Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-07-22

AUTHORS

M Föcking, L M Lopez, J A English, P Dicker, A Wolff, E Brindley, K Wynne, G Cagney, D R Cotter

ABSTRACT

The postsynaptic density (PSD) contains a complex set of proteins of known relevance to neuropsychiatric disorders, and schizophrenia specifically. We enriched for this anatomical structure, in the anterior cingulate cortex, of 20 schizophrenia samples and 20 controls from the Stanley Medical Research Institute, and used unbiased shotgun proteomics incorporating label-free quantitation to identify differentially expressed proteins. Quantitative investigation of the PSD revealed more than 700 protein identifications and 143 differentially expressed proteins. Prominent among these were altered expression of proteins involved in clathrin-mediated endocytosis (CME) (Dynamin-1, adaptor protein 2) and N-methyl-D-aspartate (NMDA)-interacting proteins such as CYFIP2, SYNPO, SHANK3, ESYT and MAPK3 (all P<0.0015). Pathway analysis of the differentially expressed proteins implicated the cellular processes of endocytosis, long-term potentiation and calcium signaling. Both single-gene and gene-set enrichment analyses in genome-wide association data from the largest schizophrenia sample to date of 13 689 cases and 18 226 controls show significant association of HIST1H1E and MAPK3, and enrichment of our PSD proteome. Taken together, our data provide robust evidence implicating PSD-associated proteins and genes in schizophrenia, and suggest that within the PSD, NMDA-interacting and endocytosis-related proteins contribute to disease pathophysiology. More... »

PAGES

424-432

References to SciGraph publications

  • 2004-03-31. Abnormalities of the NMDA Receptor and Associated Intracellular Molecules in the Thalamus in Schizophrenia and Bipolar Disorder in NEUROPSYCHOPHARMACOLOGY
  • 2011-11-15. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia in MOLECULAR PSYCHIATRY
  • 2012-11-20. Common variant at 16p11.2 conferring risk of psychosis in MOLECULAR PSYCHIATRY
  • 2007-08. Integrating molecular and network biology to decode endocytosis in NATURE
  • 2006-04-25. Mitochondrial-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders in MOLECULAR PSYCHIATRY
  • 2012-10-03. De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia in NATURE GENETICS
  • 2014-01-22. De novo mutations in schizophrenia implicate synaptic networks in NATURE
  • 2013-10-15. Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders in MOLECULAR PSYCHIATRY
  • 2000-10. Redox modulation of the NMDA receptor in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2010-12-19. Characterization of the proteome, diseases and evolution of the human postsynaptic density in NATURE NEUROSCIENCE
  • 2012-12-02. Synaptic scaffold evolution generated components of vertebrate cognitive complexity in NATURE NEUROSCIENCE
  • 2012-11-13. Responder and nonresponder patients exhibit different peripheral transcriptional signatures during major depressive episode in TRANSLATIONAL PSYCHIATRY
  • 2011-10-11. Hypothesis review: are clathrin-mediated endocytosis and clathrin-dependent membrane and protein trafficking core pathophysiological processes in schizophrenia and bipolar disorder? in MOLECULAR PSYCHIATRY
  • 2012-08-12. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes in NATURE GENETICS
  • 2010-06-23. Evidence for Abnormal Forward Trafficking of AMPA Receptors in Frontal Cortex of Elderly Patients with Schizophrenia in NEUROPSYCHOPHARMACOLOGY
  • 2007-10-16. Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder in MOLECULAR PSYCHIATRY
  • 2009-07-01. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder in NATURE
  • 2014-01-07. Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins in TRANSLATIONAL PSYCHIATRY
  • 2008-01-29. The extracellular signal-regulated kinase pathway contributes to the control of behavioral excitement in MOLECULAR PSYCHIATRY
  • 2008-06. Cell and receptor type-specific alterations in markers of GABA neurotransmission in the prefrontal cortex of subjects with schizophrenia in NEUROTOXICITY RESEARCH
  • 2014-01-22. A polygenic burden of rare disruptive mutations in schizophrenia in NATURE
  • 2008-02-12. Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression in MOLECULAR PSYCHIATRY
  • 2004-07-20. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence in MOLECULAR PSYCHIATRY
  • 2012-11-13. Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder in TRANSLATIONAL PSYCHIATRY
  • 2011-09-18. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 in NATURE GENETICS
  • 2011-02-06. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 in NATURE GENETICS
  • 2010-11-18. Analysing biological pathways in genome-wide association studies in NATURE REVIEWS GENETICS
  • 2013-08-25. Genome-wide association analysis identifies 13 new risk loci for schizophrenia in NATURE GENETICS
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    URI

    http://scigraph.springernature.com/pub.10.1038/mp.2014.63

    DOI

    http://dx.doi.org/10.1038/mp.2014.63

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004708179

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25048004


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