Use of novel immunohistochemical markers expressed in colonic adenocarcinoma to distinguish primary ovarian tumors from metastatic colorectal carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-01

AUTHORS

Sanjay Logani, Esther Oliva, Paula M Arnell, Mahul B Amin, Robert H Young

ABSTRACT

Distinguishing primary ovarian carcinoma, particularly endometrioid and mucinous subtypes, from metastatic colorectal carcinoma to the ovary is often difficult on histologic examination alone. Recently, three immunohistochemical markers CDX2, a homeobox gene encoding an intestine-specific transcription factor; alpha-methylacyl-CoA racemase (AMACR/P504S), a mitochondrial and peroxisomal enzyme with fairly restricted expression in selective tumors and beta-catenin, an adenomatous polyposis coli (APC) mutation product resulting in activation of the Wnt pathway, have been reported to have specific and sensitive expression in colorectal carcinomas. We evaluated a panel consisting of antibodies to CDX2, beta-catenin and P504S in 23 primary ovarian adenocarcinomas (13 mucinous and 10 endometrioid) and compared the findings to 22 metastatic colorectal adenocarcinomas (seven mucinous and 15 nonmucinous tumors with endometrioid-like morphology hereafter referred to as pseudo-endometrioid) to the ovary stained with the same panel. Twenty (91%) metastatic tumors expressed at least two markers and seven (32%) expressed all three. In contrast, only three (13%) primary ovarian tumors expressed at least two markers and none expressed all three. Strong (2+, 3+) and diffuse (>40%) expression for CDX2 was noted in 21 (95%) metastatic tumors and five (22%) primary ovarian tumors (three mucinous, two endometrioid). P504S was similarly expressed in seven (32%) metastatic and none of the primary ovarian carcinomas. Nuclear expression of beta-catenin was noted in 13 (59%) metastatic tumors and in eight cases (36%), it was diffuse and strong. In contrast, four (19%) primary tumors showed nuclear expression of this protein with only one (5%) case expressing it in a diffuse pattern. Immunohistochemical expression of gene products and enzymes of colorectal carcinogenesis in some primary ovarian carcinomas suggest that the morphologic similarities between colorectal and mucinous/endometrioid carcinoma of the ovary extends to the genetic level, although differences in the level of expression exist between these tumors. Diffuse expression of all three markers (CDX2, beta-catenin and P504S) in a tumor in the ovary was found to be virtually diagnostic of metastasis from a colorectal primary in this study. More... »

PAGES

3800260

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.3800260

DOI

http://dx.doi.org/10.1038/modpathol.3800260

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006630341

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15389251


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CDX2 Transcription Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeletal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diagnosis, Differential", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homeodomain Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Racemases and Epimerases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Activators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "beta Catenin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Emory University School of Medicine, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Logani", 
        "givenName": "Sanjay", 
        "id": "sg:person.01263260512.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263260512.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oliva", 
        "givenName": "Esther", 
        "id": "sg:person.01066764345.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066764345.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arnell", 
        "givenName": "Paula M", 
        "id": "sg:person.01077025206.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077025206.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University", 
          "id": "https://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Emory University School of Medicine, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amin", 
        "givenName": "Mahul B", 
        "id": "sg:person.01247242377.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247242377.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Young", 
        "givenName": "Robert H", 
        "id": "sg:person.0653637562.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653637562.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0046-8177(98)90065-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001096254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.275.5307.1787", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002102308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/382638a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002681668", 
          "https://doi.org/10.1038/382638a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3880175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004345809", 
          "https://doi.org/10.1038/modpathol.3880175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.3880175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004345809", 
          "https://doi.org/10.1038/modpathol.3880175"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200303000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006579516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200303000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006579516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/hupa.2000.6799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008546331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200307000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012746353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200307000-00014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012746353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19840301)53:5<1164::aid-cncr2820530523>3.0.co;2-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013025309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.1997.v113.pm9247466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013129500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/01.mp.0000086073.92773.55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013959390", 
          "https://doi.org/10.1097/01.mp.0000086073.92773.55"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200303000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015060150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200303000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015060150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<504::aid-ijc6>3.0.co;2-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016631034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pgp.0000101141.31270.a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019737723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pgp.0000101141.31270.a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019737723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0046-8177(03)00268-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022743801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0046-8177(03)00268-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022743801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64244-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027006503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200302000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028504123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200302000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028504123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-198702000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029617957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-198702000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029617957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-198909000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034021317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-198909000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034021317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1469-1809.1997.6150393.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035236738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2559.2003.01687.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037461565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200111000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038974864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200111000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038974864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcp/97.6.751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043392453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0046-8177(95)90006-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045014040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00428-003-0910-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045653384", 
          "https://doi.org/10.1007/s00428-003-0910-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/1.4.229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047859953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pgp.0000101080.35393.16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048334618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.pgp.0000101080.35393.16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048334618"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200207000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050768726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200207000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050768726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1994.tb18870.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051892401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1995.1132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052995180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s0003480097006465", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054755189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199710000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199710000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-199710000-00004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060122419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074721682", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075954545", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076586259", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077436600", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082929650", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083004752", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-01", 
    "datePublishedReg": "2005-01-01", 
    "description": "Distinguishing primary ovarian carcinoma, particularly endometrioid and mucinous subtypes, from metastatic colorectal carcinoma to the ovary is often difficult on histologic examination alone. Recently, three immunohistochemical markers CDX2, a homeobox gene encoding an intestine-specific transcription factor; alpha-methylacyl-CoA racemase (AMACR/P504S), a mitochondrial and peroxisomal enzyme with fairly restricted expression in selective tumors and beta-catenin, an adenomatous polyposis coli (APC) mutation product resulting in activation of the Wnt pathway, have been reported to have specific and sensitive expression in colorectal carcinomas. We evaluated a panel consisting of antibodies to CDX2, beta-catenin and P504S in 23 primary ovarian adenocarcinomas (13 mucinous and 10 endometrioid) and compared the findings to 22 metastatic colorectal adenocarcinomas (seven mucinous and 15 nonmucinous tumors with endometrioid-like morphology hereafter referred to as pseudo-endometrioid) to the ovary stained with the same panel. Twenty (91%) metastatic tumors expressed at least two markers and seven (32%) expressed all three. In contrast, only three (13%) primary ovarian tumors expressed at least two markers and none expressed all three. Strong (2+, 3+) and diffuse (>40%) expression for CDX2 was noted in 21 (95%) metastatic tumors and five (22%) primary ovarian tumors (three mucinous, two endometrioid). P504S was similarly expressed in seven (32%) metastatic and none of the primary ovarian carcinomas. Nuclear expression of beta-catenin was noted in 13 (59%) metastatic tumors and in eight cases (36%), it was diffuse and strong. In contrast, four (19%) primary tumors showed nuclear expression of this protein with only one (5%) case expressing it in a diffuse pattern. Immunohistochemical expression of gene products and enzymes of colorectal carcinogenesis in some primary ovarian carcinomas suggest that the morphologic similarities between colorectal and mucinous/endometrioid carcinoma of the ovary extends to the genetic level, although differences in the level of expression exist between these tumors. Diffuse expression of all three markers (CDX2, beta-catenin and P504S) in a tumor in the ovary was found to be virtually diagnostic of metastasis from a colorectal primary in this study.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/modpathol.3800260", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1098208", 
        "issn": [
          "0893-3952", 
          "1530-0285"
        ], 
        "name": "Modern Pathology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "name": "Use of novel immunohistochemical markers expressed in colonic adenocarcinoma to distinguish primary ovarian tumors from metastatic colorectal carcinoma", 
    "pagination": "3800260", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1f948bd63d88866a06bcdf32861ece0fec4dce162ca468edcee5e390aa65b943"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15389251"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8806605"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/modpathol.3800260"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1006630341"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/modpathol.3800260", 
      "https://app.dimensions.ai/details/publication/pub.1006630341"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:27", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87117_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/3800260"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.3800260'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.3800260'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.3800260'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.3800260'


 

This table displays all metadata directly associated to this object as RDF triples.

272 TRIPLES      21 PREDICATES      81 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/modpathol.3800260 schema:about N04303cfaf2674a1ea01b00790331f28c
2 N12f46ad28ee44d5f902c1cfd3405559e
3 N2d0fababd2344155a2f9a2116ccd0621
4 N5cafd00a3e4042488eab26020cd81e59
5 N6052d23dfe5545469566f32a2892ca0f
6 N71eaf8d432834876bc5d42f680e5585f
7 N87a3f161a4634fc3999bc533df95462a
8 N94b0d0a552b940059a090d3334868aa3
9 N96929a1ea81a4c0299833569c1339291
10 Naba2994fc8024d39be3e6fcb437cc07f
11 Ndc1fc11e99cf4a7987ded555887d1646
12 Ne014435ca8fe4e7b8541d819654c6423
13 Ne4cbe22d63cc47d78d2c84e121a41e2f
14 Nf4ebbfadd41d41a2ba5fd40568028b9e
15 Nf9557867e2a44f7ca9b7bfde06a15df6
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author N7eda438e34544a8d81aefd745bb629cb
19 schema:citation sg:pub.10.1007/s00428-003-0910-3
20 sg:pub.10.1038/382638a0
21 sg:pub.10.1038/modpathol.3880175
22 sg:pub.10.1097/01.mp.0000086073.92773.55
23 https://app.dimensions.ai/details/publication/pub.1074721682
24 https://app.dimensions.ai/details/publication/pub.1075954545
25 https://app.dimensions.ai/details/publication/pub.1076586259
26 https://app.dimensions.ai/details/publication/pub.1077436600
27 https://app.dimensions.ai/details/publication/pub.1082929650
28 https://app.dimensions.ai/details/publication/pub.1083004752
29 https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<504::aid-ijc6>3.0.co;2-6
30 https://doi.org/10.1002/1097-0142(19840301)53:5<1164::aid-cncr2820530523>3.0.co;2-4
31 https://doi.org/10.1006/geno.1995.1132
32 https://doi.org/10.1016/0046-8177(95)90006-3
33 https://doi.org/10.1016/s0002-9440(10)64244-7
34 https://doi.org/10.1016/s0046-8177(03)00268-5
35 https://doi.org/10.1016/s0046-8177(98)90065-x
36 https://doi.org/10.1017/s0003480097006465
37 https://doi.org/10.1046/j.1365-2559.2003.01687.x
38 https://doi.org/10.1046/j.1469-1809.1997.6150393.x
39 https://doi.org/10.1053/gast.1997.v113.pm9247466
40 https://doi.org/10.1053/hupa.2000.6799
41 https://doi.org/10.1093/ajcp/97.6.751
42 https://doi.org/10.1093/hmg/1.4.229
43 https://doi.org/10.1097/00000478-198702000-00005
44 https://doi.org/10.1097/00000478-198909000-00004
45 https://doi.org/10.1097/00000478-199710000-00004
46 https://doi.org/10.1097/00000478-200111000-00005
47 https://doi.org/10.1097/00000478-200207000-00012
48 https://doi.org/10.1097/00000478-200302000-00001
49 https://doi.org/10.1097/00000478-200303000-00001
50 https://doi.org/10.1097/00000478-200303000-00003
51 https://doi.org/10.1097/00000478-200307000-00014
52 https://doi.org/10.1097/01.pgp.0000101080.35393.16
53 https://doi.org/10.1097/01.pgp.0000101141.31270.a0
54 https://doi.org/10.1111/j.1432-1033.1994.tb18870.x
55 https://doi.org/10.1126/science.275.5307.1787
56 schema:datePublished 2005-01
57 schema:datePublishedReg 2005-01-01
58 schema:description Distinguishing primary ovarian carcinoma, particularly endometrioid and mucinous subtypes, from metastatic colorectal carcinoma to the ovary is often difficult on histologic examination alone. Recently, three immunohistochemical markers CDX2, a homeobox gene encoding an intestine-specific transcription factor; alpha-methylacyl-CoA racemase (AMACR/P504S), a mitochondrial and peroxisomal enzyme with fairly restricted expression in selective tumors and beta-catenin, an adenomatous polyposis coli (APC) mutation product resulting in activation of the Wnt pathway, have been reported to have specific and sensitive expression in colorectal carcinomas. We evaluated a panel consisting of antibodies to CDX2, beta-catenin and P504S in 23 primary ovarian adenocarcinomas (13 mucinous and 10 endometrioid) and compared the findings to 22 metastatic colorectal adenocarcinomas (seven mucinous and 15 nonmucinous tumors with endometrioid-like morphology hereafter referred to as pseudo-endometrioid) to the ovary stained with the same panel. Twenty (91%) metastatic tumors expressed at least two markers and seven (32%) expressed all three. In contrast, only three (13%) primary ovarian tumors expressed at least two markers and none expressed all three. Strong (2+, 3+) and diffuse (>40%) expression for CDX2 was noted in 21 (95%) metastatic tumors and five (22%) primary ovarian tumors (three mucinous, two endometrioid). P504S was similarly expressed in seven (32%) metastatic and none of the primary ovarian carcinomas. Nuclear expression of beta-catenin was noted in 13 (59%) metastatic tumors and in eight cases (36%), it was diffuse and strong. In contrast, four (19%) primary tumors showed nuclear expression of this protein with only one (5%) case expressing it in a diffuse pattern. Immunohistochemical expression of gene products and enzymes of colorectal carcinogenesis in some primary ovarian carcinomas suggest that the morphologic similarities between colorectal and mucinous/endometrioid carcinoma of the ovary extends to the genetic level, although differences in the level of expression exist between these tumors. Diffuse expression of all three markers (CDX2, beta-catenin and P504S) in a tumor in the ovary was found to be virtually diagnostic of metastasis from a colorectal primary in this study.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree true
62 schema:isPartOf N0ae68812c4af44e184b279db3bc7efe7
63 N36758734047e4079af4d89dc8a4e553b
64 sg:journal.1098208
65 schema:name Use of novel immunohistochemical markers expressed in colonic adenocarcinoma to distinguish primary ovarian tumors from metastatic colorectal carcinoma
66 schema:pagination 3800260
67 schema:productId N134059d855534f18aa497bbe03313e00
68 N8a9043e9edba4087b967503528ea58c0
69 Nae56cb1b8efb4e1d93bea667de0585f3
70 Nda30950f1ba94417b7d748443e9aa247
71 Ne7664ade32d94d549bae08c300bf5bb0
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006630341
73 https://doi.org/10.1038/modpathol.3800260
74 schema:sdDatePublished 2019-04-11T12:27
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N9eb5b3883c00415096500358971bef1c
77 schema:url http://www.nature.com/articles/3800260
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N04303cfaf2674a1ea01b00790331f28c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Diagnosis, Differential
83 rdf:type schema:DefinedTerm
84 N0ae68812c4af44e184b279db3bc7efe7 schema:volumeNumber 18
85 rdf:type schema:PublicationVolume
86 N12f46ad28ee44d5f902c1cfd3405559e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Female
88 rdf:type schema:DefinedTerm
89 N134059d855534f18aa497bbe03313e00 schema:name doi
90 schema:value 10.1038/modpathol.3800260
91 rdf:type schema:PropertyValue
92 N2d0fababd2344155a2f9a2116ccd0621 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name CDX2 Transcription Factor
94 rdf:type schema:DefinedTerm
95 N36758734047e4079af4d89dc8a4e553b schema:issueNumber 1
96 rdf:type schema:PublicationIssue
97 N48278d76b6f044449ae88afb5c560a21 schema:name The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
98 rdf:type schema:Organization
99 N5cafd00a3e4042488eab26020cd81e59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Trans-Activators
101 rdf:type schema:DefinedTerm
102 N6052d23dfe5545469566f32a2892ca0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Homeodomain Proteins
104 rdf:type schema:DefinedTerm
105 N6072b3b5c304426c974bb86e55ba5b3a rdf:first sg:person.01077025206.09
106 rdf:rest Nd87f0f0f798b4285915499f8b8da469a
107 N71eaf8d432834876bc5d42f680e5585f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Cytoskeletal Proteins
109 rdf:type schema:DefinedTerm
110 N7eda438e34544a8d81aefd745bb629cb rdf:first sg:person.01263260512.15
111 rdf:rest Nb1d99bb79707463ca5700e5971062b9b
112 N848932ecdb8742a0aef0fe9b0b10d661 schema:name The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
113 rdf:type schema:Organization
114 N87a3f161a4634fc3999bc533df95462a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name beta Catenin
116 rdf:type schema:DefinedTerm
117 N8a9043e9edba4087b967503528ea58c0 schema:name dimensions_id
118 schema:value pub.1006630341
119 rdf:type schema:PropertyValue
120 N94b0d0a552b940059a090d3334868aa3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Colonic Neoplasms
122 rdf:type schema:DefinedTerm
123 N96929a1ea81a4c0299833569c1339291 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Humans
125 rdf:type schema:DefinedTerm
126 N9eb5b3883c00415096500358971bef1c schema:name Springer Nature - SN SciGraph project
127 rdf:type schema:Organization
128 Naba2994fc8024d39be3e6fcb437cc07f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Adenocarcinoma
130 rdf:type schema:DefinedTerm
131 Nabd7a0bbb4504e988de4fb0f6a14a3e6 rdf:first sg:person.0653637562.22
132 rdf:rest rdf:nil
133 Nae56cb1b8efb4e1d93bea667de0585f3 schema:name nlm_unique_id
134 schema:value 8806605
135 rdf:type schema:PropertyValue
136 Nb1d99bb79707463ca5700e5971062b9b rdf:first sg:person.01066764345.44
137 rdf:rest N6072b3b5c304426c974bb86e55ba5b3a
138 Nd87f0f0f798b4285915499f8b8da469a rdf:first sg:person.01247242377.81
139 rdf:rest Nabd7a0bbb4504e988de4fb0f6a14a3e6
140 Nda30950f1ba94417b7d748443e9aa247 schema:name pubmed_id
141 schema:value 15389251
142 rdf:type schema:PropertyValue
143 Ndc1fc11e99cf4a7987ded555887d1646 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Biomarkers
145 rdf:type schema:DefinedTerm
146 Ne014435ca8fe4e7b8541d819654c6423 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Racemases and Epimerases
148 rdf:type schema:DefinedTerm
149 Ne4cbe22d63cc47d78d2c84e121a41e2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Ovarian Neoplasms
151 rdf:type schema:DefinedTerm
152 Ne7664ade32d94d549bae08c300bf5bb0 schema:name readcube_id
153 schema:value 1f948bd63d88866a06bcdf32861ece0fec4dce162ca468edcee5e390aa65b943
154 rdf:type schema:PropertyValue
155 Nf4ebbfadd41d41a2ba5fd40568028b9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Colorectal Neoplasms
157 rdf:type schema:DefinedTerm
158 Nf631b83b6eec46538445538201beeee9 schema:name The James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
159 rdf:type schema:Organization
160 Nf9557867e2a44f7ca9b7bfde06a15df6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Immunohistochemistry
162 rdf:type schema:DefinedTerm
163 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
164 schema:name Medical and Health Sciences
165 rdf:type schema:DefinedTerm
166 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
167 schema:name Oncology and Carcinogenesis
168 rdf:type schema:DefinedTerm
169 sg:journal.1098208 schema:issn 0893-3952
170 1530-0285
171 schema:name Modern Pathology
172 rdf:type schema:Periodical
173 sg:person.01066764345.44 schema:affiliation N48278d76b6f044449ae88afb5c560a21
174 schema:familyName Oliva
175 schema:givenName Esther
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066764345.44
177 rdf:type schema:Person
178 sg:person.01077025206.09 schema:affiliation N848932ecdb8742a0aef0fe9b0b10d661
179 schema:familyName Arnell
180 schema:givenName Paula M
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077025206.09
182 rdf:type schema:Person
183 sg:person.01247242377.81 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
184 schema:familyName Amin
185 schema:givenName Mahul B
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247242377.81
187 rdf:type schema:Person
188 sg:person.01263260512.15 schema:affiliation https://www.grid.ac/institutes/grid.189967.8
189 schema:familyName Logani
190 schema:givenName Sanjay
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263260512.15
192 rdf:type schema:Person
193 sg:person.0653637562.22 schema:affiliation Nf631b83b6eec46538445538201beeee9
194 schema:familyName Young
195 schema:givenName Robert H
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653637562.22
197 rdf:type schema:Person
198 sg:pub.10.1007/s00428-003-0910-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045653384
199 https://doi.org/10.1007/s00428-003-0910-3
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/382638a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002681668
202 https://doi.org/10.1038/382638a0
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/modpathol.3880175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004345809
205 https://doi.org/10.1038/modpathol.3880175
206 rdf:type schema:CreativeWork
207 sg:pub.10.1097/01.mp.0000086073.92773.55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013959390
208 https://doi.org/10.1097/01.mp.0000086073.92773.55
209 rdf:type schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1074721682 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1075954545 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1076586259 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1077436600 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1082929650 schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1083004752 schema:CreativeWork
216 https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<504::aid-ijc6>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016631034
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1002/1097-0142(19840301)53:5<1164::aid-cncr2820530523>3.0.co;2-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013025309
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1006/geno.1995.1132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052995180
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/0046-8177(95)90006-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045014040
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/s0002-9440(10)64244-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027006503
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/s0046-8177(03)00268-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022743801
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/s0046-8177(98)90065-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001096254
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1017/s0003480097006465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054755189
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1046/j.1365-2559.2003.01687.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037461565
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1046/j.1469-1809.1997.6150393.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035236738
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1053/gast.1997.v113.pm9247466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013129500
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1053/hupa.2000.6799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008546331
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1093/ajcp/97.6.751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043392453
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1093/hmg/1.4.229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047859953
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1097/00000478-198702000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029617957
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1097/00000478-198909000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034021317
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1097/00000478-199710000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060122419
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1097/00000478-200111000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038974864
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1097/00000478-200207000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050768726
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1097/00000478-200302000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028504123
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1097/00000478-200303000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006579516
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1097/00000478-200303000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015060150
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1097/00000478-200307000-00014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012746353
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1097/01.pgp.0000101080.35393.16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048334618
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1097/01.pgp.0000101141.31270.a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019737723
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1111/j.1432-1033.1994.tb18870.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051892401
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1126/science.275.5307.1787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002102308
269 rdf:type schema:CreativeWork
270 https://www.grid.ac/institutes/grid.189967.8 schema:alternateName Emory University
271 schema:name Emory University School of Medicine, Atlanta, GA, USA
272 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...