Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder View Full Text


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Article Info

DATE

2013-02

AUTHORS

D T Chen, X Jiang, N Akula, Y Y Shugart, J R Wendland, C J M Steele, L Kassem, J-H Park, N Chatterjee, S Jamain, A Cheng, M Leboyer, P Muglia, T G Schulze, S Cichon, M M Nöthen, M Rietschel, F J McMahon, A Farmer, P McGuffin, I Craig, C Lewis, G Hosang, S Cohen-Woods, J B Vincent, J L Kennedy, J Strauss

ABSTRACT

Meta-analyses of bipolar disorder (BD) genome-wide association studies (GWAS) have identified several genome-wide significant signals in European-ancestry samples, but so far account for little of the inherited risk. We performed a meta-analysis of ∼750,000 high-quality genetic markers on a combined sample of ∼14,000 subjects of European and Asian-ancestry (phase I). The most significant findings were further tested in an extended sample of ∼17,700 cases and controls (phase II). The results suggest novel association findings near the genes TRANK1 (LBA1), LMAN2L and PTGFR. In phase I, the most significant single nucleotide polymorphism (SNP), rs9834970 near TRANK1, was significant at the P=2.4 × 10(-11) level, with no heterogeneity. Supportive evidence for prior association findings near ANK3 and a locus on chromosome 3p21.1 was also observed. The phase II results were similar, although the heterogeneity test became significant for several SNPs. On the basis of these results and other established risk loci, we used the method developed by Park et al. to estimate the number, and the effect size distribution, of BD risk loci that could still be found by GWAS methods. We estimate that >63,000 case-control samples would be needed to identify the ∼105 BD risk loci discoverable by GWAS, and that these will together explain <6% of the inherited risk. These results support previous GWAS findings and identify three new candidate genes for BD. Further studies are needed to replicate these findings and may potentially lead to identification of functional variants. Sample size will remain a limiting factor in the discovery of common alleles associated with BD. More... »

PAGES

195

References to SciGraph publications

  • 2010-10. The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia in MOLECULAR PSYCHIATRY
  • 2011-05. Genome-wide association study of bipolar I disorder in the Han Chinese population in MOLECULAR PSYCHIATRY
  • 2008-02. Newly identified loci that influence lipid concentrations and risk of coronary artery disease in NATURE GENETICS
  • 2009-05. Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder in MOLECULAR PSYCHIATRY
  • 2009-12. Anti-depressant and anxiolytic like behaviors in PKCI/HINT1 knockout mice associated with elevated plasma corticosterone level in BMC NEUROSCIENCE
  • 2010-07. Estimation of effect size distribution from genome-wide association studies and implications for future discoveries in NATURE GENETICS
  • 2010-05. Discovery of common Asian copy number variants using integrated high-resolution array CGH and massively parallel DNA sequencing in NATURE GENETICS
  • 2008-09. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder in NATURE GENETICS
  • 2008-12. Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer in NATURE GENETICS
  • 2007-06-07. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls in NATURE
  • 2009-08. Genome-wide association study of bipolar disorder in European American and African American individuals in MOLECULAR PSYCHIATRY
  • 2008-09. Identification of loci associated with schizophrenia by genome-wide association and follow-up in NATURE GENETICS
  • 2010-02. Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1 in NATURE GENETICS
  • 2008-06. Whole-genome association study of bipolar disorder in MOLECULAR PSYCHIATRY
  • 2010-09-11. Genetics of Bipolar Disorder in BEHAVIORAL NEUROBIOLOGY OF BIPOLAR DISORDER AND ITS TREATMENT
  • 2008-10. Common variants at CD40 and other loci confer risk of rheumatoid arthritis in NATURE GENETICS
  • 2008-02. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder in MOLECULAR PSYCHIATRY
  • 2010-07. A SNAP25 promoter variant is associated with early-onset bipolar disorder and a high expression level in brain in MOLECULAR PSYCHIATRY
  • 2008-05. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes in NATURE GENETICS
  • 2008-05. Genome-wide association analysis identifies 20 loci that influence adult height in NATURE GENETICS
  • 2012-01. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned in MOLECULAR PSYCHIATRY
  • 2006-02. Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies in NATURE GENETICS
  • 2011-10. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/mp.2011.157

    DOI

    http://dx.doi.org/10.1038/mp.2011.157

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001200421

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22182935


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