Ontology type: schema:ScholarlyArticle Open Access: True
2016-05
AUTHORSMorgan Cowan, Simeon Springer, Doreen Nguyen, Diana Taheri, Gunes Guner, Maria Angelica Mendoza Rodriguez, Yuxuan Wang, Isaac Kinde, Christopher J VandenBussche, Matthew T Olson, Isabela Cunha, Kazutoshi Fujita, Dilek Ertoy, Trinity J Bivalacqua, Kenneth Kinzler, Bert Vogelstein, George J Netto, Nickolas Papadopoulos
ABSTRACTTERT promoter mutations (TERT-mut) are detectable in the majority of urothelial carcinomas. The detection of TERT-mut in urine is under investigation as a potential urine-based molecular-screening assay for bladder cancer. A small but significant number of bladder carcinomas are pure squamous cell carcinoma. We sought to assess the incidence of TERT-mut in squamous cell carcinoma of the urinary bladder. A retrospective search of the institutional pathology archives yielded 15 cystectomy specimens performed for squamous cell carcinoma (2000-2014). Histologic slides were reviewed by a senior urologic pathologist to confirm the diagnosis and select a representative formalin-fixed paraffin-embedded tissue block for mutational analysis. All cases yielded adequate material for DNA analysis. Sequencing for TERT-mut was performed using previously described SafeSeq technique. We detected TERT-mut in 12/15 (80%) of bladder squamous cell carcinomas. TERT promoter mutations, commonly found in conventional urothelial carcinoma, are also highly prevalent in urinary bladder squamous cell carcinoma suggesting a common tumorigenesis and potential utility as a molecular urine-based-screening assay. More... »
PAGES511-515
http://scigraph.springernature.com/pub.10.1038/modpathol.2016.53
DOIhttp://dx.doi.org/10.1038/modpathol.2016.53
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326 TRIPLES
21 PREDICATES
64 URIs
34 LITERALS
22 BLANK NODES