Weight loss after bariatric surgery normalizes brain opioid receptors in morbid obesity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-10-13

AUTHORS

H K Karlsson, J J Tuulari, L Tuominen, J Hirvonen, H Honka, R Parkkola, S Helin, P Salminen, P Nuutila, L Nummenmaa

ABSTRACT

Positron emission tomography (PET) studies suggest opioidergic system dysfunction in morbid obesity, while evidence for the role of the dopaminergic system is less consistent. Whether opioid dysfunction represents a state or trait in obesity remains unresolved, but could be assessed in obese subjects undergoing weight loss. Here we measured brain μ-opioid receptor (MOR) and dopamine D2 receptor (D2R) availability in 16 morbidly obese women twice—before and 6 months after bariatric surgery—using PET with [11C]carfentanil and [11C]raclopride. Data were compared with those from 14 lean control subjects. Receptor-binding potentials (BPND) were compared between the groups and between the pre- and postoperative scans among the obese subjects. Brain MOR availability was initially lower among obese subjects, but weight loss (mean=26.1 kg, s.d.=7.6 kg) reversed this and resulted in ~23% higher MOR availability in the postoperative versus preoperative scan. Changes were observed in areas implicated in reward processing, including ventral striatum, insula, amygdala and thalamus (P's<0.005). Weight loss did not influence D2R availability in any brain region. Taken together, the endogenous opioid system plays an important role in the pathophysiology of human obesity. Because bariatric surgery and concomitant weight loss recover downregulated MOR availability, lowered MOR availability is associated with an obese phenotype and may mediate excessive energy uptake. Our results highlight that understanding the opioidergic contribution to overeating is critical for developing new treatments for obesity. More... »

PAGES

1057-1062

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/mp.2015.153

DOI

http://dx.doi.org/10.1038/mp.2015.153

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26460230


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68 loss
69 loss recover
70 months
71 morbid obesity
72 new treatments
73 obese phenotype
74 obese subjects
75 obese women
76 obesity
77 opioid dysfunction
78 opioid receptors
79 opioid system
80 opioidergic contribution
81 opioidergic system dysfunction
82 overeating
83 pathophysiology
84 phenotype
85 positron emission tomography study
86 postoperative scans
87 potential
88 pre
89 preoperative scans
90 processing
91 receptor availability
92 receptor-binding potential
93 receptors
94 recovers
95 region
96 results
97 reward processing
98 role
99 scans
100 state
101 striatum
102 study
103 subjects
104 surgery
105 surgery—using PET
106 system
107 system dysfunction
108 thalamus
109 tomography study
110 traits
111 treatment
112 uptake
113 ventral striatum
114 weight loss
115 weight loss recover
116 women
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