Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-10

AUTHORS

Zhihong Zhang, Daniel G Rosen, Jorge L Yao, Jiaoti Huang, Jinsong Liu

ABSTRACT

Prostate carcinoma is a hormonally driven age-related neoplasm. Cellular senescence is an age-related process where cells remain metabolically active but in a growth-arrested state at the G1 phase. p14(ARF), p15(INK4b), and p16(INK4a), which are known to regulate G1 cell cycle arrest, and the tumor necrosis factor receptor superfamily member decoy receptor 2 (DCR2), have been recently identified as senescence markers. The purpose of this study was to characterize and compare the expression of p14(ARF), p15(INK4b), p16(INK4a), and DCR2 in tissue microarrays containing cases of normal prostate, nodular hyperplasia, prostate intraepithelial neoplasia (PIN), and malignant prostate cancer tissue. We performed immunohistochemical staining for p14(ARF), p15(INK4b), p16(INK4a), and DCR2 in tissue microarray blocks containing 41 cores of normal prostate, 65 cores of nodular hyperplasia, 21 cores of PIN, 69 cores of low-grade prostate carcinoma, and 42 cores of high-grade prostate carcinoma, derived from 80 cases of prostatectomy with adenocarcinomas. We detected positive staining of p16(INK4a) in 19% of the PIN, 25% of the low-grade carcinoma, and 43% of the high-grade carcinoma specimens but none in the normal prostate and nodular hyperplasia specimens. Expression of p14(ARF) revealed very high levels of expression in normal tissues (83%), nodular hyperplasia (88%), PIN (89%), and cancer cells (100%). P15(INK4b) and DCR2 were found positive in 81 and 33% normal, 46 and 10% nodular hyperplasia, 74 and 36% PIN tissues, 87 and 89% low-grade carcinomas, and 100 and 93% high-grade carcinomas. There is an increased protein expression of senescence-associated molecular markers, indicating that cellular senescence might play a role in prostate carcinoma. Because p16(INK4a)-positive cells were detected only in premalignant lesions and carcinomas but not in normal or benign tissues, p16(INK4a) may aid in the diagnosis of PIN and prostate cancer in difficult cases. More... »

PAGES

3800655

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.3800655

DOI

http://dx.doi.org/10.1038/modpathol.3800655

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000836922

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16799475


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p15", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclin-Dependent Kinase Inhibitor p16", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Hyperplasia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Intraepithelial Neoplasia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Tumor Necrosis Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Array Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor Decoy Receptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p14ARF", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Zhihong", 
        "id": "sg:person.01064371662.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064371662.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosen", 
        "givenName": "Daniel G", 
        "id": "sg:person.01350076527.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350076527.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Rochester Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412750.5", 
          "name": [
            "Department of Pathology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yao", 
        "givenName": "Jorge L", 
        "id": "sg:person.01336702521.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336702521.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Rochester Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412750.5", 
          "name": [
            "Department of Pathology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Jiaoti", 
        "id": "sg:person.013116006617.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013116006617.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Jinsong", 
        "id": "sg:person.010300733047.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010300733047.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1205049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000658103", 
          "https://doi.org/10.1038/sj.onc.1205049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1205049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000658103", 
          "https://doi.org/10.1038/sj.onc.1205049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4827(61)90192-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001311041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-05-0939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002411870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003324113", 
          "https://doi.org/10.1038/nature03890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003324113", 
          "https://doi.org/10.1038/nature03890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03890", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003324113", 
          "https://doi.org/10.1038/nature03890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/canjclin.51.1.15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004126277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coph.2004.02.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008403210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/436642a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011583380", 
          "https://doi.org/10.1038/436642a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/436642a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011583380", 
          "https://doi.org/10.1038/436642a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80452-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021286113"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)62490-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022722239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.16.3.859", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023692474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90214-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025466811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028026000", 
          "https://doi.org/10.1038/sj.onc.1203908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028026000", 
          "https://doi.org/10.1038/sj.onc.1203908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0045(20000515)43:3<233::aid-pros10>3.0.co;2-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035697798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-4295(00)00538-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039865657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.20041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040495618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0047-6374(02)00094-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044491577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80441-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044558434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/mthe.2000.0025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044652131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/371257a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045553304", 
          "https://doi.org/10.1038/371257a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20000701)89:1<60::aid-cncr9>3.0.co;2-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046164960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.274.5293.1672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062555127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.281.5381.1305", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062562275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cbt.4.12.2183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072293617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074482013", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076951311", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082903098", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-10", 
    "datePublishedReg": "2006-10-01", 
    "description": "Prostate carcinoma is a hormonally driven age-related neoplasm. Cellular senescence is an age-related process where cells remain metabolically active but in a growth-arrested state at the G1 phase. p14(ARF), p15(INK4b), and p16(INK4a), which are known to regulate G1 cell cycle arrest, and the tumor necrosis factor receptor superfamily member decoy receptor 2 (DCR2), have been recently identified as senescence markers. The purpose of this study was to characterize and compare the expression of p14(ARF), p15(INK4b), p16(INK4a), and DCR2 in tissue microarrays containing cases of normal prostate, nodular hyperplasia, prostate intraepithelial neoplasia (PIN), and malignant prostate cancer tissue. We performed immunohistochemical staining for p14(ARF), p15(INK4b), p16(INK4a), and DCR2 in tissue microarray blocks containing 41 cores of normal prostate, 65 cores of nodular hyperplasia, 21 cores of PIN, 69 cores of low-grade prostate carcinoma, and 42 cores of high-grade prostate carcinoma, derived from 80 cases of prostatectomy with adenocarcinomas. We detected positive staining of p16(INK4a) in 19% of the PIN, 25% of the low-grade carcinoma, and 43% of the high-grade carcinoma specimens but none in the normal prostate and nodular hyperplasia specimens. Expression of p14(ARF) revealed very high levels of expression in normal tissues (83%), nodular hyperplasia (88%), PIN (89%), and cancer cells (100%). P15(INK4b) and DCR2 were found positive in 81 and 33% normal, 46 and 10% nodular hyperplasia, 74 and 36% PIN tissues, 87 and 89% low-grade carcinomas, and 100 and 93% high-grade carcinomas. There is an increased protein expression of senescence-associated molecular markers, indicating that cellular senescence might play a role in prostate carcinoma. Because p16(INK4a)-positive cells were detected only in premalignant lesions and carcinomas but not in normal or benign tissues, p16(INK4a) may aid in the diagnosis of PIN and prostate cancer in difficult cases.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/modpathol.3800655", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1098208", 
        "issn": [
          "0893-3952", 
          "1530-0285"
        ], 
        "name": "Modern Pathology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression", 
    "pagination": "3800655", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "03fc79f8b6d9b6249da7e906741895d92f74e09872d4dda90dbe7fb8d7de3673"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16799475"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8806605"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/modpathol.3800655"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000836922"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/modpathol.3800655", 
      "https://app.dimensions.ai/details/publication/pub.1000836922"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87097_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/3800655"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.3800655'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.3800655'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.3800655'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.3800655'


 

This table displays all metadata directly associated to this object as RDF triples.

244 TRIPLES      21 PREDICATES      71 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/modpathol.3800655 schema:about N1477c78fd18741dd9bc6c98bcb117284
2 N24d2907c208b4c1f8e1593fd2f9d11c7
3 N29ed688c75c544f58ab4ba0cf1df98b4
4 N311aa49fe26343938fb81c3a32cc096f
5 N36aae59d32484b7182f79df26e542215
6 N3e0ba8b629ee49e19babec1c3f929419
7 N462c8c96c0964d5f9522c22332e82260
8 N7ac779a88b4f48b0b6b700d6996eb4b4
9 N7b2cdbe1fcda4542a3ba8e5d96c9e27c
10 N8985a5b514824ca2a84d5e496f368b99
11 N96bea3dc2e2c4134bd8a8e1e47ebcb66
12 N97ebf05cd10b4373a820d11cc554384d
13 Na6825e07322447b9967732b4b6b8cdde
14 Nb9701ef96c5d45fbafea8d58f96629cb
15 Nbf32ddd0b3424eb6beeb6d7bb416fdd4
16 Nfc597e43b58a422b894d72843008b4e4
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N80f6911b6a084b5594f27fa0cf4bff95
20 schema:citation sg:pub.10.1038/371257a0
21 sg:pub.10.1038/436642a
22 sg:pub.10.1038/nature03890
23 sg:pub.10.1038/sj.onc.1203908
24 sg:pub.10.1038/sj.onc.1205049
25 https://app.dimensions.ai/details/publication/pub.1074482013
26 https://app.dimensions.ai/details/publication/pub.1076951311
27 https://app.dimensions.ai/details/publication/pub.1082903098
28 https://doi.org/10.1002/(sici)1097-0045(20000515)43:3<233::aid-pros10>3.0.co;2-s
29 https://doi.org/10.1002/1097-0142(20000701)89:1<60::aid-cncr9>3.0.co;2-3
30 https://doi.org/10.1002/ijc.20041
31 https://doi.org/10.1006/mthe.2000.0025
32 https://doi.org/10.1016/0014-4827(61)90192-6
33 https://doi.org/10.1016/0092-8674(95)90214-7
34 https://doi.org/10.1016/j.coph.2004.02.006
35 https://doi.org/10.1016/s0002-9440(10)62490-x
36 https://doi.org/10.1016/s0047-6374(02)00094-5
37 https://doi.org/10.1016/s0090-4295(00)00538-0
38 https://doi.org/10.1016/s0092-8674(00)80441-9
39 https://doi.org/10.1016/s0092-8674(00)80452-3
40 https://doi.org/10.1126/science.274.5293.1672
41 https://doi.org/10.1126/science.281.5381.1305
42 https://doi.org/10.1128/mcb.16.3.859
43 https://doi.org/10.1158/0008-5472.can-05-0939
44 https://doi.org/10.3322/canjclin.51.1.15
45 https://doi.org/10.4161/cbt.4.12.2183
46 schema:datePublished 2006-10
47 schema:datePublishedReg 2006-10-01
48 schema:description Prostate carcinoma is a hormonally driven age-related neoplasm. Cellular senescence is an age-related process where cells remain metabolically active but in a growth-arrested state at the G1 phase. p14(ARF), p15(INK4b), and p16(INK4a), which are known to regulate G1 cell cycle arrest, and the tumor necrosis factor receptor superfamily member decoy receptor 2 (DCR2), have been recently identified as senescence markers. The purpose of this study was to characterize and compare the expression of p14(ARF), p15(INK4b), p16(INK4a), and DCR2 in tissue microarrays containing cases of normal prostate, nodular hyperplasia, prostate intraepithelial neoplasia (PIN), and malignant prostate cancer tissue. We performed immunohistochemical staining for p14(ARF), p15(INK4b), p16(INK4a), and DCR2 in tissue microarray blocks containing 41 cores of normal prostate, 65 cores of nodular hyperplasia, 21 cores of PIN, 69 cores of low-grade prostate carcinoma, and 42 cores of high-grade prostate carcinoma, derived from 80 cases of prostatectomy with adenocarcinomas. We detected positive staining of p16(INK4a) in 19% of the PIN, 25% of the low-grade carcinoma, and 43% of the high-grade carcinoma specimens but none in the normal prostate and nodular hyperplasia specimens. Expression of p14(ARF) revealed very high levels of expression in normal tissues (83%), nodular hyperplasia (88%), PIN (89%), and cancer cells (100%). P15(INK4b) and DCR2 were found positive in 81 and 33% normal, 46 and 10% nodular hyperplasia, 74 and 36% PIN tissues, 87 and 89% low-grade carcinomas, and 100 and 93% high-grade carcinomas. There is an increased protein expression of senescence-associated molecular markers, indicating that cellular senescence might play a role in prostate carcinoma. Because p16(INK4a)-positive cells were detected only in premalignant lesions and carcinomas but not in normal or benign tissues, p16(INK4a) may aid in the diagnosis of PIN and prostate cancer in difficult cases.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree true
52 schema:isPartOf N7e8e11919c4d4c5c8f46e961bd87994c
53 N995e8b68ad3944ed82ae5251640cb26f
54 sg:journal.1098208
55 schema:name Expression of p14ARF, p15INK4b, p16INK4a, and DCR2 increases during prostate cancer progression
56 schema:pagination 3800655
57 schema:productId N16193f8e0f7343bb8f6a138e0da0fb7a
58 N33a7e394a2ac4d48a83bd8b14e932ebc
59 Nc7cf3a091e184cae8926d94d87ac4b0b
60 Nd6d46bf2b4104bef997574e73d6c9058
61 Ndae7130f6f5d432dac2d24ceba2f73a4
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000836922
63 https://doi.org/10.1038/modpathol.3800655
64 schema:sdDatePublished 2019-04-11T12:24
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher N29aa1f9b0dcb41c6bc22b44bf2d15fd3
67 schema:url http://www.nature.com/articles/3800655
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N1163a2b51854467cb1a2e2cd644d4e21 rdf:first sg:person.013116006617.96
72 rdf:rest N2718a7d7456242aaa64dfb2ebb9815cb
73 N1477c78fd18741dd9bc6c98bcb117284 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Cyclin-Dependent Kinase Inhibitor p16
75 rdf:type schema:DefinedTerm
76 N16193f8e0f7343bb8f6a138e0da0fb7a schema:name doi
77 schema:value 10.1038/modpathol.3800655
78 rdf:type schema:PropertyValue
79 N24d2907c208b4c1f8e1593fd2f9d11c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Tissue Array Analysis
81 rdf:type schema:DefinedTerm
82 N2718a7d7456242aaa64dfb2ebb9815cb rdf:first sg:person.010300733047.04
83 rdf:rest rdf:nil
84 N29aa1f9b0dcb41c6bc22b44bf2d15fd3 schema:name Springer Nature - SN SciGraph project
85 rdf:type schema:Organization
86 N29ed688c75c544f58ab4ba0cf1df98b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Tumor Necrosis Factor Decoy Receptors
88 rdf:type schema:DefinedTerm
89 N311aa49fe26343938fb81c3a32cc096f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Biomarkers, Tumor
91 rdf:type schema:DefinedTerm
92 N33a7e394a2ac4d48a83bd8b14e932ebc schema:name readcube_id
93 schema:value 03fc79f8b6d9b6249da7e906741895d92f74e09872d4dda90dbe7fb8d7de3673
94 rdf:type schema:PropertyValue
95 N36aae59d32484b7182f79df26e542215 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Cell Transformation, Neoplastic
97 rdf:type schema:DefinedTerm
98 N3e0ba8b629ee49e19babec1c3f929419 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Adenocarcinoma
100 rdf:type schema:DefinedTerm
101 N462c8c96c0964d5f9522c22332e82260 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Prostatic Hyperplasia
103 rdf:type schema:DefinedTerm
104 N5f68511195e642ca9c68dc0cffa393e3 rdf:first sg:person.01336702521.01
105 rdf:rest N1163a2b51854467cb1a2e2cd644d4e21
106 N7ac779a88b4f48b0b6b700d6996eb4b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Prostatic Intraepithelial Neoplasia
108 rdf:type schema:DefinedTerm
109 N7b2cdbe1fcda4542a3ba8e5d96c9e27c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Male
111 rdf:type schema:DefinedTerm
112 N7e8e11919c4d4c5c8f46e961bd87994c schema:issueNumber 10
113 rdf:type schema:PublicationIssue
114 N80f6911b6a084b5594f27fa0cf4bff95 rdf:first sg:person.01064371662.81
115 rdf:rest Nb9c401b44eee4bf387a7eedffaf91699
116 N8985a5b514824ca2a84d5e496f368b99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Receptors, Tumor Necrosis Factor
118 rdf:type schema:DefinedTerm
119 N96bea3dc2e2c4134bd8a8e1e47ebcb66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Immunohistochemistry
121 rdf:type schema:DefinedTerm
122 N97ebf05cd10b4373a820d11cc554384d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Retrospective Studies
124 rdf:type schema:DefinedTerm
125 N995e8b68ad3944ed82ae5251640cb26f schema:volumeNumber 19
126 rdf:type schema:PublicationVolume
127 Na6825e07322447b9967732b4b6b8cdde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Prostatic Neoplasms
129 rdf:type schema:DefinedTerm
130 Nb9701ef96c5d45fbafea8d58f96629cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Tumor Suppressor Protein p14ARF
132 rdf:type schema:DefinedTerm
133 Nb9c401b44eee4bf387a7eedffaf91699 rdf:first sg:person.01350076527.15
134 rdf:rest N5f68511195e642ca9c68dc0cffa393e3
135 Nbf32ddd0b3424eb6beeb6d7bb416fdd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Humans
137 rdf:type schema:DefinedTerm
138 Nc7cf3a091e184cae8926d94d87ac4b0b schema:name dimensions_id
139 schema:value pub.1000836922
140 rdf:type schema:PropertyValue
141 Nd6d46bf2b4104bef997574e73d6c9058 schema:name nlm_unique_id
142 schema:value 8806605
143 rdf:type schema:PropertyValue
144 Ndae7130f6f5d432dac2d24ceba2f73a4 schema:name pubmed_id
145 schema:value 16799475
146 rdf:type schema:PropertyValue
147 Nfc597e43b58a422b894d72843008b4e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cyclin-Dependent Kinase Inhibitor p15
149 rdf:type schema:DefinedTerm
150 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
151 schema:name Medical and Health Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
154 schema:name Oncology and Carcinogenesis
155 rdf:type schema:DefinedTerm
156 sg:journal.1098208 schema:issn 0893-3952
157 1530-0285
158 schema:name Modern Pathology
159 rdf:type schema:Periodical
160 sg:person.010300733047.04 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
161 schema:familyName Liu
162 schema:givenName Jinsong
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010300733047.04
164 rdf:type schema:Person
165 sg:person.01064371662.81 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
166 schema:familyName Zhang
167 schema:givenName Zhihong
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064371662.81
169 rdf:type schema:Person
170 sg:person.013116006617.96 schema:affiliation https://www.grid.ac/institutes/grid.412750.5
171 schema:familyName Huang
172 schema:givenName Jiaoti
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013116006617.96
174 rdf:type schema:Person
175 sg:person.01336702521.01 schema:affiliation https://www.grid.ac/institutes/grid.412750.5
176 schema:familyName Yao
177 schema:givenName Jorge L
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336702521.01
179 rdf:type schema:Person
180 sg:person.01350076527.15 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
181 schema:familyName Rosen
182 schema:givenName Daniel G
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01350076527.15
184 rdf:type schema:Person
185 sg:pub.10.1038/371257a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045553304
186 https://doi.org/10.1038/371257a0
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/436642a schema:sameAs https://app.dimensions.ai/details/publication/pub.1011583380
189 https://doi.org/10.1038/436642a
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/nature03890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003324113
192 https://doi.org/10.1038/nature03890
193 rdf:type schema:CreativeWork
194 sg:pub.10.1038/sj.onc.1203908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028026000
195 https://doi.org/10.1038/sj.onc.1203908
196 rdf:type schema:CreativeWork
197 sg:pub.10.1038/sj.onc.1205049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000658103
198 https://doi.org/10.1038/sj.onc.1205049
199 rdf:type schema:CreativeWork
200 https://app.dimensions.ai/details/publication/pub.1074482013 schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1076951311 schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1082903098 schema:CreativeWork
203 https://doi.org/10.1002/(sici)1097-0045(20000515)43:3<233::aid-pros10>3.0.co;2-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1035697798
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1002/1097-0142(20000701)89:1<60::aid-cncr9>3.0.co;2-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046164960
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1002/ijc.20041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040495618
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1006/mthe.2000.0025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044652131
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/0014-4827(61)90192-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001311041
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/0092-8674(95)90214-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025466811
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.coph.2004.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008403210
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/s0002-9440(10)62490-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022722239
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/s0047-6374(02)00094-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044491577
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/s0090-4295(00)00538-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039865657
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/s0092-8674(00)80441-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044558434
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/s0092-8674(00)80452-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021286113
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1126/science.274.5293.1672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062555127
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1126/science.281.5381.1305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062562275
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1128/mcb.16.3.859 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023692474
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1158/0008-5472.can-05-0939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002411870
234 rdf:type schema:CreativeWork
235 https://doi.org/10.3322/canjclin.51.1.15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004126277
236 rdf:type schema:CreativeWork
237 https://doi.org/10.4161/cbt.4.12.2183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072293617
238 rdf:type schema:CreativeWork
239 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
240 schema:name Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
241 rdf:type schema:Organization
242 https://www.grid.ac/institutes/grid.412750.5 schema:alternateName University of Rochester Medical Center
243 schema:name Department of Pathology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
244 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...