Ontology type: schema:ScholarlyArticle Open Access: True
2017-10-06
AUTHORSMasashi Miyaoka, Yara Y Kikuti, Joaquim Carreras, Haruka Ikoma, Shinichiro Hiraiwa, Akifumi Ichiki, Minoru Kojima, Kiyoshi Ando, Tomoyuki Yokose, Rika Sakai, Masahiro Hoshikawa, Naoto Tomita, Ikuo Miura, Katsuyoshi Takata, Tadashi Yoshino, Jun Takizawa, Silvia Bea, Elias Campo, Naoya Nakamura
ABSTRACTMost high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements are aggressive B-cell lymphomas. Occasional double-hit follicular lymphomas have been described but the clinicopathological features of these tumors are not well known. To clarify the characteristics of double-hit follicular lymphomas, we analyzed 10 cases of double-hit follicular lymphomas and 15 cases of high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements for clinicopathological and genome-wide copy-number alterations and copy-neutral loss-of-heterozygosity profiles. For double-hit follicular lymphomas, the median age was 67.5 years (range: 48–82 years). The female/male ratio was 2.3. Eight patients presented with advanced clinical stage. The median follow-up time was 20 months (range: 1–132 months). At the end of the follow-up, 8 patients were alive, 2 patients were dead including 1 patient with diffuse large B-cell lymphoma transformation. Rearrangements of MYC/BCL2, MYC/BCL6, and MYC/BCL2/BCL6 were seen in 8, 1, and 1 cases, respectively. The partner of MYC was IGH in 6 cases. There were no cases of histological grade 1, 4 cases of grade 2, 5 cases of grade 3a, and 1 case of grade 3b. Two cases of grade 3a exhibited immunoblast-like morphology. Immunohistochemistry demonstrated 9 cases with ≥50% MYC-positive cells. There was significant difference in MYC intensity (P=0.00004) and MIB-1 positivity (P=0.001) between double-hit follicular lymphomas and high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements. The genome profile of double-hit follicular lymphomas was comparable with conventional follicular lymphomas (GSE67385, n=198) with characteristic gains of 2p25.3-p11.1, 7p22.3-q36.3, 12q11-q24.33, and loss of 18q21.32-q23 (P<0.05). In comparison with high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements, double-hit follicular lymphomas had fewer copy-number alterations and minimal common region of gain at 2p16.1 (70%), locus also significant against conventional follicular lymphomas (P=0.0001). In summary, double-hit follicular lymphomas tended to be high-grade histology, high MYC protein expression, high MYC/IGH fusion, and minimal common region of gain at 2p16.1. Double-hit follicular lymphomas seemed to be a different disease from high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements and have an indolent clinical behavior similar to follicular lymphomas without MYC rearrangement. More... »
PAGES313-326
http://scigraph.springernature.com/pub.10.1038/modpathol.2017.134
DOIhttp://dx.doi.org/10.1038/modpathol.2017.134
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1092113980
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/28984304
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged, 80 and over",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Rearrangement",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunohistochemistry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphoma, B-Cell",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphoma, Follicular",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Grading",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phenotype",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proto-Oncogene Proteins c-bcl-2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proto-Oncogene Proteins c-bcl-6",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proto-Oncogene Proteins c-myc",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Pathology, Tokai University School of Medicine, Isehara, Japan",
"id": "http://www.grid.ac/institutes/grid.265061.6",
"name": [
"Department of Pathology, Tokai University School of Medicine, Isehara, Japan"
],
"type": "Organization"
},
"familyName": "Miyaoka",
"givenName": "Masashi",
"id": "sg:person.07437371131.34",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07437371131.34"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Tokai University School of Medicine, Isehara, Japan",
"id": "http://www.grid.ac/institutes/grid.265061.6",
"name": [
"Department of Pathology, Tokai University School of Medicine, Isehara, Japan"
],
"type": "Organization"
},
"familyName": "Kikuti",
"givenName": "Yara Y",
"id": "sg:person.01002306606.30",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002306606.30"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Tokai University School of Medicine, Isehara, Japan",
"id": "http://www.grid.ac/institutes/grid.265061.6",
"name": [
"Department of Pathology, Tokai University School of Medicine, Isehara, Japan"
],
"type": "Organization"
},
"familyName": "Carreras",
"givenName": "Joaquim",
"id": "sg:person.011731530264.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011731530264.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Tokai University School of Medicine, Isehara, Japan",
"id": "http://www.grid.ac/institutes/grid.265061.6",
"name": [
"Department of Pathology, Tokai University School of Medicine, Isehara, Japan"
],
"type": "Organization"
},
"familyName": "Ikoma",
"givenName": "Haruka",
"id": "sg:person.013100423735.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013100423735.87"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Tokai University School of Medicine, Isehara, Japan",
"id": "http://www.grid.ac/institutes/grid.265061.6",
"name": [
"Department of Pathology, Tokai University School of Medicine, Isehara, Japan"
],
"type": "Organization"
},
"familyName": "Hiraiwa",
"givenName": "Shinichiro",
"id": "sg:person.0675216004.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675216004.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology/Oncology, Tokai University, School of Medicine, Isehara, Japan",
"id": "http://www.grid.ac/institutes/grid.265061.6",
"name": [
"Department of Hematology/Oncology, Tokai University, School of Medicine, Isehara, Japan"
],
"type": "Organization"
},
"familyName": "Ichiki",
"givenName": "Akifumi",
"id": "sg:person.0704105540.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704105540.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology/Oncology, Tokai University, School of Medicine, Isehara, Japan",
"id": "http://www.grid.ac/institutes/grid.265061.6",
"name": [
"Department of Hematology/Oncology, Tokai University, School of Medicine, Isehara, Japan"
],
"type": "Organization"
},
"familyName": "Kojima",
"givenName": "Minoru",
"id": "sg:person.0626746725.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626746725.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology/Oncology, Tokai University, School of Medicine, Isehara, Japan",
"id": "http://www.grid.ac/institutes/grid.265061.6",
"name": [
"Department of Hematology/Oncology, Tokai University, School of Medicine, Isehara, Japan"
],
"type": "Organization"
},
"familyName": "Ando",
"givenName": "Kiyoshi",
"id": "sg:person.015274442102.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015274442102.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Kanagawa Cancer Center, Yokohama, Japan",
"id": "http://www.grid.ac/institutes/grid.414944.8",
"name": [
"Department of Pathology, Kanagawa Cancer Center, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Yokose",
"givenName": "Tomoyuki",
"id": "sg:person.01064263076.11",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064263076.11"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Medical Oncology, Kanagawa Cancer Center, Yokohama, Japan",
"id": "http://www.grid.ac/institutes/grid.414944.8",
"name": [
"Department of Medical Oncology, Kanagawa Cancer Center, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Sakai",
"givenName": "Rika",
"id": "sg:person.01300452360.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300452360.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, St Marianna University School of Medicine, Kawasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.412764.2",
"name": [
"Department of Pathology, St Marianna University School of Medicine, Kawasaki, Japan"
],
"type": "Organization"
},
"familyName": "Hoshikawa",
"givenName": "Masahiro",
"id": "sg:person.01144352414.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144352414.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Hematology and Oncology, St. Marianna University School of Medicine, Kawasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.412764.2",
"name": [
"Division of Hematology and Oncology, St. Marianna University School of Medicine, Kawasaki, Japan"
],
"type": "Organization"
},
"familyName": "Tomita",
"givenName": "Naoto",
"id": "sg:person.01155656464.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155656464.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Hematology and Oncology, St. Marianna University School of Medicine, Kawasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.412764.2",
"name": [
"Division of Hematology and Oncology, St. Marianna University School of Medicine, Kawasaki, Japan"
],
"type": "Organization"
},
"familyName": "Miura",
"givenName": "Ikuo",
"id": "sg:person.01053556252.90",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053556252.90"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan",
"id": "http://www.grid.ac/institutes/grid.261356.5",
"name": [
"Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"
],
"type": "Organization"
},
"familyName": "Takata",
"givenName": "Katsuyoshi",
"id": "sg:person.0613773427.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613773427.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan",
"id": "http://www.grid.ac/institutes/grid.261356.5",
"name": [
"Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan"
],
"type": "Organization"
},
"familyName": "Yoshino",
"givenName": "Tadashi",
"id": "sg:person.01343240627.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343240627.22"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine, Niigata, Japan",
"id": "http://www.grid.ac/institutes/grid.260975.f",
"name": [
"Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine, Niigata, Japan"
],
"type": "Organization"
},
"familyName": "Takizawa",
"givenName": "Jun",
"id": "sg:person.01131736101.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131736101.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology and Hematopathology Unit, Hospital Clinic Barcelona, Molecular Pathology Laboratory, Institut d\u2019Investigacions Biomediques August Pi i Sunyer (IDIBAPS), CIBER de Cancer (CIBERONIC), University of Barcelona, Barcelona, Spain",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Pathology and Hematopathology Unit, Hospital Clinic Barcelona, Molecular Pathology Laboratory, Institut d\u2019Investigacions Biomediques August Pi i Sunyer (IDIBAPS), CIBER de Cancer (CIBERONIC), University of Barcelona, Barcelona, Spain"
],
"type": "Organization"
},
"familyName": "Bea",
"givenName": "Silvia",
"id": "sg:person.01151521472.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151521472.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology and Hematopathology Unit, Hospital Clinic Barcelona, Molecular Pathology Laboratory, Institut d\u2019Investigacions Biomediques August Pi i Sunyer (IDIBAPS), CIBER de Cancer (CIBERONIC), University of Barcelona, Barcelona, Spain",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Pathology and Hematopathology Unit, Hospital Clinic Barcelona, Molecular Pathology Laboratory, Institut d\u2019Investigacions Biomediques August Pi i Sunyer (IDIBAPS), CIBER de Cancer (CIBERONIC), University of Barcelona, Barcelona, Spain"
],
"type": "Organization"
},
"familyName": "Campo",
"givenName": "Elias",
"id": "sg:person.0640427171.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640427171.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Pathology, Tokai University School of Medicine, Isehara, Japan",
"id": "http://www.grid.ac/institutes/grid.265061.6",
"name": [
"Department of Pathology, Tokai University School of Medicine, Isehara, Japan"
],
"type": "Organization"
},
"familyName": "Nakamura",
"givenName": "Naoya",
"id": "sg:person.01055064002.85",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055064002.85"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/modpathol.3800500",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002858158",
"https://doi.org/10.1038/modpathol.3800500"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/modpathol.2015.85",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043960689",
"https://doi.org/10.1038/modpathol.2015.85"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/leu.2012.246",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011613327",
"https://doi.org/10.1038/leu.2012.246"
],
"type": "CreativeWork"
}
],
"datePublished": "2017-10-06",
"datePublishedReg": "2017-10-06",
"description": "Most high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements are aggressive B-cell lymphomas. Occasional double-hit follicular lymphomas have been described but the clinicopathological features of these tumors are not well known. To clarify the characteristics of double-hit follicular lymphomas, we analyzed 10 cases of double-hit follicular lymphomas and 15 cases of high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements for clinicopathological and genome-wide copy-number alterations and copy-neutral loss-of-heterozygosity profiles. For double-hit follicular lymphomas, the median age was 67.5 years (range: 48\u201382 years). The female/male ratio was 2.3. Eight patients presented with advanced clinical stage. The median follow-up time was 20 months (range: 1\u2013132 months). At the end of the follow-up, 8 patients were alive, 2 patients were dead including 1 patient with diffuse large B-cell lymphoma transformation. Rearrangements of MYC/BCL2, MYC/BCL6, and MYC/BCL2/BCL6 were seen in 8, 1, and 1 cases, respectively. The partner of MYC was IGH in 6 cases. There were no cases of histological grade 1, 4 cases of grade 2, 5 cases of grade 3a, and 1 case of grade 3b. Two cases of grade 3a exhibited immunoblast-like morphology. Immunohistochemistry demonstrated 9 cases with \u226550% MYC-positive cells. There was significant difference in MYC intensity (P=0.00004) and MIB-1 positivity (P=0.001) between double-hit follicular lymphomas and high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements. The genome profile of double-hit follicular lymphomas was comparable with conventional follicular lymphomas (GSE67385, n=198) with characteristic gains of 2p25.3-p11.1, 7p22.3-q36.3, 12q11-q24.33, and loss of 18q21.32-q23 (P<0.05). In comparison with high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements, double-hit follicular lymphomas had fewer copy-number alterations and minimal common region of gain at 2p16.1 (70%), locus also significant against conventional follicular lymphomas (P=0.0001). In summary, double-hit follicular lymphomas tended to be high-grade histology, high MYC protein expression, high MYC/IGH fusion, and minimal common region of gain at 2p16.1. Double-hit follicular lymphomas seemed to be a different disease from high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements and have an indolent clinical behavior similar to follicular lymphomas without MYC rearrangement.",
"genre": "article",
"id": "sg:pub.10.1038/modpathol.2017.134",
"inLanguage": "en",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.6142413",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1098208",
"issn": [
"0893-3952",
"1530-0285"
],
"name": "Modern Pathology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "31"
}
],
"keywords": [
"conventional follicular lymphomas",
"cell lymphoma",
"follicular lymphoma",
"BCL6 rearrangements",
"grade 3A",
"copy number alterations",
"minimal common region",
"cell lymphoma transformation",
"MYC/BCL6",
"BCL2/BCL6",
"advanced clinical stage",
"high-grade histology",
"indolent clinical behavior",
"MYC/BCL2",
"MYC/IGH fusion",
"histological grade 1",
"MIB-1 positivity",
"high MYC protein expression",
"genome-wide copy number alterations",
"median follow",
"median age",
"MYC protein expression",
"clinicopathological features",
"clinical stage",
"grade 3b",
"clinical behavior",
"lymphoma transformation",
"myc-positive cells",
"male ratio",
"lymphoma",
"grade 2",
"patients",
"MYC rearrangement",
"grade 1",
"copy-neutral loss",
"protein expression",
"heterozygosity (LOH) profiles",
"IGH fusion",
"BCL2",
"different diseases",
"significant differences",
"common region",
"Myc",
"BCL6",
"alterations",
"genome profiles",
"cases",
"immunohistochemistry",
"tumors",
"follow",
"histology",
"disease",
"months",
"positivity",
"age",
"characteristic gain",
"partner of MYC",
"loss",
"IgH",
"diffuse",
"cells",
"profile",
"expression",
"years",
"genomic analysis",
"differences",
"gain",
"rearrangement",
"summary",
"comparison",
"stage",
"partners",
"fusion",
"region",
"ratio",
"time",
"end",
"analysis",
"features",
"characteristics",
"loci",
"intensity",
"morphology",
"behavior",
"transformation"
],
"name": "Clinicopathological and genomic analysis of double-hit follicular lymphoma: comparison with high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements",
"pagination": "313-326",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1092113980"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/modpathol.2017.134"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"28984304"
]
}
],
"sameAs": [
"https://doi.org/10.1038/modpathol.2017.134",
"https://app.dimensions.ai/details/publication/pub.1092113980"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:33",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_749.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/modpathol.2017.134"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2017.134'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2017.134'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2017.134'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/modpathol.2017.134'
This table displays all metadata directly associated to this object as RDF triples.
368 TRIPLES
22 PREDICATES
129 URIs
118 LITERALS
22 BLANK NODES