Expression profiles associated with aggressive behavior in Merkel cell carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-01

AUTHORS

María-Teresa Fernández-Figueras, Lluís Puig, Eva Musulén, Montserrat Gilaberte, Enrique Lerma, Sergio Serrano, Carlos Ferrándiz, Aurelio Ariza

ABSTRACT

Primary neuroendocrine carcinoma of the skin, or Merkel cell carcinoma, is the most aggressive cutaneous neoplasm. In spite of its similarities to small cell carcinomas from other locations, Merkel cell carcinoma shows many peculiarities probably related to its epidermal origin and the etiologic role of UV radiation. We have immunohistochemically investigated 43 markers on a tissue microarray in which 31 surgically resected Merkel cell carcinomas were represented. Of these, 15 patients remained free of disease after removal, whereas 16 developed metastases. Immunoreactivity was scored according to staining intensity and the percentage of positive cells. We found statistically significant correlations between metastatic tumor spread and overexpression of matrix metalloproteinase (MMP) 7, MMP10/2, tissue inhibitor of metalloproteinase 3, vascular endothelial growth factor (VEGF), P38, stromal NF-kappaB, and synaptophysin. Also detected were statistically significant correlations between the expression levels of MMP7 and VEGF, MMP7 and P21, MMP7 and P38, MMP10/2 and VEGF, P38 and synaptophysin, P38 and P53, and P21 and stromal NF-kappaB. These findings may be helpful in predicting the clinical course of Merkel cell carcinoma and are potentially useful for the development of targeted therapies. More... »

PAGES

3800717

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/modpathol.3800717

    DOI

    http://dx.doi.org/10.1038/modpathol.3800717

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040566359

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17115023


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