447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020235966
    466 rdf:type schema:CreativeWork
    467 https://www.grid.ac/institutes/grid.1017.7 schema:alternateName RMIT University
    468 schema:name School of Health and Biomedical Sciences, RMIT, Melbourne, VIC, Australia.
    469 rdf:type schema:Organization
    470 https://www.grid.ac/institutes/grid.425902.8 schema:alternateName Institució Catalana de Recerca i Estudis Avançats
    471 schema:name Centro de Investigación en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
    472 Department of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona, Spain.
    473 Institució Catalana de Recerca i Estudis Avançats (ICREA Academia), Barcelona, Spain.
    474 Vall [Dacute ]Hebron Institut de Recerca (VHIR), Barcelona, Spain.
    475 rdf:type schema:Organization
    476 https://www.grid.ac/institutes/grid.430994.3 schema:alternateName Vall d'Hebron Research Institute
    477 schema:name Centro de Investigación en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
    478 Department of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona, Spain.
    479 Vall [Dacute ]Hebron Institut de Recerca (VHIR), Barcelona, Spain.
    480 rdf:type schema:Organization
    481 https://www.grid.ac/institutes/grid.449973.4 schema:alternateName Wellcome / MRC Cambridge Stem Cell Institute
    482 schema:name Laboratory of Cell Biophysics, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.
    483 Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
    484 rdf:type schema:Organization
    485 https://www.grid.ac/institutes/grid.5399.6 schema:alternateName Aix-Marseille University
    486 schema:name INSERM, INMED UMR S 901, Aix-Marseille Université, Marseille, France.
    487 rdf:type schema:Organization
    488 https://www.grid.ac/institutes/grid.5801.c schema:alternateName Swiss Federal Institute of Technology in Zurich
    489 schema:name Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.
    490 rdf:type schema:Organization
    491 https://www.grid.ac/institutes/grid.7400.3 schema:alternateName University of Zurich
    492 schema:name Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
    493 Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Zurich, Switzerland.
    494 Neuroscience Center Zurich (ZNZ), University of Zurich, Zurich, Switzerland.
    495 Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland.
    496 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...