Variability in the expression of polycomb proteins in different normal and tumoral tissues. A pilot study using tissue microarrays View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-03-10

AUTHORS

Margarita Sánchez-Beato, Esther Sánchez, Joaquín González-Carreró, Manuel Morente, Ana Díez, Lydia Sánchez-Verde, María Carmen Martín, Juan C Cigudosa, Miguel Vidal, Miguel A Piris

ABSTRACT

In spite of the known function of polycomb group (PcG) genes in stem cell self-renewal, control of cellular proliferation and differentiation, its role in cancer pathogenesis is still poorly understood. We studied the expression by immunohistochemistry of several PcG-maintenance complex proteins (RING1, RNF2, BMI1, MEL18, HPH1 and RYBP) in nontumoral (154 samples) and tumoral (550 samples) human tissues using Tissue Microarrays. For selected genes (BMI1 and RING1) FISH analysis has been also carried out. PcG proteins had a tissue- and cell-type-specific expression pattern. Some of them were highly selectively expressed, such as HPH1, which was detected in germ cells in testis, pituitary and parathyroid glands and Langerhans islets, and RYBP, which was found in placenta, umbilical cord and thyroid gland. By contrast, RING1 was ubiquitously expressed in every normal tissue analyzed. Changes in expression associated with tumoral transformation have been found for BMI1 and RNF2, which exhibited increased expression in a large series of tumors, including gastrointestinal tumors, pituitary and parathyroid adenomas, and lymphomas, compared with their expression in normal-cell counterparts. The high level of expression of BMI1 protein observed in mantle-cell lymphomas and pituitary adenomas is associated in some cases with amplification of BMI1 locus. These findings imply that upregulation of BMI1 may constitute a malignancy marker in different types of cancer, mainly in lymphoid and endocrine tumors. RING1 was lost in a group of renal-cell carcinomas and testicular germ-cell tumors. Lastly, RYBP is anomalously expressed in Hodgkin's lymphomas and oligodendrogliomas, among others tumors. A significant finding of the study is the identification of unique PcG profiles for some tumors, such as testicular germ-cell tumors, which have high levels of HPH1 expression and loss of RING1 and/or BMI1; pituitary adenomas, which expressed every PcG protein analyzed; and clear-cell renal-cell carcinoma, which was the only tumor other than testicular germ-cell tumors that did not express RING1. More... »

PAGES

684-694

References to SciGraph publications

  • 2004-09-22. Role of histone H2A ubiquitination in Polycomb silencing in NATURE
  • 1999. Polycomb Silencing and the Maintenance of Stable Chromatin States in GENOMIC IMPRINTING
  • 2001-05-15. The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression in BRITISH JOURNAL OF CANCER
  • 2002-01. Mutation analysis of the mel-18 gene that shows decreased expression in human breast cancer cell lines in BREAST CANCER
  • 2002-10. The polycomb group protein EZH2 is involved in progression of prostate cancer in NATURE
  • 1999-12. Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation in NATURE GENETICS
  • 2001-08. General transcription factors bind promoters repressed by Polycomb group proteins in NATURE
  • 2003-10-22. Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation in NATURE
  • 2003-04-20. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells in NATURE
  • 1999-01. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus in NATURE
  • 2004-03. Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas in NATURE
  • 1998-01. Functional analysis of mouse Polycomb group genes in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2003-04-20. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells in NATURE
  • 2001-05-28. Chromatin silencing and activation by Polycomb and trithorax group proteins in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/modpathol.3800577

    DOI

    http://dx.doi.org/10.1038/modpathol.3800577

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038761761

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/16528373


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carrier Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA-Binding Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunohistochemistry", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "In Situ Hybridization, Fluorescence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intracellular Signaling Peptides and Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nuclear Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pilot Projects", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polycomb Repressive Complex 1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polycomb-Group Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Repressor Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tissue Array Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ubiquitin-Protein Ligases", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Lymphoma Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Lymphoma Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "S\u00e1nchez-Beato", 
            "givenName": "Margarita", 
            "id": "sg:person.01026644115.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026644115.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Hospital \u2018Nuestra Se\u00f1ora del Prado\u2019, Talavera de la Reina-Toledo, Spain", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Pathology, Hospital \u2018Nuestra Se\u00f1ora del Prado\u2019, Talavera de la Reina-Toledo, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "S\u00e1nchez", 
            "givenName": "Esther", 
            "id": "sg:person.01337010372.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337010372.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, \u2018Complejo Hospitalario Universitario de Vigo' (CHUVI)\u2019, Vigo-Pontevedra, Spain", 
              "id": "http://www.grid.ac/institutes/grid.6312.6", 
              "name": [
                "Department of Pathology, \u2018Complejo Hospitalario Universitario de Vigo' (CHUVI)\u2019, Vigo-Pontevedra, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gonz\u00e1lez-Carrer\u00f3", 
            "givenName": "Joaqu\u00edn", 
            "id": "sg:person.012731050144.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012731050144.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tumour Bank, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Tumour Bank, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morente", 
            "givenName": "Manuel", 
            "id": "sg:person.01034246016.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034246016.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Immunohistochemistry and Histology Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Immunohistochemistry and Histology Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "D\u00edez", 
            "givenName": "Ana", 
            "id": "sg:person.01101104646.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101104646.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Immunohistochemistry and Histology Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Immunohistochemistry and Histology Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "S\u00e1nchez-Verde", 
            "givenName": "Lydia", 
            "id": "sg:person.0760125617.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760125617.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cytogenetics Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Cytogenetics Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mart\u00edn", 
            "givenName": "Mar\u00eda Carmen", 
            "id": "sg:person.01127724556.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127724556.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cytogenetics Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Cytogenetics Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cigudosa", 
            "givenName": "Juan C", 
            "id": "sg:person.01246512175.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246512175.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Developmental and Cell Biology, Centro de Investigaciones Biol\u00f3gicas, (CSIC), Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.418281.6", 
              "name": [
                "Department of Developmental and Cell Biology, Centro de Investigaciones Biol\u00f3gicas, (CSIC), Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vidal", 
            "givenName": "Miguel", 
            "id": "sg:person.013666477457.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013666477457.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Lymphoma Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain", 
              "id": "http://www.grid.ac/institutes/grid.7719.8", 
              "name": [
                "Lymphoma Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO), Madrid, Spain"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Piris", 
            "givenName": "Miguel A", 
            "id": "sg:person.07440427070.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07440427070.11"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature01572", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045711316", 
              "https://doi.org/10.1038/nature01572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/70602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032044171", 
              "https://doi.org/10.1038/70602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35088090", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042285289", 
              "https://doi.org/10.1038/35088090"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1054/bjoc.2001.1791", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043655970", 
              "https://doi.org/10.1054/bjoc.2001.1791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013519146", 
              "https://doi.org/10.1038/nature02060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025096861", 
              "https://doi.org/10.1038/nature01075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/16476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033156851", 
              "https://doi.org/10.1038/16476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049709002", 
              "https://doi.org/10.1038/nature02985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s000180050126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047611208", 
              "https://doi.org/10.1007/s000180050126"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008729213", 
              "https://doi.org/10.1038/nature02385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02967544", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030555269", 
              "https://doi.org/10.1007/bf02967544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049860156", 
              "https://doi.org/10.1038/sj.onc.1204330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-540-69111-2_10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020661299", 
              "https://doi.org/10.1007/978-3-540-69111-2_10"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024497082", 
              "https://doi.org/10.1038/nature01587"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2006-03-10", 
        "datePublishedReg": "2006-03-10", 
        "description": "In spite of the known function of polycomb group (PcG) genes in stem cell self-renewal, control of cellular proliferation and differentiation, its role in cancer pathogenesis is still poorly understood. We studied the expression by immunohistochemistry of several PcG-maintenance complex proteins (RING1, RNF2, BMI1, MEL18, HPH1 and RYBP) in nontumoral (154 samples) and tumoral (550 samples) human tissues using Tissue Microarrays. For selected genes (BMI1 and RING1) FISH analysis has been also carried out. PcG proteins had a tissue- and cell-type-specific expression pattern. Some of them were highly selectively expressed, such as HPH1, which was detected in germ cells in testis, pituitary and parathyroid glands and Langerhans islets, and RYBP, which was found in placenta, umbilical cord and thyroid gland. By contrast, RING1 was ubiquitously expressed in every normal tissue analyzed. Changes in expression associated with tumoral transformation have been found for BMI1 and RNF2, which exhibited increased expression in a large series of tumors, including gastrointestinal tumors, pituitary and parathyroid adenomas, and lymphomas, compared with their expression in normal-cell counterparts. The high level of expression of BMI1 protein observed in mantle-cell lymphomas and pituitary adenomas is associated in some cases with amplification of BMI1 locus. These findings imply that upregulation of BMI1 may constitute a malignancy marker in different types of cancer, mainly in lymphoid and endocrine tumors. RING1 was lost in a group of renal-cell carcinomas and testicular germ-cell tumors. Lastly, RYBP is anomalously expressed in Hodgkin's lymphomas and oligodendrogliomas, among others tumors. A significant finding of the study is the identification of unique PcG profiles for some tumors, such as testicular germ-cell tumors, which have high levels of HPH1 expression and loss of RING1 and/or BMI1; pituitary adenomas, which expressed every PcG protein analyzed; and clear-cell renal-cell carcinoma, which was the only tumor other than testicular germ-cell tumors that did not express RING1.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/modpathol.3800577", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1098208", 
            "issn": [
              "0893-3952", 
              "1530-0285"
            ], 
            "name": "Modern Pathology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "keywords": [
          "testicular germ cell tumors", 
          "germ cell tumors", 
          "renal cell carcinoma", 
          "pituitary adenomas", 
          "tissue microarray", 
          "clear cell renal cell carcinoma", 
          "PcG proteins", 
          "mantle cell lymphoma", 
          "tumoral human tissues", 
          "parathyroid adenoma", 
          "gastrointestinal tumors", 
          "Hodgkin's lymphoma", 
          "only tumors", 
          "parathyroid glands", 
          "normal cell counterparts", 
          "endocrine tumors", 
          "upregulation of BMI1", 
          "Polycomb group genes", 
          "umbilical cord", 
          "large series", 
          "malignancy marker", 
          "Langerhans islets", 
          "specific expression patterns", 
          "thyroid gland", 
          "tumors", 
          "lymphoma", 
          "cancer pathogenesis", 
          "tumoral tissue", 
          "BMI1 locus", 
          "normal tissues", 
          "adenomas", 
          "pilot study", 
          "Polycomb proteins", 
          "cellular proliferation", 
          "tumoral transformation", 
          "high levels", 
          "carcinoma", 
          "group genes", 
          "complex proteins", 
          "BMI1 protein", 
          "tissue", 
          "stem cells", 
          "expression patterns", 
          "germ cells", 
          "human tissues", 
          "RING1", 
          "gland", 
          "BMI1", 
          "significant findings", 
          "protein", 
          "expression", 
          "FISH analysis", 
          "RYBP", 
          "cells", 
          "pathogenesis", 
          "microarray", 
          "cord", 
          "immunohistochemistry", 
          "cancer", 
          "oligodendrogliomas", 
          "placenta", 
          "lymphoid", 
          "findings", 
          "islets", 
          "upregulation", 
          "levels", 
          "testis", 
          "proliferation", 
          "markers", 
          "study", 
          "RNF2", 
          "HPH1", 
          "genes", 
          "loci", 
          "group", 
          "differentiation", 
          "control", 
          "cases", 
          "role", 
          "contrast", 
          "loss", 
          "amplification", 
          "different types", 
          "profile", 
          "changes", 
          "identification", 
          "spite", 
          "function", 
          "patterns", 
          "types", 
          "variability", 
          "analysis", 
          "series", 
          "counterparts", 
          "transformation"
        ], 
        "name": "Variability in the expression of polycomb proteins in different normal and tumoral tissues. A pilot study using tissue microarrays", 
        "pagination": "684-694", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1038761761"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/modpathol.3800577"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "16528373"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/modpathol.3800577", 
          "https://app.dimensions.ai/details/publication/pub.1038761761"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-05-20T07:23", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_416.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/modpathol.3800577"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.3800577'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.3800577'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.3800577'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.3800577'


     

    This table displays all metadata directly associated to this object as RDF triples.

    359 TRIPLES      22 PREDICATES      152 URIs      130 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/modpathol.3800577 schema:about N187ed3ded49f449cbc157a6b494c293c
    2 N1b9bb85ec56c417fbcd38ded5df4dac7
    3 N24ba13c528654a51862f16f85098f46e
    4 N2de8896cad3242a9b00aac74fbae58a7
    5 N38052f82f2a0436b985db292ed308be3
    6 N3db5ae68be4240a4a198c78b7d606a42
    7 N55c365ddc8034355a0eed6c483abecac
    8 N617628d53d7644ad92f90bf8bcbd6b79
    9 N6e912856513d4f3b84464ed1a8634b5d
    10 N71546a8bf84c40f3b51426968810b488
    11 N8f134ba603d74adeba5a9693979e7621
    12 N9685776b59de41dba5cf07dd0066f9d3
    13 Nae1b1ea0ba754b37b9d370a1210bc618
    14 Nae70bc54e9e14f57a8b140776b93c016
    15 Ne7bb094a798e477a8972118f90eb3b61
    16 Nf7210b70d1504b7aac1c50060a03df89
    17 Nf91b0c2fdf814560ae365167e7d5b71f
    18 anzsrc-for:11
    19 anzsrc-for:1112
    20 schema:author Naf94570469734e0d87762483c25bf8f8
    21 schema:citation sg:pub.10.1007/978-3-540-69111-2_10
    22 sg:pub.10.1007/bf02967544
    23 sg:pub.10.1007/s000180050126
    24 sg:pub.10.1038/16476
    25 sg:pub.10.1038/35088090
    26 sg:pub.10.1038/70602
    27 sg:pub.10.1038/nature01075
    28 sg:pub.10.1038/nature01572
    29 sg:pub.10.1038/nature01587
    30 sg:pub.10.1038/nature02060
    31 sg:pub.10.1038/nature02385
    32 sg:pub.10.1038/nature02985
    33 sg:pub.10.1038/sj.onc.1204330
    34 sg:pub.10.1054/bjoc.2001.1791
    35 schema:datePublished 2006-03-10
    36 schema:datePublishedReg 2006-03-10
    37 schema:description In spite of the known function of polycomb group (PcG) genes in stem cell self-renewal, control of cellular proliferation and differentiation, its role in cancer pathogenesis is still poorly understood. We studied the expression by immunohistochemistry of several PcG-maintenance complex proteins (RING1, RNF2, BMI1, MEL18, HPH1 and RYBP) in nontumoral (154 samples) and tumoral (550 samples) human tissues using Tissue Microarrays. For selected genes (BMI1 and RING1) FISH analysis has been also carried out. PcG proteins had a tissue- and cell-type-specific expression pattern. Some of them were highly selectively expressed, such as HPH1, which was detected in germ cells in testis, pituitary and parathyroid glands and Langerhans islets, and RYBP, which was found in placenta, umbilical cord and thyroid gland. By contrast, RING1 was ubiquitously expressed in every normal tissue analyzed. Changes in expression associated with tumoral transformation have been found for BMI1 and RNF2, which exhibited increased expression in a large series of tumors, including gastrointestinal tumors, pituitary and parathyroid adenomas, and lymphomas, compared with their expression in normal-cell counterparts. The high level of expression of BMI1 protein observed in mantle-cell lymphomas and pituitary adenomas is associated in some cases with amplification of BMI1 locus. These findings imply that upregulation of BMI1 may constitute a malignancy marker in different types of cancer, mainly in lymphoid and endocrine tumors. RING1 was lost in a group of renal-cell carcinomas and testicular germ-cell tumors. Lastly, RYBP is anomalously expressed in Hodgkin's lymphomas and oligodendrogliomas, among others tumors. A significant finding of the study is the identification of unique PcG profiles for some tumors, such as testicular germ-cell tumors, which have high levels of HPH1 expression and loss of RING1 and/or BMI1; pituitary adenomas, which expressed every PcG protein analyzed; and clear-cell renal-cell carcinoma, which was the only tumor other than testicular germ-cell tumors that did not express RING1.
    38 schema:genre article
    39 schema:inLanguage en
    40 schema:isAccessibleForFree true
    41 schema:isPartOf N4604539b1faa4dcf876a61fb7b7b486e
    42 Nbebd1963c3be489aba4b2dd090884f84
    43 sg:journal.1098208
    44 schema:keywords BMI1
    45 BMI1 locus
    46 BMI1 protein
    47 FISH analysis
    48 HPH1
    49 Hodgkin's lymphoma
    50 Langerhans islets
    51 PcG proteins
    52 Polycomb group genes
    53 Polycomb proteins
    54 RING1
    55 RNF2
    56 RYBP
    57 adenomas
    58 amplification
    59 analysis
    60 cancer
    61 cancer pathogenesis
    62 carcinoma
    63 cases
    64 cells
    65 cellular proliferation
    66 changes
    67 clear cell renal cell carcinoma
    68 complex proteins
    69 contrast
    70 control
    71 cord
    72 counterparts
    73 different types
    74 differentiation
    75 endocrine tumors
    76 expression
    77 expression patterns
    78 findings
    79 function
    80 gastrointestinal tumors
    81 genes
    82 germ cell tumors
    83 germ cells
    84 gland
    85 group
    86 group genes
    87 high levels
    88 human tissues
    89 identification
    90 immunohistochemistry
    91 islets
    92 large series
    93 levels
    94 loci
    95 loss
    96 lymphoid
    97 lymphoma
    98 malignancy marker
    99 mantle cell lymphoma
    100 markers
    101 microarray
    102 normal cell counterparts
    103 normal tissues
    104 oligodendrogliomas
    105 only tumors
    106 parathyroid adenoma
    107 parathyroid glands
    108 pathogenesis
    109 patterns
    110 pilot study
    111 pituitary adenomas
    112 placenta
    113 profile
    114 proliferation
    115 protein
    116 renal cell carcinoma
    117 role
    118 series
    119 significant findings
    120 specific expression patterns
    121 spite
    122 stem cells
    123 study
    124 testicular germ cell tumors
    125 testis
    126 thyroid gland
    127 tissue
    128 tissue microarray
    129 transformation
    130 tumoral human tissues
    131 tumoral tissue
    132 tumoral transformation
    133 tumors
    134 types
    135 umbilical cord
    136 upregulation
    137 upregulation of BMI1
    138 variability
    139 schema:name Variability in the expression of polycomb proteins in different normal and tumoral tissues. A pilot study using tissue microarrays
    140 schema:pagination 684-694
    141 schema:productId N1515de065d704978b38c0b7e166be7b0
    142 N6e3f66efc1054e658f4519db49142fa1
    143 Nf6dfcf4aa42c40fcb2e7dcc52ebe20d2
    144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038761761
    145 https://doi.org/10.1038/modpathol.3800577
    146 schema:sdDatePublished 2022-05-20T07:23
    147 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    148 schema:sdPublisher N8793814ab07348f69183a0b3f82ddce0
    149 schema:url https://doi.org/10.1038/modpathol.3800577
    150 sgo:license sg:explorer/license/
    151 sgo:sdDataset articles
    152 rdf:type schema:ScholarlyArticle
    153 N1515de065d704978b38c0b7e166be7b0 schema:name pubmed_id
    154 schema:value 16528373
    155 rdf:type schema:PropertyValue
    156 N187ed3ded49f449cbc157a6b494c293c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Humans
    158 rdf:type schema:DefinedTerm
    159 N1b9bb85ec56c417fbcd38ded5df4dac7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Nuclear Proteins
    161 rdf:type schema:DefinedTerm
    162 N241a5d521a894cb78fc338be15d580cf rdf:first sg:person.01246512175.01
    163 rdf:rest N354644690a61492ba8cbbbe54e659082
    164 N24ba13c528654a51862f16f85098f46e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Proto-Oncogene Proteins
    166 rdf:type schema:DefinedTerm
    167 N27333d9ab4614b8994b14435751249e1 rdf:first sg:person.01337010372.24
    168 rdf:rest N4efc1f7ce20149aea25b4539adf69829
    169 N2de8896cad3242a9b00aac74fbae58a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Neoplasms
    171 rdf:type schema:DefinedTerm
    172 N354644690a61492ba8cbbbe54e659082 rdf:first sg:person.013666477457.51
    173 rdf:rest Nf9f8c2f98d0b49fe9f46becd6a05dc35
    174 N38052f82f2a0436b985db292ed308be3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Immunohistochemistry
    176 rdf:type schema:DefinedTerm
    177 N3bc4b8f42e5a454986310b917482282a rdf:first sg:person.01101104646.91
    178 rdf:rest Nef18c9a577b84e6cb886b2cedc06d37b
    179 N3db5ae68be4240a4a198c78b7d606a42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Ubiquitin-Protein Ligases
    181 rdf:type schema:DefinedTerm
    182 N4604539b1faa4dcf876a61fb7b7b486e schema:issueNumber 5
    183 rdf:type schema:PublicationIssue
    184 N4efc1f7ce20149aea25b4539adf69829 rdf:first sg:person.012731050144.15
    185 rdf:rest Ne72ae72a77b348b592a2bb832d772356
    186 N55c365ddc8034355a0eed6c483abecac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    187 schema:name DNA-Binding Proteins
    188 rdf:type schema:DefinedTerm
    189 N617628d53d7644ad92f90bf8bcbd6b79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Female
    191 rdf:type schema:DefinedTerm
    192 N6e3f66efc1054e658f4519db49142fa1 schema:name dimensions_id
    193 schema:value pub.1038761761
    194 rdf:type schema:PropertyValue
    195 N6e912856513d4f3b84464ed1a8634b5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Polycomb-Group Proteins
    197 rdf:type schema:DefinedTerm
    198 N71546a8bf84c40f3b51426968810b488 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Male
    200 rdf:type schema:DefinedTerm
    201 N8793814ab07348f69183a0b3f82ddce0 schema:name Springer Nature - SN SciGraph project
    202 rdf:type schema:Organization
    203 N8e018997dd7944c3b1285eaef9030a8a rdf:first sg:person.01127724556.83
    204 rdf:rest N241a5d521a894cb78fc338be15d580cf
    205 N8f134ba603d74adeba5a9693979e7621 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Pilot Projects
    207 rdf:type schema:DefinedTerm
    208 N9685776b59de41dba5cf07dd0066f9d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Tissue Array Analysis
    210 rdf:type schema:DefinedTerm
    211 Nae1b1ea0ba754b37b9d370a1210bc618 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Carrier Proteins
    213 rdf:type schema:DefinedTerm
    214 Nae70bc54e9e14f57a8b140776b93c016 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Polycomb Repressive Complex 1
    216 rdf:type schema:DefinedTerm
    217 Naf94570469734e0d87762483c25bf8f8 rdf:first sg:person.01026644115.63
    218 rdf:rest N27333d9ab4614b8994b14435751249e1
    219 Nbebd1963c3be489aba4b2dd090884f84 schema:volumeNumber 19
    220 rdf:type schema:PublicationVolume
    221 Ne72ae72a77b348b592a2bb832d772356 rdf:first sg:person.01034246016.74
    222 rdf:rest N3bc4b8f42e5a454986310b917482282a
    223 Ne7bb094a798e477a8972118f90eb3b61 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    224 schema:name In Situ Hybridization, Fluorescence
    225 rdf:type schema:DefinedTerm
    226 Nef18c9a577b84e6cb886b2cedc06d37b rdf:first sg:person.0760125617.29
    227 rdf:rest N8e018997dd7944c3b1285eaef9030a8a
    228 Nf6dfcf4aa42c40fcb2e7dcc52ebe20d2 schema:name doi
    229 schema:value 10.1038/modpathol.3800577
    230 rdf:type schema:PropertyValue
    231 Nf7210b70d1504b7aac1c50060a03df89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Repressor Proteins
    233 rdf:type schema:DefinedTerm
    234 Nf91b0c2fdf814560ae365167e7d5b71f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    235 schema:name Intracellular Signaling Peptides and Proteins
    236 rdf:type schema:DefinedTerm
    237 Nf9f8c2f98d0b49fe9f46becd6a05dc35 rdf:first sg:person.07440427070.11
    238 rdf:rest rdf:nil
    239 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    240 schema:name Medical and Health Sciences
    241 rdf:type schema:DefinedTerm
    242 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    243 schema:name Oncology and Carcinogenesis
    244 rdf:type schema:DefinedTerm
    245 sg:journal.1098208 schema:issn 0893-3952
    246 1530-0285
    247 schema:name Modern Pathology
    248 schema:publisher Springer Nature
    249 rdf:type schema:Periodical
    250 sg:person.01026644115.63 schema:affiliation grid-institutes:grid.7719.8
    251 schema:familyName Sánchez-Beato
    252 schema:givenName Margarita
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026644115.63
    254 rdf:type schema:Person
    255 sg:person.01034246016.74 schema:affiliation grid-institutes:grid.7719.8
    256 schema:familyName Morente
    257 schema:givenName Manuel
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034246016.74
    259 rdf:type schema:Person
    260 sg:person.01101104646.91 schema:affiliation grid-institutes:grid.7719.8
    261 schema:familyName Díez
    262 schema:givenName Ana
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101104646.91
    264 rdf:type schema:Person
    265 sg:person.01127724556.83 schema:affiliation grid-institutes:grid.7719.8
    266 schema:familyName Martín
    267 schema:givenName María Carmen
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127724556.83
    269 rdf:type schema:Person
    270 sg:person.01246512175.01 schema:affiliation grid-institutes:grid.7719.8
    271 schema:familyName Cigudosa
    272 schema:givenName Juan C
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246512175.01
    274 rdf:type schema:Person
    275 sg:person.012731050144.15 schema:affiliation grid-institutes:grid.6312.6
    276 schema:familyName González-Carreró
    277 schema:givenName Joaquín
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012731050144.15
    279 rdf:type schema:Person
    280 sg:person.01337010372.24 schema:affiliation grid-institutes:None
    281 schema:familyName Sánchez
    282 schema:givenName Esther
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337010372.24
    284 rdf:type schema:Person
    285 sg:person.013666477457.51 schema:affiliation grid-institutes:grid.418281.6
    286 schema:familyName Vidal
    287 schema:givenName Miguel
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013666477457.51
    289 rdf:type schema:Person
    290 sg:person.07440427070.11 schema:affiliation grid-institutes:grid.7719.8
    291 schema:familyName Piris
    292 schema:givenName Miguel A
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07440427070.11
    294 rdf:type schema:Person
    295 sg:person.0760125617.29 schema:affiliation grid-institutes:grid.7719.8
    296 schema:familyName Sánchez-Verde
    297 schema:givenName Lydia
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760125617.29
    299 rdf:type schema:Person
    300 sg:pub.10.1007/978-3-540-69111-2_10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020661299
    301 https://doi.org/10.1007/978-3-540-69111-2_10
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1007/bf02967544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030555269
    304 https://doi.org/10.1007/bf02967544
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1007/s000180050126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047611208
    307 https://doi.org/10.1007/s000180050126
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1038/16476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033156851
    310 https://doi.org/10.1038/16476
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/35088090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042285289
    313 https://doi.org/10.1038/35088090
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/70602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032044171
    316 https://doi.org/10.1038/70602
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/nature01075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025096861
    319 https://doi.org/10.1038/nature01075
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/nature01572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045711316
    322 https://doi.org/10.1038/nature01572
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/nature01587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024497082
    325 https://doi.org/10.1038/nature01587
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/nature02060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013519146
    328 https://doi.org/10.1038/nature02060
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/nature02385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008729213
    331 https://doi.org/10.1038/nature02385
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/nature02985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049709002
    334 https://doi.org/10.1038/nature02985
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/sj.onc.1204330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049860156
    337 https://doi.org/10.1038/sj.onc.1204330
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1054/bjoc.2001.1791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043655970
    340 https://doi.org/10.1054/bjoc.2001.1791
    341 rdf:type schema:CreativeWork
    342 grid-institutes:None schema:alternateName Department of Pathology, Hospital ‘Nuestra Señora del Prado’, Talavera de la Reina-Toledo, Spain
    343 schema:name Department of Pathology, Hospital ‘Nuestra Señora del Prado’, Talavera de la Reina-Toledo, Spain
    344 rdf:type schema:Organization
    345 grid-institutes:grid.418281.6 schema:alternateName Department of Developmental and Cell Biology, Centro de Investigaciones Biológicas, (CSIC), Madrid, Spain
    346 schema:name Department of Developmental and Cell Biology, Centro de Investigaciones Biológicas, (CSIC), Madrid, Spain
    347 rdf:type schema:Organization
    348 grid-institutes:grid.6312.6 schema:alternateName Department of Pathology, ‘Complejo Hospitalario Universitario de Vigo' (CHUVI)’, Vigo-Pontevedra, Spain
    349 schema:name Department of Pathology, ‘Complejo Hospitalario Universitario de Vigo' (CHUVI)’, Vigo-Pontevedra, Spain
    350 rdf:type schema:Organization
    351 grid-institutes:grid.7719.8 schema:alternateName Cytogenetics Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
    352 Immunohistochemistry and Histology Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
    353 Lymphoma Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
    354 Tumour Bank, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
    355 schema:name Cytogenetics Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
    356 Immunohistochemistry and Histology Unit, Biotechnology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
    357 Lymphoma Group, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
    358 Tumour Bank, Molecular Pathology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain
    359 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...