Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid are genetically distinct from primary colorectal-type adenocarcinoma of the appendix View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-05

AUTHORS

Moritz Jesinghaus, Björn Konukiewitz, Sebastian Foersch, Albrecht Stenzinger, Katja Steiger, Alexander Muckenhuber, Claudia Groß, Martin Mollenhauer, Wilfried Roth, Sönke Detlefsen, Wilko Weichert, Günter Klöppel, Nicole Pfarr, Anna Melissa Schlitter

ABSTRACT

The appendix gives rise to goblet cell carcinoids, which represent special carcinomas with distinct biological and histological features. Their genetic background and molecular relationship to colorectal adenocarcinoma is largely unknown. We therefore performed a next-generation sequencing analysis of 25 appendiceal carcinomas including 11 goblet cell carcinoids, 7 adenocarcinomas ex-goblet cell carcinoid, and 7 primary colorectal-type adenocarcinomas, using a modified Colorectal Cancer specific Panel comprising 32 genes linked to colorectal and neuroendocrine tumorigenesis. The mutational profiles of these neoplasms were compared with those of conventional adenocarcinomas, mixed adenoneuroendocrine carcinomas, and neuroendocrine carcinomas of the colorectum. In addition, a large-scale pan-cancer sequencing panel covering 409 genes was applied to selected cases of goblet cell carcinoid/adenocarcinoma ex-goblet cell carcinoid (n=2, respectively). Mutations in colorectal cancer-related genes (eg, TP53, KRAS, APC) were rare to absent in both, goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid, but frequent in primary colorectal-type adenocarcinomas of the appendix. Additional large-scale sequencing of selected goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid revealed mutations in Wnt-signaling-associated genes (USP9X, NOTCH1, CTNNA1, CTNNB1, TRRAP). These data suggest that appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid constitute a morphomolecular entity, histologically and genetically distinct from appendiceal colorectal-type adenocarcinomas and its colorectal counterparts. Altered Wnt-signaling associated genes, apart from APC, may act as potential drivers of these neoplasms. The absence of KRAS/NRAS mutations might render some of these tumors eligible for anti-EGFR directed therapy regimens. More... »

PAGES

829

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/modpathol.2017.184

DOI

http://dx.doi.org/10.1038/modpathol.2017.184

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100345475

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29327707


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Institute of Pathology, Technical University of Munich, Munich, Germany", 
            "German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jesinghaus", 
        "givenName": "Moritz", 
        "id": "sg:person.0664756621.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664756621.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Institute of Pathology, Technical University of Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Konukiewitz", 
        "givenName": "Bj\u00f6rn", 
        "id": "sg:person.01327422305.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327422305.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center of the Johannes Gutenberg University Mainz", 
          "id": "https://www.grid.ac/institutes/grid.410607.4", 
          "name": [
            "Institute of Pathology, University Hospital Mainz, Mainz, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Foersch", 
        "givenName": "Sebastian", 
        "id": "sg:person.01115105357.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115105357.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Heidelberg", 
          "id": "https://www.grid.ac/institutes/grid.5253.1", 
          "name": [
            "Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany", 
            "National Center for Tumor Diseases (NCT), Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stenzinger", 
        "givenName": "Albrecht", 
        "id": "sg:person.0642700650.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642700650.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Institute of Pathology, Technical University of Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Steiger", 
        "givenName": "Katja", 
        "id": "sg:person.0727677465.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727677465.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Institute of Pathology, Technical University of Munich, Munich, Germany", 
            "German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muckenhuber", 
        "givenName": "Alexander", 
        "id": "sg:person.0640431223.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640431223.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Institute of Pathology, Technical University of Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gro\u00df", 
        "givenName": "Claudia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Institute of Pathology, Technical University of Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mollenhauer", 
        "givenName": "Martin", 
        "id": "sg:person.0662321427.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662321427.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center of the Johannes Gutenberg University Mainz", 
          "id": "https://www.grid.ac/institutes/grid.410607.4", 
          "name": [
            "Institute of Pathology, University Hospital Mainz, Mainz, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roth", 
        "givenName": "Wilfried", 
        "id": "sg:person.0632134523.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632134523.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Odense University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.7143.1", 
          "name": [
            "Department of Clinical Pathology, University Hospital Odense, Odense, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Detlefsen", 
        "givenName": "S\u00f6nke", 
        "id": "sg:person.01222357400.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222357400.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Institute of Pathology, Technical University of Munich, Munich, Germany", 
            "German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weichert", 
        "givenName": "Wilko", 
        "id": "sg:person.0657434205.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657434205.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Institute of Pathology, Technical University of Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kl\u00f6ppel", 
        "givenName": "G\u00fcnter", 
        "id": "sg:person.016522011357.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016522011357.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Institute of Pathology, Technical University of Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pfarr", 
        "givenName": "Nicole", 
        "id": "sg:person.01070571704.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070571704.79"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Technical University Munich", 
          "id": "https://www.grid.ac/institutes/grid.6936.a", 
          "name": [
            "Institute of Pathology, Technical University of Munich, Munich, Germany", 
            "German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schlitter", 
        "givenName": "Anna Melissa", 
        "id": "sg:person.01077551404.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077551404.77"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/modpathol.2016.105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003594532", 
          "https://doi.org/10.1038/modpathol.2016.105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.05.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005670808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/29.1.308", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005817660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.22330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006023804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.22378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006479020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5858/arpa.2013-0047-oa", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009538281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010619765", 
          "https://doi.org/10.1038/nature11252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.22352", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010794579"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19950201)75:3<757::aid-cncr2820750303>3.0.co;2-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011687199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014438312", 
          "https://doi.org/10.1038/nm.3967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0065995", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015631894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.12819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015691417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.12819", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015691417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmoldx.2013.06.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015693520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2016.220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017465930", 
          "https://doi.org/10.1038/modpathol.2016.220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31804f7aa1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020111425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31804f7aa1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020111425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19990701)86:1<14::aid-cncr4>3.0.co;2-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020428292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31817f1816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020591539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31817f1816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020591539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0b013e31817f1816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020591539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkq603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020792304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.suronc.2015.01.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021472741"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2016.150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022493987", 
          "https://doi.org/10.1038/modpathol.2016.150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(02)00888-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023542752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2009.12.064", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030932765"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.prp.2014.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031138961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031454446", 
          "https://doi.org/10.1038/ng.2821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2013.11.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032143992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gku1075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035514003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036890034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/pas.0000000000000423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036890034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(10)70130-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038656599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1373/clinchem.2014.225565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041180465"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2443.1999.00297.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043758467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2443.1999.00297.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043758467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdr464", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048800530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2014-0280", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051399369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8259519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062653867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.20.4.1043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064202813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.7.24.7354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072299808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1043/2010-0073-ccr.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078294023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.22480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086118484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-05451-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091109899", 
          "https://doi.org/10.1038/s41598-017-05451-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-05451-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091109899", 
          "https://doi.org/10.1038/s41598-017-05451-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-05451-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091109899", 
          "https://doi.org/10.1038/s41598-017-05451-5"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-05", 
    "datePublishedReg": "2018-05-01", 
    "description": "The appendix gives rise to goblet cell carcinoids, which represent special carcinomas with distinct biological and histological features. Their genetic background and molecular relationship to colorectal adenocarcinoma is largely unknown. We therefore performed a next-generation sequencing analysis of 25 appendiceal carcinomas including 11 goblet cell carcinoids, 7 adenocarcinomas ex-goblet cell carcinoid, and 7 primary colorectal-type adenocarcinomas, using a modified Colorectal Cancer specific Panel comprising 32 genes linked to colorectal and neuroendocrine tumorigenesis. The mutational profiles of these neoplasms were compared with those of conventional adenocarcinomas, mixed adenoneuroendocrine carcinomas, and neuroendocrine carcinomas of the colorectum. In addition, a large-scale pan-cancer sequencing panel covering 409 genes was applied to selected cases of goblet cell carcinoid/adenocarcinoma ex-goblet cell carcinoid (n=2, respectively). Mutations in colorectal cancer-related genes (eg, TP53, KRAS, APC) were rare to absent in both, goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid, but frequent in primary colorectal-type adenocarcinomas of the appendix. Additional large-scale sequencing of selected goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid revealed mutations in Wnt-signaling-associated genes (USP9X, NOTCH1, CTNNA1, CTNNB1, TRRAP). These data suggest that appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid constitute a morphomolecular entity, histologically and genetically distinct from appendiceal colorectal-type adenocarcinomas and its colorectal counterparts. Altered Wnt-signaling associated genes, apart from APC, may act as potential drivers of these neoplasms. The absence of KRAS/NRAS mutations might render some of these tumors eligible for anti-EGFR directed therapy regimens.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/modpathol.2017.184", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1098208", 
        "issn": [
          "0893-3952", 
          "1530-0285"
        ], 
        "name": "Modern Pathology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "31"
      }
    ], 
    "name": "Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid are genetically distinct from primary colorectal-type adenocarcinoma of the appendix", 
    "pagination": "829", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "44d864c91c2241906bdb4af5b354923b83c561bac0aac8f0025b27070c4847c8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29327707"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8806605"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/modpathol.2017.184"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100345475"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/modpathol.2017.184", 
      "https://app.dimensions.ai/details/publication/pub.1100345475"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000422.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/modpathol2017184"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2017.184'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2017.184'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2017.184'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2017.184'


 

This table displays all metadata directly associated to this object as RDF triples.

291 TRIPLES      21 PREDICATES      67 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/modpathol.2017.184 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N644d640e4f374efb9657554e37200bc5
4 schema:citation sg:pub.10.1038/modpathol.2016.105
5 sg:pub.10.1038/modpathol.2016.150
6 sg:pub.10.1038/modpathol.2016.220
7 sg:pub.10.1038/nature11252
8 sg:pub.10.1038/ng.2821
9 sg:pub.10.1038/nm.3967
10 sg:pub.10.1038/s41598-017-05451-5
11 https://doi.org/10.1002/(sici)1097-0142(19990701)86:1<14::aid-cncr4>3.0.co;2-x
12 https://doi.org/10.1002/1097-0142(19950201)75:3<757::aid-cncr2820750303>3.0.co;2-f
13 https://doi.org/10.1002/gcc.22330
14 https://doi.org/10.1002/gcc.22352
15 https://doi.org/10.1002/gcc.22378
16 https://doi.org/10.1002/gcc.22480
17 https://doi.org/10.1016/j.cell.2012.05.012
18 https://doi.org/10.1016/j.cellsig.2013.11.032
19 https://doi.org/10.1016/j.jmoldx.2013.06.002
20 https://doi.org/10.1016/j.prp.2014.01.002
21 https://doi.org/10.1016/j.suronc.2015.01.001
22 https://doi.org/10.1016/s0960-9822(02)00888-6
23 https://doi.org/10.1016/s1470-2045(10)70130-3
24 https://doi.org/10.1043/2010-0073-ccr.1
25 https://doi.org/10.1046/j.1365-2443.1999.00297.x
26 https://doi.org/10.1053/j.gastro.2009.12.064
27 https://doi.org/10.1093/annonc/mdr464
28 https://doi.org/10.1093/nar/29.1.308
29 https://doi.org/10.1093/nar/gkq603
30 https://doi.org/10.1093/nar/gku1075
31 https://doi.org/10.1097/pas.0000000000000423
32 https://doi.org/10.1097/pas.0b013e31804f7aa1
33 https://doi.org/10.1097/pas.0b013e31817f1816
34 https://doi.org/10.1126/science.8259519
35 https://doi.org/10.1200/jco.20.4.1043
36 https://doi.org/10.1371/journal.pone.0065995
37 https://doi.org/10.1373/clinchem.2014.225565
38 https://doi.org/10.1634/theoncologist.2014-0280
39 https://doi.org/10.18632/oncotarget.12819
40 https://doi.org/10.4161/cc.7.24.7354
41 https://doi.org/10.5858/arpa.2013-0047-oa
42 schema:datePublished 2018-05
43 schema:datePublishedReg 2018-05-01
44 schema:description The appendix gives rise to goblet cell carcinoids, which represent special carcinomas with distinct biological and histological features. Their genetic background and molecular relationship to colorectal adenocarcinoma is largely unknown. We therefore performed a next-generation sequencing analysis of 25 appendiceal carcinomas including 11 goblet cell carcinoids, 7 adenocarcinomas ex-goblet cell carcinoid, and 7 primary colorectal-type adenocarcinomas, using a modified Colorectal Cancer specific Panel comprising 32 genes linked to colorectal and neuroendocrine tumorigenesis. The mutational profiles of these neoplasms were compared with those of conventional adenocarcinomas, mixed adenoneuroendocrine carcinomas, and neuroendocrine carcinomas of the colorectum. In addition, a large-scale pan-cancer sequencing panel covering 409 genes was applied to selected cases of goblet cell carcinoid/adenocarcinoma ex-goblet cell carcinoid (n=2, respectively). Mutations in colorectal cancer-related genes (eg, TP53, KRAS, APC) were rare to absent in both, goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid, but frequent in primary colorectal-type adenocarcinomas of the appendix. Additional large-scale sequencing of selected goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid revealed mutations in Wnt-signaling-associated genes (USP9X, NOTCH1, CTNNA1, CTNNB1, TRRAP). These data suggest that appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid constitute a morphomolecular entity, histologically and genetically distinct from appendiceal colorectal-type adenocarcinomas and its colorectal counterparts. Altered Wnt-signaling associated genes, apart from APC, may act as potential drivers of these neoplasms. The absence of KRAS/NRAS mutations might render some of these tumors eligible for anti-EGFR directed therapy regimens.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf N1237b0059c4548c6b2ee23d0f36c69f6
49 Ne92958846b574d9c9c76d70e845244c5
50 sg:journal.1098208
51 schema:name Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid are genetically distinct from primary colorectal-type adenocarcinoma of the appendix
52 schema:pagination 829
53 schema:productId N0bee0ef7452d4e77bf72aacbbac18b0c
54 N2b328292982d469b8a763d14e9843f0d
55 N6bf9010ac7a0454985abc006564ff102
56 Nba4169e3eb904a2382c096a37afbc19a
57 Nf372b70a9fc345e3988245b64db1c477
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100345475
59 https://doi.org/10.1038/modpathol.2017.184
60 schema:sdDatePublished 2019-04-10T17:19
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher N2eaddeadbfa74f1197370c6f85166809
63 schema:url https://www.nature.com/articles/modpathol2017184
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N0bee0ef7452d4e77bf72aacbbac18b0c schema:name doi
68 schema:value 10.1038/modpathol.2017.184
69 rdf:type schema:PropertyValue
70 N1237b0059c4548c6b2ee23d0f36c69f6 schema:volumeNumber 31
71 rdf:type schema:PublicationVolume
72 N1d94fd5c574e4794869bbc12294fb534 rdf:first sg:person.01077551404.77
73 rdf:rest rdf:nil
74 N2599646f4e3045b7a4d4a51a569f63e4 rdf:first sg:person.0640431223.57
75 rdf:rest N72c09b3fc7004dc7ac435310102b5f48
76 N2b328292982d469b8a763d14e9843f0d schema:name pubmed_id
77 schema:value 29327707
78 rdf:type schema:PropertyValue
79 N2e53499d82764eeaaee55e12808f0685 rdf:first sg:person.01222357400.15
80 rdf:rest N65fecd2ba1a44b18aff7dc525f196935
81 N2eaddeadbfa74f1197370c6f85166809 schema:name Springer Nature - SN SciGraph project
82 rdf:type schema:Organization
83 N600224374da74f609d09e4ce9603335e rdf:first sg:person.0662321427.79
84 rdf:rest Ndd53ee9fb5fa4fce94817d6d6b552129
85 N644d640e4f374efb9657554e37200bc5 rdf:first sg:person.0664756621.35
86 rdf:rest Nc54dceeffd7d4d16ae086d71456fa475
87 N65fecd2ba1a44b18aff7dc525f196935 rdf:first sg:person.0657434205.21
88 rdf:rest Nc6b817430ba44fdeb4a66c9024caced8
89 N679fcd7255c54960ae95945dc14ace7d schema:affiliation https://www.grid.ac/institutes/grid.6936.a
90 schema:familyName Groß
91 schema:givenName Claudia
92 rdf:type schema:Person
93 N6bf9010ac7a0454985abc006564ff102 schema:name dimensions_id
94 schema:value pub.1100345475
95 rdf:type schema:PropertyValue
96 N70a07d3335744cd8a8812518b94aae9e rdf:first sg:person.01070571704.79
97 rdf:rest N1d94fd5c574e4794869bbc12294fb534
98 N72c09b3fc7004dc7ac435310102b5f48 rdf:first N679fcd7255c54960ae95945dc14ace7d
99 rdf:rest N600224374da74f609d09e4ce9603335e
100 N848a76fff055407883a33c060cd870ce rdf:first sg:person.0727677465.50
101 rdf:rest N2599646f4e3045b7a4d4a51a569f63e4
102 N952b7efb1ea44d36ae9f358db693f171 rdf:first sg:person.01115105357.20
103 rdf:rest Nb2c7f17a9b614a1198b576df64117486
104 Nb2c7f17a9b614a1198b576df64117486 rdf:first sg:person.0642700650.98
105 rdf:rest N848a76fff055407883a33c060cd870ce
106 Nba4169e3eb904a2382c096a37afbc19a schema:name nlm_unique_id
107 schema:value 8806605
108 rdf:type schema:PropertyValue
109 Nc54dceeffd7d4d16ae086d71456fa475 rdf:first sg:person.01327422305.43
110 rdf:rest N952b7efb1ea44d36ae9f358db693f171
111 Nc6b817430ba44fdeb4a66c9024caced8 rdf:first sg:person.016522011357.98
112 rdf:rest N70a07d3335744cd8a8812518b94aae9e
113 Ndd53ee9fb5fa4fce94817d6d6b552129 rdf:first sg:person.0632134523.42
114 rdf:rest N2e53499d82764eeaaee55e12808f0685
115 Ne92958846b574d9c9c76d70e845244c5 schema:issueNumber 5
116 rdf:type schema:PublicationIssue
117 Nf372b70a9fc345e3988245b64db1c477 schema:name readcube_id
118 schema:value 44d864c91c2241906bdb4af5b354923b83c561bac0aac8f0025b27070c4847c8
119 rdf:type schema:PropertyValue
120 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
121 schema:name Medical and Health Sciences
122 rdf:type schema:DefinedTerm
123 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
124 schema:name Oncology and Carcinogenesis
125 rdf:type schema:DefinedTerm
126 sg:journal.1098208 schema:issn 0893-3952
127 1530-0285
128 schema:name Modern Pathology
129 rdf:type schema:Periodical
130 sg:person.01070571704.79 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
131 schema:familyName Pfarr
132 schema:givenName Nicole
133 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070571704.79
134 rdf:type schema:Person
135 sg:person.01077551404.77 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
136 schema:familyName Schlitter
137 schema:givenName Anna Melissa
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077551404.77
139 rdf:type schema:Person
140 sg:person.01115105357.20 schema:affiliation https://www.grid.ac/institutes/grid.410607.4
141 schema:familyName Foersch
142 schema:givenName Sebastian
143 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115105357.20
144 rdf:type schema:Person
145 sg:person.01222357400.15 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
146 schema:familyName Detlefsen
147 schema:givenName Sönke
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222357400.15
149 rdf:type schema:Person
150 sg:person.01327422305.43 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
151 schema:familyName Konukiewitz
152 schema:givenName Björn
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327422305.43
154 rdf:type schema:Person
155 sg:person.016522011357.98 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
156 schema:familyName Klöppel
157 schema:givenName Günter
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016522011357.98
159 rdf:type schema:Person
160 sg:person.0632134523.42 schema:affiliation https://www.grid.ac/institutes/grid.410607.4
161 schema:familyName Roth
162 schema:givenName Wilfried
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632134523.42
164 rdf:type schema:Person
165 sg:person.0640431223.57 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
166 schema:familyName Muckenhuber
167 schema:givenName Alexander
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640431223.57
169 rdf:type schema:Person
170 sg:person.0642700650.98 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
171 schema:familyName Stenzinger
172 schema:givenName Albrecht
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642700650.98
174 rdf:type schema:Person
175 sg:person.0657434205.21 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
176 schema:familyName Weichert
177 schema:givenName Wilko
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657434205.21
179 rdf:type schema:Person
180 sg:person.0662321427.79 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
181 schema:familyName Mollenhauer
182 schema:givenName Martin
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662321427.79
184 rdf:type schema:Person
185 sg:person.0664756621.35 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
186 schema:familyName Jesinghaus
187 schema:givenName Moritz
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664756621.35
189 rdf:type schema:Person
190 sg:person.0727677465.50 schema:affiliation https://www.grid.ac/institutes/grid.6936.a
191 schema:familyName Steiger
192 schema:givenName Katja
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0727677465.50
194 rdf:type schema:Person
195 sg:pub.10.1038/modpathol.2016.105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003594532
196 https://doi.org/10.1038/modpathol.2016.105
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/modpathol.2016.150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022493987
199 https://doi.org/10.1038/modpathol.2016.150
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/modpathol.2016.220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017465930
202 https://doi.org/10.1038/modpathol.2016.220
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/nature11252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619765
205 https://doi.org/10.1038/nature11252
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/ng.2821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031454446
208 https://doi.org/10.1038/ng.2821
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/nm.3967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014438312
211 https://doi.org/10.1038/nm.3967
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/s41598-017-05451-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091109899
214 https://doi.org/10.1038/s41598-017-05451-5
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1002/(sici)1097-0142(19990701)86:1<14::aid-cncr4>3.0.co;2-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020428292
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1002/1097-0142(19950201)75:3<757::aid-cncr2820750303>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1011687199
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1002/gcc.22330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006023804
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1002/gcc.22352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010794579
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1002/gcc.22378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006479020
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1002/gcc.22480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086118484
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.cell.2012.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005670808
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.cellsig.2013.11.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032143992
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.jmoldx.2013.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015693520
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.prp.2014.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031138961
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.suronc.2015.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021472741
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/s0960-9822(02)00888-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023542752
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s1470-2045(10)70130-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038656599
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1043/2010-0073-ccr.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078294023
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1046/j.1365-2443.1999.00297.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043758467
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1053/j.gastro.2009.12.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030932765
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1093/annonc/mdr464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048800530
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1093/nar/29.1.308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005817660
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1093/nar/gkq603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020792304
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1093/nar/gku1075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035514003
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1097/pas.0000000000000423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036890034
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1097/pas.0b013e31804f7aa1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020111425
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1097/pas.0b013e31817f1816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020591539
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1126/science.8259519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653867
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1200/jco.20.4.1043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064202813
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1371/journal.pone.0065995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015631894
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1373/clinchem.2014.225565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041180465
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1634/theoncologist.2014-0280 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051399369
271 rdf:type schema:CreativeWork
272 https://doi.org/10.18632/oncotarget.12819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015691417
273 rdf:type schema:CreativeWork
274 https://doi.org/10.4161/cc.7.24.7354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072299808
275 rdf:type schema:CreativeWork
276 https://doi.org/10.5858/arpa.2013-0047-oa schema:sameAs https://app.dimensions.ai/details/publication/pub.1009538281
277 rdf:type schema:CreativeWork
278 https://www.grid.ac/institutes/grid.410607.4 schema:alternateName University Medical Center of the Johannes Gutenberg University Mainz
279 schema:name Institute of Pathology, University Hospital Mainz, Mainz, Germany
280 rdf:type schema:Organization
281 https://www.grid.ac/institutes/grid.5253.1 schema:alternateName University Hospital Heidelberg
282 schema:name Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany
283 National Center for Tumor Diseases (NCT), Heidelberg, Germany
284 rdf:type schema:Organization
285 https://www.grid.ac/institutes/grid.6936.a schema:alternateName Technical University Munich
286 schema:name German Cancer Consortium (DKTK), Partner Site Munich, Munich, Germany
287 Institute of Pathology, Technical University of Munich, Munich, Germany
288 rdf:type schema:Organization
289 https://www.grid.ac/institutes/grid.7143.1 schema:alternateName Odense University Hospital
290 schema:name Department of Clinical Pathology, University Hospital Odense, Odense, Denmark
291 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...