Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-08

AUTHORS

Aidong Yuan, Henry Sershen, Veeranna, Balapal S. Basavarajappa, Asok Kumar, Audrey Hashim, Martin Berg, Ju-Hyun Lee, Yutaka Sato, Mala V. Rao, Panaiyur S. Mohan, Victor Dyakin, Jean-Pierre Julien, Virginia M-Y Lee, Ralph A. Nixon

ABSTRACT

Synaptic roles for neurofilament (NF) proteins have rarely been considered. Here, we establish all four NF subunits as integral resident proteins of synapses. Compared with the population in axons, NF subunits isolated from synapses have distinctive stoichiometry and phosphorylation state, and respond differently to perturbations in vivo. Completely eliminating NF proteins from brain by genetically deleting three subunits (α-internexin, NFH and NFL) markedly depresses hippocampal long-term potentiation induction without detectably altering synapse morphology. Deletion of NFM in mice, but not the deletion of any other NF subunit, amplifies dopamine D1-receptor-mediated motor responses to cocaine while redistributing postsynaptic D1-receptors from endosomes to plasma membrane, consistent with a specific modulatory role of NFM in D1-receptor recycling. These results identify a distinct pool of synaptic NF subunits and establish their key role in neurotransmission in vivo, suggesting potential novel influences of NF proteins in psychiatric as well as neurological states. More... »

PAGES

986-994

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/mp.2015.45

DOI

http://dx.doi.org/10.1038/mp.2015.45

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037046760

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25869803


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