USP6 activation in nodular fasciitis by promoter-swapping gene fusions View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-11

AUTHORS

Nimesh R Patel, John S A Chrisinger, Elizabeth G Demicco, Stephen F Sarabia, Jacquelyn Reuther, Erica Kumar, Andre M Oliveira, Steven D Billings, Judith V M G Bovée, Angshumoy Roy, Alexander J Lazar, Dolores H Lopez-Terrada, Wei-Lien Wang

ABSTRACT

Nodular fasciitis is a self-limited myofibroblastic lesion that can be misdiagnosed as a sarcoma as a result of its rapid growth, cellularity, and sometimes prominent mitotic activity. A recurrent translocation t(17;22) has been identified in nodular fasciitis, fusing the coding region of USP6 to the promoter region of MYH9, and resulting in increased USP6 expression. A subset of cases show USP6 rearrangement without the typical fusion variants by RT-PCR, or any MYH9 rearrangement by FISH. We sought to further characterize such tumors using molecular diagnostic assays. A novel RT-PCR assay was designed to detect the two known MYH9-USP6 fusion types in formalin-fixed paraffin-embedded and frozen tissue, and a break-apart FISH assay was designed to detect USP6 rearrangement. Twenty-six cases of nodular fasciitis diagnosed between 2002 and 2013 were retrieved from the pathology files of our institutions and were confirmed to be positive by FISH and/or RT-PCR. Seven samples showed USP6 rearrangement by FISH but were negative for MYH9-USP6 fusion by RT-PCR; these cases were subjected to a next-generation sequencing assay utilizing anchored multiplex PCR technology. This assay targets a single partner gene associated with fusions in bone and soft tissue tumors for agnostic detection of gene fusion partners. Novel fusion partners were identified in all seven cases and confirmed by RT-PCR. Structurally, all fusions consisted of the juxtaposition of the entire coding region of USP6 with the promoter of the partner gene, driving increased USP6 expression. This study confirms the neoplastic nature of nodular fasciitis, defines additional pathogenic fusion partners, and adds to the growing body of literature on USP6-associated neoplasia. Given the diagnostic challenges of these tumors, molecular assays can be useful ancillary tools; however, the prevalence of promoter swapping must be recognized when interpreting results. More... »

PAGES

1577-1588

References to SciGraph publications

  • 2007-12. Mutational analysis of the TRE2 oncogene encoding an inactive RabGAP in BIOTECHNOLOGY LETTERS
  • 2017-10. Unusual Signal Patterns of Break-apart FISH Probes Used in the Diagnosis of Soft Tissue Sarcomas in PATHOLOGY & ONCOLOGY RESEARCH
  • 2016-08. USP6 genetic rearrangements in cellular fibroma of tendon sheath in MODERN PATHOLOGY
  • 2014-12. Anchored multiplex PCR for targeted next-generation sequencing in NATURE MEDICINE
  • 2010-06. TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-κB in ONCOGENE
  • 1997-02. Promoter swapping between the genes for a novel zinc finger protein and β-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations in NATURE GENETICS
  • 2006-02. The Tre2 Oncoprotein, Implicated in Ewing’s Sarcoma, Interacts with Two Components of the Cytoskeleton in BIOTECHNOLOGY LETTERS
  • 2012-07. Atypical mechanism of NF-κB activation by TRE17/ubiquitin-specific protease 6 (USP6) oncogene and its requirement in tumorigenesis in ONCOGENE
  • 2016-07. Implication of Long noncoding RNAs in the endothelial cell response to hypoxia revealed by RNA-sequencing in SCIENTIFIC REPORTS
  • 2013-07. Detection of USP6 gene rearrangement in nodular fasciitis: an important diagnostic tool in VIRCHOWS ARCHIV
  • 2005-05. Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes in ONCOGENE
  • 2013-07. MRI characteristics of nodular fasciitis of the musculoskeletal system in SKELETAL RADIOLOGY
  • 2009-09. Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in clear cell sarcoma (melanoma of soft parts) in MODERN PATHOLOGY
  • 2011-10. Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion in LABORATORY INVESTIGATION
  • 2011-05. Aberrant PLAG1 expression in pleomorphic adenomas of the salivary gland: a molecular genetic and immunohistochemical study in VIRCHOWS ARCHIV
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/modpathol.2017.78

    DOI

    http://dx.doi.org/10.1038/modpathol.2017.78

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090916254

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28752842


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adolescent", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Child", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fasciitis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myofibroma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oncogene Fusion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oncogene Proteins, Fusion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Promoter Regions, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Translocation, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ubiquitin Thiolesterase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Baylor College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Department of Pathology, Texas Children's Hospital, Houston, TX, USA.", 
                "Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Patel", 
            "givenName": "Nimesh R", 
            "id": "sg:person.0720246125.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720246125.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chrisinger", 
            "givenName": "John S A", 
            "id": "sg:person.010534707637.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010534707637.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Demicco", 
            "givenName": "Elizabeth G", 
            "id": "sg:person.0751521705.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751521705.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Baylor College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Department of Pathology, Texas Children's Hospital, Houston, TX, USA.", 
                "Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sarabia", 
            "givenName": "Stephen F", 
            "id": "sg:person.0743144317.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743144317.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Baylor College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Department of Pathology, Texas Children's Hospital, Houston, TX, USA.", 
                "Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Reuther", 
            "givenName": "Jacquelyn", 
            "id": "sg:person.016466066107.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016466066107.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kumar", 
            "givenName": "Erica", 
            "id": "sg:person.012210064161.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012210064161.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Mayo Clinic", 
              "id": "https://www.grid.ac/institutes/grid.66875.3a", 
              "name": [
                "Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oliveira", 
            "givenName": "Andre M", 
            "id": "sg:person.01336022204.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336022204.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Cleveland Clinic", 
              "id": "https://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Department of Pathology, Cleveland Clinic, Cleveland, OH, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Billings", 
            "givenName": "Steven D", 
            "id": "sg:person.015531203757.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015531203757.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leiden University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.10419.3d", 
              "name": [
                "Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bov\u00e9e", 
            "givenName": "Judith V M G", 
            "id": "sg:person.0675664562.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675664562.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Baylor College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Department of Pathology, Texas Children's Hospital, Houston, TX, USA.", 
                "Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Roy", 
            "givenName": "Angshumoy", 
            "id": "sg:person.01032505657.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032505657.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.", 
                "Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lazar", 
            "givenName": "Alexander J", 
            "id": "sg:person.010255222337.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010255222337.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Baylor College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.39382.33", 
              "name": [
                "Department of Pathology, Texas Children's Hospital, Houston, TX, USA.", 
                "Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lopez-Terrada", 
            "givenName": "Dolores H", 
            "id": "sg:person.014633403267.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014633403267.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The University of Texas MD Anderson Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.240145.6", 
              "name": [
                "Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.", 
                "Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Wei-Lien", 
            "id": "sg:person.010331373604.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010331373604.53"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1093/ajcp/35.2.122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003677453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(19820415)49:8<1668::aid-cncr2820490823>3.0.co;2-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004353411"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004728146", 
              "https://doi.org/10.1038/onc.2010.116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004728146", 
              "https://doi.org/10.1038/onc.2010.116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.24.22.9752-9762.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005565335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.24.22.9752-9762.2004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005565335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)63432-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007199230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)63432-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007199230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humpath.2014.01.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008319173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humpath.2014.01.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008319173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-011-1063-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008937190", 
              "https://doi.org/10.1007/s00428-011-1063-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1017/s0022215100095839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009477715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0955-0674(00)00143-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010139482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0106282", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011704736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m505220200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015060941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m505220200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015060941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m505220200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015060941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.22366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016118701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.22366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016118701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3729", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016683041", 
              "https://doi.org/10.1038/nm.3729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/bph.13653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018220604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-13-1130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018425546"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000478-199110000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019000868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000478-199110000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019000868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.22099", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019408213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2009.85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020925266", 
              "https://doi.org/10.1038/modpathol.2009.85"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2009.85", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020925266", 
              "https://doi.org/10.1038/modpathol.2009.85"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mph.0b013e3181df6305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022158283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mph.0b013e3181df6305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022158283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0297-170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022198651", 
              "https://doi.org/10.1038/ng0297-170"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9440(10)63093-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022404471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.anndiagpath.2015.03.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023117766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1605691113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024162263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1605691113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024162263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024165127", 
              "https://doi.org/10.1038/sj.onc.1208506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024165127", 
              "https://doi.org/10.1038/sj.onc.1208506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0135958", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024705844"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.10232", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025101965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/his.13011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026828161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/his.13011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026828161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-013-1418-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027757011", 
              "https://doi.org/10.1007/s00428-013-1418-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-013-1418-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027757011", 
              "https://doi.org/10.1007/s00428-013-1418-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.156786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029459091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1242/jcs.156786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029459091"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.matbio.2016.02.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031423869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00256-013-1620-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031602483", 
              "https://doi.org/10.1007/s00256-013-1620-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2016.09.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032184509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2016.09.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032184509"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-5793(99)01780-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032259999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humpath.2013.03.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032464062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humpath.2013.03.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032464062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10529-007-9475-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032547044", 
              "https://doi.org/10.1007/s10529-007-9475-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10529-007-9475-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032547044", 
              "https://doi.org/10.1007/s10529-007-9475-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10529-007-9475-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032547044", 
              "https://doi.org/10.1007/s10529-007-9475-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.23.6.2151-2161.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032727705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.23.6.2151-2161.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032727705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jpedsurg.2009.01.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032872394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mph.0b013e318257a64b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032952747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mph.0b013e318257a64b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032952747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2016.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035798868", 
              "https://doi.org/10.1038/modpathol.2016.83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2016.83", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035798868", 
              "https://doi.org/10.1038/modpathol.2016.83"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.22432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037301178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/gcc.22432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037301178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1309/425h-nw4w-xc9a-005h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038254670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.phrs.2015.05.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038409262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2011.520", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038668184", 
              "https://doi.org/10.1038/onc.2011.520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2011.520", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038668184", 
              "https://doi.org/10.1038/onc.2011.520"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10529-005-5523-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039110763", 
              "https://doi.org/10.1007/s10529-005-5523-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10529-005-5523-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039110763", 
              "https://doi.org/10.1007/s10529-005-5523-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10529-005-5523-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039110763", 
              "https://doi.org/10.1007/s10529-005-5523-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m110.175133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040454125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcp/25.3.241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041153446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/his.12697", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041612446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/scs.0b013e318176ac1a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041989681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/scs.0b013e318176ac1a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041989681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/scs.0b013e318176ac1a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041989681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-03-2827", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042579917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-03-2827", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042579917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-4140", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043092977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2350/11-07-1064-oa.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043103355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2350/11-07-1064-oa.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043103355"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/jcp.2008.061630", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044668389"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.4836", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045660017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep24141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046031662", 
              "https://doi.org/10.1038/srep24141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(196111/12)14:6<1216::aid-cncr2820140611>3.0.co;2-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047557725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2005.07.159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048093175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2005.07.159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048093175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2005.07.159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048093175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cup.12828", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048118512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cup.12828", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048118512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.2011.118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050206813", 
              "https://doi.org/10.1038/labinvest.2011.118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.2011.118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050206813", 
              "https://doi.org/10.1038/labinvest.2011.118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12253-017-0200-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054035550", 
              "https://doi.org/10.1007/s12253-017-0200-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12253-017-0200-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054035550", 
              "https://doi.org/10.1007/s12253-017-0200-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-15-2391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063215976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-15-2391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063215976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2741/s271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070918373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1043/1543-2165(2008)132[579:post]2.0.co;2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077627817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077940976", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078994351", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078994351", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079290586", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079290586", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-11", 
        "datePublishedReg": "2017-11-01", 
        "description": "Nodular fasciitis is a self-limited myofibroblastic lesion that can be misdiagnosed as a sarcoma as a result of its rapid growth, cellularity, and sometimes prominent mitotic activity. A recurrent translocation t(17;22) has been identified in nodular fasciitis, fusing the coding region of USP6 to the promoter region of MYH9, and resulting in increased USP6 expression. A subset of cases show USP6 rearrangement without the typical fusion variants by RT-PCR, or any MYH9 rearrangement by FISH. We sought to further characterize such tumors using molecular diagnostic assays. A novel RT-PCR assay was designed to detect the two known MYH9-USP6 fusion types in formalin-fixed paraffin-embedded and frozen tissue, and a break-apart FISH assay was designed to detect USP6 rearrangement. Twenty-six cases of nodular fasciitis diagnosed between 2002 and 2013 were retrieved from the pathology files of our institutions and were confirmed to be positive by FISH and/or RT-PCR. Seven samples showed USP6 rearrangement by FISH but were negative for MYH9-USP6 fusion by RT-PCR; these cases were subjected to a next-generation sequencing assay utilizing anchored multiplex PCR technology. This assay targets a single partner gene associated with fusions in bone and soft tissue tumors for agnostic detection of gene fusion partners. Novel fusion partners were identified in all seven cases and confirmed by RT-PCR. Structurally, all fusions consisted of the juxtaposition of the entire coding region of USP6 with the promoter of the partner gene, driving increased USP6 expression. This study confirms the neoplastic nature of nodular fasciitis, defines additional pathogenic fusion partners, and adds to the growing body of literature on USP6-associated neoplasia. Given the diagnostic challenges of these tumors, molecular assays can be useful ancillary tools; however, the prevalence of promoter swapping must be recognized when interpreting results.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/modpathol.2017.78", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1098208", 
            "issn": [
              "0893-3952", 
              "1530-0285"
            ], 
            "name": "Modern Pathology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "11", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "30"
          }
        ], 
        "name": "USP6 activation in nodular fasciitis by promoter-swapping gene fusions", 
        "pagination": "1577-1588", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "e15f961c4f429759320cbc82e58efd4cb8e5c298f775693c984306ea52cfbd16"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28752842"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8806605"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/modpathol.2017.78"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1090916254"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/modpathol.2017.78", 
          "https://app.dimensions.ai/details/publication/pub.1090916254"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:59", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130823_00000005.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/modpathol/journal/v30/n11/full/modpathol201778a.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2017.78'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2017.78'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2017.78'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2017.78'


     

    This table displays all metadata directly associated to this object as RDF triples.

    442 TRIPLES      21 PREDICATES      111 URIs      38 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/modpathol.2017.78 schema:about N357d48144d554939a2ec825c93982f90
    2 N39c11ab17ad14adead6006fbcc72314c
    3 N5792b8ac8ac34e52a023ad045ed0b6d9
    4 N5bf48312614241a49751db776f5dd069
    5 N7ead0c35723f44e9b1f0c47cae670881
    6 N85c51dbd0b1d4dc58c3d0002c6473ab6
    7 N9c29fd7d35c74e0eb3f0e0abc6ef18e4
    8 N9c94763ee28847f29b7a5a2f8dd25392
    9 Na3e62413d6f74f62acdaebc35e129db5
    10 Na682759828724eb4af73842d8cca1edd
    11 Na937bb79e380466d9cdd83adb224a7b3
    12 Nab415df793f148c09a582154f91822ca
    13 Ncf8eb3b1b1ff4c77a77b15b5e0fb5c5c
    14 Nd437d6b50d45465bbc69e058279f4997
    15 Nd4dc1f80af6c41c59e3134416a71cbb4
    16 Ne8eb147392314e7882931d7392f3ce6b
    17 Nf07c12ad3cdd4852a19ad5574f4fc01b
    18 anzsrc-for:06
    19 anzsrc-for:0604
    20 schema:author N20c645c4e9724e19b1c39c4068785344
    21 schema:citation sg:pub.10.1007/s00256-013-1620-9
    22 sg:pub.10.1007/s00428-011-1063-4
    23 sg:pub.10.1007/s00428-013-1418-0
    24 sg:pub.10.1007/s10529-005-5523-2
    25 sg:pub.10.1007/s10529-007-9475-6
    26 sg:pub.10.1007/s12253-017-0200-z
    27 sg:pub.10.1038/labinvest.2011.118
    28 sg:pub.10.1038/modpathol.2009.85
    29 sg:pub.10.1038/modpathol.2016.83
    30 sg:pub.10.1038/ng0297-170
    31 sg:pub.10.1038/nm.3729
    32 sg:pub.10.1038/onc.2010.116
    33 sg:pub.10.1038/onc.2011.520
    34 sg:pub.10.1038/sj.onc.1208506
    35 sg:pub.10.1038/srep24141
    36 https://app.dimensions.ai/details/publication/pub.1077940976
    37 https://app.dimensions.ai/details/publication/pub.1078994351
    38 https://app.dimensions.ai/details/publication/pub.1079290586
    39 https://doi.org/10.1002/1097-0142(196111/12)14:6<1216::aid-cncr2820140611>3.0.co;2-w
    40 https://doi.org/10.1002/1097-0142(19820415)49:8<1668::aid-cncr2820490823>3.0.co;2-9
    41 https://doi.org/10.1002/cncr.22099
    42 https://doi.org/10.1002/gcc.10232
    43 https://doi.org/10.1002/gcc.22366
    44 https://doi.org/10.1002/gcc.22432
    45 https://doi.org/10.1002/path.4836
    46 https://doi.org/10.1016/j.anndiagpath.2015.03.013
    47 https://doi.org/10.1016/j.bbrc.2005.07.159
    48 https://doi.org/10.1016/j.humpath.2013.03.005
    49 https://doi.org/10.1016/j.humpath.2014.01.020
    50 https://doi.org/10.1016/j.jpedsurg.2009.01.047
    51 https://doi.org/10.1016/j.matbio.2016.02.012
    52 https://doi.org/10.1016/j.phrs.2015.05.001
    53 https://doi.org/10.1016/j.stem.2016.09.010
    54 https://doi.org/10.1016/s0002-9440(10)63093-3
    55 https://doi.org/10.1016/s0002-9440(10)63432-3
    56 https://doi.org/10.1016/s0014-5793(99)01780-9
    57 https://doi.org/10.1016/s0955-0674(00)00143-5
    58 https://doi.org/10.1017/s0022215100095839
    59 https://doi.org/10.1043/1543-2165(2008)132[579:post]2.0.co;2
    60 https://doi.org/10.1073/pnas.1605691113
    61 https://doi.org/10.1074/jbc.m110.175133
    62 https://doi.org/10.1074/jbc.m505220200
    63 https://doi.org/10.1093/ajcp/25.3.241
    64 https://doi.org/10.1093/ajcp/35.2.122
    65 https://doi.org/10.1097/00000478-199110000-00004
    66 https://doi.org/10.1097/mph.0b013e3181df6305
    67 https://doi.org/10.1097/mph.0b013e318257a64b
    68 https://doi.org/10.1097/scs.0b013e318176ac1a
    69 https://doi.org/10.1111/bph.13653
    70 https://doi.org/10.1111/cup.12828
    71 https://doi.org/10.1111/his.12697
    72 https://doi.org/10.1111/his.13011
    73 https://doi.org/10.1128/mcb.23.6.2151-2161.2003
    74 https://doi.org/10.1128/mcb.24.22.9752-9762.2004
    75 https://doi.org/10.1136/jcp.2008.061630
    76 https://doi.org/10.1158/0008-5472.can-03-2827
    77 https://doi.org/10.1158/0008-5472.can-06-4140
    78 https://doi.org/10.1158/0008-5472.can-15-2391
    79 https://doi.org/10.1158/1078-0432.ccr-13-1130
    80 https://doi.org/10.1242/jcs.156786
    81 https://doi.org/10.1309/425h-nw4w-xc9a-005h
    82 https://doi.org/10.1371/journal.pone.0106282
    83 https://doi.org/10.1371/journal.pone.0135958
    84 https://doi.org/10.2350/11-07-1064-oa.1
    85 https://doi.org/10.2741/s271
    86 schema:datePublished 2017-11
    87 schema:datePublishedReg 2017-11-01
    88 schema:description Nodular fasciitis is a self-limited myofibroblastic lesion that can be misdiagnosed as a sarcoma as a result of its rapid growth, cellularity, and sometimes prominent mitotic activity. A recurrent translocation t(17;22) has been identified in nodular fasciitis, fusing the coding region of USP6 to the promoter region of MYH9, and resulting in increased USP6 expression. A subset of cases show USP6 rearrangement without the typical fusion variants by RT-PCR, or any MYH9 rearrangement by FISH. We sought to further characterize such tumors using molecular diagnostic assays. A novel RT-PCR assay was designed to detect the two known MYH9-USP6 fusion types in formalin-fixed paraffin-embedded and frozen tissue, and a break-apart FISH assay was designed to detect USP6 rearrangement. Twenty-six cases of nodular fasciitis diagnosed between 2002 and 2013 were retrieved from the pathology files of our institutions and were confirmed to be positive by FISH and/or RT-PCR. Seven samples showed USP6 rearrangement by FISH but were negative for MYH9-USP6 fusion by RT-PCR; these cases were subjected to a next-generation sequencing assay utilizing anchored multiplex PCR technology. This assay targets a single partner gene associated with fusions in bone and soft tissue tumors for agnostic detection of gene fusion partners. Novel fusion partners were identified in all seven cases and confirmed by RT-PCR. Structurally, all fusions consisted of the juxtaposition of the entire coding region of USP6 with the promoter of the partner gene, driving increased USP6 expression. This study confirms the neoplastic nature of nodular fasciitis, defines additional pathogenic fusion partners, and adds to the growing body of literature on USP6-associated neoplasia. Given the diagnostic challenges of these tumors, molecular assays can be useful ancillary tools; however, the prevalence of promoter swapping must be recognized when interpreting results.
    89 schema:genre research_article
    90 schema:inLanguage en
    91 schema:isAccessibleForFree true
    92 schema:isPartOf N7d3c770025074d739470891f953973b9
    93 N8f9a304971884c0b8834c9b90496fe4e
    94 sg:journal.1098208
    95 schema:name USP6 activation in nodular fasciitis by promoter-swapping gene fusions
    96 schema:pagination 1577-1588
    97 schema:productId N2d750cb478394329a4c9152f8b8ccca1
    98 N51c87d790f3042a28bf6b581988ca54b
    99 N9a6c03d7c60e430a95bb02fa052c1646
    100 Nc7b2f7519df840588d855501fd7bc76e
    101 Ne5ee9d08e3f6471b8b57e1e52ff6b5c4
    102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090916254
    103 https://doi.org/10.1038/modpathol.2017.78
    104 schema:sdDatePublished 2019-04-11T13:59
    105 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    106 schema:sdPublisher N3f03ac6a32c84e1cb37d9e79542ca87a
    107 schema:url http://www.nature.com/modpathol/journal/v30/n11/full/modpathol201778a.html
    108 sgo:license sg:explorer/license/
    109 sgo:sdDataset articles
    110 rdf:type schema:ScholarlyArticle
    111 N116f7827577946c5bb5274cc16d11d26 rdf:first sg:person.0743144317.03
    112 rdf:rest Nc318cf088e4a4fa485bb8cc6ea1a2760
    113 N12a869c4b26f43a6a9f0401ed1735583 rdf:first sg:person.012210064161.14
    114 rdf:rest N76b2dc7793c6437985bec2e4ad18ce7b
    115 N17841d6a7130415c871b62f2b14d7c41 rdf:first sg:person.0751521705.20
    116 rdf:rest N116f7827577946c5bb5274cc16d11d26
    117 N20c645c4e9724e19b1c39c4068785344 rdf:first sg:person.0720246125.32
    118 rdf:rest Na21e7aa47d8b4494b1538d28fb2a6499
    119 N24bf3d89d7c34d959a57b48d803f142f rdf:first sg:person.01032505657.11
    120 rdf:rest Na0936264a3ef462299dfed5ce7af98c5
    121 N2d750cb478394329a4c9152f8b8ccca1 schema:name readcube_id
    122 schema:value e15f961c4f429759320cbc82e58efd4cb8e5c298f775693c984306ea52cfbd16
    123 rdf:type schema:PropertyValue
    124 N357d48144d554939a2ec825c93982f90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Male
    126 rdf:type schema:DefinedTerm
    127 N39c11ab17ad14adead6006fbcc72314c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Fasciitis
    129 rdf:type schema:DefinedTerm
    130 N3f03ac6a32c84e1cb37d9e79542ca87a schema:name Springer Nature - SN SciGraph project
    131 rdf:type schema:Organization
    132 N45a3e7fa773e4549a0bca726d19dbd07 rdf:first sg:person.014633403267.66
    133 rdf:rest N6380032ce50245cdb380bd99ebd5d499
    134 N51c87d790f3042a28bf6b581988ca54b schema:name dimensions_id
    135 schema:value pub.1090916254
    136 rdf:type schema:PropertyValue
    137 N5792b8ac8ac34e52a023ad045ed0b6d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Adolescent
    139 rdf:type schema:DefinedTerm
    140 N5bf48312614241a49751db776f5dd069 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Promoter Regions, Genetic
    142 rdf:type schema:DefinedTerm
    143 N6380032ce50245cdb380bd99ebd5d499 rdf:first sg:person.010331373604.53
    144 rdf:rest rdf:nil
    145 N712db229beaf441aaa9173a8401f37ed rdf:first sg:person.0675664562.78
    146 rdf:rest N24bf3d89d7c34d959a57b48d803f142f
    147 N76b2dc7793c6437985bec2e4ad18ce7b rdf:first sg:person.01336022204.52
    148 rdf:rest Ndc80c25af1c84b99956cd59650301020
    149 N7d3c770025074d739470891f953973b9 schema:issueNumber 11
    150 rdf:type schema:PublicationIssue
    151 N7ead0c35723f44e9b1f0c47cae670881 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Humans
    153 rdf:type schema:DefinedTerm
    154 N85c51dbd0b1d4dc58c3d0002c6473ab6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Young Adult
    156 rdf:type schema:DefinedTerm
    157 N8f9a304971884c0b8834c9b90496fe4e schema:volumeNumber 30
    158 rdf:type schema:PublicationVolume
    159 N9a6c03d7c60e430a95bb02fa052c1646 schema:name doi
    160 schema:value 10.1038/modpathol.2017.78
    161 rdf:type schema:PropertyValue
    162 N9c29fd7d35c74e0eb3f0e0abc6ef18e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Oncogene Proteins, Fusion
    164 rdf:type schema:DefinedTerm
    165 N9c94763ee28847f29b7a5a2f8dd25392 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Translocation, Genetic
    167 rdf:type schema:DefinedTerm
    168 Na0936264a3ef462299dfed5ce7af98c5 rdf:first sg:person.010255222337.53
    169 rdf:rest N45a3e7fa773e4549a0bca726d19dbd07
    170 Na21e7aa47d8b4494b1538d28fb2a6499 rdf:first sg:person.010534707637.06
    171 rdf:rest N17841d6a7130415c871b62f2b14d7c41
    172 Na3e62413d6f74f62acdaebc35e129db5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Child
    174 rdf:type schema:DefinedTerm
    175 Na682759828724eb4af73842d8cca1edd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Female
    177 rdf:type schema:DefinedTerm
    178 Na937bb79e380466d9cdd83adb224a7b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Proto-Oncogene Proteins
    180 rdf:type schema:DefinedTerm
    181 Nab415df793f148c09a582154f91822ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Ubiquitin Thiolesterase
    183 rdf:type schema:DefinedTerm
    184 Nc318cf088e4a4fa485bb8cc6ea1a2760 rdf:first sg:person.016466066107.29
    185 rdf:rest N12a869c4b26f43a6a9f0401ed1735583
    186 Nc7b2f7519df840588d855501fd7bc76e schema:name nlm_unique_id
    187 schema:value 8806605
    188 rdf:type schema:PropertyValue
    189 Ncf8eb3b1b1ff4c77a77b15b5e0fb5c5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Adult
    191 rdf:type schema:DefinedTerm
    192 Nd437d6b50d45465bbc69e058279f4997 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Myofibroma
    194 rdf:type schema:DefinedTerm
    195 Nd4dc1f80af6c41c59e3134416a71cbb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Aged
    197 rdf:type schema:DefinedTerm
    198 Ndc80c25af1c84b99956cd59650301020 rdf:first sg:person.015531203757.22
    199 rdf:rest N712db229beaf441aaa9173a8401f37ed
    200 Ne5ee9d08e3f6471b8b57e1e52ff6b5c4 schema:name pubmed_id
    201 schema:value 28752842
    202 rdf:type schema:PropertyValue
    203 Ne8eb147392314e7882931d7392f3ce6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Middle Aged
    205 rdf:type schema:DefinedTerm
    206 Nf07c12ad3cdd4852a19ad5574f4fc01b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Oncogene Fusion
    208 rdf:type schema:DefinedTerm
    209 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    210 schema:name Biological Sciences
    211 rdf:type schema:DefinedTerm
    212 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    213 schema:name Genetics
    214 rdf:type schema:DefinedTerm
    215 sg:journal.1098208 schema:issn 0893-3952
    216 1530-0285
    217 schema:name Modern Pathology
    218 rdf:type schema:Periodical
    219 sg:person.010255222337.53 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    220 schema:familyName Lazar
    221 schema:givenName Alexander J
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010255222337.53
    223 rdf:type schema:Person
    224 sg:person.01032505657.11 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
    225 schema:familyName Roy
    226 schema:givenName Angshumoy
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032505657.11
    228 rdf:type schema:Person
    229 sg:person.010331373604.53 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    230 schema:familyName Wang
    231 schema:givenName Wei-Lien
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010331373604.53
    233 rdf:type schema:Person
    234 sg:person.010534707637.06 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    235 schema:familyName Chrisinger
    236 schema:givenName John S A
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010534707637.06
    238 rdf:type schema:Person
    239 sg:person.012210064161.14 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    240 schema:familyName Kumar
    241 schema:givenName Erica
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012210064161.14
    243 rdf:type schema:Person
    244 sg:person.01336022204.52 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
    245 schema:familyName Oliveira
    246 schema:givenName Andre M
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336022204.52
    248 rdf:type schema:Person
    249 sg:person.014633403267.66 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
    250 schema:familyName Lopez-Terrada
    251 schema:givenName Dolores H
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014633403267.66
    253 rdf:type schema:Person
    254 sg:person.015531203757.22 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
    255 schema:familyName Billings
    256 schema:givenName Steven D
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015531203757.22
    258 rdf:type schema:Person
    259 sg:person.016466066107.29 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
    260 schema:familyName Reuther
    261 schema:givenName Jacquelyn
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016466066107.29
    263 rdf:type schema:Person
    264 sg:person.0675664562.78 schema:affiliation https://www.grid.ac/institutes/grid.10419.3d
    265 schema:familyName Bovée
    266 schema:givenName Judith V M G
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675664562.78
    268 rdf:type schema:Person
    269 sg:person.0720246125.32 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
    270 schema:familyName Patel
    271 schema:givenName Nimesh R
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720246125.32
    273 rdf:type schema:Person
    274 sg:person.0743144317.03 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
    275 schema:familyName Sarabia
    276 schema:givenName Stephen F
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743144317.03
    278 rdf:type schema:Person
    279 sg:person.0751521705.20 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
    280 schema:familyName Demicco
    281 schema:givenName Elizabeth G
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751521705.20
    283 rdf:type schema:Person
    284 sg:pub.10.1007/s00256-013-1620-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031602483
    285 https://doi.org/10.1007/s00256-013-1620-9
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1007/s00428-011-1063-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008937190
    288 https://doi.org/10.1007/s00428-011-1063-4
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1007/s00428-013-1418-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027757011
    291 https://doi.org/10.1007/s00428-013-1418-0
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1007/s10529-005-5523-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039110763
    294 https://doi.org/10.1007/s10529-005-5523-2
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1007/s10529-007-9475-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032547044
    297 https://doi.org/10.1007/s10529-007-9475-6
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1007/s12253-017-0200-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1054035550
    300 https://doi.org/10.1007/s12253-017-0200-z
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/labinvest.2011.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050206813
    303 https://doi.org/10.1038/labinvest.2011.118
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/modpathol.2009.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020925266
    306 https://doi.org/10.1038/modpathol.2009.85
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/modpathol.2016.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035798868
    309 https://doi.org/10.1038/modpathol.2016.83
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/ng0297-170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022198651
    312 https://doi.org/10.1038/ng0297-170
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1038/nm.3729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016683041
    315 https://doi.org/10.1038/nm.3729
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1038/onc.2010.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004728146
    318 https://doi.org/10.1038/onc.2010.116
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1038/onc.2011.520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038668184
    321 https://doi.org/10.1038/onc.2011.520
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1038/sj.onc.1208506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024165127
    324 https://doi.org/10.1038/sj.onc.1208506
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1038/srep24141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046031662
    327 https://doi.org/10.1038/srep24141
    328 rdf:type schema:CreativeWork
    329 https://app.dimensions.ai/details/publication/pub.1077940976 schema:CreativeWork
    330 https://app.dimensions.ai/details/publication/pub.1078994351 schema:CreativeWork
    331 https://app.dimensions.ai/details/publication/pub.1079290586 schema:CreativeWork
    332 https://doi.org/10.1002/1097-0142(196111/12)14:6<1216::aid-cncr2820140611>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1047557725
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1002/1097-0142(19820415)49:8<1668::aid-cncr2820490823>3.0.co;2-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004353411
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1002/cncr.22099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019408213
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1002/gcc.10232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025101965
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1002/gcc.22366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016118701
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1002/gcc.22432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037301178
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1002/path.4836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045660017
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1016/j.anndiagpath.2015.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023117766
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1016/j.bbrc.2005.07.159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048093175
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1016/j.humpath.2013.03.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032464062
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1016/j.humpath.2014.01.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008319173
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1016/j.jpedsurg.2009.01.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032872394
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1016/j.matbio.2016.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031423869
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1016/j.phrs.2015.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038409262
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1016/j.stem.2016.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032184509
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1016/s0002-9440(10)63093-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022404471
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1016/s0002-9440(10)63432-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007199230
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1016/s0014-5793(99)01780-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032259999
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1016/s0955-0674(00)00143-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010139482
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1017/s0022215100095839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009477715
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1043/1543-2165(2008)132[579:post]2.0.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077627817
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1073/pnas.1605691113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024162263
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1074/jbc.m110.175133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040454125
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1074/jbc.m505220200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015060941
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1093/ajcp/25.3.241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041153446
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1093/ajcp/35.2.122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003677453
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1097/00000478-199110000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019000868
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1097/mph.0b013e3181df6305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022158283
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1097/mph.0b013e318257a64b schema:sameAs https://app.dimensions.ai/details/publication/pub.1032952747
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1097/scs.0b013e318176ac1a schema:sameAs https://app.dimensions.ai/details/publication/pub.1041989681
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1111/bph.13653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018220604
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1111/cup.12828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048118512
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1111/his.12697 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041612446
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1111/his.13011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026828161
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1128/mcb.23.6.2151-2161.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032727705
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1128/mcb.24.22.9752-9762.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005565335
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1136/jcp.2008.061630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044668389
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1158/0008-5472.can-03-2827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042579917
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1158/0008-5472.can-06-4140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043092977
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1158/0008-5472.can-15-2391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063215976
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1158/1078-0432.ccr-13-1130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018425546
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1242/jcs.156786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029459091
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1309/425h-nw4w-xc9a-005h schema:sameAs https://app.dimensions.ai/details/publication/pub.1038254670
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1371/journal.pone.0106282 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011704736
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1371/journal.pone.0135958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024705844
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.2350/11-07-1064-oa.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043103355
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.2741/s271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070918373
    425 rdf:type schema:CreativeWork
    426 https://www.grid.ac/institutes/grid.10419.3d schema:alternateName Leiden University Medical Center
    427 schema:name Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
    428 rdf:type schema:Organization
    429 https://www.grid.ac/institutes/grid.239578.2 schema:alternateName Cleveland Clinic
    430 schema:name Department of Pathology, Cleveland Clinic, Cleveland, OH, USA.
    431 rdf:type schema:Organization
    432 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
    433 schema:name Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    434 Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
    435 rdf:type schema:Organization
    436 https://www.grid.ac/institutes/grid.39382.33 schema:alternateName Baylor College of Medicine
    437 schema:name Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX, USA.
    438 Department of Pathology, Texas Children's Hospital, Houston, TX, USA.
    439 rdf:type schema:Organization
    440 https://www.grid.ac/institutes/grid.66875.3a schema:alternateName Mayo Clinic
    441 schema:name Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
    442 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...