AIDS and non-AIDS diffuse large B-cell lymphomas express different antigen profiles View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-03

AUTHORS

Rashna Madan, Robert Gormley, Alina Dulau, Dongsheng Xu, Daniel Walsh, K H Ramesh, Linda Cannizaro, Ecaterina F Tamas, Pankaj Kumar, Joseph Sparano, Aaron LeValley, Xiaonan Xue, Pritish K Bhattacharyya, Harry L Ioachim, Howard Ratech

ABSTRACT

Based on gene expression profiling, diffuse large B-cell lymphomas arising in immunocompetent patients can be divided into germinal center and activated B-cell types. Since little is known about acquired immunodeficiency syndrome associated diffuse large B-cell lymphomas, we tested whether the protein expression of germinal center and activated B-cell markers differed between acquired immunodeficiency syndrome (AIDS) vs non-AIDS diffuse large B-cell lymphomas. We immunohistochemically stained tissue microarrays of 39 de novo diffuse large B-cell lymphomas: 12 AIDS associated and 27 non-AIDS, with germinal center (BCL6, CD10, CyclinH) and activated B-cell markers (MUM1, CD138, PAK1, CD44, BCL2). We scored each case for percent positive cells (0-19%=0; 20-49%=1; 50-100%=2). The activated B-cell and germinal center summation scores of each case were used as (x, y) coordinate data points to construct two-dimensional contour-frequency plots. The contour plot of non-AIDS diffuse large B-cell lymphomas showed two distinct clusters: a cluster with a high germinal center phenotype (cluster 1) and a cluster with a high activated B-cell phenotype (cluster 3). In contrast, the AIDS-related diffuse large B-cell lymphomas formed a single aggregate (cluster 2) (P=0.02, Fisher exact test). When the contour plots of the AIDS-related and the non-AIDS cases were superimposed, cluster 2 of the AIDS cases expressed an intermediate germinal center/activated B-cell phenotype compared to clusters 1 and 3 of the non-AIDS diffuse large B-cell lymphomas. Our results confirm that non-AIDS diffuse large B-cell lymphomas segregate into two groups with either germinal center or activated B-cell phenotype. We report the new finding that the AIDS status of the patient predicts the immunophenotype of the diffuse large B-cell lymphomas. More... »

PAGES

3800493

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.3800493

DOI

http://dx.doi.org/10.1038/modpathol.3800493

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051073085

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16444194


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