Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-02

AUTHORS

D T Chen, X Jiang, N Akula, Y Y Shugart, J R Wendland, C J M Steele, L Kassem, J-H Park, N Chatterjee, S Jamain, A Cheng, M Leboyer, P Muglia, T G Schulze, S Cichon, M M Nöthen, M Rietschel, F J McMahon, A Farmer, P McGuffin, I Craig, C Lewis, G Hosang, S Cohen-Woods, J B Vincent, J L Kennedy, J Strauss

ABSTRACT

Meta-analyses of bipolar disorder (BD) genome-wide association studies (GWAS) have identified several genome-wide significant signals in European-ancestry samples, but so far account for little of the inherited risk. We performed a meta-analysis of ∼750,000 high-quality genetic markers on a combined sample of ∼14,000 subjects of European and Asian-ancestry (phase I). The most significant findings were further tested in an extended sample of ∼17,700 cases and controls (phase II). The results suggest novel association findings near the genes TRANK1 (LBA1), LMAN2L and PTGFR. In phase I, the most significant single nucleotide polymorphism (SNP), rs9834970 near TRANK1, was significant at the P=2.4 × 10(-11) level, with no heterogeneity. Supportive evidence for prior association findings near ANK3 and a locus on chromosome 3p21.1 was also observed. The phase II results were similar, although the heterogeneity test became significant for several SNPs. On the basis of these results and other established risk loci, we used the method developed by Park et al. to estimate the number, and the effect size distribution, of BD risk loci that could still be found by GWAS methods. We estimate that >63,000 case-control samples would be needed to identify the ∼105 BD risk loci discoverable by GWAS, and that these will together explain <6% of the inherited risk. These results support previous GWAS findings and identify three new candidate genes for BD. Further studies are needed to replicate these findings and may potentially lead to identification of functional variants. Sample size will remain a limiting factor in the discovery of common alleles associated with BD. More... »

PAGES

195

References to SciGraph publications

  • 2010-10. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia in MOLECULAR PSYCHIATRY
  • 2011-05. Genome-wide association study of bipolar I disorder in the Han Chinese population in MOLECULAR PSYCHIATRY
  • 2008-02. Newly identified loci that influence lipid concentrations and risk of coronary artery disease in NATURE GENETICS
  • 2009-05. Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder in MOLECULAR PSYCHIATRY
  • 2009-12. Anti-depressant and anxiolytic like behaviors in PKCI/HINT1 knockout mice associated with elevated plasma corticosterone level in BMC NEUROSCIENCE
  • 2010-07. Estimation of effect size distribution from genome-wide association studies and implications for future discoveries in NATURE GENETICS
  • 2010-05. Discovery of common Asian copy number variants using integrated high-resolution array CGH and massively parallel DNA sequencing in NATURE GENETICS
  • 2008-09. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder in NATURE GENETICS
  • 2008-12. Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer in NATURE GENETICS
  • 2007-06-07. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls in NATURE
  • 2009-08. Genome-wide association study of bipolar disorder in European American and African American individuals in MOLECULAR PSYCHIATRY
  • 2008-09. Identification of loci associated with schizophrenia by genome-wide association and follow-up in NATURE GENETICS
  • 2010-02. Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1 in NATURE GENETICS
  • 2008-06. Whole-genome association study of bipolar disorder in MOLECULAR PSYCHIATRY
  • 2010-09-11. Genetics of Bipolar Disorder in BEHAVIORAL NEUROBIOLOGY OF BIPOLAR DISORDER AND ITS TREATMENT
  • 2008-10. Common variants at CD40 and other loci confer risk of rheumatoid arthritis in NATURE GENETICS
  • 2008-02. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder in MOLECULAR PSYCHIATRY
  • 2010-07. A SNAP25 promoter variant is associated with early-onset bipolar disorder and a high expression level in brain in MOLECULAR PSYCHIATRY
  • 2008-05. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes in NATURE GENETICS
  • 2008-05. Genome-wide association analysis identifies 20 loci that influence adult height in NATURE GENETICS
  • 2012-01. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned in MOLECULAR PSYCHIATRY
  • 2006-02. Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies in NATURE GENETICS
  • 2011-10. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/mp.2011.157

    DOI

    http://dx.doi.org/10.1038/mp.2011.157

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001200421

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22182935


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ankyrins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antidepressive Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Asian Continental Ancestry Group", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bipolar Disorder", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Transformed", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytokines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dose-Response Relationship, Drug", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "European Continental Ancestry Group", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Frequency", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Predisposition to Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome-Wide Association Study", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lectins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lithium Chloride", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Membrane Transport Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Meta-Analysis as Topic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Messenger", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Prostaglandin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Time Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Valproic Acid", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "National Institute of Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.416868.5", 
              "name": [
                "Human Genetics Branch, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA. chend4@mail.nih.gov"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "D T", 
            "type": "Person"
          }, 
          {
            "familyName": "Jiang", 
            "givenName": "X", 
            "type": "Person"
          }, 
          {
            "familyName": "Akula", 
            "givenName": "N", 
            "type": "Person"
          }, 
          {
            "familyName": "Shugart", 
            "givenName": "Y Y", 
            "type": "Person"
          }, 
          {
            "familyName": "Wendland", 
            "givenName": "J R", 
            "type": "Person"
          }, 
          {
            "familyName": "Steele", 
            "givenName": "C J M", 
            "type": "Person"
          }, 
          {
            "familyName": "Kassem", 
            "givenName": "L", 
            "type": "Person"
          }, 
          {
            "familyName": "Park", 
            "givenName": "J-H", 
            "type": "Person"
          }, 
          {
            "familyName": "Chatterjee", 
            "givenName": "N", 
            "type": "Person"
          }, 
          {
            "familyName": "Jamain", 
            "givenName": "S", 
            "id": "sg:person.01027131353.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027131353.11"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Cheng", 
            "givenName": "A", 
            "type": "Person"
          }, 
          {
            "familyName": "Leboyer", 
            "givenName": "M", 
            "id": "sg:person.01020732460.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020732460.64"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Muglia", 
            "givenName": "P", 
            "type": "Person"
          }, 
          {
            "familyName": "Schulze", 
            "givenName": "T G", 
            "type": "Person"
          }, 
          {
            "familyName": "Cichon", 
            "givenName": "S", 
            "id": "sg:person.01271354173.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271354173.03"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "N\u00f6then", 
            "givenName": "M M", 
            "id": "sg:person.016071142772.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016071142772.72"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Rietschel", 
            "givenName": "M", 
            "type": "Person"
          }, 
          {
            "familyName": "McMahon", 
            "givenName": "F J", 
            "id": "sg:person.012033643424.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012033643424.99"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Farmer", 
            "givenName": "A", 
            "type": "Person"
          }, 
          {
            "familyName": "McGuffin", 
            "givenName": "P", 
            "type": "Person"
          }, 
          {
            "familyName": "Craig", 
            "givenName": "I", 
            "id": "sg:person.01324664506.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324664506.39"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Lewis", 
            "givenName": "C", 
            "type": "Person"
          }, 
          {
            "familyName": "Hosang", 
            "givenName": "G", 
            "type": "Person"
          }, 
          {
            "familyName": "Cohen-Woods", 
            "givenName": "S", 
            "id": "sg:person.01252332263.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252332263.35"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Vincent", 
            "givenName": "J B", 
            "type": "Person"
          }, 
          {
            "familyName": "Kennedy", 
            "givenName": "J L", 
            "type": "Person"
          }, 
          {
            "familyName": "Strauss", 
            "givenName": "J", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1001/archpsyc.56.2.162", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000353584"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2009.43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000951564", 
              "https://doi.org/10.1038/mp.2009.43"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2009.43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000951564", 
              "https://doi.org/10.1038/mp.2009.43"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004556449", 
              "https://doi.org/10.1038/nature05911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006325160", 
              "https://doi.org/10.1038/ng.120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006886726", 
              "https://doi.org/10.1038/ng.555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2010.43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008148053", 
              "https://doi.org/10.1038/mp.2010.43"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gepi.20303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008645052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2008.148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009055502", 
              "https://doi.org/10.1038/mp.2008.148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009205998", 
              "https://doi.org/10.1038/ng1706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng1706", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009205998", 
              "https://doi.org/10.1038/ng1706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.76", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009408087", 
              "https://doi.org/10.1038/ng.76"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/7854_2010_74", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009462365", 
              "https://doi.org/10.1007/7854_2010_74"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/7854_2010_74", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009462365", 
              "https://doi.org/10.1007/7854_2010_74"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2011.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009526716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.58.11.1005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011149395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2008.03.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012504018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ypg.0b013e32833a2050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013489912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ypg.0b013e32833a2050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013489912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ypg.0b013e32833a2050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013489912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ypg.0b013e32833a2050", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013489912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/19.1.149", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013784960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014682139", 
              "https://doi.org/10.1038/ng.943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/519795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019061180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1192/bjp.184.5.386", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019566613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2753.2008.00986.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020333614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0006-341x.1999.00997.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021081768"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2010.109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021123995", 
              "https://doi.org/10.1038/mp.2010.109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2008.134", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021162050", 
              "https://doi.org/10.1038/mp.2008.134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021719447", 
              "https://doi.org/10.1038/ng.523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.523", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021719447", 
              "https://doi.org/10.1038/ng.523"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddn288", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022365148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gr.229102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022792016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022836479", 
              "https://doi.org/10.1038/ng.201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023921533", 
              "https://doi.org/10.1038/ng.121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.1982.04290100031006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025127088"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025253932", 
              "https://doi.org/10.1038/ng.610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.610", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025253932", 
              "https://doi.org/10.1038/ng.610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025725602", 
              "https://doi.org/10.1038/ng.262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/bti042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027115436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.1993.01820210033004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027730822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gepi.20497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027811451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gepi.20497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027811451"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.64.9.1032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027812438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.0060001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028776993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0004324", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031304002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2011.04.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031378484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.209", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031924597", 
              "https://doi.org/10.1038/ng.209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2009.01.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033548087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2202-10-132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035094236", 
              "https://doi.org/10.1186/1471-2202-10-132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwp262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037069664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwp262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037069664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4002151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037491398", 
              "https://doi.org/10.1038/sj.mp.4002151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m101287200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037618835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2009.49", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043020826", 
              "https://doi.org/10.1038/mp.2009.49"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2009.49", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043020826", 
              "https://doi.org/10.1038/mp.2009.49"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci34772", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046196569"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048421356", 
              "https://doi.org/10.1038/ng.233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.c.20013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049546644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0813386106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050677827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jad.2007.07.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051597937"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2009.11.055", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051673317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gepi.20297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052087865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000952", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053012854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ajhg.2011.01.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053256066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/jpet.102.045419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053420370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4002012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053535114", 
              "https://doi.org/10.1038/sj.mp.4002012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1142364", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062456030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1190532", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062462456"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1192/bjp.130.4.330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064166772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmg.36.8.585", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074513347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jmg.36.8.585", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074513347"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/acprof:oso/9780195326543.001.0001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1098739860"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-02", 
        "datePublishedReg": "2013-02-01", 
        "description": "Meta-analyses of bipolar disorder (BD) genome-wide association studies (GWAS) have identified several genome-wide significant signals in European-ancestry samples, but so far account for little of the inherited risk. We performed a meta-analysis of \u223c750,000 high-quality genetic markers on a combined sample of \u223c14,000 subjects of European and Asian-ancestry (phase I). The most significant findings were further tested in an extended sample of \u223c17,700 cases and controls (phase II). The results suggest novel association findings near the genes TRANK1 (LBA1), LMAN2L and PTGFR. In phase I, the most significant single nucleotide polymorphism (SNP), rs9834970 near TRANK1, was significant at the P=2.4 \u00d7 10(-11) level, with no heterogeneity. Supportive evidence for prior association findings near ANK3 and a locus on chromosome 3p21.1 was also observed. The phase II results were similar, although the heterogeneity test became significant for several SNPs. On the basis of these results and other established risk loci, we used the method developed by Park et al. to estimate the number, and the effect size distribution, of BD risk loci that could still be found by GWAS methods. We estimate that >63,000 case-control samples would be needed to identify the \u223c105\u2009BD risk loci discoverable by GWAS, and that these will together explain <6% of the inherited risk. These results support previous GWAS findings and identify three new candidate genes for BD. Further studies are needed to replicate these findings and may potentially lead to identification of functional variants. Sample size will remain a limiting factor in the discovery of common alleles associated with BD.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/mp.2011.157", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2552478", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2726130", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2726192", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1115540", 
            "issn": [
              "1359-4184", 
              "1476-5578"
            ], 
            "name": "Molecular Psychiatry", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "18"
          }
        ], 
        "name": "Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder", 
        "pagination": "195", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "05b8088d7378e54e675dbc1a9e6e976b02d6b8b6200d6f88890c19e71508295c"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22182935"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9607835"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/mp.2011.157"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1001200421"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/mp.2011.157", 
          "https://app.dimensions.ai/details/publication/pub.1001200421"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:00", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000435.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/mp2011157"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/mp.2011.157'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/mp.2011.157'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/mp.2011.157'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/mp.2011.157'


     

    This table displays all metadata directly associated to this object as RDF triples.

    513 TRIPLES      21 PREDICATES      114 URIs      45 LITERALS      33 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/mp.2011.157 schema:about N0c33905dab6c490fb777b43a71a34e19
    2 N166cbfe6f41b496480d081b8b9b7d00c
    3 N20756c3eb7be44ad93bf08fdd1492a35
    4 N2e4e430418fe4f1cb3f8b1de1a73a499
    5 N2ec3671bebac4ea6b8b56093c2ebb13b
    6 N3b0291e2fa644222a75786bfdae36cef
    7 N41bf70c33fc84f35befd1ed453727fc7
    8 N54fcf76c96704c0489fde256ebdb64ae
    9 N5d7f1c1dbb8f480393b6c9d6ddaf9081
    10 N7216e948d7394397b1077850ab3659de
    11 N78f597674e9f459b831a977bdd616cf6
    12 N854586b0bb8f4a148c06d020f80ccf28
    13 N9c18e44271824ea7a698628de9e37990
    14 N9d3624139e874e2bab7136470fe19bde
    15 Na677f2dfe1074716a881ac05e97821e1
    16 Na70f9f0b3d6a4bff9d5cbece3e10091e
    17 Nab04b1487a4f42f2b3c1c3b0392a2392
    18 Nae673e3b46464aedbbcf1b41030e0ad0
    19 Nb3383f51c3644ffaa3b060d653104fbf
    20 Nc88d4e5219654a6b954762c043f09546
    21 Ne34fb79e8b23492ba7379dc03caf94fb
    22 Nea44b6f278d94fa8908a30598ae461fc
    23 Nee0c80a65095449c823729dc4b27cca2
    24 Nf3e0fb87ac2b4cc88d0d6537fdeb6ecc
    25 anzsrc-for:06
    26 anzsrc-for:0604
    27 schema:author N300397896d67426e81988c226db69fdf
    28 schema:citation sg:pub.10.1007/7854_2010_74
    29 sg:pub.10.1038/mp.2008.134
    30 sg:pub.10.1038/mp.2008.148
    31 sg:pub.10.1038/mp.2009.43
    32 sg:pub.10.1038/mp.2009.49
    33 sg:pub.10.1038/mp.2010.109
    34 sg:pub.10.1038/mp.2010.43
    35 sg:pub.10.1038/nature05911
    36 sg:pub.10.1038/ng.120
    37 sg:pub.10.1038/ng.121
    38 sg:pub.10.1038/ng.201
    39 sg:pub.10.1038/ng.209
    40 sg:pub.10.1038/ng.233
    41 sg:pub.10.1038/ng.262
    42 sg:pub.10.1038/ng.523
    43 sg:pub.10.1038/ng.555
    44 sg:pub.10.1038/ng.610
    45 sg:pub.10.1038/ng.76
    46 sg:pub.10.1038/ng.943
    47 sg:pub.10.1038/ng1706
    48 sg:pub.10.1038/sj.mp.4002012
    49 sg:pub.10.1038/sj.mp.4002151
    50 sg:pub.10.1186/1471-2202-10-132
    51 https://doi.org/10.1001/archpsyc.1982.04290100031006
    52 https://doi.org/10.1001/archpsyc.1993.01820210033004
    53 https://doi.org/10.1001/archpsyc.56.2.162
    54 https://doi.org/10.1001/archpsyc.58.11.1005
    55 https://doi.org/10.1001/archpsyc.64.9.1032
    56 https://doi.org/10.1002/ajmg.c.20013
    57 https://doi.org/10.1002/gepi.20297
    58 https://doi.org/10.1002/gepi.20303
    59 https://doi.org/10.1002/gepi.20497
    60 https://doi.org/10.1016/j.ajhg.2008.03.002
    61 https://doi.org/10.1016/j.ajhg.2009.01.005
    62 https://doi.org/10.1016/j.ajhg.2011.01.017
    63 https://doi.org/10.1016/j.ajhg.2011.02.002
    64 https://doi.org/10.1016/j.ajhg.2011.04.014
    65 https://doi.org/10.1016/j.cub.2009.11.055
    66 https://doi.org/10.1016/j.jad.2007.07.001
    67 https://doi.org/10.1073/pnas.0813386106
    68 https://doi.org/10.1074/jbc.m101287200
    69 https://doi.org/10.1086/519795
    70 https://doi.org/10.1093/acprof:oso/9780195326543.001.0001
    71 https://doi.org/10.1093/aje/kwp262
    72 https://doi.org/10.1093/bioinformatics/19.1.149
    73 https://doi.org/10.1093/bioinformatics/bti042
    74 https://doi.org/10.1093/hmg/ddn288
    75 https://doi.org/10.1097/ypg.0b013e32833a2050
    76 https://doi.org/10.1101/gr.229102
    77 https://doi.org/10.1111/j.0006-341x.1999.00997.x
    78 https://doi.org/10.1111/j.1365-2753.2008.00986.x
    79 https://doi.org/10.1124/jpet.102.045419
    80 https://doi.org/10.1126/science.1142364
    81 https://doi.org/10.1126/science.1190532
    82 https://doi.org/10.1136/jmg.36.8.585
    83 https://doi.org/10.1172/jci34772
    84 https://doi.org/10.1192/bjp.130.4.330
    85 https://doi.org/10.1192/bjp.184.5.386
    86 https://doi.org/10.1371/journal.pbio.0060001
    87 https://doi.org/10.1371/journal.pgen.1000952
    88 https://doi.org/10.1371/journal.pone.0004324
    89 schema:datePublished 2013-02
    90 schema:datePublishedReg 2013-02-01
    91 schema:description Meta-analyses of bipolar disorder (BD) genome-wide association studies (GWAS) have identified several genome-wide significant signals in European-ancestry samples, but so far account for little of the inherited risk. We performed a meta-analysis of ∼750,000 high-quality genetic markers on a combined sample of ∼14,000 subjects of European and Asian-ancestry (phase I). The most significant findings were further tested in an extended sample of ∼17,700 cases and controls (phase II). The results suggest novel association findings near the genes TRANK1 (LBA1), LMAN2L and PTGFR. In phase I, the most significant single nucleotide polymorphism (SNP), rs9834970 near TRANK1, was significant at the P=2.4 × 10(-11) level, with no heterogeneity. Supportive evidence for prior association findings near ANK3 and a locus on chromosome 3p21.1 was also observed. The phase II results were similar, although the heterogeneity test became significant for several SNPs. On the basis of these results and other established risk loci, we used the method developed by Park et al. to estimate the number, and the effect size distribution, of BD risk loci that could still be found by GWAS methods. We estimate that >63,000 case-control samples would be needed to identify the ∼105 BD risk loci discoverable by GWAS, and that these will together explain <6% of the inherited risk. These results support previous GWAS findings and identify three new candidate genes for BD. Further studies are needed to replicate these findings and may potentially lead to identification of functional variants. Sample size will remain a limiting factor in the discovery of common alleles associated with BD.
    92 schema:genre research_article
    93 schema:inLanguage en
    94 schema:isAccessibleForFree true
    95 schema:isPartOf N172016c577784b1cb469e8aa1d238270
    96 Nde6cb5f7d84b46b499c5b4f10beca3bb
    97 sg:journal.1115540
    98 schema:name Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder
    99 schema:pagination 195
    100 schema:productId N013069961e0a4350aec0c7e79514f1f4
    101 N2adba873deb142a787d7e94ccdc9b126
    102 N5981fb73c4b94b2d9252c9350a9a1865
    103 N8a11205b24d44a08b981abee781fe31d
    104 N8bad9ef535d04222b9190c9a993cb281
    105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001200421
    106 https://doi.org/10.1038/mp.2011.157
    107 schema:sdDatePublished 2019-04-10T13:00
    108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    109 schema:sdPublisher Ne338e6fdfb524d0eb2d370726eebd727
    110 schema:url https://www.nature.com/articles/mp2011157
    111 sgo:license sg:explorer/license/
    112 sgo:sdDataset articles
    113 rdf:type schema:ScholarlyArticle
    114 N011c13e856ec407189789d2c6b36172b schema:familyName Wendland
    115 schema:givenName J R
    116 rdf:type schema:Person
    117 N013069961e0a4350aec0c7e79514f1f4 schema:name dimensions_id
    118 schema:value pub.1001200421
    119 rdf:type schema:PropertyValue
    120 N0179e5350c304660bba212977a23091f rdf:first Nd4f0256726704e3a9ce7034a1c965759
    121 rdf:rest N0f902f48d7264cb281f99953d9fc2fe3
    122 N07dbc1f562d644cc8c7cfd9391113851 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
    123 schema:familyName Chen
    124 schema:givenName D T
    125 rdf:type schema:Person
    126 N0c33905dab6c490fb777b43a71a34e19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name Humans
    128 rdf:type schema:DefinedTerm
    129 N0f6de5d487724576af26e7c7ff849030 schema:familyName Farmer
    130 schema:givenName A
    131 rdf:type schema:Person
    132 N0f902f48d7264cb281f99953d9fc2fe3 rdf:first sg:person.01252332263.35
    133 rdf:rest Nda931375b65946579c7005cf15095d85
    134 N166cbfe6f41b496480d081b8b9b7d00c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Genetic Predisposition to Disease
    136 rdf:type schema:DefinedTerm
    137 N172016c577784b1cb469e8aa1d238270 schema:volumeNumber 18
    138 rdf:type schema:PublicationVolume
    139 N176303b5fa93485ca8b34f7e7927a3a3 rdf:first N1ec1e78b71364376a4a0361b20db96e1
    140 rdf:rest N3cbc76b00a134004b225911c8d82d99d
    141 N1b3e5ced183b451e93b2e328f12c09a8 schema:familyName Rietschel
    142 schema:givenName M
    143 rdf:type schema:Person
    144 N1ec1e78b71364376a4a0361b20db96e1 schema:familyName Kennedy
    145 schema:givenName J L
    146 rdf:type schema:Person
    147 N20756c3eb7be44ad93bf08fdd1492a35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Dose-Response Relationship, Drug
    149 rdf:type schema:DefinedTerm
    150 N2535e170f18545d486124367ec6dca0a schema:familyName Muglia
    151 schema:givenName P
    152 rdf:type schema:Person
    153 N297a143770814c50acffddb5aa792c7f rdf:first N9e275c3e23dd4f7c8227eef22ac3d6b8
    154 rdf:rest Nfc47be6e85054108b622133491e8befb
    155 N2adba873deb142a787d7e94ccdc9b126 schema:name nlm_unique_id
    156 schema:value 9607835
    157 rdf:type schema:PropertyValue
    158 N2e4e430418fe4f1cb3f8b1de1a73a499 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name RNA, Messenger
    160 rdf:type schema:DefinedTerm
    161 N2ec3671bebac4ea6b8b56093c2ebb13b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Antidepressive Agents
    163 rdf:type schema:DefinedTerm
    164 N300397896d67426e81988c226db69fdf rdf:first N07dbc1f562d644cc8c7cfd9391113851
    165 rdf:rest N9d3d773b97f04784bf3bcd1576aa0b41
    166 N3b0291e2fa644222a75786bfdae36cef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Ankyrins
    168 rdf:type schema:DefinedTerm
    169 N3cbc76b00a134004b225911c8d82d99d rdf:first Ncbfc98062deb4788898ec0ed1f45434d
    170 rdf:rest rdf:nil
    171 N41bf70c33fc84f35befd1ed453727fc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Time Factors
    173 rdf:type schema:DefinedTerm
    174 N439827ee762c47f897b6a3ba181a49d4 schema:familyName Steele
    175 schema:givenName C J M
    176 rdf:type schema:Person
    177 N51ca9695a9764e38aa9a4f8b63513b2c rdf:first Ncd94748c4cd2466999bbf4e68e79029c
    178 rdf:rest Nc0891ac3d72540d3b43b4a2c569d7fd5
    179 N51d9aaec3287416496bfc17fbe9bab72 schema:familyName Akula
    180 schema:givenName N
    181 rdf:type schema:Person
    182 N53d8a733f30c4b53bb002e4e6e933a34 schema:familyName Vincent
    183 schema:givenName J B
    184 rdf:type schema:Person
    185 N54fcf76c96704c0489fde256ebdb64ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Meta-Analysis as Topic
    187 rdf:type schema:DefinedTerm
    188 N5981fb73c4b94b2d9252c9350a9a1865 schema:name doi
    189 schema:value 10.1038/mp.2011.157
    190 rdf:type schema:PropertyValue
    191 N5d7f1c1dbb8f480393b6c9d6ddaf9081 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Gene Expression Regulation
    193 rdf:type schema:DefinedTerm
    194 N622618e532a24f2c8cb639354f067061 rdf:first Nff640330a40546398cdd8fc280c3b84d
    195 rdf:rest N8a32162cf8684dbc990c64a9238d78d3
    196 N7216e948d7394397b1077850ab3659de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Cell Line, Transformed
    198 rdf:type schema:DefinedTerm
    199 N78f597674e9f459b831a977bdd616cf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Bipolar Disorder
    201 rdf:type schema:DefinedTerm
    202 N7eb203d6ed8746aeaab28bd119401121 rdf:first N0f6de5d487724576af26e7c7ff849030
    203 rdf:rest N297a143770814c50acffddb5aa792c7f
    204 N8335e81ea2e04dcab5a78de2fa2f9f4f rdf:first Ncf4271ee702f494d8c416a6b25c38984
    205 rdf:rest Nd70f64c47e334d6eb1a39461fd89db9d
    206 N854586b0bb8f4a148c06d020f80ccf28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Lectins
    208 rdf:type schema:DefinedTerm
    209 N8a11205b24d44a08b981abee781fe31d schema:name pubmed_id
    210 schema:value 22182935
    211 rdf:type schema:PropertyValue
    212 N8a32162cf8684dbc990c64a9238d78d3 rdf:first sg:person.01020732460.64
    213 rdf:rest N95f9783b704142ef905d816847d038e5
    214 N8bad9ef535d04222b9190c9a993cb281 schema:name readcube_id
    215 schema:value 05b8088d7378e54e675dbc1a9e6e976b02d6b8b6200d6f88890c19e71508295c
    216 rdf:type schema:PropertyValue
    217 N95f9783b704142ef905d816847d038e5 rdf:first N2535e170f18545d486124367ec6dca0a
    218 rdf:rest N9656cc40a9764a76a58c746a6135924e
    219 N9656cc40a9764a76a58c746a6135924e rdf:first Ne5e05d9a809c46038448ffbf0c386010
    220 rdf:rest Nc7d73a84ec4b4cb4b00d1101a9e2a997
    221 N96df419c3be643d79ee20251d266c698 rdf:first sg:person.016071142772.72
    222 rdf:rest Nea89a6e9b91d4532bf7ece7b1a34d232
    223 N9c18e44271824ea7a698628de9e37990 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    224 schema:name Membrane Transport Proteins
    225 rdf:type schema:DefinedTerm
    226 N9d3624139e874e2bab7136470fe19bde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    227 schema:name Cytokines
    228 rdf:type schema:DefinedTerm
    229 N9d3d773b97f04784bf3bcd1576aa0b41 rdf:first Nbdb8285f31f246c4a87673efa744ca70
    230 rdf:rest Nb9a1058d98d44a96b6402305ea36968d
    231 N9e275c3e23dd4f7c8227eef22ac3d6b8 schema:familyName McGuffin
    232 schema:givenName P
    233 rdf:type schema:Person
    234 Na677f2dfe1074716a881ac05e97821e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    235 schema:name Female
    236 rdf:type schema:DefinedTerm
    237 Na69da52a3dfe41ffbfb77ff42d24b193 rdf:first Nc3c5268f9afe44ffbeb21d11c7c32b8f
    238 rdf:rest N51ca9695a9764e38aa9a4f8b63513b2c
    239 Na70f9f0b3d6a4bff9d5cbece3e10091e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    240 schema:name Gene Frequency
    241 rdf:type schema:DefinedTerm
    242 Na834a70a72d34fe19fe9d9ed8bb3766d rdf:first Nf968f5520f3044248dc14c7f3b9a95af
    243 rdf:rest N0179e5350c304660bba212977a23091f
    244 Nab04b1487a4f42f2b3c1c3b0392a2392 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    245 schema:name Asian Continental Ancestry Group
    246 rdf:type schema:DefinedTerm
    247 Nae673e3b46464aedbbcf1b41030e0ad0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    248 schema:name Valproic Acid
    249 rdf:type schema:DefinedTerm
    250 Nb2d287be8c72407e949b302017670137 rdf:first sg:person.01027131353.11
    251 rdf:rest N622618e532a24f2c8cb639354f067061
    252 Nb3383f51c3644ffaa3b060d653104fbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    253 schema:name Lithium Chloride
    254 rdf:type schema:DefinedTerm
    255 Nb9a1058d98d44a96b6402305ea36968d rdf:first N51d9aaec3287416496bfc17fbe9bab72
    256 rdf:rest N8335e81ea2e04dcab5a78de2fa2f9f4f
    257 Nba7637c621ea4a30ae0a8c06342677e2 rdf:first N439827ee762c47f897b6a3ba181a49d4
    258 rdf:rest Na69da52a3dfe41ffbfb77ff42d24b193
    259 Nbdb8285f31f246c4a87673efa744ca70 schema:familyName Jiang
    260 schema:givenName X
    261 rdf:type schema:Person
    262 Nc04852a2bdba4b3aa62501d7462a8ad3 schema:familyName Chatterjee
    263 schema:givenName N
    264 rdf:type schema:Person
    265 Nc0891ac3d72540d3b43b4a2c569d7fd5 rdf:first Nc04852a2bdba4b3aa62501d7462a8ad3
    266 rdf:rest Nb2d287be8c72407e949b302017670137
    267 Nc3c5268f9afe44ffbeb21d11c7c32b8f schema:familyName Kassem
    268 schema:givenName L
    269 rdf:type schema:Person
    270 Nc7d73a84ec4b4cb4b00d1101a9e2a997 rdf:first sg:person.01271354173.03
    271 rdf:rest N96df419c3be643d79ee20251d266c698
    272 Nc88d4e5219654a6b954762c043f09546 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    273 schema:name Receptors, Prostaglandin
    274 rdf:type schema:DefinedTerm
    275 Ncbfc98062deb4788898ec0ed1f45434d schema:familyName Strauss
    276 schema:givenName J
    277 rdf:type schema:Person
    278 Ncd94748c4cd2466999bbf4e68e79029c schema:familyName Park
    279 schema:givenName J-H
    280 rdf:type schema:Person
    281 Ncf4271ee702f494d8c416a6b25c38984 schema:familyName Shugart
    282 schema:givenName Y Y
    283 rdf:type schema:Person
    284 Nd4f0256726704e3a9ce7034a1c965759 schema:familyName Hosang
    285 schema:givenName G
    286 rdf:type schema:Person
    287 Nd70f64c47e334d6eb1a39461fd89db9d rdf:first N011c13e856ec407189789d2c6b36172b
    288 rdf:rest Nba7637c621ea4a30ae0a8c06342677e2
    289 Nda931375b65946579c7005cf15095d85 rdf:first N53d8a733f30c4b53bb002e4e6e933a34
    290 rdf:rest N176303b5fa93485ca8b34f7e7927a3a3
    291 Nde6cb5f7d84b46b499c5b4f10beca3bb schema:issueNumber 2
    292 rdf:type schema:PublicationIssue
    293 Ne338e6fdfb524d0eb2d370726eebd727 schema:name Springer Nature - SN SciGraph project
    294 rdf:type schema:Organization
    295 Ne34fb79e8b23492ba7379dc03caf94fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    296 schema:name European Continental Ancestry Group
    297 rdf:type schema:DefinedTerm
    298 Ne5e05d9a809c46038448ffbf0c386010 schema:familyName Schulze
    299 schema:givenName T G
    300 rdf:type schema:Person
    301 Nea44b6f278d94fa8908a30598ae461fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    302 schema:name Polymorphism, Single Nucleotide
    303 rdf:type schema:DefinedTerm
    304 Nea89a6e9b91d4532bf7ece7b1a34d232 rdf:first N1b3e5ced183b451e93b2e328f12c09a8
    305 rdf:rest Nf2be13bba2cb44a28421c86adfeaa3e6
    306 Nee0c80a65095449c823729dc4b27cca2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    307 schema:name Genome-Wide Association Study
    308 rdf:type schema:DefinedTerm
    309 Nf2be13bba2cb44a28421c86adfeaa3e6 rdf:first sg:person.012033643424.99
    310 rdf:rest N7eb203d6ed8746aeaab28bd119401121
    311 Nf3e0fb87ac2b4cc88d0d6537fdeb6ecc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    312 schema:name Male
    313 rdf:type schema:DefinedTerm
    314 Nf968f5520f3044248dc14c7f3b9a95af schema:familyName Lewis
    315 schema:givenName C
    316 rdf:type schema:Person
    317 Nfc47be6e85054108b622133491e8befb rdf:first sg:person.01324664506.39
    318 rdf:rest Na834a70a72d34fe19fe9d9ed8bb3766d
    319 Nff640330a40546398cdd8fc280c3b84d schema:familyName Cheng
    320 schema:givenName A
    321 rdf:type schema:Person
    322 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    323 schema:name Biological Sciences
    324 rdf:type schema:DefinedTerm
    325 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    326 schema:name Genetics
    327 rdf:type schema:DefinedTerm
    328 sg:grant.2552478 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2011.157
    329 rdf:type schema:MonetaryGrant
    330 sg:grant.2726130 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2011.157
    331 rdf:type schema:MonetaryGrant
    332 sg:grant.2726192 http://pending.schema.org/fundedItem sg:pub.10.1038/mp.2011.157
    333 rdf:type schema:MonetaryGrant
    334 sg:journal.1115540 schema:issn 1359-4184
    335 1476-5578
    336 schema:name Molecular Psychiatry
    337 rdf:type schema:Periodical
    338 sg:person.01020732460.64 schema:familyName Leboyer
    339 schema:givenName M
    340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020732460.64
    341 rdf:type schema:Person
    342 sg:person.01027131353.11 schema:familyName Jamain
    343 schema:givenName S
    344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027131353.11
    345 rdf:type schema:Person
    346 sg:person.012033643424.99 schema:familyName McMahon
    347 schema:givenName F J
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012033643424.99
    349 rdf:type schema:Person
    350 sg:person.01252332263.35 schema:familyName Cohen-Woods
    351 schema:givenName S
    352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252332263.35
    353 rdf:type schema:Person
    354 sg:person.01271354173.03 schema:familyName Cichon
    355 schema:givenName S
    356 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271354173.03
    357 rdf:type schema:Person
    358 sg:person.01324664506.39 schema:familyName Craig
    359 schema:givenName I
    360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324664506.39
    361 rdf:type schema:Person
    362 sg:person.016071142772.72 schema:familyName Nöthen
    363 schema:givenName M M
    364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016071142772.72
    365 rdf:type schema:Person
    366 sg:pub.10.1007/7854_2010_74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009462365
    367 https://doi.org/10.1007/7854_2010_74
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/mp.2008.134 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021162050
    370 https://doi.org/10.1038/mp.2008.134
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1038/mp.2008.148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009055502
    373 https://doi.org/10.1038/mp.2008.148
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1038/mp.2009.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000951564
    376 https://doi.org/10.1038/mp.2009.43
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1038/mp.2009.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043020826
    379 https://doi.org/10.1038/mp.2009.49
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1038/mp.2010.109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021123995
    382 https://doi.org/10.1038/mp.2010.109
    383 rdf:type schema:CreativeWork
    384 sg:pub.10.1038/mp.2010.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008148053
    385 https://doi.org/10.1038/mp.2010.43
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1038/nature05911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004556449
    388 https://doi.org/10.1038/nature05911
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1038/ng.120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006325160
    391 https://doi.org/10.1038/ng.120
    392 rdf:type schema:CreativeWork
    393 sg:pub.10.1038/ng.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023921533
    394 https://doi.org/10.1038/ng.121
    395 rdf:type schema:CreativeWork
    396 sg:pub.10.1038/ng.201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022836479
    397 https://doi.org/10.1038/ng.201
    398 rdf:type schema:CreativeWork
    399 sg:pub.10.1038/ng.209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031924597
    400 https://doi.org/10.1038/ng.209
    401 rdf:type schema:CreativeWork
    402 sg:pub.10.1038/ng.233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048421356
    403 https://doi.org/10.1038/ng.233
    404 rdf:type schema:CreativeWork
    405 sg:pub.10.1038/ng.262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025725602
    406 https://doi.org/10.1038/ng.262
    407 rdf:type schema:CreativeWork
    408 sg:pub.10.1038/ng.523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021719447
    409 https://doi.org/10.1038/ng.523
    410 rdf:type schema:CreativeWork
    411 sg:pub.10.1038/ng.555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006886726
    412 https://doi.org/10.1038/ng.555
    413 rdf:type schema:CreativeWork
    414 sg:pub.10.1038/ng.610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025253932
    415 https://doi.org/10.1038/ng.610
    416 rdf:type schema:CreativeWork
    417 sg:pub.10.1038/ng.76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009408087
    418 https://doi.org/10.1038/ng.76
    419 rdf:type schema:CreativeWork
    420 sg:pub.10.1038/ng.943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014682139
    421 https://doi.org/10.1038/ng.943
    422 rdf:type schema:CreativeWork
    423 sg:pub.10.1038/ng1706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009205998
    424 https://doi.org/10.1038/ng1706
    425 rdf:type schema:CreativeWork
    426 sg:pub.10.1038/sj.mp.4002012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053535114
    427 https://doi.org/10.1038/sj.mp.4002012
    428 rdf:type schema:CreativeWork
    429 sg:pub.10.1038/sj.mp.4002151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037491398
    430 https://doi.org/10.1038/sj.mp.4002151
    431 rdf:type schema:CreativeWork
    432 sg:pub.10.1186/1471-2202-10-132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035094236
    433 https://doi.org/10.1186/1471-2202-10-132
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1001/archpsyc.1982.04290100031006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025127088
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1001/archpsyc.1993.01820210033004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027730822
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1001/archpsyc.56.2.162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000353584
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1001/archpsyc.58.11.1005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011149395
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1001/archpsyc.64.9.1032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027812438
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1002/ajmg.c.20013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049546644
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1002/gepi.20297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052087865
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1002/gepi.20303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008645052
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1002/gepi.20497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027811451
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1016/j.ajhg.2008.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012504018
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1016/j.ajhg.2009.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033548087
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1016/j.ajhg.2011.01.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053256066
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1016/j.ajhg.2011.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009526716
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1016/j.ajhg.2011.04.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031378484
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1016/j.cub.2009.11.055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051673317
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1016/j.jad.2007.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051597937
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1073/pnas.0813386106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050677827
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1074/jbc.m101287200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037618835
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1086/519795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061180
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1093/acprof:oso/9780195326543.001.0001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1098739860
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1093/aje/kwp262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037069664
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1093/bioinformatics/19.1.149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013784960
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1093/bioinformatics/bti042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027115436
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1093/hmg/ddn288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022365148
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1097/ypg.0b013e32833a2050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013489912
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1101/gr.229102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022792016
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1111/j.0006-341x.1999.00997.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021081768
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1111/j.1365-2753.2008.00986.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020333614
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1124/jpet.102.045419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053420370
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1126/science.1142364 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062456030
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1126/science.1190532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062462456
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1136/jmg.36.8.585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074513347
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1172/jci34772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046196569
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1192/bjp.130.4.330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064166772
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1192/bjp.184.5.386 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019566613
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1371/journal.pbio.0060001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028776993
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1371/journal.pgen.1000952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053012854
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1371/journal.pone.0004324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031304002
    510 rdf:type schema:CreativeWork
    511 https://www.grid.ac/institutes/grid.416868.5 schema:alternateName National Institute of Mental Health
    512 schema:name Human Genetics Branch, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA. chend4@mail.nih.gov
    513 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...