The neurobiological properties of Tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation View Full Text


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Article Info

DATE

2009-08-25

AUTHORS

Bruce S. McEwen, Sumantra Chattarji, David M. Diamond, Thérèse M. Jay, Lawrence P. Reagan, Per Svenningsson, Eberhard Fuchs

ABSTRACT

Tianeptine is a clinically used antidepressant that has drawn much attention, because this compound challenges traditional monoaminergic hypotheses of depression. It is now acknowledged that the antidepressant actions of tianeptine, together with its remarkable clinical tolerance, can be attributed to its particular neurobiological properties. The involvement of glutamate in the mechanism of action of the antidepressant tianeptine is consistent with a well-developed preclinical literature demonstrating the key function of glutamate in the mechanism of altered neuroplasticity that underlies the symptoms of depression. This article reviews the latest evidence on tianeptine's mechanism of action with a focus on the glutamatergic system, which could provide a key pathway for its antidepressant action. Converging lines of evidences demonstrate actions of tianeptine on the glutamatergic system, and therefore offer new insights into how tianeptine may be useful in the treatment of depressive disorders. More... »

PAGES

237-249

References to SciGraph publications

  • 2001-03. Tianeptine in CNS DRUGS
  • 2006-02-08. Genetic Inactivation of the NMDA Receptor NR2A Subunit has Anxiolytic- and Antidepressant-Like Effects in Mice in NEUROPSYCHOPHARMACOLOGY
  • 1995-02. Effect of prolonged administration of tianeptine on 5-HT neurotransmission: an electrophysiological study in the rat hippocampus and dorsal raphe in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1987-11. Tianeptine, a selective enhancer of serotonin uptake in rat brain in NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY
  • 1990-10. Action of tianeptine on focalization of attention in cat in PSYCHOPHARMACOLOGY
  • 2001-02. Chronic treatment with the atypical antidepressant tianeptine attenuates sickness behavior induced by peripheral but not central lipopolysaccharide and interleukin-1β in the rat in PSYCHOPHARMACOLOGY
  • 1991-05. Effects of tianeptine on stress-induced behavioural deficits and 5-HT dependent behaviour in PSYCHOPHARMACOLOGY
  • 2001-04. Effects of tianeptine and mianserin on car driving skills in PSYCHOPHARMACOLOGY
  • 2002-01. Efficacy and Safety of Tianeptine in Major Depression in CNS DRUGS
  • 2008-01. Neurobiological and Clinical Effects of the Antidepressant Tianeptine in CNS DRUGS
  • 1995-03. Tianeptine in DRUGS
  • 2007-09-12. Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms in NEUROPSYCHOPHARMACOLOGY
  • 2005-03-08. Neurobiology of mood, anxiety, and emotions as revealed by studies of a unique antidepressant: tianeptine in MOLECULAR PSYCHIATRY
  • 2003-06. Enhancement of Antidepressant Potency by a Potentiator of AMPA Receptors in CELLULAR AND MOLECULAR NEUROBIOLOGY
  • 1998-06. Chronic administration of imipramine and citalopram alters the expression of NMDA receptor subunit mRNAs in mouse brain in JOURNAL OF MOLECULAR NEUROSCIENCE
  • Journal

    TITLE

    Molecular Psychiatry

    ISSUE

    3

    VOLUME

    15

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/mp.2009.80

    DOI

    http://dx.doi.org/10.1038/mp.2009.80

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19704408


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    35 schema:description Tianeptine is a clinically used antidepressant that has drawn much attention, because this compound challenges traditional monoaminergic hypotheses of depression. It is now acknowledged that the antidepressant actions of tianeptine, together with its remarkable clinical tolerance, can be attributed to its particular neurobiological properties. The involvement of glutamate in the mechanism of action of the antidepressant tianeptine is consistent with a well-developed preclinical literature demonstrating the key function of glutamate in the mechanism of altered neuroplasticity that underlies the symptoms of depression. This article reviews the latest evidence on tianeptine's mechanism of action with a focus on the glutamatergic system, which could provide a key pathway for its antidepressant action. Converging lines of evidences demonstrate actions of tianeptine on the glutamatergic system, and therefore offer new insights into how tianeptine may be useful in the treatment of depressive disorders.
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