708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-06

AUTHORS

P A Thomson, J S Parla, A F McRae, M Kramer, K Ramakrishnan, J Yao, D C Soares, S McCarthy, S W Morris, L Cardone, S Cass, E Ghiban, W Hennah, K L Evans, D Rebolini, J K Millar, S E Harris, J M Starr, D J MacIntyre, , A M McIntosh, J D Watson, I J Deary, P M Visscher, D H Blackwood, W R McCombie, D J Porteous

ABSTRACT

A balanced t(1;11) translocation that transects the Disrupted in schizophrenia 1 (DISC1) gene shows genome-wide significant linkage for schizophrenia and recurrent major depressive disorder (rMDD) in a single large Scottish family, but genome-wide and exome sequencing-based association studies have not supported a role for DISC1 in psychiatric illness. To explore DISC1 in more detail, we sequenced 528 kb of the DISC1 locus in 653 cases and 889 controls. We report 2718 validated single-nucleotide polymorphisms (SNPs) of which 2010 have a minor allele frequency of <1%. Only 38% of these variants are reported in the 1000 Genomes Project European subset. This suggests that many DISC1 SNPs remain undiscovered and are essentially private. Rare coding variants identified exclusively in patients were found in likely functional protein domains. Significant region-wide association was observed between rs16856199 and rMDD (P=0.026, unadjusted P=6.3 × 10(-5), OR=3.48). This was not replicated in additional recurrent major depression samples (replication P=0.11). Combined analysis of both the original and replication set supported the original association (P=0.0058, OR=1.46). Evidence for segregation of this variant with disease in families was limited to those of rMDD individuals referred from primary care. Burden analysis for coding and non-coding variants gave nominal associations with diagnosis and measures of mood and cognition. Together, these observations are likely to generalise to other candidate genes for major mental illness and may thus provide guidelines for the design of future studies. More... »

PAGES

668

References to SciGraph publications

  • 2007-12. The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond in BMC GERIATRICS
  • 2012. Using and Understanding RepeatMasker in MOBILE GENETIC ELEMENTS
  • 2012-08. Genetic architectures of psychiatric disorders: the emerging picture and its implications in NATURE REVIEWS GENETICS
  • 2009-08. Meta-analysis of 32 genome-wide linkage studies of schizophrenia in MOLECULAR PSYCHIATRY
  • 2012-09. Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction in MOLECULAR PSYCHIATRY
  • 2012-02. Genetic contributions to stability and change in intelligence from childhood to old age in NATURE
  • 2010-11-11. Rethinking schizophrenia in NATURE
  • 2011-11. Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes in MOLECULAR PSYCHIATRY
  • 2012-06. Exome sequencing and the genetic basis of complex traits in NATURE GENETICS
  • 2011-02. Disrupted in Schizophrenia-1 regulates intracellular trafficking of mitochondria in neurons in MOLECULAR PSYCHIATRY
  • 2009-06. DISC-1 Leu607Phe alleles differentially affect centrosomal PCM1 localization and neurotransmitter release in MOLECULAR PSYCHIATRY
  • 2010-07. Insoluble DISC1–Boymaw fusion proteins in MOLECULAR PSYCHIATRY
  • 2011-10. Genome-wide association studies establish that human intelligence is highly heritable and polygenic in MOLECULAR PSYCHIATRY
  • 2008-12. Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly in MOLECULAR PSYCHIATRY
  • 2013-04. A mega-analysis of genome-wide association studies for major depressive disorder in MOLECULAR PSYCHIATRY
  • 2012-09. An integrated encyclopedia of DNA elements in the human genome in NATURE
  • 2009-07-01. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder in NATURE
  • 2013-02. Deep resequencing and association analysis of schizophrenia candidate genes in MOLECULAR PSYCHIATRY
  • 2010-04. A method and server for predicting damaging missense mutations in NATURE METHODS
  • 2010-07. Insoluble DISC1–Boymaw fusion proteins generated by DISC1 translocation in MOLECULAR PSYCHIATRY
  • 2011-12. Linking neurodevelopmental and synaptic theories of mental illness through DISC1 in NATURE REVIEWS NEUROSCIENCE
  • 2012-06. Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia in MOLECULAR PSYCHIATRY
  • 2011-10. Temporal dynamics and genetic control of transcription in the human prefrontal cortex in NATURE
  • 2013-07. Association of DISC1 variants with age of onset in a population-based sample of recurrent major depression in MOLECULAR PSYCHIATRY
  • 2010-10-28. A map of human genome variation from population-scale sequencing in NATURE
  • 2012-01. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned in MOLECULAR PSYCHIATRY
  • 2009-09. DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder in MOLECULAR PSYCHIATRY
  • 2011-10. Genome-wide association study identifies five new schizophrenia loci in NATURE GENETICS
  • 2011-10. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/mp.2013.68

    DOI

    http://dx.doi.org/10.1038/mp.2013.68

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026605403

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23732877


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bipolar Disorder", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cognition", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Mutational Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Depressive Disorder, Major", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "European Continental Ancestry Group", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Exons", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Family", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Frequency", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Predisposition to Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mental Disorders", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nerve Tissue Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pedigree", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Schizophrenia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Scotland", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Western General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417068.c", 
              "name": [
                "Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK", 
                "Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Thomson", 
            "givenName": "P A", 
            "id": "sg:person.014571343717.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014571343717.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cold Spring Harbor Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.225279.9", 
              "name": [
                "Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Parla", 
            "givenName": "J S", 
            "id": "sg:person.0737544450.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737544450.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, QLD, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McRae", 
            "givenName": "A F", 
            "id": "sg:person.0744736347.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744736347.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cold Spring Harbor Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.225279.9", 
              "name": [
                "Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kramer", 
            "givenName": "M", 
            "id": "sg:person.0742613220.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742613220.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417068.c", 
              "name": [
                "Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ramakrishnan", 
            "givenName": "K", 
            "id": "sg:person.01232736651.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232736651.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cold Spring Harbor Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.225279.9", 
              "name": [
                "Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yao", 
            "givenName": "J", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417068.c", 
              "name": [
                "Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Soares", 
            "givenName": "D C", 
            "id": "sg:person.0720630455.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720630455.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cold Spring Harbor Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.225279.9", 
              "name": [
                "Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McCarthy", 
            "givenName": "S", 
            "id": "sg:person.01305054157.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305054157.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417068.c", 
              "name": [
                "Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morris", 
            "givenName": "S W", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cold Spring Harbor Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.225279.9", 
              "name": [
                "Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cardone", 
            "givenName": "L", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417068.c", 
              "name": [
                "Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cass", 
            "givenName": "S", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cold Spring Harbor Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.225279.9", 
              "name": [
                "Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ghiban", 
            "givenName": "E", 
            "id": "sg:person.01021256117.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021256117.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Helsinki", 
              "id": "https://www.grid.ac/institutes/grid.7737.4", 
              "name": [
                "Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK", 
                "Institute for Molecular Medicine, Finland FIMM, University of Helsinki, Helsinki, Finland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hennah", 
            "givenName": "W", 
            "id": "sg:person.01350645663.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350645663.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417068.c", 
              "name": [
                "Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK", 
                "Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Evans", 
            "givenName": "K L", 
            "id": "sg:person.0576277223.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576277223.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cold Spring Harbor Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.225279.9", 
              "name": [
                "Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rebolini", 
            "givenName": "D", 
            "id": "sg:person.01144267326.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144267326.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417068.c", 
              "name": [
                "Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Millar", 
            "givenName": "J K", 
            "id": "sg:person.0655434105.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655434105.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417068.c", 
              "name": [
                "Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK", 
                "Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Harris", 
            "givenName": "S E", 
            "id": "sg:person.01345057751.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345057751.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Starr", 
            "givenName": "J M", 
            "id": "sg:person.01146242611.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146242611.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Edinburgh", 
              "id": "https://www.grid.ac/institutes/grid.4305.2", 
              "name": [
                "Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "MacIntyre", 
            "givenName": "D J", 
            "id": "sg:person.013112201404.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013112201404.58"
            ], 
            "type": "Person"
          }, 
          {}, 
          {
            "affiliation": {
              "alternateName": "University of Edinburgh", 
              "id": "https://www.grid.ac/institutes/grid.4305.2", 
              "name": [
                "Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McIntosh", 
            "givenName": "A M", 
            "id": "sg:person.0754274002.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754274002.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cold Spring Harbor Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.225279.9", 
              "name": [
                "Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watson", 
            "givenName": "J D", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deary", 
            "givenName": "I J", 
            "id": "sg:person.011026120037.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011026120037.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Queensland", 
              "id": "https://www.grid.ac/institutes/grid.1003.2", 
              "name": [
                "University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, QLD, Australia", 
                "Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Visscher", 
            "givenName": "P M", 
            "id": "sg:person.01033044533.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033044533.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Edinburgh", 
              "id": "https://www.grid.ac/institutes/grid.4305.2", 
              "name": [
                "Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blackwood", 
            "givenName": "D H", 
            "id": "sg:person.0762174003.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762174003.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cold Spring Harbor Laboratory", 
              "id": "https://www.grid.ac/institutes/grid.225279.9", 
              "name": [
                "Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McCombie", 
            "givenName": "W R", 
            "id": "sg:person.01130577442.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130577442.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Western General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417068.c", 
              "name": [
                "Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK", 
                "Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Porteous", 
            "givenName": "D J", 
            "id": "sg:person.012230156744.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012230156744.42"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ng.2303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000345582", 
              "https://doi.org/10.1038/ng.2303"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archgenpsychiatry.2010.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000352501"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/geno.2000.6239", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000510153"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/cn200062k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001005717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2010.77", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001664802", 
              "https://doi.org/10.1038/mp.2010.77"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuropharm.2010.12.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002764276"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2012.117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004756644", 
              "https://doi.org/10.1038/mp.2012.117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btn653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005887834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.1999.3310", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007216874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth0410-248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007489634", 
              "https://doi.org/10.1038/nmeth0410-248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth0410-248", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007489634", 
              "https://doi.org/10.1038/nmeth0410-248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.b.30887", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007795059"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.1997.01830230023003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009213967"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1037/a0014780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010132938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0023450", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010342895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010608717", 
              "https://doi.org/10.1038/nature09534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09534", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010608717", 
              "https://doi.org/10.1038/nature09534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molmed.2011.09.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010896867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molmed.2011.09.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010896867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c2ib20066j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011553131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/schbul/sbq135", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014489818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/schbul/sbq135", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014489818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddq130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014556055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014682139", 
              "https://doi.org/10.1038/ng.943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddl407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015833792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/dds111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016667076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg3240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017191272", 
              "https://doi.org/10.1038/nrg3240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(09)60072-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017806629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/519795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019061180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.b.31187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019871762"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/9.9.1415", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020182158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2010.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021123995", 
              "https://doi.org/10.1038/mp.2010.109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2011.41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021175695", 
              "https://doi.org/10.1038/mp.2011.41"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddn146", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023944379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2008.22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024727521", 
              "https://doi.org/10.1038/mp.2008.22"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2011.09.030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024853706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025133227", 
              "https://doi.org/10.1038/nature08185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08185", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025133227", 
              "https://doi.org/10.1038/nature08185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2009.127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025214199", 
              "https://doi.org/10.1038/mp.2009.127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2009.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025650003", 
              "https://doi.org/10.1038/mp.2009.13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2009.13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025650003", 
              "https://doi.org/10.1038/mp.2009.13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-0327(96)00056-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025727484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2012.21", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026938504", 
              "https://doi.org/10.1038/mp.2012.21"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2008.135", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028300839", 
              "https://doi.org/10.1038/mp.2008.135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-61779-603-6_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028890056", 
              "https://doi.org/10.1007/978-1-61779-603-6_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029065430", 
              "https://doi.org/10.1038/nature11247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0004906", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029709924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.772403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030905286"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddl244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032152115"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2010.110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032956083", 
              "https://doi.org/10.1038/mp.2010.110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2011.37", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038780291", 
              "https://doi.org/10.1038/mp.2011.37"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2012.28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039069606", 
              "https://doi.org/10.1038/mp.2012.28"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/dds106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040084586"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.b.31076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040486052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.b.31076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040486052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2011.85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040881599", 
              "https://doi.org/10.1038/mp.2011.85"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1493-07.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041363321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2012.37", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041400039", 
              "https://doi.org/10.1038/mp.2012.37"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.a.34081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041529453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn3120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041723266", 
              "https://doi.org/10.1038/nrn3120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.12.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043034796"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/321969", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043832960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2318-7-28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044028214", 
              "https://doi.org/10.1186/1471-2318-7-28"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10524", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044236818", 
              "https://doi.org/10.1038/nature10524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.a.32941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044648061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neulet.2010.09.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045191749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10781", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046948029", 
              "https://doi.org/10.1038/nature10781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bti486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046984261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.078212.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047542880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047852061", 
              "https://doi.org/10.1038/nature09552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09552", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047852061", 
              "https://doi.org/10.1038/nature09552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pcbi.1002587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048642114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2008.101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049536157", 
              "https://doi.org/10.1038/mp.2008.101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/dds169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049607004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.1997.01830230033005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050645669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2007.12.117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050973562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053172161", 
              "https://doi.org/10.1038/ng.940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053172161", 
              "https://doi.org/10.1038/ng.940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi900901e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055209940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi900901e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055209940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1112915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062452232"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-06", 
        "datePublishedReg": "2014-06-01", 
        "description": "A balanced t(1;11) translocation that transects the Disrupted in schizophrenia 1 (DISC1) gene shows genome-wide significant linkage for schizophrenia and recurrent major depressive disorder (rMDD) in a single large Scottish family, but genome-wide and exome sequencing-based association studies have not supported a role for DISC1 in psychiatric illness. To explore DISC1 in more detail, we sequenced 528\u2009kb of the DISC1 locus in 653 cases and 889 controls. We report 2718 validated single-nucleotide polymorphisms (SNPs) of which 2010 have a minor allele frequency of <1%. Only 38% of these variants are reported in the 1000 Genomes Project European subset. This suggests that many DISC1 SNPs remain undiscovered and are essentially private. Rare coding variants identified exclusively in patients were found in likely functional protein domains. Significant region-wide association was observed between rs16856199 and rMDD (P=0.026, unadjusted P=6.3 \u00d7 10(-5), OR=3.48). This was not replicated in additional recurrent major depression samples (replication P=0.11). Combined analysis of both the original and replication set supported the original association (P=0.0058, OR=1.46). Evidence for segregation of this variant with disease in families was limited to those of rMDD individuals referred from primary care. Burden analysis for coding and non-coding variants gave nominal associations with diagnosis and measures of mood and cognition. Together, these observations are likely to generalise to other candidate genes for major mental illness and may thus provide guidelines for the design of future studies. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/mp.2013.68", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5147354", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3862679", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5146883", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2779536", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2751630", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2764985", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2782709", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1115540", 
            "issn": [
              "1359-4184", 
              "1476-5578"
            ], 
            "name": "Molecular Psychiatry", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "name": "708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits", 
        "pagination": "668", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "7ebecfb9aef848f7ed199a9fb00a5bd2ec4273c62782d738fdf3a6c5db079af1"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23732877"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9607835"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/mp.2013.68"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1026605403"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/mp.2013.68", 
          "https://app.dimensions.ai/details/publication/pub.1026605403"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:57", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000437.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/mp201368"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/mp.2013.68'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/mp.2013.68'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/mp.2013.68'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/mp.2013.68'


     

    This table displays all metadata directly associated to this object as RDF triples.

    582 TRIPLES      21 PREDICATES      116 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/mp.2013.68 schema:about N0fb4d4f3d63249a8a34e7d78ec03dc4a
    2 N117c6e166708463b9984f6dec9847be8
    3 N1241e52db12643d0be751225bc972927
    4 N16e6bbc400c947c4a4c5f21d39d04586
    5 N387dccbf8d5f4ad19f5904a5869935fb
    6 N3e12466178b44f4490db5e9e72b20165
    7 N464166ec449e41678511f617d51239e2
    8 N6374a73cbca64a27902fc31630cd5cd1
    9 N666e5a645ac54b4bbcc9203884b5d596
    10 N80adab42562448c8ab6001bffdbd1281
    11 N82189e4f03584df6bdcc23fee604a2ad
    12 N944bec50016c41318bf4f40a22b305e6
    13 Nb7c0e1c18e0b4a30b3ce96558f135978
    14 Nf626b64d0ac947ec8293349d70479ff7
    15 Nfc934762534848cc826524d845dffac3
    16 Nff14e36549054ee099437724b0ee4d55
    17 anzsrc-for:06
    18 anzsrc-for:0604
    19 schema:author Nfb8ed0a24ab5498eba4cee70a71a8d26
    20 schema:citation sg:pub.10.1007/978-1-61779-603-6_2
    21 sg:pub.10.1038/mp.2008.101
    22 sg:pub.10.1038/mp.2008.135
    23 sg:pub.10.1038/mp.2008.22
    24 sg:pub.10.1038/mp.2009.127
    25 sg:pub.10.1038/mp.2009.13
    26 sg:pub.10.1038/mp.2010.109
    27 sg:pub.10.1038/mp.2010.110
    28 sg:pub.10.1038/mp.2010.77
    29 sg:pub.10.1038/mp.2011.37
    30 sg:pub.10.1038/mp.2011.41
    31 sg:pub.10.1038/mp.2011.85
    32 sg:pub.10.1038/mp.2012.117
    33 sg:pub.10.1038/mp.2012.21
    34 sg:pub.10.1038/mp.2012.28
    35 sg:pub.10.1038/mp.2012.37
    36 sg:pub.10.1038/nature08185
    37 sg:pub.10.1038/nature09534
    38 sg:pub.10.1038/nature09552
    39 sg:pub.10.1038/nature10524
    40 sg:pub.10.1038/nature10781
    41 sg:pub.10.1038/nature11247
    42 sg:pub.10.1038/ng.2303
    43 sg:pub.10.1038/ng.940
    44 sg:pub.10.1038/ng.943
    45 sg:pub.10.1038/nmeth0410-248
    46 sg:pub.10.1038/nrg3240
    47 sg:pub.10.1038/nrn3120
    48 sg:pub.10.1186/1471-2318-7-28
    49 https://doi.org/10.1001/archgenpsychiatry.2010.1
    50 https://doi.org/10.1001/archpsyc.1997.01830230023003
    51 https://doi.org/10.1001/archpsyc.1997.01830230033005
    52 https://doi.org/10.1002/ajmg.a.32941
    53 https://doi.org/10.1002/ajmg.a.34081
    54 https://doi.org/10.1002/ajmg.b.30887
    55 https://doi.org/10.1002/ajmg.b.31076
    56 https://doi.org/10.1002/ajmg.b.31187
    57 https://doi.org/10.1006/geno.2000.6239
    58 https://doi.org/10.1006/jmbi.1999.3310
    59 https://doi.org/10.1016/0165-0327(96)00056-0
    60 https://doi.org/10.1016/j.bbrc.2007.12.117
    61 https://doi.org/10.1016/j.cell.2008.12.044
    62 https://doi.org/10.1016/j.molmed.2011.09.002
    63 https://doi.org/10.1016/j.neulet.2010.09.027
    64 https://doi.org/10.1016/j.neuron.2011.09.030
    65 https://doi.org/10.1016/j.neuropharm.2010.12.027
    66 https://doi.org/10.1016/s0140-6736(09)60072-6
    67 https://doi.org/10.1021/bi900901e
    68 https://doi.org/10.1021/cn200062k
    69 https://doi.org/10.1037/a0014780
    70 https://doi.org/10.1039/c2ib20066j
    71 https://doi.org/10.1086/321969
    72 https://doi.org/10.1086/519795
    73 https://doi.org/10.1093/bioinformatics/bti486
    74 https://doi.org/10.1093/bioinformatics/btn653
    75 https://doi.org/10.1093/hmg/9.9.1415
    76 https://doi.org/10.1093/hmg/ddl244
    77 https://doi.org/10.1093/hmg/ddl407
    78 https://doi.org/10.1093/hmg/ddn146
    79 https://doi.org/10.1093/hmg/ddq130
    80 https://doi.org/10.1093/hmg/dds106
    81 https://doi.org/10.1093/hmg/dds111
    82 https://doi.org/10.1093/hmg/dds169
    83 https://doi.org/10.1093/schbul/sbq135
    84 https://doi.org/10.1101/gr.078212.108
    85 https://doi.org/10.1101/gr.772403
    86 https://doi.org/10.1126/science.1112915
    87 https://doi.org/10.1371/journal.pcbi.1002587
    88 https://doi.org/10.1371/journal.pone.0004906
    89 https://doi.org/10.1371/journal.pone.0023450
    90 https://doi.org/10.1523/jneurosci.1493-07.2007
    91 schema:datePublished 2014-06
    92 schema:datePublishedReg 2014-06-01
    93 schema:description A balanced t(1;11) translocation that transects the Disrupted in schizophrenia 1 (DISC1) gene shows genome-wide significant linkage for schizophrenia and recurrent major depressive disorder (rMDD) in a single large Scottish family, but genome-wide and exome sequencing-based association studies have not supported a role for DISC1 in psychiatric illness. To explore DISC1 in more detail, we sequenced 528 kb of the DISC1 locus in 653 cases and 889 controls. We report 2718 validated single-nucleotide polymorphisms (SNPs) of which 2010 have a minor allele frequency of <1%. Only 38% of these variants are reported in the 1000 Genomes Project European subset. This suggests that many DISC1 SNPs remain undiscovered and are essentially private. Rare coding variants identified exclusively in patients were found in likely functional protein domains. Significant region-wide association was observed between rs16856199 and rMDD (P=0.026, unadjusted P=6.3 × 10(-5), OR=3.48). This was not replicated in additional recurrent major depression samples (replication P=0.11). Combined analysis of both the original and replication set supported the original association (P=0.0058, OR=1.46). Evidence for segregation of this variant with disease in families was limited to those of rMDD individuals referred from primary care. Burden analysis for coding and non-coding variants gave nominal associations with diagnosis and measures of mood and cognition. Together, these observations are likely to generalise to other candidate genes for major mental illness and may thus provide guidelines for the design of future studies.
    94 schema:genre research_article
    95 schema:inLanguage en
    96 schema:isAccessibleForFree true
    97 schema:isPartOf N3b39019aea384bd1b0ec7ab7390b8fc4
    98 Ndfcf6e0667a94aed826112aad4f3371b
    99 sg:journal.1115540
    100 schema:name 708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits
    101 schema:pagination 668
    102 schema:productId N8510bd938f2241d2a6b6050803e3068b
    103 N94ddaa34063b4398be2f132ad06a5fc2
    104 N967cd507d9ab417f8374551f3b03d79d
    105 Nc6cf1dd80d2c460399545b141b2de02e
    106 Nf103e4d5f3df43d591f587daf80924ef
    107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026605403
    108 https://doi.org/10.1038/mp.2013.68
    109 schema:sdDatePublished 2019-04-10T13:57
    110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    111 schema:sdPublisher N8c8692e15bda4ac299caa48058b5fb97
    112 schema:url https://www.nature.com/articles/mp201368
    113 sgo:license sg:explorer/license/
    114 sgo:sdDataset articles
    115 rdf:type schema:ScholarlyArticle
    116 N0ce25c92f513442e97e9d9cb935bec79 rdf:first sg:person.0720630455.24
    117 rdf:rest Nc7dbbc16a5574b6fa9d92605c650f37a
    118 N0fb4d4f3d63249a8a34e7d78ec03dc4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Bipolar Disorder
    120 rdf:type schema:DefinedTerm
    121 N10d75a1dcbf648dfb28e62cb7f00b2d5 rdf:first sg:person.0762174003.83
    122 rdf:rest N7884cf02340e406bad5c39c6d22893ae
    123 N117c6e166708463b9984f6dec9847be8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Gene Frequency
    125 rdf:type schema:DefinedTerm
    126 N1241e52db12643d0be751225bc972927 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Polymorphism, Single Nucleotide
    128 rdf:type schema:DefinedTerm
    129 N16e6bbc400c947c4a4c5f21d39d04586 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Genetic Predisposition to Disease
    131 rdf:type schema:DefinedTerm
    132 N2e1bc06b225043c9b0da1d50b4dfcb0f schema:affiliation https://www.grid.ac/institutes/grid.225279.9
    133 schema:familyName Cardone
    134 schema:givenName L
    135 rdf:type schema:Person
    136 N32086456d42544448508af23f53c91c6 rdf:first sg:person.01350645663.24
    137 rdf:rest Naec4b63e35b3434ea71fca0548cb8c2e
    138 N325bf1cecbfd454da171e15002395476 rdf:first sg:person.01033044533.08
    139 rdf:rest N10d75a1dcbf648dfb28e62cb7f00b2d5
    140 N387dccbf8d5f4ad19f5904a5869935fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Depressive Disorder, Major
    142 rdf:type schema:DefinedTerm
    143 N3b39019aea384bd1b0ec7ab7390b8fc4 schema:volumeNumber 19
    144 rdf:type schema:PublicationVolume
    145 N3e12466178b44f4490db5e9e72b20165 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Schizophrenia
    147 rdf:type schema:DefinedTerm
    148 N408bc08c050e4254bc6e363b1559cdfa rdf:first Nf1baa786bfbb4de58afd5d3b53bf6f3d
    149 rdf:rest Ncd3975048c394b9b9fdcd88a9a969119
    150 N449335a933c946cebf114c301157f309 rdf:first Nd211544025ad4ab785cc42ac90c5bcf2
    151 rdf:rest N61f3d5d063c945859d329279de8156ae
    152 N464166ec449e41678511f617d51239e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Cognition
    154 rdf:type schema:DefinedTerm
    155 N4cc0ba49b7dd411382c39c729d7ae425 schema:name Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK
    156 rdf:type schema:Organization
    157 N4d1dfdcd7151484da319240639db9702 rdf:first sg:person.012230156744.42
    158 rdf:rest rdf:nil
    159 N5382db990e854695850414037ac1b59c rdf:first Nd49d04f7fb024ff89142934373d5a6c2
    160 rdf:rest Nc614da150ecd4001ad541e3b895fc05a
    161 N61f3d5d063c945859d329279de8156ae rdf:first sg:person.01021256117.82
    162 rdf:rest N32086456d42544448508af23f53c91c6
    163 N620e1cbebddb4432b4252ed8f185d871 rdf:first sg:person.01232736651.08
    164 rdf:rest Na05ff20ce8ce486999b149a536b54919
    165 N6374a73cbca64a27902fc31630cd5cd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Humans
    167 rdf:type schema:DefinedTerm
    168 N64bdcd0a3413453a919ce8e0ee2e8410 schema:affiliation https://www.grid.ac/institutes/grid.225279.9
    169 schema:familyName Yao
    170 schema:givenName J
    171 rdf:type schema:Person
    172 N666e5a645ac54b4bbcc9203884b5d596 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Family
    174 rdf:type schema:DefinedTerm
    175 N6c5c7d44e12543499fb49a8700813e2c rdf:first sg:person.0744736347.37
    176 rdf:rest Nd176e4f8ccfa44c181bb1ea254771965
    177 N72e31e48c8354402b383ddfdf642fcb1 rdf:first sg:person.0655434105.43
    178 rdf:rest Nba5bbb19fad44dd2a02b9cb9e2a0508f
    179 N7884cf02340e406bad5c39c6d22893ae rdf:first sg:person.01130577442.35
    180 rdf:rest N4d1dfdcd7151484da319240639db9702
    181 N80adab42562448c8ab6001bffdbd1281 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Pedigree
    183 rdf:type schema:DefinedTerm
    184 N817b1176cdd8415389d4671730a15f68 rdf:first sg:person.01146242611.08
    185 rdf:rest Nf5162d8caf504c2fa3aecb2381dc1348
    186 N82189e4f03584df6bdcc23fee604a2ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name Nerve Tissue Proteins
    188 rdf:type schema:DefinedTerm
    189 N8510bd938f2241d2a6b6050803e3068b schema:name nlm_unique_id
    190 schema:value 9607835
    191 rdf:type schema:PropertyValue
    192 N8c8692e15bda4ac299caa48058b5fb97 schema:name Springer Nature - SN SciGraph project
    193 rdf:type schema:Organization
    194 N944bec50016c41318bf4f40a22b305e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Scotland
    196 rdf:type schema:DefinedTerm
    197 N94ddaa34063b4398be2f132ad06a5fc2 schema:name pubmed_id
    198 schema:value 23732877
    199 rdf:type schema:PropertyValue
    200 N967cd507d9ab417f8374551f3b03d79d schema:name dimensions_id
    201 schema:value pub.1026605403
    202 rdf:type schema:PropertyValue
    203 Na05ff20ce8ce486999b149a536b54919 rdf:first N64bdcd0a3413453a919ce8e0ee2e8410
    204 rdf:rest N0ce25c92f513442e97e9d9cb935bec79
    205 Naec4b63e35b3434ea71fca0548cb8c2e rdf:first sg:person.0576277223.05
    206 rdf:rest Nf5e4e8c44f3e491e98c245e101fdf6c8
    207 Nb7c0e1c18e0b4a30b3ce96558f135978 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    208 schema:name Exons
    209 rdf:type schema:DefinedTerm
    210 Nba5bbb19fad44dd2a02b9cb9e2a0508f rdf:first sg:person.01345057751.89
    211 rdf:rest N817b1176cdd8415389d4671730a15f68
    212 Nbb989f704b5548e98f2315461f4d875a schema:name Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK
    213 rdf:type schema:Organization
    214 Nc614da150ecd4001ad541e3b895fc05a rdf:first sg:person.011026120037.74
    215 rdf:rest N325bf1cecbfd454da171e15002395476
    216 Nc6cf1dd80d2c460399545b141b2de02e schema:name doi
    217 schema:value 10.1038/mp.2013.68
    218 rdf:type schema:PropertyValue
    219 Nc7dbbc16a5574b6fa9d92605c650f37a rdf:first sg:person.01305054157.91
    220 rdf:rest N408bc08c050e4254bc6e363b1559cdfa
    221 Ncd3975048c394b9b9fdcd88a9a969119 rdf:first N2e1bc06b225043c9b0da1d50b4dfcb0f
    222 rdf:rest N449335a933c946cebf114c301157f309
    223 Nd176e4f8ccfa44c181bb1ea254771965 rdf:first sg:person.0742613220.12
    224 rdf:rest N620e1cbebddb4432b4252ed8f185d871
    225 Nd211544025ad4ab785cc42ac90c5bcf2 schema:affiliation https://www.grid.ac/institutes/grid.417068.c
    226 schema:familyName Cass
    227 schema:givenName S
    228 rdf:type schema:Person
    229 Nd49d04f7fb024ff89142934373d5a6c2 schema:affiliation https://www.grid.ac/institutes/grid.225279.9
    230 schema:familyName Watson
    231 schema:givenName J D
    232 rdf:type schema:Person
    233 Ndef4b2894ffc47f7b829c5a90508b5db rdf:first sg:person.0737544450.35
    234 rdf:rest N6c5c7d44e12543499fb49a8700813e2c
    235 Ndfcf6e0667a94aed826112aad4f3371b schema:issueNumber 6
    236 rdf:type schema:PublicationIssue
    237 Ne2f24652794a420c906f59a2f92ac6c1 rdf:first sg:person.0754274002.97
    238 rdf:rest N5382db990e854695850414037ac1b59c
    239 Ned4af12a3c974aaf882be3df1eae0158 schema:name University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, QLD, Australia
    240 rdf:type schema:Organization
    241 Nf0c7ff05e6824d6daf1242cf1597b8e6 rdf:first Nf2abe3dacb6741f49d19300a436410a3
    242 rdf:rest Ne2f24652794a420c906f59a2f92ac6c1
    243 Nf103e4d5f3df43d591f587daf80924ef schema:name readcube_id
    244 schema:value 7ebecfb9aef848f7ed199a9fb00a5bd2ec4273c62782d738fdf3a6c5db079af1
    245 rdf:type schema:PropertyValue
    246 Nf1baa786bfbb4de58afd5d3b53bf6f3d schema:affiliation https://www.grid.ac/institutes/grid.417068.c
    247 schema:familyName Morris
    248 schema:givenName S W
    249 rdf:type schema:Person
    250 Nf5162d8caf504c2fa3aecb2381dc1348 rdf:first sg:person.013112201404.58
    251 rdf:rest Nf0c7ff05e6824d6daf1242cf1597b8e6
    252 Nf5e4e8c44f3e491e98c245e101fdf6c8 rdf:first sg:person.01144267326.10
    253 rdf:rest N72e31e48c8354402b383ddfdf642fcb1
    254 Nf626b64d0ac947ec8293349d70479ff7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    255 schema:name DNA Mutational Analysis
    256 rdf:type schema:DefinedTerm
    257 Nfb8ed0a24ab5498eba4cee70a71a8d26 rdf:first sg:person.014571343717.54
    258 rdf:rest Ndef4b2894ffc47f7b829c5a90508b5db
    259 Nfc934762534848cc826524d845dffac3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    260 schema:name European Continental Ancestry Group
    261 rdf:type schema:DefinedTerm
    262 Nff14e36549054ee099437724b0ee4d55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    263 schema:name Mental Disorders
    264 rdf:type schema:DefinedTerm
    265 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    266 schema:name Biological Sciences
    267 rdf:type schema:DefinedTerm
    268 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    269 schema:name Genetics
    270 rdf:type schema:DefinedTerm
    271 sg:grant.2751630 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2013.68
    272 rdf:type schema:MonetaryGrant
    273 sg:grant.2764985 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2013.68
    274 rdf:type schema:MonetaryGrant
    275 sg:grant.2779536 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2013.68
    276 rdf:type schema:MonetaryGrant
    277 sg:grant.2782709 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2013.68
    278 rdf:type schema:MonetaryGrant
    279 sg:grant.3862679 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2013.68
    280 rdf:type schema:MonetaryGrant
    281 sg:grant.5146883 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2013.68
    282 rdf:type schema:MonetaryGrant
    283 sg:grant.5147354 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2013.68
    284 rdf:type schema:MonetaryGrant
    285 sg:journal.1115540 schema:issn 1359-4184
    286 1476-5578
    287 schema:name Molecular Psychiatry
    288 rdf:type schema:Periodical
    289 sg:person.01021256117.82 schema:affiliation https://www.grid.ac/institutes/grid.225279.9
    290 schema:familyName Ghiban
    291 schema:givenName E
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021256117.82
    293 rdf:type schema:Person
    294 sg:person.01033044533.08 schema:affiliation https://www.grid.ac/institutes/grid.1003.2
    295 schema:familyName Visscher
    296 schema:givenName P M
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033044533.08
    298 rdf:type schema:Person
    299 sg:person.011026120037.74 schema:affiliation N4cc0ba49b7dd411382c39c729d7ae425
    300 schema:familyName Deary
    301 schema:givenName I J
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011026120037.74
    303 rdf:type schema:Person
    304 sg:person.01130577442.35 schema:affiliation https://www.grid.ac/institutes/grid.225279.9
    305 schema:familyName McCombie
    306 schema:givenName W R
    307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130577442.35
    308 rdf:type schema:Person
    309 sg:person.01144267326.10 schema:affiliation https://www.grid.ac/institutes/grid.225279.9
    310 schema:familyName Rebolini
    311 schema:givenName D
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144267326.10
    313 rdf:type schema:Person
    314 sg:person.01146242611.08 schema:affiliation Nbb989f704b5548e98f2315461f4d875a
    315 schema:familyName Starr
    316 schema:givenName J M
    317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146242611.08
    318 rdf:type schema:Person
    319 sg:person.012230156744.42 schema:affiliation https://www.grid.ac/institutes/grid.417068.c
    320 schema:familyName Porteous
    321 schema:givenName D J
    322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012230156744.42
    323 rdf:type schema:Person
    324 sg:person.01232736651.08 schema:affiliation https://www.grid.ac/institutes/grid.417068.c
    325 schema:familyName Ramakrishnan
    326 schema:givenName K
    327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232736651.08
    328 rdf:type schema:Person
    329 sg:person.01305054157.91 schema:affiliation https://www.grid.ac/institutes/grid.225279.9
    330 schema:familyName McCarthy
    331 schema:givenName S
    332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305054157.91
    333 rdf:type schema:Person
    334 sg:person.013112201404.58 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
    335 schema:familyName MacIntyre
    336 schema:givenName D J
    337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013112201404.58
    338 rdf:type schema:Person
    339 sg:person.01345057751.89 schema:affiliation https://www.grid.ac/institutes/grid.417068.c
    340 schema:familyName Harris
    341 schema:givenName S E
    342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345057751.89
    343 rdf:type schema:Person
    344 sg:person.01350645663.24 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
    345 schema:familyName Hennah
    346 schema:givenName W
    347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350645663.24
    348 rdf:type schema:Person
    349 sg:person.014571343717.54 schema:affiliation https://www.grid.ac/institutes/grid.417068.c
    350 schema:familyName Thomson
    351 schema:givenName P A
    352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014571343717.54
    353 rdf:type schema:Person
    354 sg:person.0576277223.05 schema:affiliation https://www.grid.ac/institutes/grid.417068.c
    355 schema:familyName Evans
    356 schema:givenName K L
    357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576277223.05
    358 rdf:type schema:Person
    359 sg:person.0655434105.43 schema:affiliation https://www.grid.ac/institutes/grid.417068.c
    360 schema:familyName Millar
    361 schema:givenName J K
    362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655434105.43
    363 rdf:type schema:Person
    364 sg:person.0720630455.24 schema:affiliation https://www.grid.ac/institutes/grid.417068.c
    365 schema:familyName Soares
    366 schema:givenName D C
    367 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720630455.24
    368 rdf:type schema:Person
    369 sg:person.0737544450.35 schema:affiliation https://www.grid.ac/institutes/grid.225279.9
    370 schema:familyName Parla
    371 schema:givenName J S
    372 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737544450.35
    373 rdf:type schema:Person
    374 sg:person.0742613220.12 schema:affiliation https://www.grid.ac/institutes/grid.225279.9
    375 schema:familyName Kramer
    376 schema:givenName M
    377 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742613220.12
    378 rdf:type schema:Person
    379 sg:person.0744736347.37 schema:affiliation Ned4af12a3c974aaf882be3df1eae0158
    380 schema:familyName McRae
    381 schema:givenName A F
    382 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744736347.37
    383 rdf:type schema:Person
    384 sg:person.0754274002.97 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
    385 schema:familyName McIntosh
    386 schema:givenName A M
    387 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754274002.97
    388 rdf:type schema:Person
    389 sg:person.0762174003.83 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
    390 schema:familyName Blackwood
    391 schema:givenName D H
    392 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762174003.83
    393 rdf:type schema:Person
    394 sg:pub.10.1007/978-1-61779-603-6_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028890056
    395 https://doi.org/10.1007/978-1-61779-603-6_2
    396 rdf:type schema:CreativeWork
    397 sg:pub.10.1038/mp.2008.101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049536157
    398 https://doi.org/10.1038/mp.2008.101
    399 rdf:type schema:CreativeWork
    400 sg:pub.10.1038/mp.2008.135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028300839
    401 https://doi.org/10.1038/mp.2008.135
    402 rdf:type schema:CreativeWork
    403 sg:pub.10.1038/mp.2008.22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024727521
    404 https://doi.org/10.1038/mp.2008.22
    405 rdf:type schema:CreativeWork
    406 sg:pub.10.1038/mp.2009.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025214199
    407 https://doi.org/10.1038/mp.2009.127
    408 rdf:type schema:CreativeWork
    409 sg:pub.10.1038/mp.2009.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025650003
    410 https://doi.org/10.1038/mp.2009.13
    411 rdf:type schema:CreativeWork
    412 sg:pub.10.1038/mp.2010.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021123995
    413 https://doi.org/10.1038/mp.2010.109
    414 rdf:type schema:CreativeWork
    415 sg:pub.10.1038/mp.2010.110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032956083
    416 https://doi.org/10.1038/mp.2010.110
    417 rdf:type schema:CreativeWork
    418 sg:pub.10.1038/mp.2010.77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001664802
    419 https://doi.org/10.1038/mp.2010.77
    420 rdf:type schema:CreativeWork
    421 sg:pub.10.1038/mp.2011.37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038780291
    422 https://doi.org/10.1038/mp.2011.37
    423 rdf:type schema:CreativeWork
    424 sg:pub.10.1038/mp.2011.41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021175695
    425 https://doi.org/10.1038/mp.2011.41
    426 rdf:type schema:CreativeWork
    427 sg:pub.10.1038/mp.2011.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040881599
    428 https://doi.org/10.1038/mp.2011.85
    429 rdf:type schema:CreativeWork
    430 sg:pub.10.1038/mp.2012.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004756644
    431 https://doi.org/10.1038/mp.2012.117
    432 rdf:type schema:CreativeWork
    433 sg:pub.10.1038/mp.2012.21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026938504
    434 https://doi.org/10.1038/mp.2012.21
    435 rdf:type schema:CreativeWork
    436 sg:pub.10.1038/mp.2012.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039069606
    437 https://doi.org/10.1038/mp.2012.28
    438 rdf:type schema:CreativeWork
    439 sg:pub.10.1038/mp.2012.37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041400039
    440 https://doi.org/10.1038/mp.2012.37
    441 rdf:type schema:CreativeWork
    442 sg:pub.10.1038/nature08185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025133227
    443 https://doi.org/10.1038/nature08185
    444 rdf:type schema:CreativeWork
    445 sg:pub.10.1038/nature09534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010608717
    446 https://doi.org/10.1038/nature09534
    447 rdf:type schema:CreativeWork
    448 sg:pub.10.1038/nature09552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047852061
    449 https://doi.org/10.1038/nature09552
    450 rdf:type schema:CreativeWork
    451 sg:pub.10.1038/nature10524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044236818
    452 https://doi.org/10.1038/nature10524
    453 rdf:type schema:CreativeWork
    454 sg:pub.10.1038/nature10781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046948029
    455 https://doi.org/10.1038/nature10781
    456 rdf:type schema:CreativeWork
    457 sg:pub.10.1038/nature11247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029065430
    458 https://doi.org/10.1038/nature11247
    459 rdf:type schema:CreativeWork
    460 sg:pub.10.1038/ng.2303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000345582
    461 https://doi.org/10.1038/ng.2303
    462 rdf:type schema:CreativeWork
    463 sg:pub.10.1038/ng.940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053172161
    464 https://doi.org/10.1038/ng.940
    465 rdf:type schema:CreativeWork
    466 sg:pub.10.1038/ng.943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014682139
    467 https://doi.org/10.1038/ng.943
    468 rdf:type schema:CreativeWork
    469 sg:pub.10.1038/nmeth0410-248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007489634
    470 https://doi.org/10.1038/nmeth0410-248
    471 rdf:type schema:CreativeWork
    472 sg:pub.10.1038/nrg3240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017191272
    473 https://doi.org/10.1038/nrg3240
    474 rdf:type schema:CreativeWork
    475 sg:pub.10.1038/nrn3120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041723266
    476 https://doi.org/10.1038/nrn3120
    477 rdf:type schema:CreativeWork
    478 sg:pub.10.1186/1471-2318-7-28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044028214
    479 https://doi.org/10.1186/1471-2318-7-28
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1001/archgenpsychiatry.2010.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000352501
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1001/archpsyc.1997.01830230023003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009213967
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1001/archpsyc.1997.01830230033005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050645669
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1002/ajmg.a.32941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044648061
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1002/ajmg.a.34081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041529453
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1002/ajmg.b.30887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007795059
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1002/ajmg.b.31076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040486052
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1002/ajmg.b.31187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019871762
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1006/geno.2000.6239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000510153
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1006/jmbi.1999.3310 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007216874
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1016/0165-0327(96)00056-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025727484
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1016/j.bbrc.2007.12.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050973562
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1016/j.cell.2008.12.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043034796
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1016/j.molmed.2011.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010896867
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1016/j.neulet.2010.09.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045191749
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1016/j.neuron.2011.09.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024853706
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1016/j.neuropharm.2010.12.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002764276
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1016/s0140-6736(09)60072-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017806629
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1021/bi900901e schema:sameAs https://app.dimensions.ai/details/publication/pub.1055209940
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1021/cn200062k schema:sameAs https://app.dimensions.ai/details/publication/pub.1001005717
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1037/a0014780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010132938
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1039/c2ib20066j schema:sameAs https://app.dimensions.ai/details/publication/pub.1011553131
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1086/321969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043832960
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1086/519795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061180
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1093/bioinformatics/bti486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046984261
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.1093/bioinformatics/btn653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005887834
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.1093/hmg/9.9.1415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020182158
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.1093/hmg/ddl244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032152115
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.1093/hmg/ddl407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015833792
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.1093/hmg/ddn146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023944379
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.1093/hmg/ddq130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014556055
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.1093/hmg/dds106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040084586
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.1093/hmg/dds111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016667076
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.1093/hmg/dds169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049607004
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.1093/schbul/sbq135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014489818
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.1101/gr.078212.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047542880
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.1101/gr.772403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030905286
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.1126/science.1112915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062452232
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.1371/journal.pcbi.1002587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048642114
    558 rdf:type schema:CreativeWork
    559 https://doi.org/10.1371/journal.pone.0004906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029709924
    560 rdf:type schema:CreativeWork
    561 https://doi.org/10.1371/journal.pone.0023450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010342895
    562 rdf:type schema:CreativeWork
    563 https://doi.org/10.1523/jneurosci.1493-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041363321
    564 rdf:type schema:CreativeWork
    565 https://www.grid.ac/institutes/grid.1003.2 schema:alternateName University of Queensland
    566 schema:name Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia
    567 University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, QLD, Australia
    568 rdf:type schema:Organization
    569 https://www.grid.ac/institutes/grid.225279.9 schema:alternateName Cold Spring Harbor Laboratory
    570 schema:name Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA
    571 rdf:type schema:Organization
    572 https://www.grid.ac/institutes/grid.417068.c schema:alternateName Western General Hospital
    573 schema:name Centre for Cognitive Ageing and Cognitive Epidemiology, Edinburgh, UK
    574 Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
    575 rdf:type schema:Organization
    576 https://www.grid.ac/institutes/grid.4305.2 schema:alternateName University of Edinburgh
    577 schema:name Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    578 rdf:type schema:Organization
    579 https://www.grid.ac/institutes/grid.7737.4 schema:alternateName University of Helsinki
    580 schema:name Institute for Molecular Medicine, Finland FIMM, University of Helsinki, Helsinki, Finland
    581 Medical Genetics Section, University of Edinburgh Molecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
    582 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...