Valence-dependent influence of serotonin depletion on model-based choice strategy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-05

AUTHORS

Y Worbe, S Palminteri, G Savulich, N.D Daw, E Fernandez-Egea, T.W Robbins, V Voon

ABSTRACT

Human decision-making arises from both reflective and reflexive mechanisms, which underpin goal-directed and habitual behavioural control. Computationally, these two systems of behavioural control have been described by different learning algorithms, model-based and model-free learning, respectively. Here, we investigated the effect of diminished serotonin (5-hydroxytryptamine) neurotransmission using dietary tryptophan depletion (TD) in healthy volunteers on the performance of a two-stage decision-making task, which allows discrimination between model-free and model-based behavioural strategies. A novel version of the task was used, which not only examined choice balance for monetary reward but also for punishment (monetary loss). TD impaired goal-directed (model-based) behaviour in the reward condition, but promoted it under punishment. This effect on appetitive and aversive goal-directed behaviour is likely mediated by alteration of the average reward representation produced by TD, which is consistent with previous studies. Overall, the major implication of this study is that serotonin differentially affects goal-directed learning as a function of affective valence. These findings are relevant for a further understanding of psychiatric disorders associated with breakdown of goal-directed behavioural control such as obsessive-compulsive disorders or addictions. More... »

PAGES

624-629

References to SciGraph publications

  • 2015-03. Disorders of compulsivity: a common bias towards learning habits in MOLECULAR PSYCHIATRY
  • 1998-07. Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects in NEUROPSYCHOPHARMACOLOGY
  • 2010-01. Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual Action in NEUROPSYCHOPHARMACOLOGY
  • 2012-05. Mapping value based planning and extensively trained choice in the human brain in NATURE NEUROSCIENCE
  • 2012-02. Converging evidence for central 5-HT effects in acute tryptophan depletion in MOLECULAR PSYCHIATRY
  • 2014-05. Serotonin Depletion Induces ‘Waiting Impulsivity’ on the Human Four-Choice Serial Reaction Time Task: Cross-Species Translational Significance in NEUROPSYCHOPHARMACOLOGY
  • 2015-04. Acute serotonin depletion releases motivated inhibition of response vigour in PSYCHOPHARMACOLOGY
  • 2007-09. Learning the value of information in an uncertain world in NATURE NEUROSCIENCE
  • 2006-08. Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans in NATURE
  • 2005-12. Uncertainty-based competition between prefrontal and dorsolateral striatal systems for behavioral control in NATURE NEUROSCIENCE
  • 2011-01. Opponency Revisited: Competition and Cooperation Between Dopamine and Serotonin in NEUROPSYCHOPHARMACOLOGY
  • 2007-04. Tonic dopamine: opportunity costs and the control of response vigor in PSYCHOPHARMACOLOGY
  • 2011-01. Serotonin and Dopamine: Unifying Affective, Activational, and Decision Functions in NEUROPSYCHOPHARMACOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/mp.2015.46

    DOI

    http://dx.doi.org/10.1038/mp.2015.46

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018411520

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25869808


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1701", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Psychology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/17", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Psychology and Cognitive Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Appetitive Behavior", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Choice Behavior", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diet", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Double-Blind Method", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Factor Analysis, Statistical", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Psychological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neuropsychological Tests", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Punishment", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reward", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Serotonin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tryptophan", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Cambridge", 
              "id": "https://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Worbe", 
            "givenName": "Y", 
            "id": "sg:person.01256622422.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256622422.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratoire de Neurosciences Cognitives", 
              "id": "https://www.grid.ac/institutes/grid.462870.f", 
              "name": [
                "Institute of Cognitive science, University College of London, London, UK", 
                "Laboratoire des Neurosciences Cognitives, Ecole Normal Sup\u00e9rieure, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Palminteri", 
            "givenName": "S", 
            "id": "sg:person.01170764101.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170764101.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Cambridge", 
              "id": "https://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK", 
                "Department of Psychiatry, University of Cambridge, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Savulich", 
            "givenName": "G", 
            "id": "sg:person.0774555472.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774555472.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "New York University", 
              "id": "https://www.grid.ac/institutes/grid.137628.9", 
              "name": [
                "Center for Neural Science and Department of Psychology, New York University, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Daw", 
            "givenName": "N.D", 
            "id": "sg:person.0700070374.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700070374.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Health Service", 
              "id": "https://www.grid.ac/institutes/grid.451052.7", 
              "name": [
                "Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK", 
                "Department of Psychiatry, University of Cambridge, Cambridge, UK", 
                "Cambridgeshere and Peterborough NHS Foundation Trust, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fernandez-Egea", 
            "givenName": "E", 
            "id": "sg:person.0630474346.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630474346.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Cambridge", 
              "id": "https://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK", 
                "Department of Psychology, University of Cambridge, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Robbins", 
            "givenName": "T.W", 
            "id": "sg:person.01013072757.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013072757.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Cambridge", 
              "id": "https://www.grid.ac/institutes/grid.5335.0", 
              "name": [
                "Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK", 
                "Department of Psychiatry, University of Cambridge, Cambridge, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Voon", 
            "givenName": "V", 
            "id": "sg:person.01314223603.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314223603.63"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1111/j.1460-9568.2012.08026.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000282334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/scan/nsp020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001244209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2013.08.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001823734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2513-09.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002326603"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1192/bjp.bp.110.084178", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003067958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.2009.06796.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003931497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.2009.06796.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003931497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2010.04.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004293988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2749-13.2013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004350136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rstb.2013.0482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008557588"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.neuro.051508.135607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008826820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0564-07.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009136726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biopsych.2009.11.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013710139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rstb.1985.0010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013939683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropharm.2011.11.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016002317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.3068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016194209", 
              "https://doi.org/10.1038/nn.3068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0893-6080(02)00052-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017664061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archgenpsychiatry.2011.137", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018101319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rstb.2013.0475", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019214670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0269881113482531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019585801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0269881113482531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019585801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(74)90440-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019617755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(74)90440-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019617755"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2013.351", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020192025", 
              "https://doi.org/10.1038/npp.2013.351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2011.02.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020297092"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biopsych.2011.12.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020801472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2014.07.041", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022443169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0269881108089597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026396579"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/0269881108089597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026396579"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s0893-133x(97)00198-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026927202", 
              "https://doi.org/10.1016/s0893-133x(97)00198-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2010.151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027414175", 
              "https://doi.org/10.1038/npp.2010.151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2010.151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027414175", 
              "https://doi.org/10.1038/npp.2010.151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pcbi.1002055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028648676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00213-006-0502-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029000639", 
              "https://doi.org/10.1007/s00213-006-0502-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00213-006-0502-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029000639", 
              "https://doi.org/10.1007/s00213-006-0502-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.4982-07.2008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029454842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0053-12.2012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029504677"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2013.09.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032043566"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cercor/13.4.400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033197334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1560", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035060211", 
              "https://doi.org/10.1038/nn1560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1560", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035060211", 
              "https://doi.org/10.1038/nn1560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnsys.2014.00101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039310196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00213-014-3762-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039604562", 
              "https://doi.org/10.1007/s00213-014-3762-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2009.131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041054380", 
              "https://doi.org/10.1038/npp.2009.131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2009.131", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041054380", 
              "https://doi.org/10.1038/npp.2009.131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/appi.ajp.2011.10071062", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043247069"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1102941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044210205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044617179", 
              "https://doi.org/10.1038/nature05051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044617179", 
              "https://doi.org/10.1038/nature05051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044617179", 
              "https://doi.org/10.1038/nature05051"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2011.106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046790947", 
              "https://doi.org/10.1038/mp.2011.106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.euroneuro.2012.09.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047139823"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2012.03.042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047563476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0904035106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048909773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2010.121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050169227", 
              "https://doi.org/10.1038/npp.2010.121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2010.121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050169227", 
              "https://doi.org/10.1038/npp.2010.121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tics.2006.05.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050269167"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2013.08.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052431666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1312011110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052771165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0915-12.2012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053098803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2014.44", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053569332", 
              "https://doi.org/10.1038/mp.2014.44"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053677811", 
              "https://doi.org/10.1038/nn1954"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-05", 
        "datePublishedReg": "2016-05-01", 
        "description": "Human decision-making arises from both reflective and reflexive mechanisms, which underpin goal-directed and habitual behavioural control. Computationally, these two systems of behavioural control have been described by different learning algorithms, model-based and model-free learning, respectively. Here, we investigated the effect of diminished serotonin (5-hydroxytryptamine) neurotransmission using dietary tryptophan depletion (TD) in healthy volunteers on the performance of a two-stage decision-making task, which allows discrimination between model-free and model-based behavioural strategies. A novel version of the task was used, which not only examined choice balance for monetary reward but also for punishment (monetary loss). TD impaired goal-directed (model-based) behaviour in the reward condition, but promoted it under punishment. This effect on appetitive and aversive goal-directed behaviour is likely mediated by alteration of the average reward representation produced by TD, which is consistent with previous studies. Overall, the major implication of this study is that serotonin differentially affects goal-directed learning as a function of affective valence. These findings are relevant for a further understanding of psychiatric disorders associated with breakdown of goal-directed behavioural control such as obsessive-compulsive disorders or addictions. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/mp.2015.46", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2762165", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2774904", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6665067", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3643118", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2763718", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3636509", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1115540", 
            "issn": [
              "1359-4184", 
              "1476-5578"
            ], 
            "name": "Molecular Psychiatry", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "21"
          }
        ], 
        "name": "Valence-dependent influence of serotonin depletion on model-based choice strategy", 
        "pagination": "624-629", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "57b9b7a8057a57f79d12ce0292a76ca4655bffa8f0a004fde819a7af292941b8"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25869808"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9607835"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/mp.2015.46"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1018411520"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/mp.2015.46", 
          "https://app.dimensions.ai/details/publication/pub.1018411520"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T16:28", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000424.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/mp/journal/v21/n5/full/mp201546a.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/mp.2015.46'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/mp.2015.46'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/mp.2015.46'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/mp.2015.46'


     

    This table displays all metadata directly associated to this object as RDF triples.

    363 TRIPLES      21 PREDICATES      95 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/mp.2015.46 schema:about N1c294b851f0941eb9b075aa46445f1f1
    2 N2312558057a5463eb613d59cc9de8cfe
    3 N2ad8077a589e41fc96dd2905d2cd44ee
    4 N3ecdb9afa13f4d69bd8690349a6706c5
    5 N3fd26006165945ab951accf53fed5041
    6 N4201788736274b8da4b12302beb933d0
    7 N4d2fed45cc1b424db9cb9a251869d467
    8 N5a6f4b8b729c4965abf5e3750e9b9e42
    9 N655c56cb2fac4910bb8d86ce8e729391
    10 Na1fb22abca3347b98bac49ed2592e3d2
    11 Nd1b1007d10954e70941908253be32c26
    12 Nddeb7a8e7fb74fa19e4dbb9731d753a6
    13 Nf16db11b9bbc48cb957997b12c4534a1
    14 Nfdf56014292c4bb4af85e7c928190579
    15 Nffc93a36b268479ebe5e0be419f9a6fd
    16 anzsrc-for:17
    17 anzsrc-for:1701
    18 schema:author N24b575a9b760434b8b9b046ec24912a5
    19 schema:citation sg:pub.10.1007/s00213-006-0502-4
    20 sg:pub.10.1007/s00213-014-3762-4
    21 sg:pub.10.1016/s0893-133x(97)00198-x
    22 sg:pub.10.1038/mp.2011.106
    23 sg:pub.10.1038/mp.2014.44
    24 sg:pub.10.1038/nature05051
    25 sg:pub.10.1038/nn.3068
    26 sg:pub.10.1038/nn1560
    27 sg:pub.10.1038/nn1954
    28 sg:pub.10.1038/npp.2009.131
    29 sg:pub.10.1038/npp.2010.121
    30 sg:pub.10.1038/npp.2010.151
    31 sg:pub.10.1038/npp.2013.351
    32 https://doi.org/10.1001/archgenpsychiatry.2011.137
    33 https://doi.org/10.1016/0024-3205(74)90440-8
    34 https://doi.org/10.1016/j.biopsych.2009.11.001
    35 https://doi.org/10.1016/j.biopsych.2011.12.028
    36 https://doi.org/10.1016/j.cub.2014.07.041
    37 https://doi.org/10.1016/j.euroneuro.2012.09.006
    38 https://doi.org/10.1016/j.neuron.2010.04.016
    39 https://doi.org/10.1016/j.neuron.2011.02.027
    40 https://doi.org/10.1016/j.neuron.2012.03.042
    41 https://doi.org/10.1016/j.neuron.2013.08.009
    42 https://doi.org/10.1016/j.neuron.2013.08.030
    43 https://doi.org/10.1016/j.neuron.2013.09.007
    44 https://doi.org/10.1016/j.neuropharm.2011.11.002
    45 https://doi.org/10.1016/j.tics.2006.05.004
    46 https://doi.org/10.1016/s0893-6080(02)00052-7
    47 https://doi.org/10.1073/pnas.0904035106
    48 https://doi.org/10.1073/pnas.1312011110
    49 https://doi.org/10.1093/cercor/13.4.400
    50 https://doi.org/10.1093/scan/nsp020
    51 https://doi.org/10.1098/rstb.1985.0010
    52 https://doi.org/10.1098/rstb.2013.0475
    53 https://doi.org/10.1098/rstb.2013.0482
    54 https://doi.org/10.1111/j.1460-9568.2009.06796.x
    55 https://doi.org/10.1111/j.1460-9568.2012.08026.x
    56 https://doi.org/10.1126/science.1102941
    57 https://doi.org/10.1146/annurev.neuro.051508.135607
    58 https://doi.org/10.1176/appi.ajp.2011.10071062
    59 https://doi.org/10.1177/0269881108089597
    60 https://doi.org/10.1177/0269881113482531
    61 https://doi.org/10.1192/bjp.bp.110.084178
    62 https://doi.org/10.1371/journal.pcbi.1002055
    63 https://doi.org/10.1523/jneurosci.0053-12.2012
    64 https://doi.org/10.1523/jneurosci.0564-07.2007
    65 https://doi.org/10.1523/jneurosci.0915-12.2012
    66 https://doi.org/10.1523/jneurosci.2513-09.2009
    67 https://doi.org/10.1523/jneurosci.2749-13.2013
    68 https://doi.org/10.1523/jneurosci.4982-07.2008
    69 https://doi.org/10.3389/fnsys.2014.00101
    70 schema:datePublished 2016-05
    71 schema:datePublishedReg 2016-05-01
    72 schema:description Human decision-making arises from both reflective and reflexive mechanisms, which underpin goal-directed and habitual behavioural control. Computationally, these two systems of behavioural control have been described by different learning algorithms, model-based and model-free learning, respectively. Here, we investigated the effect of diminished serotonin (5-hydroxytryptamine) neurotransmission using dietary tryptophan depletion (TD) in healthy volunteers on the performance of a two-stage decision-making task, which allows discrimination between model-free and model-based behavioural strategies. A novel version of the task was used, which not only examined choice balance for monetary reward but also for punishment (monetary loss). TD impaired goal-directed (model-based) behaviour in the reward condition, but promoted it under punishment. This effect on appetitive and aversive goal-directed behaviour is likely mediated by alteration of the average reward representation produced by TD, which is consistent with previous studies. Overall, the major implication of this study is that serotonin differentially affects goal-directed learning as a function of affective valence. These findings are relevant for a further understanding of psychiatric disorders associated with breakdown of goal-directed behavioural control such as obsessive-compulsive disorders or addictions.
    73 schema:genre research_article
    74 schema:inLanguage en
    75 schema:isAccessibleForFree true
    76 schema:isPartOf N7ee2b72d8bd64f6a991460759cfa25c3
    77 Nd8a9a67986b348dbbb79bc24ccc7fe7a
    78 sg:journal.1115540
    79 schema:name Valence-dependent influence of serotonin depletion on model-based choice strategy
    80 schema:pagination 624-629
    81 schema:productId N14a0a8238f484afaaef760c1f3ee9b58
    82 N38ff8b5a4298484da21a32ccc337ddfc
    83 N6e31fbd2166041c5b98d5a5dbaaaeae9
    84 Nbf2ceb973381433fa19bc999396fb9a4
    85 Nc00d3ec789f14907800e8fea54c5dc10
    86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018411520
    87 https://doi.org/10.1038/mp.2015.46
    88 schema:sdDatePublished 2019-04-10T16:28
    89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    90 schema:sdPublisher Nab5701c44c624d9cbf449113549f396e
    91 schema:url http://www.nature.com/mp/journal/v21/n5/full/mp201546a.html
    92 sgo:license sg:explorer/license/
    93 sgo:sdDataset articles
    94 rdf:type schema:ScholarlyArticle
    95 N14a0a8238f484afaaef760c1f3ee9b58 schema:name nlm_unique_id
    96 schema:value 9607835
    97 rdf:type schema:PropertyValue
    98 N1c294b851f0941eb9b075aa46445f1f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Choice Behavior
    100 rdf:type schema:DefinedTerm
    101 N2312558057a5463eb613d59cc9de8cfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Appetitive Behavior
    103 rdf:type schema:DefinedTerm
    104 N24b575a9b760434b8b9b046ec24912a5 rdf:first sg:person.01256622422.16
    105 rdf:rest N9ae01205e5354c70bdad38e038854ad9
    106 N2ad8077a589e41fc96dd2905d2cd44ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Tryptophan
    108 rdf:type schema:DefinedTerm
    109 N38ff8b5a4298484da21a32ccc337ddfc schema:name dimensions_id
    110 schema:value pub.1018411520
    111 rdf:type schema:PropertyValue
    112 N3ecdb9afa13f4d69bd8690349a6706c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Neuropsychological Tests
    114 rdf:type schema:DefinedTerm
    115 N3fd26006165945ab951accf53fed5041 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Female
    117 rdf:type schema:DefinedTerm
    118 N4201788736274b8da4b12302beb933d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Diet
    120 rdf:type schema:DefinedTerm
    121 N4d2fed45cc1b424db9cb9a251869d467 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Factor Analysis, Statistical
    123 rdf:type schema:DefinedTerm
    124 N5a6f4b8b729c4965abf5e3750e9b9e42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Double-Blind Method
    126 rdf:type schema:DefinedTerm
    127 N5d57a5ab9298450997deccca09815134 rdf:first sg:person.01314223603.63
    128 rdf:rest rdf:nil
    129 N655c56cb2fac4910bb8d86ce8e729391 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Adult
    131 rdf:type schema:DefinedTerm
    132 N6e31fbd2166041c5b98d5a5dbaaaeae9 schema:name readcube_id
    133 schema:value 57b9b7a8057a57f79d12ce0292a76ca4655bffa8f0a004fde819a7af292941b8
    134 rdf:type schema:PropertyValue
    135 N7ee2b72d8bd64f6a991460759cfa25c3 schema:issueNumber 5
    136 rdf:type schema:PublicationIssue
    137 N91308ba2580b4ccd86b5adbf2f464639 rdf:first sg:person.0774555472.40
    138 rdf:rest Nda395438326b41d4a69dbe8f27714b16
    139 N9ae01205e5354c70bdad38e038854ad9 rdf:first sg:person.01170764101.19
    140 rdf:rest N91308ba2580b4ccd86b5adbf2f464639
    141 Na1fb22abca3347b98bac49ed2592e3d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Punishment
    143 rdf:type schema:DefinedTerm
    144 Na9b8c1ea965a495995ba239a2ef752d4 rdf:first sg:person.0630474346.25
    145 rdf:rest Nd41318eb99dd40bbb0c80adda861a5e8
    146 Nab5701c44c624d9cbf449113549f396e schema:name Springer Nature - SN SciGraph project
    147 rdf:type schema:Organization
    148 Nbf2ceb973381433fa19bc999396fb9a4 schema:name doi
    149 schema:value 10.1038/mp.2015.46
    150 rdf:type schema:PropertyValue
    151 Nc00d3ec789f14907800e8fea54c5dc10 schema:name pubmed_id
    152 schema:value 25869808
    153 rdf:type schema:PropertyValue
    154 Nd1b1007d10954e70941908253be32c26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Serotonin
    156 rdf:type schema:DefinedTerm
    157 Nd41318eb99dd40bbb0c80adda861a5e8 rdf:first sg:person.01013072757.77
    158 rdf:rest N5d57a5ab9298450997deccca09815134
    159 Nd8a9a67986b348dbbb79bc24ccc7fe7a schema:volumeNumber 21
    160 rdf:type schema:PublicationVolume
    161 Nda395438326b41d4a69dbe8f27714b16 rdf:first sg:person.0700070374.35
    162 rdf:rest Na9b8c1ea965a495995ba239a2ef752d4
    163 Nddeb7a8e7fb74fa19e4dbb9731d753a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Models, Psychological
    165 rdf:type schema:DefinedTerm
    166 Nf16db11b9bbc48cb957997b12c4534a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Reward
    168 rdf:type schema:DefinedTerm
    169 Nfdf56014292c4bb4af85e7c928190579 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Male
    171 rdf:type schema:DefinedTerm
    172 Nffc93a36b268479ebe5e0be419f9a6fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Humans
    174 rdf:type schema:DefinedTerm
    175 anzsrc-for:17 schema:inDefinedTermSet anzsrc-for:
    176 schema:name Psychology and Cognitive Sciences
    177 rdf:type schema:DefinedTerm
    178 anzsrc-for:1701 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Psychology
    180 rdf:type schema:DefinedTerm
    181 sg:grant.2762165 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2015.46
    182 rdf:type schema:MonetaryGrant
    183 sg:grant.2763718 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2015.46
    184 rdf:type schema:MonetaryGrant
    185 sg:grant.2774904 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2015.46
    186 rdf:type schema:MonetaryGrant
    187 sg:grant.3636509 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2015.46
    188 rdf:type schema:MonetaryGrant
    189 sg:grant.3643118 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2015.46
    190 rdf:type schema:MonetaryGrant
    191 sg:grant.6665067 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2015.46
    192 rdf:type schema:MonetaryGrant
    193 sg:journal.1115540 schema:issn 1359-4184
    194 1476-5578
    195 schema:name Molecular Psychiatry
    196 rdf:type schema:Periodical
    197 sg:person.01013072757.77 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
    198 schema:familyName Robbins
    199 schema:givenName T.W
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013072757.77
    201 rdf:type schema:Person
    202 sg:person.01170764101.19 schema:affiliation https://www.grid.ac/institutes/grid.462870.f
    203 schema:familyName Palminteri
    204 schema:givenName S
    205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170764101.19
    206 rdf:type schema:Person
    207 sg:person.01256622422.16 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
    208 schema:familyName Worbe
    209 schema:givenName Y
    210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256622422.16
    211 rdf:type schema:Person
    212 sg:person.01314223603.63 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
    213 schema:familyName Voon
    214 schema:givenName V
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314223603.63
    216 rdf:type schema:Person
    217 sg:person.0630474346.25 schema:affiliation https://www.grid.ac/institutes/grid.451052.7
    218 schema:familyName Fernandez-Egea
    219 schema:givenName E
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630474346.25
    221 rdf:type schema:Person
    222 sg:person.0700070374.35 schema:affiliation https://www.grid.ac/institutes/grid.137628.9
    223 schema:familyName Daw
    224 schema:givenName N.D
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700070374.35
    226 rdf:type schema:Person
    227 sg:person.0774555472.40 schema:affiliation https://www.grid.ac/institutes/grid.5335.0
    228 schema:familyName Savulich
    229 schema:givenName G
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774555472.40
    231 rdf:type schema:Person
    232 sg:pub.10.1007/s00213-006-0502-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029000639
    233 https://doi.org/10.1007/s00213-006-0502-4
    234 rdf:type schema:CreativeWork
    235 sg:pub.10.1007/s00213-014-3762-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039604562
    236 https://doi.org/10.1007/s00213-014-3762-4
    237 rdf:type schema:CreativeWork
    238 sg:pub.10.1016/s0893-133x(97)00198-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026927202
    239 https://doi.org/10.1016/s0893-133x(97)00198-x
    240 rdf:type schema:CreativeWork
    241 sg:pub.10.1038/mp.2011.106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046790947
    242 https://doi.org/10.1038/mp.2011.106
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/mp.2014.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053569332
    245 https://doi.org/10.1038/mp.2014.44
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/nature05051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044617179
    248 https://doi.org/10.1038/nature05051
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/nn.3068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016194209
    251 https://doi.org/10.1038/nn.3068
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/nn1560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035060211
    254 https://doi.org/10.1038/nn1560
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/nn1954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053677811
    257 https://doi.org/10.1038/nn1954
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/npp.2009.131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041054380
    260 https://doi.org/10.1038/npp.2009.131
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/npp.2010.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050169227
    263 https://doi.org/10.1038/npp.2010.121
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/npp.2010.151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027414175
    266 https://doi.org/10.1038/npp.2010.151
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/npp.2013.351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020192025
    269 https://doi.org/10.1038/npp.2013.351
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1001/archgenpsychiatry.2011.137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018101319
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/0024-3205(74)90440-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019617755
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/j.biopsych.2009.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013710139
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1016/j.biopsych.2011.12.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020801472
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1016/j.cub.2014.07.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022443169
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1016/j.euroneuro.2012.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047139823
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1016/j.neuron.2010.04.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004293988
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.neuron.2011.02.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020297092
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.neuron.2012.03.042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047563476
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.neuron.2013.08.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001823734
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.neuron.2013.08.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052431666
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.neuron.2013.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032043566
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.neuropharm.2011.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016002317
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.tics.2006.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050269167
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/s0893-6080(02)00052-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017664061
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1073/pnas.0904035106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048909773
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1073/pnas.1312011110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052771165
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1093/cercor/13.4.400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033197334
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1093/scan/nsp020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001244209
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1098/rstb.1985.0010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013939683
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1098/rstb.2013.0475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019214670
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1098/rstb.2013.0482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008557588
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1111/j.1460-9568.2009.06796.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003931497
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1111/j.1460-9568.2012.08026.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000282334
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1126/science.1102941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044210205
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1146/annurev.neuro.051508.135607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008826820
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1176/appi.ajp.2011.10071062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043247069
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1177/0269881108089597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026396579
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1177/0269881113482531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019585801
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1192/bjp.bp.110.084178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003067958
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1371/journal.pcbi.1002055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028648676
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1523/jneurosci.0053-12.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029504677
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1523/jneurosci.0564-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009136726
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1523/jneurosci.0915-12.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053098803
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1523/jneurosci.2513-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002326603
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1523/jneurosci.2749-13.2013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004350136
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1523/jneurosci.4982-07.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029454842
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.3389/fnsys.2014.00101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039310196
    346 rdf:type schema:CreativeWork
    347 https://www.grid.ac/institutes/grid.137628.9 schema:alternateName New York University
    348 schema:name Center for Neural Science and Department of Psychology, New York University, New York, USA
    349 rdf:type schema:Organization
    350 https://www.grid.ac/institutes/grid.451052.7 schema:alternateName National Health Service
    351 schema:name Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    352 Cambridgeshere and Peterborough NHS Foundation Trust, UK
    353 Department of Psychiatry, University of Cambridge, Cambridge, UK
    354 rdf:type schema:Organization
    355 https://www.grid.ac/institutes/grid.462870.f schema:alternateName Laboratoire de Neurosciences Cognitives
    356 schema:name Institute of Cognitive science, University College of London, London, UK
    357 Laboratoire des Neurosciences Cognitives, Ecole Normal Supérieure, Paris, France
    358 rdf:type schema:Organization
    359 https://www.grid.ac/institutes/grid.5335.0 schema:alternateName University of Cambridge
    360 schema:name Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    361 Department of Psychiatry, University of Cambridge, Cambridge, UK
    362 Department of Psychology, University of Cambridge, Cambridge, UK
    363 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...