Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-05

AUTHORS

Bijan Haghighi, Bruce R Smoller, Philip E LeBoit, Roger A Warnke, Christian A Sander, S Kohler

ABSTRACT

Pagetoid reticulosis (PR), also known as Woringer-Kolopp disease, is a form of cutaneous T-cell lymphoma that demonstrates striking epidermotropism on histologic examination. We present the histologic, immunologic, and molecular findings for seven patients who had PR. The patients ranged in age from 33 to 67 years. All patients presented with one or several thick plaques involving the distal extremities except for one patient, who presented with a tongue lesion. Immunohistochemical staining of the atypical lymphoid cells demonstrated a T-cell phenotype in all cases. In one of four frozen cases, the neoplastic cells were of T-helper cell phenotype (CD4 positive). Four of seven cases demonstrated a T-cytotoxic/suppressor cell phenotype (CD8 positive). The T-cell subset for the remaining two cases could not be determined. CD30 positivity and a high growth fraction as indicated by staining with Ki-67 were seen in three of seven and three of four cases, respectively. Genotypic analysis performed on three of our cases revealed T-cell receptor (gamma and/or beta) rearrangement, indicating a clonal proliferation. The clinical follow-up ranged from 15 months to 13 years. Four of seven patients are alive and free of disease after treatment with excision or local irradiation. One patient relapsed twice after treatment with radiation and photochemotherapy with 8-methoxypsoralen and UVA and was then lost to follow-up. The lesions of another patient resolved spontaneously but recurred at the same and in an additional site 5 years later. One patient recurred after electron beam therapy. The recurrent lesion improved with radiation therapy and local wound care but never resolved completely. The patient died of unrelated causes. Our findings suggest that PR is a distinct clinicopathologic entity, separate from unilesional mycosis fungoides, demonstrating a slow disease course. The disease is a clonal cutaneous T-cell lymphoma with relatively consistent clinical and histopathologic findings but a heterogeneous immunophenotypic profile. More... »

PAGES

3880088

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.3880088

DOI

http://dx.doi.org/10.1038/modpathol.3880088

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028536357

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10824921


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Rearrangement, T-Lymphocyte", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, T-Cell Receptor beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, T-Cell Receptor gamma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunophenotyping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoma, T-Cell, Cutaneous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Stanford Medicine", 
          "id": "https://www.grid.ac/institutes/grid.240952.8", 
          "name": [
            "Department of Pathology, Stanford University Medical Center, Stanford, California", 
            "Department of Dermatology, Stanford University Medical Center, Stanford, California"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haghighi", 
        "givenName": "Bijan", 
        "id": "sg:person.01005041574.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005041574.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arkansas for Medical Sciences", 
          "id": "https://www.grid.ac/institutes/grid.241054.6", 
          "name": [
            "Departments of Pathology and Dermatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smoller", 
        "givenName": "Bruce R", 
        "id": "sg:person.0640471313.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640471313.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Departments of Pathology and Dermatology, University of California, San Francisco, Medical Center, San Francisco, California"
          ], 
          "type": "Organization"
        }, 
        "familyName": "LeBoit", 
        "givenName": "Philip E", 
        "id": "sg:person.01005052336.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005052336.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford Medicine", 
          "id": "https://www.grid.ac/institutes/grid.240952.8", 
          "name": [
            "Department of Pathology, Stanford University Medical Center, Stanford, California"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Warnke", 
        "givenName": "Roger A", 
        "id": "sg:person.0751135564.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751135564.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludwig Maximilian University of Munich", 
          "id": "https://www.grid.ac/institutes/grid.5252.0", 
          "name": [
            "Department of Dermatology, Ludwig-Maximilians-University (CAS), Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sander", 
        "givenName": "Christian A", 
        "id": "sg:person.01137274403.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137274403.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford Medicine", 
          "id": "https://www.grid.ac/institutes/grid.240952.8", 
          "name": [
            "Department of Pathology, Stanford University Medical Center, Stanford, California", 
            "Department of Dermatology, Stanford University Medical Center, Stanford, California"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kohler", 
        "givenName": "S", 
        "id": "sg:person.01177235173.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177235173.93"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0190-9622(86)70107-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000357258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-199410000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002263138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-199410000-00017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002263138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.1992.01680140106013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002434267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.1991.tb14747.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006545275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199407000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013866141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199407000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013866141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199407000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013866141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0190-9622(83)80011-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013915778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcp/85.4.490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014415263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.1995.01690150089018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016229083"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199206000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017132753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199206000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017132753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199206000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017132753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0190-9622(89)70008-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020589728"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.1984.tb04053.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024562200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.1995.01690210082013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029716466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0560.1981.tb00984.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033633330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.1989.01670150092016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037600517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0190-9622(94)70037-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038505037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.1984.01650370082014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041526490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcp/95.2.188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041656019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.1987.tb05792.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041688322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.1996.03890280134021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042088730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198801213180307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043361078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.1984.tb07317.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044334597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.1984.01650440075023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045897864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.1980.tb06584.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046235308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0190-9622(84)80507-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050464327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0560.1995.tb00733.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052212876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-198304000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053116098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-198304000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053116098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.120.8.1045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054096223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.125.3.402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054097759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.128.4.526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054098721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.131.3.325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054099542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archderm.131.9.1052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054099699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-199704000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060111567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-199704000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060111567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-199704000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060111567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-199806000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060111880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-199806000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060111880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000372-199806000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060111880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199609000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078831806", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079048802", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080008704", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080535120", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081619267", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082989296", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2000-05", 
    "datePublishedReg": "2000-05-01", 
    "description": "Pagetoid reticulosis (PR), also known as Woringer-Kolopp disease, is a form of cutaneous T-cell lymphoma that demonstrates striking epidermotropism on histologic examination. We present the histologic, immunologic, and molecular findings for seven patients who had PR. The patients ranged in age from 33 to 67 years. All patients presented with one or several thick plaques involving the distal extremities except for one patient, who presented with a tongue lesion. Immunohistochemical staining of the atypical lymphoid cells demonstrated a T-cell phenotype in all cases. In one of four frozen cases, the neoplastic cells were of T-helper cell phenotype (CD4 positive). Four of seven cases demonstrated a T-cytotoxic/suppressor cell phenotype (CD8 positive). The T-cell subset for the remaining two cases could not be determined. CD30 positivity and a high growth fraction as indicated by staining with Ki-67 were seen in three of seven and three of four cases, respectively. Genotypic analysis performed on three of our cases revealed T-cell receptor (gamma and/or beta) rearrangement, indicating a clonal proliferation. The clinical follow-up ranged from 15 months to 13 years. Four of seven patients are alive and free of disease after treatment with excision or local irradiation. One patient relapsed twice after treatment with radiation and photochemotherapy with 8-methoxypsoralen and UVA and was then lost to follow-up. The lesions of another patient resolved spontaneously but recurred at the same and in an additional site 5 years later. One patient recurred after electron beam therapy. The recurrent lesion improved with radiation therapy and local wound care but never resolved completely. The patient died of unrelated causes. Our findings suggest that PR is a distinct clinicopathologic entity, separate from unilesional mycosis fungoides, demonstrating a slow disease course. The disease is a clonal cutaneous T-cell lymphoma with relatively consistent clinical and histopathologic findings but a heterogeneous immunophenotypic profile.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/modpathol.3880088", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1098208", 
        "issn": [
          "0893-3952", 
          "1530-0285"
        ], 
        "name": "Modern Pathology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "name": "Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study", 
    "pagination": "3880088", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "87f0466c3022ddebc8d6006aad434a27cc3b725a1fb445b3f27e86c5597d6082"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10824921"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8806605"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/modpathol.3880088"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028536357"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/modpathol.3880088", 
      "https://app.dimensions.ai/details/publication/pub.1028536357"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87088_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/3880088"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.3880088'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.3880088'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.3880088'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.3880088'


 

This table displays all metadata directly associated to this object as RDF triples.

292 TRIPLES      21 PREDICATES      85 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/modpathol.3880088 schema:about N00e3669d97b345f586d30f99d2a55c10
2 N04c9b14439a0414b9e84f3467f637e6a
3 N08aca67cf72f48c8a11afe0caeffcc0f
4 N0f96cebeb8e0498da60198033eef170e
5 N21db8d1f20c64a36a9dc81c04bad7a09
6 N3905a6c67ef74f73acc7e715ccb841ee
7 N3acc2275bd774dfcac9c41b579d20da9
8 N3da74534b39b4e438e925e2e3ad915aa
9 N45b5f65ccfb1404482317c4e33ea4071
10 N5d0c33ff17024650a2779fe255a8ae4f
11 Na29c4fce00144aeda6d5bd7828be57e7
12 Na678104a60044947a0380bc89cede0c3
13 Nb8ff7aad9f4e4a06b6e472236245f83b
14 Nca7fd410122243e0bb4560940062f711
15 Ned2060a3ee654f7db0bbfc46b159a4b4
16 Nf1e7f57e1dcb463a835aab3949f5b92b
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author Nf11cc5786e914550890813d73c6ddf5b
20 schema:citation https://app.dimensions.ai/details/publication/pub.1078831806
21 https://app.dimensions.ai/details/publication/pub.1079048802
22 https://app.dimensions.ai/details/publication/pub.1080008704
23 https://app.dimensions.ai/details/publication/pub.1080535120
24 https://app.dimensions.ai/details/publication/pub.1081619267
25 https://app.dimensions.ai/details/publication/pub.1082989296
26 https://doi.org/10.1001/archderm.120.8.1045
27 https://doi.org/10.1001/archderm.125.3.402
28 https://doi.org/10.1001/archderm.128.4.526
29 https://doi.org/10.1001/archderm.131.3.325
30 https://doi.org/10.1001/archderm.131.9.1052
31 https://doi.org/10.1001/archderm.1984.01650370082014
32 https://doi.org/10.1001/archderm.1984.01650440075023
33 https://doi.org/10.1001/archderm.1989.01670150092016
34 https://doi.org/10.1001/archderm.1992.01680140106013
35 https://doi.org/10.1001/archderm.1995.01690150089018
36 https://doi.org/10.1001/archderm.1995.01690210082013
37 https://doi.org/10.1001/archderm.1996.03890280134021
38 https://doi.org/10.1016/s0190-9622(83)80011-5
39 https://doi.org/10.1016/s0190-9622(84)80507-1
40 https://doi.org/10.1016/s0190-9622(86)70107-2
41 https://doi.org/10.1016/s0190-9622(89)70008-6
42 https://doi.org/10.1016/s0190-9622(94)70037-0
43 https://doi.org/10.1056/nejm198801213180307
44 https://doi.org/10.1093/ajcp/85.4.490
45 https://doi.org/10.1093/ajcp/95.2.188
46 https://doi.org/10.1097/00000372-198304000-00013
47 https://doi.org/10.1097/00000372-199410000-00017
48 https://doi.org/10.1097/00000372-199704000-00003
49 https://doi.org/10.1097/00000372-199806000-00009
50 https://doi.org/10.1097/00000478-199206000-00002
51 https://doi.org/10.1097/00000478-199407000-00001
52 https://doi.org/10.1097/00000478-199609000-00013
53 https://doi.org/10.1111/j.1365-2133.1980.tb06584.x
54 https://doi.org/10.1111/j.1365-2133.1984.tb04053.x
55 https://doi.org/10.1111/j.1365-2133.1984.tb07317.x
56 https://doi.org/10.1111/j.1365-2133.1987.tb05792.x
57 https://doi.org/10.1111/j.1365-2133.1991.tb14747.x
58 https://doi.org/10.1111/j.1600-0560.1981.tb00984.x
59 https://doi.org/10.1111/j.1600-0560.1995.tb00733.x
60 schema:datePublished 2000-05
61 schema:datePublishedReg 2000-05-01
62 schema:description Pagetoid reticulosis (PR), also known as Woringer-Kolopp disease, is a form of cutaneous T-cell lymphoma that demonstrates striking epidermotropism on histologic examination. We present the histologic, immunologic, and molecular findings for seven patients who had PR. The patients ranged in age from 33 to 67 years. All patients presented with one or several thick plaques involving the distal extremities except for one patient, who presented with a tongue lesion. Immunohistochemical staining of the atypical lymphoid cells demonstrated a T-cell phenotype in all cases. In one of four frozen cases, the neoplastic cells were of T-helper cell phenotype (CD4 positive). Four of seven cases demonstrated a T-cytotoxic/suppressor cell phenotype (CD8 positive). The T-cell subset for the remaining two cases could not be determined. CD30 positivity and a high growth fraction as indicated by staining with Ki-67 were seen in three of seven and three of four cases, respectively. Genotypic analysis performed on three of our cases revealed T-cell receptor (gamma and/or beta) rearrangement, indicating a clonal proliferation. The clinical follow-up ranged from 15 months to 13 years. Four of seven patients are alive and free of disease after treatment with excision or local irradiation. One patient relapsed twice after treatment with radiation and photochemotherapy with 8-methoxypsoralen and UVA and was then lost to follow-up. The lesions of another patient resolved spontaneously but recurred at the same and in an additional site 5 years later. One patient recurred after electron beam therapy. The recurrent lesion improved with radiation therapy and local wound care but never resolved completely. The patient died of unrelated causes. Our findings suggest that PR is a distinct clinicopathologic entity, separate from unilesional mycosis fungoides, demonstrating a slow disease course. The disease is a clonal cutaneous T-cell lymphoma with relatively consistent clinical and histopathologic findings but a heterogeneous immunophenotypic profile.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree true
66 schema:isPartOf N70b0628575e749ae9961e4144b371696
67 Nfb2c95676e2246218453c16531d47eee
68 sg:journal.1098208
69 schema:name Pagetoid Reticulosis (Woringer-Kolopp Disease): An Immunophenotypic, Molecular, and Clinicopathologic Study
70 schema:pagination 3880088
71 schema:productId N04fbd6dc9dee4834a5beff69d3aa64de
72 N18377ae1e6584bf997a5f51d3ee1b357
73 N38e352d026e044dd95bfdcefaa49360a
74 N70074bb450094d818bfd9e45acaf241f
75 Ndf83d759122e4a03b33c529b5bcc27ac
76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028536357
77 https://doi.org/10.1038/modpathol.3880088
78 schema:sdDatePublished 2019-04-11T12:22
79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
80 schema:sdPublisher N64eca51c28134d0cb7f93112c8650362
81 schema:url http://www.nature.com/articles/3880088
82 sgo:license sg:explorer/license/
83 sgo:sdDataset articles
84 rdf:type schema:ScholarlyArticle
85 N00e3669d97b345f586d30f99d2a55c10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Genes, T-Cell Receptor gamma
87 rdf:type schema:DefinedTerm
88 N04c9b14439a0414b9e84f3467f637e6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Adult
90 rdf:type schema:DefinedTerm
91 N04fbd6dc9dee4834a5beff69d3aa64de schema:name doi
92 schema:value 10.1038/modpathol.3880088
93 rdf:type schema:PropertyValue
94 N08aca67cf72f48c8a11afe0caeffcc0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Humans
96 rdf:type schema:DefinedTerm
97 N0f96cebeb8e0498da60198033eef170e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Lymphoma, T-Cell, Cutaneous
99 rdf:type schema:DefinedTerm
100 N18377ae1e6584bf997a5f51d3ee1b357 schema:name dimensions_id
101 schema:value pub.1028536357
102 rdf:type schema:PropertyValue
103 N21db8d1f20c64a36a9dc81c04bad7a09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Antigens, CD
105 rdf:type schema:DefinedTerm
106 N38e352d026e044dd95bfdcefaa49360a schema:name nlm_unique_id
107 schema:value 8806605
108 rdf:type schema:PropertyValue
109 N3905a6c67ef74f73acc7e715ccb841ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Lymphatic Diseases
111 rdf:type schema:DefinedTerm
112 N3acc2275bd774dfcac9c41b579d20da9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Genotype
114 rdf:type schema:DefinedTerm
115 N3da74534b39b4e438e925e2e3ad915aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Immunophenotyping
117 rdf:type schema:DefinedTerm
118 N451842a596c84f59b4e40510897b061d rdf:first sg:person.01005052336.82
119 rdf:rest Nb0fb6542647f41f987ed78f066a3bc3c
120 N45b5f65ccfb1404482317c4e33ea4071 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Female
122 rdf:type schema:DefinedTerm
123 N5d0c33ff17024650a2779fe255a8ae4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Skin Neoplasms
125 rdf:type schema:DefinedTerm
126 N5fdee959e83d432880bdc6ee8ec62926 rdf:first sg:person.01177235173.93
127 rdf:rest rdf:nil
128 N64eca51c28134d0cb7f93112c8650362 schema:name Springer Nature - SN SciGraph project
129 rdf:type schema:Organization
130 N70074bb450094d818bfd9e45acaf241f schema:name readcube_id
131 schema:value 87f0466c3022ddebc8d6006aad434a27cc3b725a1fb445b3f27e86c5597d6082
132 rdf:type schema:PropertyValue
133 N70b0628575e749ae9961e4144b371696 schema:volumeNumber 13
134 rdf:type schema:PublicationVolume
135 Na29c4fce00144aeda6d5bd7828be57e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Middle Aged
137 rdf:type schema:DefinedTerm
138 Na678104a60044947a0380bc89cede0c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Gene Rearrangement, T-Lymphocyte
140 rdf:type schema:DefinedTerm
141 Nb0fb6542647f41f987ed78f066a3bc3c rdf:first sg:person.0751135564.89
142 rdf:rest Nf2a237dfe0e44cdfb4e7492a4d8d3ed6
143 Nb8ff7aad9f4e4a06b6e472236245f83b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Male
145 rdf:type schema:DefinedTerm
146 Nbb23cc80135e4fdfb9e6194b753857fe rdf:first sg:person.0640471313.99
147 rdf:rest N451842a596c84f59b4e40510897b061d
148 Nca7fd410122243e0bb4560940062f711 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Aged
150 rdf:type schema:DefinedTerm
151 Ndf83d759122e4a03b33c529b5bcc27ac schema:name pubmed_id
152 schema:value 10824921
153 rdf:type schema:PropertyValue
154 Ned2060a3ee654f7db0bbfc46b159a4b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Immunohistochemistry
156 rdf:type schema:DefinedTerm
157 Nf11cc5786e914550890813d73c6ddf5b rdf:first sg:person.01005041574.86
158 rdf:rest Nbb23cc80135e4fdfb9e6194b753857fe
159 Nf1e7f57e1dcb463a835aab3949f5b92b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Genes, T-Cell Receptor beta
161 rdf:type schema:DefinedTerm
162 Nf2a237dfe0e44cdfb4e7492a4d8d3ed6 rdf:first sg:person.01137274403.75
163 rdf:rest N5fdee959e83d432880bdc6ee8ec62926
164 Nfb2c95676e2246218453c16531d47eee schema:issueNumber 5
165 rdf:type schema:PublicationIssue
166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
167 schema:name Medical and Health Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
170 schema:name Oncology and Carcinogenesis
171 rdf:type schema:DefinedTerm
172 sg:journal.1098208 schema:issn 0893-3952
173 1530-0285
174 schema:name Modern Pathology
175 rdf:type schema:Periodical
176 sg:person.01005041574.86 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
177 schema:familyName Haghighi
178 schema:givenName Bijan
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005041574.86
180 rdf:type schema:Person
181 sg:person.01005052336.82 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
182 schema:familyName LeBoit
183 schema:givenName Philip E
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005052336.82
185 rdf:type schema:Person
186 sg:person.01137274403.75 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
187 schema:familyName Sander
188 schema:givenName Christian A
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137274403.75
190 rdf:type schema:Person
191 sg:person.01177235173.93 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
192 schema:familyName Kohler
193 schema:givenName S
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177235173.93
195 rdf:type schema:Person
196 sg:person.0640471313.99 schema:affiliation https://www.grid.ac/institutes/grid.241054.6
197 schema:familyName Smoller
198 schema:givenName Bruce R
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640471313.99
200 rdf:type schema:Person
201 sg:person.0751135564.89 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
202 schema:familyName Warnke
203 schema:givenName Roger A
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751135564.89
205 rdf:type schema:Person
206 https://app.dimensions.ai/details/publication/pub.1078831806 schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1079048802 schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1080008704 schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1080535120 schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1081619267 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1082989296 schema:CreativeWork
212 https://doi.org/10.1001/archderm.120.8.1045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054096223
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1001/archderm.125.3.402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054097759
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1001/archderm.128.4.526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054098721
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1001/archderm.131.3.325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054099542
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1001/archderm.131.9.1052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054099699
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1001/archderm.1984.01650370082014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041526490
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1001/archderm.1984.01650440075023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045897864
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1001/archderm.1989.01670150092016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037600517
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1001/archderm.1992.01680140106013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002434267
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1001/archderm.1995.01690150089018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016229083
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1001/archderm.1995.01690210082013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029716466
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1001/archderm.1996.03890280134021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042088730
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0190-9622(83)80011-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013915778
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/s0190-9622(84)80507-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050464327
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0190-9622(86)70107-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000357258
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s0190-9622(89)70008-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020589728
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/s0190-9622(94)70037-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038505037
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1056/nejm198801213180307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043361078
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1093/ajcp/85.4.490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014415263
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1093/ajcp/95.2.188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041656019
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1097/00000372-198304000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053116098
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1097/00000372-199410000-00017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002263138
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1097/00000372-199704000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060111567
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1097/00000372-199806000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060111880
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1097/00000478-199206000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017132753
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1097/00000478-199407000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013866141
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1097/00000478-199609000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060122146
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1111/j.1365-2133.1980.tb06584.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046235308
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1111/j.1365-2133.1984.tb04053.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024562200
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1111/j.1365-2133.1984.tb07317.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044334597
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1111/j.1365-2133.1987.tb05792.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041688322
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1111/j.1365-2133.1991.tb14747.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006545275
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1111/j.1600-0560.1981.tb00984.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033633330
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1111/j.1600-0560.1995.tb00733.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052212876
279 rdf:type schema:CreativeWork
280 https://www.grid.ac/institutes/grid.240952.8 schema:alternateName Stanford Medicine
281 schema:name Department of Dermatology, Stanford University Medical Center, Stanford, California
282 Department of Pathology, Stanford University Medical Center, Stanford, California
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.241054.6 schema:alternateName University of Arkansas for Medical Sciences
285 schema:name Departments of Pathology and Dermatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas
286 rdf:type schema:Organization
287 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
288 schema:name Departments of Pathology and Dermatology, University of California, San Francisco, Medical Center, San Francisco, California
289 rdf:type schema:Organization
290 https://www.grid.ac/institutes/grid.5252.0 schema:alternateName Ludwig Maximilian University of Munich
291 schema:name Department of Dermatology, Ludwig-Maximilians-University (CAS), Munich, Germany
292 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...