Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC View Full Text


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Article Info

DATE

2013-06

AUTHORS

M L Hamshere, J T R Walters, R Smith, A L Richards, E Green, D Grozeva, I Jones, L Forty, L Jones, K Gordon-Smith, B Riley, T O'Neill, K S Kendler, P Sklar, S Purcell, J Kranz, D Morris, M Gill, P Holmans, N Craddock, A Corvin, M J Owen, M C O'Donovan

ABSTRACT

The Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC) highlighted 81 single-nucleotide polymorphisms (SNPs) with moderate evidence for association to schizophrenia. After follow-up in independent samples, seven loci attained genome-wide significance (GWS), but multi-locus tests suggested some SNPs that did not do so represented true associations. We tested 78 of the 81 SNPs in 2640 individuals with a clinical diagnosis of schizophrenia attending a clozapine clinic (CLOZUK), 2504 cases with a research diagnosis of bipolar disorder, and 2878 controls. In CLOZUK, we obtained significant replication to the PGC-associated allele for no fewer than 37 (47%) of the SNPs, including many prior GWS major histocompatibility complex (MHC) SNPs as well as 3/6 non-MHC SNPs for which we had data that were reported as GWS by the PGC. After combining the new schizophrenia data with those of the PGC, variants at three loci (ITIH3/4, CACNA1C and SDCCAG8) that had not previously been GWS in schizophrenia attained that level of support. In bipolar disorder, we also obtained significant evidence for association for 21% of the alleles that had been associated with schizophrenia in the PGC. Our study independently confirms association to three loci previously reported to be GWS in schizophrenia, and identifies the first GWS evidence in schizophrenia for a further three loci. Given the number of independent replications and the power of our sample, we estimate 98% (confidence interval (CI) 78-100%) of the original set of 78 SNPs represent true associations. We also provide strong evidence for overlap in genetic risk between schizophrenia and bipolar disorder. More... »

PAGES

708

References to SciGraph publications

  • 2007-06-07. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls in NATURE
  • 2008-09. Identification of loci associated with schizophrenia by genome-wide association and follow-up in NATURE GENETICS
  • 2012-02. De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia in MOLECULAR PSYCHIATRY
  • 2011-10. Genome-wide association study identifies five new schizophrenia loci in NATURE GENETICS
  • 2008-09. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder in NATURE GENETICS
  • 2009-03. Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk in MOLECULAR PSYCHIATRY
  • 2010-10. Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy in NATURE GENETICS
  • 2010-02. Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1 in NATURE GENETICS
  • 2012-09. Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe in MOLECULAR PSYCHIATRY
  • 2009-07-01. Common variants on chromosome 6p22.1 are associated with schizophrenia in NATURE
  • 2009-07-01. Common variants conferring risk of schizophrenia in NATURE
  • 2009-07-01. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder in NATURE
  • 2011-10. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/mp.2012.67

    DOI

    http://dx.doi.org/10.1038/mp.2012.67

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044122748

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22614287


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