Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08-04

AUTHORS

Olca Basturk, Michael F Berger, Hiroshi Yamaguchi, Volkan Adsay, Gokce Askan, Umesh K Bhanot, Ahmet Zehir, Fatima Carneiro, Seung-Mo Hong, Giuseppe Zamboni, Esra Dikoglu, Vaidehi Jobanputra, Kazimierz O Wrzeszczynski, Serdar Balci, Peter Allen, Naoki Ikari, Shoko Takeuchi, Hiroyuki Akagawa, Atsushi Kanno, Tooru Shimosegawa, Takanori Morikawa, Fuyuhiko Motoi, Michiaki Unno, Ryota Higuchi, Masakazu Yamamoto, Kyoko Shimizu, Toru Furukawa, David S Klimstra

ABSTRACT

Intraductal tubulopapillary neoplasm is a relatively recently described member of the pancreatic intraductal neoplasm family. The more common member of this family, intraductal papillary mucinous neoplasm, often carries genetic alterations typical of pancreatic infiltrating ductal adenocarcinoma (KRAS, TP53, and CDKN2A) but additionally has mutations in GNAS and RNF43 genes. However, the genetic characteristics of intraductal tubulopapillary neoplasm have not been well characterized. Twenty-two intraductal tubulopapillary neoplasms were analyzed by either targeted next-generation sequencing, which enabled the identification of sequence mutations, copy number alterations, and selected structural rearrangements involving all targeted (≥300) genes, or whole-exome sequencing. Three of these intraductal tubulopapillary neoplasms were also subjected to whole-genome sequencing. All intraductal tubulopapillary neoplasms revealed the characteristic histologic (cellular intraductal nodules of back-to-back tubular glands lined by predominantly cuboidal cells with atypical nuclei and no obvious intracellular mucin) and immunohistochemical (immunolabeled with MUC1 and MUC6 but were negative for MUC2 and MUC5AC) features. By genomic analyses, there was loss of CDKN2A in 5/20 (25%) of these cases. However, the majority of the previously reported intraductal papillary mucinous neoplasm-related alterations were absent. Moreover, in contrast to most ductal neoplasms of the pancreas, MAP-kinase pathway was not involved. In fact, 2/22 (9%) of intraductal tubulopapillary neoplasms did not reveal any mutations in the tested genes. However, certain chromatin remodeling genes (MLL1, MLL2, MLL3, BAP1, PBRM1, EED, and ATRX) were found to be mutated in 7/22 (32%) of intraductal tubulopapillary neoplasms and 27% harbored phosphatidylinositol 3-kinase (PI3K) pathway (PIK3CA, PIK3CB, INPP4A, and PTEN) mutations. In addition, 4/18 (18%) of intraductal tubulopapillary neoplasms had FGFR2 fusions (FGFR2-CEP55, FGFR2-SASS6, DISP1-FGFR2, FGFR2-TXLNA, and FGFR2-VCL) and 1/18 (5.5%) had STRN-ALK fusion. Intraductal tubulopapillary neoplasm is a distinct clinicopathologic entity in the pancreas. Although its intraductal nature and some clinicopathologic features resemble those of intraductal papillary mucinous neoplasm, our results suggest that intraductal tubulopapillary neoplasm has distinguishing genetic characteristics. Some of these mutated genes are potentially targetable. Future functional studies will be needed to determine the consequences of these gene alterations. More... »

PAGES

1760-1772

References to SciGraph publications

  • 2015-08-10. Genomic spectra of biliary tract cancer in NATURE GENETICS
  • 2006-06. Intraductal tubular carcinoma in an adenoma of the main pancreatic duct of the pancreas head in JOURNAL OF GASTROENTEROLOGY
  • 2013-07-12. Clinicopathological Correlates of Activating GNAS Mutations in Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas in ANNALS OF SURGICAL ONCOLOGY
  • 2016-06-06. Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response in ONCOGENE
  • <error retrieving object. in <ERROR RETRIEVING OBJECT
  • 2009-05-02. Increased K-ras mutation and expression of S100A4 and MUC2 protein in the malignant intraductal papillary mucinous tumor of the pancreas in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2015-07-07. Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients in NATURE COMMUNICATIONS
  • 1998-03-05. BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression in ONCOGENE
  • 2011-01-01. Integrative genomics viewer in NATURE BIOTECHNOLOGY
  • 2015-06-26. Intraductal tubulopapillary neoplasms of the bile ducts: clinicopathologic, immunohistochemical, and molecular analysis of 20 cases in MODERN PATHOLOGY
  • 2016-03-21. Clinicopathological features and surgical outcomes of intraductal tubulopapillary neoplasm of the pancreas: a systematic review in LANGENBECK'S ARCHIVES OF SURGERY
  • 2013-02-10. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples in NATURE BIOTECHNOLOGY
  • 2002-09. The expression of several types of mucin is related to the biological behavior of pancreatic neoplasms in JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
  • 2011-11-18. Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas in SCIENTIFIC REPORTS
  • 2014-08-24. Genetic landscape of esophageal squamous cell carcinoma in NATURE GENETICS
  • 2014-08-17. Accurate de novo and transmitted indel detection in exome-capture data using microassembly in NATURE METHODS
  • 1994-11. Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients in VIRCHOWS ARCHIV
  • 2010-02. The landscape of somatic copy-number alteration across human cancers in NATURE
  • 2008-02-21. PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas in LANGENBECK'S ARCHIVES OF SURGERY
  • 2004-03-11. Microcystic tubulopapillary carcinoma of the pancreas: a new tumor entity? in VIRCHOWS ARCHIV
  • 2011-07-27. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma in NATURE
  • 2015-01-22. Massive parallel sequencing uncovers actionable FGFR2–PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma in NATURE COMMUNICATIONS
  • 2010-01-06. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes in NATURE
  • 2015-03-06. Whole exome sequencing reveals recurrent mutations in BRCA2 and FAT genes in acinar cell carcinomas of the pancreas in SCIENTIFIC REPORTS
  • 2009-10. Histone Deacetylase Inhibitors in DRUGS
  • 2014-08-12. Exome sequencing identifies frequent mutation of MLL2 in non–small cell lung carcinoma from Chinese patients in SCIENTIFIC REPORTS
  • 2009-08-09. BreakDancer: an algorithm for high-resolution mapping of genomic structural variation in NATURE METHODS
  • 2011-06-12. CREST maps somatic structural variation in cancer genomes with base-pair resolution in NATURE METHODS
  • 2011-04-10. A framework for variation discovery and genotyping using next-generation DNA sequencing data in NATURE GENETICS
  • Journal

    TITLE

    Modern Pathology

    ISSUE

    12

    VOLUME

    30

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/modpathol.2017.60

    DOI

    http://dx.doi.org/10.1038/modpathol.2017.60

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090990730

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28776573


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adenocarcinoma, Mucinous", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adenocarcinoma, Papillary", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biomarkers, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Pancreatic Ductal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Mutational Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pancreatic Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Basturk", 
            "givenName": "Olca", 
            "id": "sg:person.0672650056.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672650056.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Berger", 
            "givenName": "Michael F", 
            "id": "sg:person.0653777340.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653777340.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Tokyo Medical University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410793.8", 
              "name": [
                "Department of Pathology, Tokyo Medical University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamaguchi", 
            "givenName": "Hiroshi", 
            "id": "sg:person.0646162022.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646162022.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Emory University, Atlanta, GA, USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Department of Pathology, Emory University, Atlanta, GA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Adsay", 
            "givenName": "Volkan", 
            "id": "sg:person.01172223364.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172223364.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Askan", 
            "givenName": "Gokce", 
            "id": "sg:person.01352434007.71", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352434007.71"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bhanot", 
            "givenName": "Umesh K", 
            "id": "sg:person.01267161677.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267161677.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zehir", 
            "givenName": "Ahmet", 
            "id": "sg:person.01242016756.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242016756.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Centro Hospitalar S\u00e3o Jo\u00e3o/Faculty of Medicine of Porto University and Institute for Research and Innovation in Health/Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal", 
              "id": "http://www.grid.ac/institutes/grid.5808.5", 
              "name": [
                "Department of Pathology, Centro Hospitalar S\u00e3o Jo\u00e3o/Faculty of Medicine of Porto University and Institute for Research and Innovation in Health/Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Carneiro", 
            "givenName": "Fatima", 
            "id": "sg:person.01234506371.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234506371.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea", 
              "id": "http://www.grid.ac/institutes/grid.413967.e", 
              "name": [
                "Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hong", 
            "givenName": "Seung-Mo", 
            "id": "sg:person.013167714057.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013167714057.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, University of Verona, Ospedale S.C.-Don Calabria-Negrar, Verona, Italy", 
              "id": "http://www.grid.ac/institutes/grid.5611.3", 
              "name": [
                "Department of Pathology, University of Verona, Ospedale S.C.-Don Calabria-Negrar, Verona, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zamboni", 
            "givenName": "Giuseppe", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "New York Genome Center, Molecular Diagnostics, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.429884.b", 
              "name": [
                "New York Genome Center, Molecular Diagnostics, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dikoglu", 
            "givenName": "Esra", 
            "id": "sg:person.0740724104.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740724104.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Colombia University Medical Center, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "New York Genome Center, Molecular Diagnostics, New York, NY, USA", 
                "Department of Pathology, Colombia University Medical Center, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jobanputra", 
            "givenName": "Vaidehi", 
            "id": "sg:person.0577272442.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577272442.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "New York Genome Center, Molecular Diagnostics, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.429884.b", 
              "name": [
                "New York Genome Center, Molecular Diagnostics, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wrzeszczynski", 
            "givenName": "Kazimierz O", 
            "id": "sg:person.0605250074.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605250074.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Emory University, Atlanta, GA, USA", 
              "id": "http://www.grid.ac/institutes/grid.189967.8", 
              "name": [
                "Department of Pathology, Emory University, Atlanta, GA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Balci", 
            "givenName": "Serdar", 
            "id": "sg:person.01312134274.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312134274.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Memorial Sloan Kettering Cancer Center, New YorkNY, USA", 
              "id": "http://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Department of Surgery, Memorial Sloan Kettering Cancer Center, New YorkNY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Allen", 
            "givenName": "Peter", 
            "id": "sg:person.01311111353.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311111353.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Integrated Medical Sciences, Tokyo Women\u2019s Medical University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410818.4", 
              "name": [
                "Institute for Integrated Medical Sciences, Tokyo Women\u2019s Medical University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ikari", 
            "givenName": "Naoki", 
            "id": "sg:person.0622515042.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622515042.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Integrated Medical Sciences, Tokyo Women\u2019s Medical University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410818.4", 
              "name": [
                "Institute for Integrated Medical Sciences, Tokyo Women\u2019s Medical University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takeuchi", 
            "givenName": "Shoko", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute for Integrated Medical Sciences, Tokyo Women\u2019s Medical University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410818.4", 
              "name": [
                "Institute for Integrated Medical Sciences, Tokyo Women\u2019s Medical University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Akagawa", 
            "givenName": "Hiroyuki", 
            "id": "sg:person.01065307117.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065307117.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kanno", 
            "givenName": "Atsushi", 
            "id": "sg:person.01025060707.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025060707.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shimosegawa", 
            "givenName": "Tooru", 
            "id": "sg:person.01255535707.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255535707.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Morikawa", 
            "givenName": "Takanori", 
            "id": "sg:person.01023230545.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023230545.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Motoi", 
            "givenName": "Fuyuhiko", 
            "id": "sg:person.01260427553.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260427553.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan", 
              "id": "http://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Unno", 
            "givenName": "Michiaki", 
            "id": "sg:person.01101727053.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101727053.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Tokyo Women\u2019s Medical University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410818.4", 
              "name": [
                "Department of Surgery, Tokyo Women\u2019s Medical University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Higuchi", 
            "givenName": "Ryota", 
            "id": "sg:person.01363063767.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363063767.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Tokyo Women\u2019s Medical University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410818.4", 
              "name": [
                "Department of Surgery, Tokyo Women\u2019s Medical University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yamamoto", 
            "givenName": "Masakazu", 
            "id": "sg:person.012472631104.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012472631104.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Tokyo Women\u2019s Medical University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410818.4", 
              "name": [
                "Department of Gastroenterology, Tokyo Women\u2019s Medical University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shimizu", 
            "givenName": "Kyoko", 
            "id": "sg:person.0743265465.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743265465.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Tokyo Women\u2019s Medical University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410818.4", 
              "name": [
                "Department of Pathology, Tokyo Women\u2019s Medical University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Furukawa", 
            "givenName": "Toru", 
            "id": "sg:person.014527056622.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014527056622.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA", 
              "id": "http://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Klimstra", 
            "givenName": "David S", 
            "id": "sg:person.011206476464.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011206476464.16"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ng.3076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029451229", 
              "https://doi.org/10.1038/ng.3076"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00534-009-0105-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011659012", 
              "https://doi.org/10.1007/s00534-009-0105-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.2514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000477771", 
              "https://doi.org/10.1038/nbt.2514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020581697", 
              "https://doi.org/10.1038/nmeth.1363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep00161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019748053", 
              "https://doi.org/10.1038/srep00161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-004-0984-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026778707", 
              "https://doi.org/10.1007/s00428-004-0984-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep08829", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031072563", 
              "https://doi.org/10.1038/srep08829"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08672", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032969139", 
              "https://doi.org/10.1038/nature08672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms7087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022244232", 
              "https://doi.org/10.1038/ncomms7087"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1628", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004171938", 
              "https://doi.org/10.1038/nmeth.1628"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.3069", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006401732", 
              "https://doi.org/10.1038/nmeth.3069"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010244476", 
              "https://doi.org/10.1038/ng.806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms8686", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009287444", 
              "https://doi.org/10.1038/ncomms8686"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-006-1821-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029766265", 
              "https://doi.org/10.1007/s00535-006-1821-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-013-3096-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017917551", 
              "https://doi.org/10.1245/s10434-013-3096-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201861", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049332185", 
              "https://doi.org/10.1038/sj.onc.1201861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010635813", 
              "https://doi.org/10.1038/nature08822"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00423-008-0285-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019199187", 
              "https://doi.org/10.1007/s00423-008-0285-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2015.61", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007092445", 
              "https://doi.org/10.1038/modpathol.2015.61"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10351", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019649945", 
              "https://doi.org/10.1038/nature10351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3375", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040279504", 
              "https://doi.org/10.1038/ng.3375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2016.172", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019767778", 
              "https://doi.org/10.1038/onc.2016.172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep06036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036868305", 
              "https://doi.org/10.1038/srep06036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00189573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044745628", 
              "https://doi.org/10.1007/bf00189573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.2806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048130718", 
              "https://doi.org/10.1038/ng.2806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/11315680-000000000-00000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014688288", 
              "https://doi.org/10.2165/11315680-000000000-00000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt.1754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019307928", 
              "https://doi.org/10.1038/nbt.1754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00423-016-1391-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046271380", 
              "https://doi.org/10.1007/s00423-016-1391-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s005340200037", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024147644", 
              "https://doi.org/10.1007/s005340200037"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-08-04", 
        "datePublishedReg": "2017-08-04", 
        "description": "Intraductal tubulopapillary neoplasm is a relatively recently described member of the pancreatic intraductal neoplasm family. The more common member of this family, intraductal papillary mucinous neoplasm, often carries genetic alterations typical of pancreatic infiltrating ductal adenocarcinoma (KRAS, TP53, and CDKN2A) but additionally has mutations in GNAS and RNF43 genes. However, the genetic characteristics of intraductal tubulopapillary neoplasm have not been well characterized. Twenty-two intraductal tubulopapillary neoplasms were analyzed by either targeted next-generation sequencing, which enabled the identification of sequence mutations, copy number alterations, and selected structural rearrangements involving all targeted (\u2265300) genes, or whole-exome sequencing. Three of these intraductal tubulopapillary neoplasms were also subjected to whole-genome sequencing. All intraductal tubulopapillary neoplasms revealed the characteristic histologic (cellular intraductal nodules of back-to-back tubular glands lined by predominantly cuboidal cells with atypical nuclei and no obvious intracellular mucin) and immunohistochemical (immunolabeled with MUC1 and MUC6 but were negative for MUC2 and MUC5AC) features. By genomic analyses, there was loss of CDKN2A in 5/20 (25%) of these cases. However, the majority of the previously reported intraductal papillary mucinous neoplasm-related alterations were absent. Moreover, in contrast to most ductal neoplasms of the pancreas, MAP-kinase pathway was not involved. In fact, 2/22 (9%) of intraductal tubulopapillary neoplasms did not reveal any mutations in the tested genes. However, certain chromatin remodeling genes (MLL1, MLL2, MLL3, BAP1, PBRM1, EED, and ATRX) were found to be mutated in 7/22 (32%) of intraductal tubulopapillary neoplasms and 27% harbored phosphatidylinositol 3-kinase (PI3K) pathway (PIK3CA, PIK3CB, INPP4A, and PTEN) mutations. In addition, 4/18 (18%) of intraductal tubulopapillary neoplasms had FGFR2 fusions (FGFR2-CEP55, FGFR2-SASS6, DISP1-FGFR2, FGFR2-TXLNA, and FGFR2-VCL) and 1/18 (5.5%) had STRN-ALK fusion. Intraductal tubulopapillary neoplasm is a distinct clinicopathologic entity in the pancreas. Although its intraductal nature and some clinicopathologic features resemble those of intraductal papillary mucinous neoplasm, our results suggest that intraductal tubulopapillary neoplasm has distinguishing genetic characteristics. Some of these mutated genes are potentially targetable. Future functional studies will be needed to determine the consequences of these gene alterations.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/modpathol.2017.60", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2438793", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1098208", 
            "issn": [
              "0893-3952", 
              "1530-0285"
            ], 
            "name": "Modern Pathology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "12", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "30"
          }
        ], 
        "keywords": [
          "intraductal papillary mucinous neoplasm", 
          "intraductal tubulopapillary neoplasm", 
          "papillary mucinous neoplasm", 
          "mucinous neoplasms", 
          "future functional studies", 
          "ductal adenocarcinoma", 
          "MAP kinase pathway", 
          "chromatin remodeling genes", 
          "genetic characteristics", 
          "Pancreatic intraductal tubulopapillary neoplasm", 
          "whole-genome sequencing", 
          "STRN-ALK fusion", 
          "distinct clinicopathologic entity", 
          "genomic analysis", 
          "next-generation sequencing", 
          "loss of CDKN2A", 
          "whole-exome sequencing", 
          "sequence mutations", 
          "common members", 
          "genes", 
          "functional studies", 
          "clinicopathologic features", 
          "clinicopathologic entity", 
          "FGFR2 fusions", 
          "characteristic histologic", 
          "number alterations", 
          "genetic alterations", 
          "pathway mutations", 
          "ductal neoplasms", 
          "structural rearrangements", 
          "neoplasms", 
          "mutations", 
          "sequencing", 
          "gene alterations", 
          "adenocarcinoma", 
          "pancreas", 
          "alterations", 
          "family", 
          "phosphatidylinositol", 
          "members", 
          "fusion", 
          "histologic", 
          "pathway", 
          "CDKN2A", 
          "GNAS", 
          "rearrangement", 
          "identification", 
          "majority", 
          "cases", 
          "study", 
          "entities", 
          "contrast", 
          "loss", 
          "consequences", 
          "characteristics", 
          "addition", 
          "analysis", 
          "features", 
          "results", 
          "nature", 
          "fact"
        ], 
        "name": "Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma", 
        "pagination": "1760-1772", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1090990730"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/modpathol.2017.60"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28776573"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/modpathol.2017.60", 
          "https://app.dimensions.ai/details/publication/pub.1090990730"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:04", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_734.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/modpathol.2017.60"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2017.60'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2017.60'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2017.60'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2017.60'


     

    This table displays all metadata directly associated to this object as RDF triples.

    513 TRIPLES      21 PREDICATES      127 URIs      91 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/modpathol.2017.60 schema:about N10db57a77ead4a44bb460099f0d03edb
    2 N1f1239c4c92b4f47896099e5c7a30429
    3 N2e816c78f6624aa680741c2e17be4483
    4 N4933b8a6b44b43e39c3e56a1571f5a40
    5 N4ff219d4d2c4493aabe132dad9fbfec7
    6 N699d30b5e5b542058a130941228932c5
    7 N6cf2b21cc3a54cd3a991cb02fc8c63fb
    8 N7d79d5bdfdcb485fbeb383cf913e8981
    9 Nae18ff9eb87340e7912ea2c14b8f484e
    10 Nb3ab53f4e4ef419fba415e0cbe97125e
    11 Nc71fc27daa5744fcb927b1e2d7fa521b
    12 Ne7e86d1a32404e52ae62556183ebb9de
    13 Nf62ff95c196346a1a5874bb95a3ea773
    14 anzsrc-for:11
    15 schema:author N16e88f37fc534a63ba0b6d2288495e1a
    16 schema:citation sg:pub.10.1007/bf00189573
    17 sg:pub.10.1007/s00423-008-0285-7
    18 sg:pub.10.1007/s00423-016-1391-6
    19 sg:pub.10.1007/s00428-004-0984-6
    20 sg:pub.10.1007/s00534-009-0105-7
    21 sg:pub.10.1007/s005340200037
    22 sg:pub.10.1007/s00535-006-1821-2
    23 sg:pub.10.1038/modpathol.2015.61
    24 sg:pub.10.1038/nature08672
    25 sg:pub.10.1038/nature08822
    26 sg:pub.10.1038/nature10351
    27 sg:pub.10.1038/nbt.1754
    28 sg:pub.10.1038/nbt.2514
    29 sg:pub.10.1038/ncomms7087
    30 sg:pub.10.1038/ncomms8686
    31 sg:pub.10.1038/ng.2806
    32 sg:pub.10.1038/ng.3076
    33 sg:pub.10.1038/ng.3375
    34 sg:pub.10.1038/ng.806
    35 sg:pub.10.1038/nmeth.1363
    36 sg:pub.10.1038/nmeth.1628
    37 sg:pub.10.1038/nmeth.3069
    38 sg:pub.10.1038/onc.2016.172
    39 sg:pub.10.1038/sj.onc.1201861
    40 sg:pub.10.1038/srep00161
    41 sg:pub.10.1038/srep06036
    42 sg:pub.10.1038/srep08829
    43 sg:pub.10.1245/s10434-013-3096-1
    44 sg:pub.10.2165/11315680-000000000-00000
    45 schema:datePublished 2017-08-04
    46 schema:datePublishedReg 2017-08-04
    47 schema:description Intraductal tubulopapillary neoplasm is a relatively recently described member of the pancreatic intraductal neoplasm family. The more common member of this family, intraductal papillary mucinous neoplasm, often carries genetic alterations typical of pancreatic infiltrating ductal adenocarcinoma (KRAS, TP53, and CDKN2A) but additionally has mutations in GNAS and RNF43 genes. However, the genetic characteristics of intraductal tubulopapillary neoplasm have not been well characterized. Twenty-two intraductal tubulopapillary neoplasms were analyzed by either targeted next-generation sequencing, which enabled the identification of sequence mutations, copy number alterations, and selected structural rearrangements involving all targeted (≥300) genes, or whole-exome sequencing. Three of these intraductal tubulopapillary neoplasms were also subjected to whole-genome sequencing. All intraductal tubulopapillary neoplasms revealed the characteristic histologic (cellular intraductal nodules of back-to-back tubular glands lined by predominantly cuboidal cells with atypical nuclei and no obvious intracellular mucin) and immunohistochemical (immunolabeled with MUC1 and MUC6 but were negative for MUC2 and MUC5AC) features. By genomic analyses, there was loss of CDKN2A in 5/20 (25%) of these cases. However, the majority of the previously reported intraductal papillary mucinous neoplasm-related alterations were absent. Moreover, in contrast to most ductal neoplasms of the pancreas, MAP-kinase pathway was not involved. In fact, 2/22 (9%) of intraductal tubulopapillary neoplasms did not reveal any mutations in the tested genes. However, certain chromatin remodeling genes (MLL1, MLL2, MLL3, BAP1, PBRM1, EED, and ATRX) were found to be mutated in 7/22 (32%) of intraductal tubulopapillary neoplasms and 27% harbored phosphatidylinositol 3-kinase (PI3K) pathway (PIK3CA, PIK3CB, INPP4A, and PTEN) mutations. In addition, 4/18 (18%) of intraductal tubulopapillary neoplasms had FGFR2 fusions (FGFR2-CEP55, FGFR2-SASS6, DISP1-FGFR2, FGFR2-TXLNA, and FGFR2-VCL) and 1/18 (5.5%) had STRN-ALK fusion. Intraductal tubulopapillary neoplasm is a distinct clinicopathologic entity in the pancreas. Although its intraductal nature and some clinicopathologic features resemble those of intraductal papillary mucinous neoplasm, our results suggest that intraductal tubulopapillary neoplasm has distinguishing genetic characteristics. Some of these mutated genes are potentially targetable. Future functional studies will be needed to determine the consequences of these gene alterations.
    48 schema:genre article
    49 schema:isAccessibleForFree false
    50 schema:isPartOf Nbea9b423aacb45db9ea5058a8e97feb7
    51 Nf8acfe1089b24cbdb7ec8eeb4a3fb102
    52 sg:journal.1098208
    53 schema:keywords CDKN2A
    54 FGFR2 fusions
    55 GNAS
    56 MAP kinase pathway
    57 Pancreatic intraductal tubulopapillary neoplasm
    58 STRN-ALK fusion
    59 addition
    60 adenocarcinoma
    61 alterations
    62 analysis
    63 cases
    64 characteristic histologic
    65 characteristics
    66 chromatin remodeling genes
    67 clinicopathologic entity
    68 clinicopathologic features
    69 common members
    70 consequences
    71 contrast
    72 distinct clinicopathologic entity
    73 ductal adenocarcinoma
    74 ductal neoplasms
    75 entities
    76 fact
    77 family
    78 features
    79 functional studies
    80 fusion
    81 future functional studies
    82 gene alterations
    83 genes
    84 genetic alterations
    85 genetic characteristics
    86 genomic analysis
    87 histologic
    88 identification
    89 intraductal papillary mucinous neoplasm
    90 intraductal tubulopapillary neoplasm
    91 loss
    92 loss of CDKN2A
    93 majority
    94 members
    95 mucinous neoplasms
    96 mutations
    97 nature
    98 neoplasms
    99 next-generation sequencing
    100 number alterations
    101 pancreas
    102 papillary mucinous neoplasm
    103 pathway
    104 pathway mutations
    105 phosphatidylinositol
    106 rearrangement
    107 results
    108 sequence mutations
    109 sequencing
    110 structural rearrangements
    111 study
    112 whole-exome sequencing
    113 whole-genome sequencing
    114 schema:name Pancreatic intraductal tubulopapillary neoplasm is genetically distinct from intraductal papillary mucinous neoplasm and ductal adenocarcinoma
    115 schema:pagination 1760-1772
    116 schema:productId N58483baa27e3498394055d47fd255069
    117 Nbe5a4b342b894edb8fb07325c7b2d531
    118 Nddcc4549839340babdc36e5642a08362
    119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090990730
    120 https://doi.org/10.1038/modpathol.2017.60
    121 schema:sdDatePublished 2022-08-04T17:04
    122 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    123 schema:sdPublisher N7c81031689a14490a3eae2936bd23c9f
    124 schema:url https://doi.org/10.1038/modpathol.2017.60
    125 sgo:license sg:explorer/license/
    126 sgo:sdDataset articles
    127 rdf:type schema:ScholarlyArticle
    128 N04c58d8751844d168140648b8dbb6279 rdf:first sg:person.013167714057.20
    129 rdf:rest Nfb9623f4cd3b47c49fb15c79705ad5b4
    130 N10db57a77ead4a44bb460099f0d03edb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Biomarkers, Tumor
    132 rdf:type schema:DefinedTerm
    133 N16e88f37fc534a63ba0b6d2288495e1a rdf:first sg:person.0672650056.09
    134 rdf:rest N8946eb8afe6e435fb9cf774cabc60ff6
    135 N1905eb0059ca4d1596755a2fd7c199c3 rdf:first sg:person.01363063767.39
    136 rdf:rest N516a5b9291ea49b7a578e0bf351f0ceb
    137 N1f1239c4c92b4f47896099e5c7a30429 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Humans
    139 rdf:type schema:DefinedTerm
    140 N25861a1241ff430aa08f4b7b20e8652c rdf:first sg:person.01260427553.25
    141 rdf:rest N281301274d19476ca4116809680f3a22
    142 N281301274d19476ca4116809680f3a22 rdf:first sg:person.01101727053.65
    143 rdf:rest N1905eb0059ca4d1596755a2fd7c199c3
    144 N2e816c78f6624aa680741c2e17be4483 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Middle Aged
    146 rdf:type schema:DefinedTerm
    147 N30c2d6000af247beb0bb58b46226ce9f rdf:first sg:person.01312134274.29
    148 rdf:rest N4f76c4ee85e4416188f09344e2f1c27f
    149 N39292392c5d74bdcaed01a93ee31277d rdf:first sg:person.0740724104.78
    150 rdf:rest N47a53806d53e4f339dbce7e8cbc44635
    151 N3a2cea87e35247fa9c0eed0ca9b65b0f rdf:first sg:person.01352434007.71
    152 rdf:rest N7411ee16b07847cab35b14698115b508
    153 N47a53806d53e4f339dbce7e8cbc44635 rdf:first sg:person.0577272442.57
    154 rdf:rest Nd834be6cbfe64b4e92025b7c50c60125
    155 N4933b8a6b44b43e39c3e56a1571f5a40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Carcinoma, Pancreatic Ductal
    157 rdf:type schema:DefinedTerm
    158 N4a803cc7b6d94f0cac8da0dae908d81b rdf:first sg:person.014527056622.06
    159 rdf:rest Nd7cdfe28007f420ba6b44ed2229d80cc
    160 N4ed2f46b093b4f10ad7197aacb0962cf schema:affiliation grid-institutes:grid.5611.3
    161 schema:familyName Zamboni
    162 schema:givenName Giuseppe
    163 rdf:type schema:Person
    164 N4f76c4ee85e4416188f09344e2f1c27f rdf:first sg:person.01311111353.87
    165 rdf:rest Nc98c033c9b704f7f8b290eba30883755
    166 N4ff219d4d2c4493aabe132dad9fbfec7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Aged
    168 rdf:type schema:DefinedTerm
    169 N516a5b9291ea49b7a578e0bf351f0ceb rdf:first sg:person.012472631104.65
    170 rdf:rest N769023b6888044169d579c1386aea5eb
    171 N58483baa27e3498394055d47fd255069 schema:name doi
    172 schema:value 10.1038/modpathol.2017.60
    173 rdf:type schema:PropertyValue
    174 N68ef510b944846188f0a0641fd5b75c5 rdf:first sg:person.01242016756.35
    175 rdf:rest Nb7c6b82b76c04a1e9675907c85b3b6c2
    176 N699d30b5e5b542058a130941228932c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Adenocarcinoma, Mucinous
    178 rdf:type schema:DefinedTerm
    179 N6cf2b21cc3a54cd3a991cb02fc8c63fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Adult
    181 rdf:type schema:DefinedTerm
    182 N7411ee16b07847cab35b14698115b508 rdf:first sg:person.01267161677.10
    183 rdf:rest N68ef510b944846188f0a0641fd5b75c5
    184 N769023b6888044169d579c1386aea5eb rdf:first sg:person.0743265465.81
    185 rdf:rest N4a803cc7b6d94f0cac8da0dae908d81b
    186 N7c81031689a14490a3eae2936bd23c9f schema:name Springer Nature - SN SciGraph project
    187 rdf:type schema:Organization
    188 N7d79d5bdfdcb485fbeb383cf913e8981 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name DNA Mutational Analysis
    190 rdf:type schema:DefinedTerm
    191 N8946eb8afe6e435fb9cf774cabc60ff6 rdf:first sg:person.0653777340.46
    192 rdf:rest Ndaa32e7ab8fe48d7a6393c2d97e113d2
    193 N999479949c2944c28d323bff3256dff7 rdf:first sg:person.01023230545.08
    194 rdf:rest N25861a1241ff430aa08f4b7b20e8652c
    195 Nae18ff9eb87340e7912ea2c14b8f484e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Young Adult
    197 rdf:type schema:DefinedTerm
    198 Nb3ab53f4e4ef419fba415e0cbe97125e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Pancreatic Neoplasms
    200 rdf:type schema:DefinedTerm
    201 Nb7c6b82b76c04a1e9675907c85b3b6c2 rdf:first sg:person.01234506371.89
    202 rdf:rest N04c58d8751844d168140648b8dbb6279
    203 Nbe5a4b342b894edb8fb07325c7b2d531 schema:name pubmed_id
    204 schema:value 28776573
    205 rdf:type schema:PropertyValue
    206 Nbea9b423aacb45db9ea5058a8e97feb7 schema:issueNumber 12
    207 rdf:type schema:PublicationIssue
    208 Nc71fc27daa5744fcb927b1e2d7fa521b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Male
    210 rdf:type schema:DefinedTerm
    211 Nc98c033c9b704f7f8b290eba30883755 rdf:first sg:person.0622515042.48
    212 rdf:rest Ne1649af67db947cfb9c45912922a752e
    213 Ncd3a73e0a818442c998e336fde5ec654 rdf:first sg:person.01255535707.76
    214 rdf:rest N999479949c2944c28d323bff3256dff7
    215 Nd022b5906c154fecbdc7233ff92e9272 rdf:first sg:person.01172223364.25
    216 rdf:rest N3a2cea87e35247fa9c0eed0ca9b65b0f
    217 Nd297d13efe964e33b6024e5467d69f29 rdf:first sg:person.01025060707.33
    218 rdf:rest Ncd3a73e0a818442c998e336fde5ec654
    219 Nd7cdfe28007f420ba6b44ed2229d80cc rdf:first sg:person.011206476464.16
    220 rdf:rest rdf:nil
    221 Nd834be6cbfe64b4e92025b7c50c60125 rdf:first sg:person.0605250074.08
    222 rdf:rest N30c2d6000af247beb0bb58b46226ce9f
    223 Ndaa32e7ab8fe48d7a6393c2d97e113d2 rdf:first sg:person.0646162022.38
    224 rdf:rest Nd022b5906c154fecbdc7233ff92e9272
    225 Nddcc4549839340babdc36e5642a08362 schema:name dimensions_id
    226 schema:value pub.1090990730
    227 rdf:type schema:PropertyValue
    228 Ne1649af67db947cfb9c45912922a752e rdf:first Ne6f364b5b2834f0cb008e982f04f6c30
    229 rdf:rest Nf275fa44a94043e4b373ce1558cca684
    230 Ne6f364b5b2834f0cb008e982f04f6c30 schema:affiliation grid-institutes:grid.410818.4
    231 schema:familyName Takeuchi
    232 schema:givenName Shoko
    233 rdf:type schema:Person
    234 Ne7e86d1a32404e52ae62556183ebb9de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    235 schema:name Female
    236 rdf:type schema:DefinedTerm
    237 Nf275fa44a94043e4b373ce1558cca684 rdf:first sg:person.01065307117.79
    238 rdf:rest Nd297d13efe964e33b6024e5467d69f29
    239 Nf62ff95c196346a1a5874bb95a3ea773 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    240 schema:name Adenocarcinoma, Papillary
    241 rdf:type schema:DefinedTerm
    242 Nf8acfe1089b24cbdb7ec8eeb4a3fb102 schema:volumeNumber 30
    243 rdf:type schema:PublicationVolume
    244 Nfb9623f4cd3b47c49fb15c79705ad5b4 rdf:first N4ed2f46b093b4f10ad7197aacb0962cf
    245 rdf:rest N39292392c5d74bdcaed01a93ee31277d
    246 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    247 schema:name Medical and Health Sciences
    248 rdf:type schema:DefinedTerm
    249 sg:grant.2438793 http://pending.schema.org/fundedItem sg:pub.10.1038/modpathol.2017.60
    250 rdf:type schema:MonetaryGrant
    251 sg:journal.1098208 schema:issn 0893-3952
    252 1530-0285
    253 schema:name Modern Pathology
    254 schema:publisher Springer Nature
    255 rdf:type schema:Periodical
    256 sg:person.01023230545.08 schema:affiliation grid-institutes:grid.69566.3a
    257 schema:familyName Morikawa
    258 schema:givenName Takanori
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023230545.08
    260 rdf:type schema:Person
    261 sg:person.01025060707.33 schema:affiliation grid-institutes:grid.69566.3a
    262 schema:familyName Kanno
    263 schema:givenName Atsushi
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025060707.33
    265 rdf:type schema:Person
    266 sg:person.01065307117.79 schema:affiliation grid-institutes:grid.410818.4
    267 schema:familyName Akagawa
    268 schema:givenName Hiroyuki
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065307117.79
    270 rdf:type schema:Person
    271 sg:person.01101727053.65 schema:affiliation grid-institutes:grid.69566.3a
    272 schema:familyName Unno
    273 schema:givenName Michiaki
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101727053.65
    275 rdf:type schema:Person
    276 sg:person.011206476464.16 schema:affiliation grid-institutes:grid.51462.34
    277 schema:familyName Klimstra
    278 schema:givenName David S
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011206476464.16
    280 rdf:type schema:Person
    281 sg:person.01172223364.25 schema:affiliation grid-institutes:grid.189967.8
    282 schema:familyName Adsay
    283 schema:givenName Volkan
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172223364.25
    285 rdf:type schema:Person
    286 sg:person.01234506371.89 schema:affiliation grid-institutes:grid.5808.5
    287 schema:familyName Carneiro
    288 schema:givenName Fatima
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234506371.89
    290 rdf:type schema:Person
    291 sg:person.01242016756.35 schema:affiliation grid-institutes:grid.51462.34
    292 schema:familyName Zehir
    293 schema:givenName Ahmet
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242016756.35
    295 rdf:type schema:Person
    296 sg:person.012472631104.65 schema:affiliation grid-institutes:grid.410818.4
    297 schema:familyName Yamamoto
    298 schema:givenName Masakazu
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012472631104.65
    300 rdf:type schema:Person
    301 sg:person.01255535707.76 schema:affiliation grid-institutes:grid.69566.3a
    302 schema:familyName Shimosegawa
    303 schema:givenName Tooru
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255535707.76
    305 rdf:type schema:Person
    306 sg:person.01260427553.25 schema:affiliation grid-institutes:grid.69566.3a
    307 schema:familyName Motoi
    308 schema:givenName Fuyuhiko
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260427553.25
    310 rdf:type schema:Person
    311 sg:person.01267161677.10 schema:affiliation grid-institutes:grid.51462.34
    312 schema:familyName Bhanot
    313 schema:givenName Umesh K
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267161677.10
    315 rdf:type schema:Person
    316 sg:person.01311111353.87 schema:affiliation grid-institutes:grid.51462.34
    317 schema:familyName Allen
    318 schema:givenName Peter
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311111353.87
    320 rdf:type schema:Person
    321 sg:person.01312134274.29 schema:affiliation grid-institutes:grid.189967.8
    322 schema:familyName Balci
    323 schema:givenName Serdar
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312134274.29
    325 rdf:type schema:Person
    326 sg:person.013167714057.20 schema:affiliation grid-institutes:grid.413967.e
    327 schema:familyName Hong
    328 schema:givenName Seung-Mo
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013167714057.20
    330 rdf:type schema:Person
    331 sg:person.01352434007.71 schema:affiliation grid-institutes:grid.51462.34
    332 schema:familyName Askan
    333 schema:givenName Gokce
    334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352434007.71
    335 rdf:type schema:Person
    336 sg:person.01363063767.39 schema:affiliation grid-institutes:grid.410818.4
    337 schema:familyName Higuchi
    338 schema:givenName Ryota
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363063767.39
    340 rdf:type schema:Person
    341 sg:person.014527056622.06 schema:affiliation grid-institutes:grid.410818.4
    342 schema:familyName Furukawa
    343 schema:givenName Toru
    344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014527056622.06
    345 rdf:type schema:Person
    346 sg:person.0577272442.57 schema:affiliation grid-institutes:None
    347 schema:familyName Jobanputra
    348 schema:givenName Vaidehi
    349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577272442.57
    350 rdf:type schema:Person
    351 sg:person.0605250074.08 schema:affiliation grid-institutes:grid.429884.b
    352 schema:familyName Wrzeszczynski
    353 schema:givenName Kazimierz O
    354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605250074.08
    355 rdf:type schema:Person
    356 sg:person.0622515042.48 schema:affiliation grid-institutes:grid.410818.4
    357 schema:familyName Ikari
    358 schema:givenName Naoki
    359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622515042.48
    360 rdf:type schema:Person
    361 sg:person.0646162022.38 schema:affiliation grid-institutes:grid.410793.8
    362 schema:familyName Yamaguchi
    363 schema:givenName Hiroshi
    364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646162022.38
    365 rdf:type schema:Person
    366 sg:person.0653777340.46 schema:affiliation grid-institutes:grid.51462.34
    367 schema:familyName Berger
    368 schema:givenName Michael F
    369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653777340.46
    370 rdf:type schema:Person
    371 sg:person.0672650056.09 schema:affiliation grid-institutes:grid.51462.34
    372 schema:familyName Basturk
    373 schema:givenName Olca
    374 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672650056.09
    375 rdf:type schema:Person
    376 sg:person.0740724104.78 schema:affiliation grid-institutes:grid.429884.b
    377 schema:familyName Dikoglu
    378 schema:givenName Esra
    379 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740724104.78
    380 rdf:type schema:Person
    381 sg:person.0743265465.81 schema:affiliation grid-institutes:grid.410818.4
    382 schema:familyName Shimizu
    383 schema:givenName Kyoko
    384 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743265465.81
    385 rdf:type schema:Person
    386 sg:pub.10.1007/bf00189573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044745628
    387 https://doi.org/10.1007/bf00189573
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1007/s00423-008-0285-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019199187
    390 https://doi.org/10.1007/s00423-008-0285-7
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1007/s00423-016-1391-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046271380
    393 https://doi.org/10.1007/s00423-016-1391-6
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1007/s00428-004-0984-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026778707
    396 https://doi.org/10.1007/s00428-004-0984-6
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1007/s00534-009-0105-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011659012
    399 https://doi.org/10.1007/s00534-009-0105-7
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1007/s005340200037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024147644
    402 https://doi.org/10.1007/s005340200037
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1007/s00535-006-1821-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029766265
    405 https://doi.org/10.1007/s00535-006-1821-2
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1038/modpathol.2015.61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007092445
    408 https://doi.org/10.1038/modpathol.2015.61
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1038/nature08672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032969139
    411 https://doi.org/10.1038/nature08672
    412 rdf:type schema:CreativeWork
    413 sg:pub.10.1038/nature08822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010635813
    414 https://doi.org/10.1038/nature08822
    415 rdf:type schema:CreativeWork
    416 sg:pub.10.1038/nature10351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019649945
    417 https://doi.org/10.1038/nature10351
    418 rdf:type schema:CreativeWork
    419 sg:pub.10.1038/nbt.1754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019307928
    420 https://doi.org/10.1038/nbt.1754
    421 rdf:type schema:CreativeWork
    422 sg:pub.10.1038/nbt.2514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000477771
    423 https://doi.org/10.1038/nbt.2514
    424 rdf:type schema:CreativeWork
    425 sg:pub.10.1038/ncomms7087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022244232
    426 https://doi.org/10.1038/ncomms7087
    427 rdf:type schema:CreativeWork
    428 sg:pub.10.1038/ncomms8686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009287444
    429 https://doi.org/10.1038/ncomms8686
    430 rdf:type schema:CreativeWork
    431 sg:pub.10.1038/ng.2806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048130718
    432 https://doi.org/10.1038/ng.2806
    433 rdf:type schema:CreativeWork
    434 sg:pub.10.1038/ng.3076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029451229
    435 https://doi.org/10.1038/ng.3076
    436 rdf:type schema:CreativeWork
    437 sg:pub.10.1038/ng.3375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040279504
    438 https://doi.org/10.1038/ng.3375
    439 rdf:type schema:CreativeWork
    440 sg:pub.10.1038/ng.806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010244476
    441 https://doi.org/10.1038/ng.806
    442 rdf:type schema:CreativeWork
    443 sg:pub.10.1038/nmeth.1363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020581697
    444 https://doi.org/10.1038/nmeth.1363
    445 rdf:type schema:CreativeWork
    446 sg:pub.10.1038/nmeth.1628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004171938
    447 https://doi.org/10.1038/nmeth.1628
    448 rdf:type schema:CreativeWork
    449 sg:pub.10.1038/nmeth.3069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006401732
    450 https://doi.org/10.1038/nmeth.3069
    451 rdf:type schema:CreativeWork
    452 sg:pub.10.1038/onc.2016.172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019767778
    453 https://doi.org/10.1038/onc.2016.172
    454 rdf:type schema:CreativeWork
    455 sg:pub.10.1038/sj.onc.1201861 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049332185
    456 https://doi.org/10.1038/sj.onc.1201861
    457 rdf:type schema:CreativeWork
    458 sg:pub.10.1038/srep00161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019748053
    459 https://doi.org/10.1038/srep00161
    460 rdf:type schema:CreativeWork
    461 sg:pub.10.1038/srep06036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036868305
    462 https://doi.org/10.1038/srep06036
    463 rdf:type schema:CreativeWork
    464 sg:pub.10.1038/srep08829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031072563
    465 https://doi.org/10.1038/srep08829
    466 rdf:type schema:CreativeWork
    467 sg:pub.10.1245/s10434-013-3096-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017917551
    468 https://doi.org/10.1245/s10434-013-3096-1
    469 rdf:type schema:CreativeWork
    470 sg:pub.10.2165/11315680-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014688288
    471 https://doi.org/10.2165/11315680-000000000-00000
    472 rdf:type schema:CreativeWork
    473 grid-institutes:None schema:alternateName Department of Pathology, Colombia University Medical Center, New York, NY, USA
    474 schema:name Department of Pathology, Colombia University Medical Center, New York, NY, USA
    475 New York Genome Center, Molecular Diagnostics, New York, NY, USA
    476 rdf:type schema:Organization
    477 grid-institutes:grid.189967.8 schema:alternateName Department of Pathology, Emory University, Atlanta, GA, USA
    478 schema:name Department of Pathology, Emory University, Atlanta, GA, USA
    479 rdf:type schema:Organization
    480 grid-institutes:grid.410793.8 schema:alternateName Department of Pathology, Tokyo Medical University, Tokyo, Japan
    481 schema:name Department of Pathology, Tokyo Medical University, Tokyo, Japan
    482 rdf:type schema:Organization
    483 grid-institutes:grid.410818.4 schema:alternateName Department of Gastroenterology, Tokyo Women’s Medical University, Tokyo, Japan
    484 Department of Pathology, Tokyo Women’s Medical University, Tokyo, Japan
    485 Department of Surgery, Tokyo Women’s Medical University, Tokyo, Japan
    486 Institute for Integrated Medical Sciences, Tokyo Women’s Medical University, Tokyo, Japan
    487 schema:name Department of Gastroenterology, Tokyo Women’s Medical University, Tokyo, Japan
    488 Department of Pathology, Tokyo Women’s Medical University, Tokyo, Japan
    489 Department of Surgery, Tokyo Women’s Medical University, Tokyo, Japan
    490 Institute for Integrated Medical Sciences, Tokyo Women’s Medical University, Tokyo, Japan
    491 rdf:type schema:Organization
    492 grid-institutes:grid.413967.e schema:alternateName Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    493 schema:name Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
    494 rdf:type schema:Organization
    495 grid-institutes:grid.429884.b schema:alternateName New York Genome Center, Molecular Diagnostics, New York, NY, USA
    496 schema:name New York Genome Center, Molecular Diagnostics, New York, NY, USA
    497 rdf:type schema:Organization
    498 grid-institutes:grid.51462.34 schema:alternateName Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    499 Department of Surgery, Memorial Sloan Kettering Cancer Center, New YorkNY, USA
    500 schema:name Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    501 Department of Surgery, Memorial Sloan Kettering Cancer Center, New YorkNY, USA
    502 rdf:type schema:Organization
    503 grid-institutes:grid.5611.3 schema:alternateName Department of Pathology, University of Verona, Ospedale S.C.-Don Calabria-Negrar, Verona, Italy
    504 schema:name Department of Pathology, University of Verona, Ospedale S.C.-Don Calabria-Negrar, Verona, Italy
    505 rdf:type schema:Organization
    506 grid-institutes:grid.5808.5 schema:alternateName Department of Pathology, Centro Hospitalar São João/Faculty of Medicine of Porto University and Institute for Research and Innovation in Health/Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
    507 schema:name Department of Pathology, Centro Hospitalar São João/Faculty of Medicine of Porto University and Institute for Research and Innovation in Health/Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal
    508 rdf:type schema:Organization
    509 grid-institutes:grid.69566.3a schema:alternateName Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    510 Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    511 schema:name Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan
    512 Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    513 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...